Alzheimer DiseaseFIND-ADNCT06033066
Financial Incentives and Recruitment to the APT Webstudy
A study testing Financial Incentives and Message in people with Alzheimer Disease and Dementia, run by University of Southern California at 1 site in United States.
Trial summary
This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. Read more about this study
- Who is it for?
- Ages 50 years and olderHealthy volunteers can take part
- Conditions the study is for
- Alzheimer Disease, Dementia, Preclinical Alzheimer's Disease
- What is being tested?
- Financial Incentives and Message
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44,844 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Mar 2024to 30 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- To be eligible to participate in this study, an individual must meet all of the following criteria:
- Patients empaneled at Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers.
- Age 50 or older
- Literate in either English or Spanish
Who cannot join
- Below age 50
- Documentation of prior dementia diagnosis
Trial locations and contacts
1 site in 1 country.
United States1 site
Contra Costa Health Plan
Martinez, California, 94553
About this study
Official title: A Randomized Trial of Financial Incentives for the Recruitment of County Health System Patients to the Alzheimer Prevention Trials (APT) Webstudy
This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpose of the current study is to test whether we can increase enrollment of diverse individuals into the registry. To do this, we will work with Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers in Contra Costa County, California, to test whether sending messages with and without financial incentives to patients who receive primary care with the health system can increase enrollment to the APT Webstudy. The investigators hypothesize that 1) a certain small financial incentive and an award opportunity based incentive (or a drawing with a prize) will increase enrollment rates of CCHS members into the APT Webstudy relative to the control group. The investigators further hypothesize that the award opportunity incentive will increase the enrollment rate of CCRMC patients into the APT Webstudy more than a certain financial incentive with the same expected value.
- Conditions
- Alzheimer Disease, Dementia, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease
- Being tested
- Financial Incentives, Message
- Keywords
- Alzheimer's, Prevention, Observational, Trial-Ready Cohort
- Medical subject headings
- Alzheimer Disease, Dementia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Financial IncentivesBehavioural
Small financial incentive or prize incentive
MessageBehavioural
Message inviting participant to enroll
| Study group | Role | What they receive |
|---|---|---|
| Messaging Only | Active comparator | 16,000 participants will be randomized to Arm 1 where no monetary incentive is offered. Receives: Behavioral: Message |
| Small Incentive | Experimental | 16,000 participants will be randomized to Arm 2 where a small one-time monetary incentive is offered. Receives: Behavioral: Financial Incentives |
| Prize Incentive | Experimental | 16,000 participants will be randomized to Arm 3 where an opportunity based incentive (or a drawing with a prize) with a single winner will be offered. Receives: Behavioral: Financial Incentives |
What is being measured
The primary outcome is the main question the study is designed to answer.
Enrollment status into the APT Webstudy
APT Webstudy enrollment rate based on completion of at least one of the two APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery).
Measured: 2-weeks
Secondary outcomes (2)
Cost per enrollee
Cost to acquire an enrollment
Measured: annual
Completion of cognitive assessments within the APT Webstudy
Completion of both APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery).
Measured: 2-weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Sep 2023
- Study start1 Mar 2024
- Primary completion30 Apr 2024
- Study completion30 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Alzheimer DiseaseStudies of the same condition, open and under way.
- More trials run by University of Southern CaliforniaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 44,844 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Southern California
- Sponsor type
- University, hospital or other
- Collaborators
- American Heart Association, Schaeffer Center for Health Policy & Economics, Alzheimer's Therapeutic Research Institute
- Responsible party
- Principal investigator, Mireille Jacobson, University of Southern California
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06033066
- Sponsor's protocol ID
- UP-22-01037
- Acronym
- FIND-AD
- Status last verified
- Dec 2023
- First submitted
- 9 Aug 2023
- Last updated
- 25 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The health system will not allow sharing of individual data on a public site. However, we will share data on request from investigators.
Publications
Jacobson M, Molina-Henry D, Chang TY, Jimenez-Maggiora GA, Pramanik R, Shah SB, Aisen PS. Financial Incentives to Increase Diversity of Older Participants in a Memory Concerns Registry: A Randomized Clinical Trial. JAMA Health Forum. 2025 Aug 1;6(8):e252273. doi: 10.1001/jamahealthforum.2025.2273.
PubMed 40844772
Study at a glance
From the registry record, last updated by the sponsor on 25 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Trial of Financial Incentives for the Recruitment of County Health System Patients to the Alzheimer Prevention Trials (APT) Webstudy
- ClinicalTrials.gov ID
- NCT06033066
- Acronym / sponsor ID
- FIND-AD / UP-22-01037
- Conditions
- Alzheimer Disease, Dementia, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease
- Keywords
- Alzheimer's, Prevention, Observational, Trial-Ready Cohort
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44,844 participants (actual)
- Lead sponsor
- University of Southern CaliforniaUniversity, hospital or other
- Collaborators
- American Heart Association, Schaeffer Center for Health Policy & Economics, Alzheimer's Therapeutic Research Institute
- Study start
- 1 Mar 2024 (actual)
- Primary completion
- 30 Apr 2024 (actual)
- Study completion
- 30 Apr 2024 (actual)
- First posted
- 13 Sep 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpose of the current study is to test whether we can increase enrollment of diverse individuals into the registry. To do this, we will work with Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers in Contra Costa County, California, to test whether sending messages with and without financial incentives to patients who receive primary care with the health system can increase enrollment to the APT Webstudy. The investigators hypothesize that 1) a certain small financial incentive and an award opportunity based incentive (or a drawing with a prize) will increase enrollment rates of CCHS members into the APT Webstudy relative to the control group. The investigators further hypothesize that the award opportunity incentive will increase the enrollment rate of CCRMC patients into the APT Webstudy more than a certain financial incentive with the same expected value.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Messaging Only | Active comparator | Behavioral: Message16,000 participants will be randomized to Arm 1 where no monetary incentive is offered. |
| Small Incentive | Experimental | Behavioral: Financial Incentives16,000 participants will be randomized to Arm 2 where a small one-time monetary incentive is offered. |
| Prize Incentive | Experimental | Behavioral: Financial Incentives16,000 participants will be randomized to Arm 3 where an opportunity based incentive (or a drawing with a prize) with a single winner will be offered. |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- To be eligible to participate in this study, an individual must meet all of the following criteria:
- Patients empaneled at Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers.
- Age 50 or older
- Literate in either English or Spanish
Key exclusion criteria (2 listed)
- Below age 50
- Documentation of prior dementia diagnosis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Financial IncentivesSmall financial incentive or prize incentive | Behavioural | Prize Incentive, Small Incentive |
| MessageMessage inviting participant to enroll | Behavioural | Messaging Only |
Primary outcome
Enrollment status into the APT Webstudy
Time frame: 2-weeks
APT Webstudy enrollment rate based on completion of at least one of the two APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery).
2 secondary outcomes
Cost per enrollee
Time frame: annual
Completion of cognitive assessments within the APT Webstudy
Time frame: 2-weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Jun 2025.
- Derived from this study: PubMed 40844772Jacobson M, Molina-Henry D, Chang TY, Jimenez-Maggiora GA, Pramanik R, Shah SB, Aisen PS. Financial Incentives to Increase Diversity of Older Participants in a Memory Concerns Registry: A Randomized Clinical Trial. JAMA Health Forum. 2025 Aug 1;6(8):e252273. doi: 10.1001/jamahealthforum.2025.2273.
- APT WebstudyLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. The health system will not allow sharing of individual data on a public site. However, we will share data on request from investigators.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Financial Incentives and Message in people with Alzheimer Disease and Dementia, run by University of Southern California at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Enrollment status into the APT Webstudy (time frame: 2-weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06033066, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Jun 2025.