HealthyBIONEXNCT06041087
Bone and Inflammatory Outcomes - Nutrition and Exercise Trials
A study testing High-Intensity Exercise, Carbohydrate (Maltodextrin powder mixed with water) and Skim Milk in people with Healthy and Bone, run by York University at 1 site in Canada.
Trial summary
This study investigates whether dairy products will positively impact loading exercise-induced bone turnover and bone cell activity and/or the post-exercise inflammatory response in healthy young adults compared to a carbohydrate drink and/or water. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy, Bone, Inflammation
- What is being tested?
- High-Intensity Exercise, Carbohydrate (Maltodextrin powder mixed with water) and Skim Milk
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 20 participants
- Where
- 1 siteCanada
- Study dates
- 1 Nov 2023to 1 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Between the ages of 18-30 years
- Normal BMI (18.5-24.9) kg/m^2
- Low to moderately physically active (0-2 times/week)
- No allergy to dairy protein or lactose intolerance
- On no medication related to a chronic condition
- On birth control or naturally cycling with a regular menstrual cycle)
Who cannot join
- Regular smoker (cigarettes, e-cigarettes (e.g., vapes) or cannabis)
- Any chronic condition, inflammatory, or auto-immune condition
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Dairy Supplementation and the Post-Exercise Bone and Inflammatory Response
This study investigates whether dairy products will positively impact loading exercise-induced bone turnover and bone cell activity and/or the post-exercise inflammatory response in healthy young adults compared to a carbohydrate drink and/or water.
Read the detailed description
Introduction: Two million individuals at a cost of around 4.6 billion dollars a year in Canada suffer from osteoporosis. It is important to investigate strategies that can reduce bone loss and/or increase bone mass. Similarly, inflammation is associated with many different disease states, and investigating strategies to reduce systemic inflammation is prudent. Nutrition and exercise may be inexpensive and accessible strategies to improve bone health and inflammation and should be explored in different contexts and implemented. Our proposed research combines both nutrition and exercise along with the assessment of bone turnover and inflammatory markers in healthy young adults.
Design: Randomized controlled crossover trial
Participants: Healthy, university aged males and females.
Methods: During the study participants will complete 4 different acute exercise and nutritional supplement trials, in random order. The four trials are: 1) exercise+carbohydrate (CHO), 2) exercise+milk (Milk), 3) exercise+Greek yogurt (GY), and 4) exercise+water (W). The whole study will take a maximum of 16 weeks and each supplement trial will be separated by 2-4 weeks.
Outcomes: several markers of bone turnover and bone cell activity as well as markers of inflammation will be measured in the blood, before exercise and at different times post-exercise and post supplement consumption.
- Conditions
- Healthy, Bone, Inflammation
- Being tested
- High-Intensity Exercise, Carbohydrate (Maltodextrin powder mixed with water), Skim Milk, Greek yogurt, Water
- Keywords
- Bone health, Females, Dairy, Exercise, Inflammation
- Medical subject headings
- Inflammation, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-Intensity ExerciseBehavioural
A single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial.
Carbohydrate (Maltodextrin powder mixed with water)Dietary supplement
Also called CHO
50g consumed immediately after exercise and 1h after exercise.
Skim MilkDietary supplement
Also called Milk
500ml consumed immediately after exercise and 1h after exercise.
Greek yogurtDietary supplement
Also called GY
200g consumed immediately after exercise and 1h after exercise.
WaterDietary supplement
Also called W
500ml consumed immediately after exercise and 1h after exercise.
| Study group | Role | What they receive |
|---|---|---|
| Exercise and Greek Yogurt (GY) | Experimental | Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~200g Greek yogurt (0% milk fat). An additional blood sample will be taken at 1h post-exercise, followed by an additional ~200g of Greek yogurt. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. Receives: Behavioral: High-Intensity Exercise; Dietary Supplement: Greek yogurt |
| Exercise and Milk (Milk) | Experimental | Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~500ml plain skim milk (0% milk fat). An additional blood sample will be taken at 1h post-exercise, followed by an additional ~500ml of skim milk. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. Receives: Behavioral: High-Intensity Exercise; Dietary Supplement: Skim Milk |
| Exercise and Carbohydrate (CHO) | Active comparator | Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~50g of maltodextrin mixed with water (~500ml). An additional blood sample will be taken at 1h post-exercise, followed by an additional ~500ml of the maltodextrin drink. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. Receives: Behavioral: High-Intensity Exercise; Dietary Supplement: Carbohydrate (Maltodextrin powder mixed with water) |
| Exercise and Water (W) | Placebo comparator | Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~500ml water. An additional blood sample will be taken at 1h post-exercise, followed by an additional ~500ml water. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. Receives: Behavioral: High-Intensity Exercise; Dietary Supplement: Water |
What is being measured
The primary outcome is the main question the study is designed to answer.
Acute Bone Turnover/Cell Activity
OPG measured in serum/plasma
Measured: Pre-exercise
Acute Bone Turnover/Cell Activity
RANKL measured in serum/plasma
Measured: Pre-exercise
Acute Bone Turnover/Cell Activity
OC measured in serum/plasma
Measured: Pre-exercise
Acute Bone Turnover/Cell Activity
SOST measured in serum/plasma
Measured: Pre-exercise
Acute Bone Turnover/Cell Activity
CTX measured in serum/plasma
Measured: Pre-exercise
Acute Bone Turnover/Cell Activity
OPG measured in serum/plasma
Measured: 5 minutes post-exercise
Acute Bone Turnover/Cell Activity
RANKL measured in serum/plasma
Measured: 5 minutes post-exercise
Acute Bone Turnover/Cell Activity
OC measured in serum/plasma
Measured: 5 minutes post-exercise
Acute Bone Turnover/Cell Activity
SOST measured in serum/plasma
Measured: 5 minutes post-exercise
Acute Bone Turnover/Cell Activity
CTX measured in serum/plasma
Measured: 5 minutes post-exercise
Acute Bone Turnover/Cell Activity
OPG measured in serum/plasma
Measured: 1 hour post-exercise
Acute Bone Turnover/Cell Activity
RANKL measured in serum/plasma
Measured: 1 hour post-exercise
Acute Bone Turnover/Cell Activity
OC measured in serum/plasma
Measured: 1 hour post-exercise
Acute Bone Turnover/Cell Activity
SOST measured in serum/plasma
Measured: 1 hour post-exercise
Acute Bone Turnover/Cell Activity
CTX measured in serum/plasma
Measured: 1 hour post-exercise
Acute Bone Turnover/Cell Activity
OPG measured in serum/plasma
Measured: 4 hours post-exercise
Acute Bone Turnover/Cell Activity
RANKL measured in serum/plasma
Measured: 4 hours post-exercise
Acute Bone Turnover/Cell Activity
OC measured in serum/plasma
Measured: 4 hours post-exercise
Acute Bone Turnover/Cell Activity
SOST measured in serum/plasma
Measured: 4 hours post-exercise
Acute Bone Turnover/Cell Activity
CTX measured in serum/plasma
Measured: 4 hours post-exercise
Acute Bone Turnover/Cell Activity
OPG measured in serum/plasma
Measured: 24 hours post-exercise
Acute Bone Turnover/Cell Activity
RANKL measured in serum/plasma
Measured: 24 hours post-exercise
Acute Bone Turnover/Cell Activity
OC measured in serum/plasma
Measured: 24 hours post-exercise
Acute Bone Turnover/Cell Activity
SOST measured in serum/plasma
Measured: 24 hours post-exercise
Acute Bone Turnover/Cell Activity
CTX measured in serum/plasma
Measured: 24 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
TNF-alpha measured in serum/plasma.
Measured: Pre-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-6 measured in serum/plasma.
Measured: Pre-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-1B measured in serum/plasma.
Measured: Pre-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-10 measured in serum/plasma.
Measured: Pre-exercise
Systemic Inflammation - Serum/Plasma Cytokines
TNF-alpha measured in serum/plasma.
Measured: 5 minutes post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-6 measured in serum/plasma.
Measured: 5 minutes post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-1B measured in serum/plasma.
Measured: 5 minutes post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-10 measured in serum/plasma.
Measured: 5 minutes post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
TNF-alpha measured in serum/plasma.
Measured: 1 hour post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-6 measured in serum/plasma.
Measured: 1 hour post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-1B measured in serum/plasma.
Measured: 1 hour post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-10 measured in serum/plasma.
Measured: 1 hour post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
TNF-alpha measured in serum/plasma.
Measured: 4 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-6 measured in serum/plasma.
Measured: 4 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-1B measured in serum/plasma.
Measured: 4 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-10 measured in serum/plasma.
Measured: 4 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
TNF-alpha measured in serum/plasma.
Measured: 24 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-6 measured in serum/plasma.
Measured: 24 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-1B measured in serum/plasma.
Measured: 24 hours post-exercise
Systemic Inflammation - Serum/Plasma Cytokines
IL-10 measured in serum/plasma.
Measured: 24 hours post-exercise
Systemic inflammation - Immune Cells
Leukocytes measured via flow cytometry
Measured: Pre-exercise
Systemic inflammation - Immune Cells
Leukocytes measured via flow cytometry
Measured: 1 hour post-exercise
Systemic inflammation - Immune Cells
Leukocytes measured via flow cytometry
Measured: 4 hours post-exercise
Systemic inflammation - Immune Cells
Leukocytes measured via flow cytometry
Measured: 24 hours post-exercise
Secondary outcomes (8)
Muscle soreness
Muscle soreness rated on a 0-5 scale.
Measured: Pre-exercise
Muscle soreness
Muscle soreness rated on a 0-5 scale.
Measured: 5 minutes post-exercise
Muscle soreness
Muscle soreness rated on a 0-5 scale.
Measured: 4 hours post-exercise
Muscle soreness
Muscle soreness rated on a 0-5 scale.
Measured: 24 hours post-exercise
Performance - Jump Height
Vertical jump height measured using a counter movement jump technique.
Measured: Pre-exercise
Performance - Jump Height
Vertical jump height measured using a counter movement jump technique.
Measured: 5 minutes post-exercise
Performance - Jump Height
Vertical jump height measured using a counter movement jump technique.
Measured: 4 hours post-exercise
Performance - Jump Height
Vertical jump height measured using a counter movement jump technique.
Measured: 24 hours post-exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Sep 2023
- Study start1 Nov 2023
- Primary completion30 Apr 2025
- Study completion1 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- York University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Andrea Josse, York University
- Investigators
- Andrea R Josse, PhD, Principal investigator, York University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06041087
- Sponsor's protocol ID
- 2019-045b
- Acronym
- BIONEX
- Status last verified
- Jan 2026
- First submitted
- 25 Aug 2023
- Last updated
- 16 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dairy Supplementation and the Post-Exercise Bone and Inflammatory Response
- ClinicalTrials.gov ID
- NCT06041087
- Acronym / sponsor ID
- BIONEX / 2019-045b
- Conditions
- Healthy, Bone, Inflammation
- Keywords
- Bone health, Females, Dairy, Exercise, Inflammation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- York UniversityUniversity, hospital or other
- Study start
- 1 Nov 2023 (actual)
- Primary completion
- 30 Apr 2025 (actual)
- Study completion
- 1 Sep 2025 (actual)
- First posted
- 18 Sep 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates whether dairy products will positively impact loading exercise-induced bone turnover and bone cell activity and/or the post-exercise inflammatory response in healthy young adults compared to a carbohydrate drink and/or water.
Detailed description
Introduction: Two million individuals at a cost of around 4.6 billion dollars a year in Canada suffer from osteoporosis. It is important to investigate strategies that can reduce bone loss and/or increase bone mass. Similarly, inflammation is associated with many different disease states, and investigating strategies to reduce systemic inflammation is prudent. Nutrition and exercise may be inexpensive and accessible strategies to improve bone health and inflammation and should be explored in different contexts and implemented. Our proposed research combines both nutrition and exercise along with the assessment of bone turnover and inflammatory markers in healthy young adults.
Design: Randomized controlled crossover trial
Participants: Healthy, university aged males and females.
Methods: During the study participants will complete 4 different acute exercise and nutritional supplement trials, in random order. The four trials are: 1) exercise+carbohydrate (CHO), 2) exercise+milk (Milk), 3) exercise+Greek yogurt (GY), and 4) exercise+water (W). The whole study will take a maximum of 16 weeks and each supplement trial will be separated by 2-4 weeks.
Outcomes: several markers of bone turnover and bone cell activity as well as markers of inflammation will be measured in the blood, before exercise and at different times post-exercise and post supplement consumption.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Exercise and Greek Yogurt (GY) | Experimental | Behavioral: High-Intensity Exercise, Dietary Supplement: Greek yogurtParticipants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~200g Greek yogurt (0% milk fat). An additional blood sample will be taken at 1h post-exercise, followed by an additional ~200g of Greek yogurt. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. |
| Exercise and Milk (Milk) | Experimental | Behavioral: High-Intensity Exercise, Dietary Supplement: Skim MilkParticipants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~500ml plain skim milk (0% milk fat). An additional blood sample will be taken at 1h post-exercise, followed by an additional ~500ml of skim milk. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. |
| Exercise and Carbohydrate (CHO) | Active comparator | Behavioral: High-Intensity Exercise, Dietary Supplement: Carbohydrate (Maltodextrin powder mixed with water)Participants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~50g of maltodextrin mixed with water (~500ml). An additional blood sample will be taken at 1h post-exercise, followed by an additional ~500ml of the maltodextrin drink. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. |
| Exercise and Water (W) | Placebo comparator | Behavioral: High-Intensity Exercise, Dietary Supplement: WaterParticipants will have a fasted baseline blood sample taken upon arrival to the lab. Then they will take part in a high-intensity exercise protocol, consisting of high-intensity interval cycling, resistance exercise, and plyometrics. Following exercise, participants will return to the lab for a 5min post-exercise blood sample, and then consume ~500ml water. An additional blood sample will be taken at 1h post-exercise, followed by an additional ~500ml water. Blood samples will also be taken at 4h and 24h post-exercise. Participants will also rate their muscle soreness and perform a jump height test at pre-exercise, 5min post-exercise, 4h and 24h post-exercise. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Between the ages of 18-30 years
- Normal BMI (18.5-24.9) kg/m^2
- Low to moderately physically active (0-2 times/week)
- No allergy to dairy protein or lactose intolerance
- On no medication related to a chronic condition
Key exclusion criteria (2 listed)
- Regular smoker (cigarettes, e-cigarettes (e.g., vapes) or cannabis)
- Any chronic condition, inflammatory, or auto-immune condition
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-Intensity ExerciseA single bout of high-intensity exercise (cycling intervals, resistance exercise, plyometrics) per trial. | Behavioural | Exercise and Carbohydrate (CHO), Exercise and Greek Yogurt (GY), Exercise and Milk (Milk), Exercise and Water (W) |
| Carbohydrate (Maltodextrin powder mixed with water)Also: CHO50g consumed immediately after exercise and 1h after exercise. | Dietary supplement | Exercise and Carbohydrate (CHO) |
| Skim MilkAlso: Milk500ml consumed immediately after exercise and 1h after exercise. | Dietary supplement | Exercise and Milk (Milk) |
| Greek yogurtAlso: GY200g consumed immediately after exercise and 1h after exercise. | Dietary supplement | Exercise and Greek Yogurt (GY) |
| WaterAlso: W500ml consumed immediately after exercise and 1h after exercise. | Dietary supplement | Exercise and Water (W) |
Primary outcome
Acute Bone Turnover/Cell Activity
Time frame: Pre-exercise
OPG measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: Pre-exercise
RANKL measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: Pre-exercise
OC measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: Pre-exercise
SOST measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: Pre-exercise
CTX measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 5 minutes post-exercise
OPG measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 5 minutes post-exercise
RANKL measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 5 minutes post-exercise
OC measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 5 minutes post-exercise
SOST measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 5 minutes post-exercise
CTX measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 1 hour post-exercise
OPG measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 1 hour post-exercise
RANKL measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 1 hour post-exercise
OC measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 1 hour post-exercise
SOST measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 1 hour post-exercise
CTX measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 4 hours post-exercise
OPG measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 4 hours post-exercise
RANKL measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 4 hours post-exercise
OC measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 4 hours post-exercise
SOST measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 4 hours post-exercise
CTX measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 24 hours post-exercise
OPG measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 24 hours post-exercise
RANKL measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 24 hours post-exercise
OC measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 24 hours post-exercise
SOST measured in serum/plasma
Acute Bone Turnover/Cell Activity
Time frame: 24 hours post-exercise
CTX measured in serum/plasma
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: Pre-exercise
TNF-alpha measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: Pre-exercise
IL-6 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: Pre-exercise
IL-1B measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: Pre-exercise
IL-10 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 5 minutes post-exercise
TNF-alpha measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 5 minutes post-exercise
IL-6 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 5 minutes post-exercise
IL-1B measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 5 minutes post-exercise
IL-10 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 1 hour post-exercise
TNF-alpha measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 1 hour post-exercise
IL-6 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 1 hour post-exercise
IL-1B measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 1 hour post-exercise
IL-10 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 4 hours post-exercise
TNF-alpha measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 4 hours post-exercise
IL-6 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 4 hours post-exercise
IL-1B measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 4 hours post-exercise
IL-10 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 24 hours post-exercise
TNF-alpha measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 24 hours post-exercise
IL-6 measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 24 hours post-exercise
IL-1B measured in serum/plasma.
Systemic Inflammation - Serum/Plasma Cytokines
Time frame: 24 hours post-exercise
IL-10 measured in serum/plasma.
Systemic inflammation - Immune Cells
Time frame: Pre-exercise
Leukocytes measured via flow cytometry
Systemic inflammation - Immune Cells
Time frame: 1 hour post-exercise
Leukocytes measured via flow cytometry
Systemic inflammation - Immune Cells
Time frame: 4 hours post-exercise
Leukocytes measured via flow cytometry
Systemic inflammation - Immune Cells
Time frame: 24 hours post-exercise
Leukocytes measured via flow cytometry
8 secondary outcomes
Muscle soreness
Time frame: Pre-exercise
Muscle soreness
Time frame: 5 minutes post-exercise
Muscle soreness
Time frame: 4 hours post-exercise
Muscle soreness
Time frame: 24 hours post-exercise
Performance - Jump Height
Time frame: Pre-exercise
Performance - Jump Height
Time frame: 5 minutes post-exercise
Performance - Jump Height
Time frame: 4 hours post-exercise
Performance - Jump Height
Time frame: 24 hours post-exercise
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Andrea R Josse, PhD principal investigator
York University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-Intensity Exercise, Carbohydrate (Maltodextrin powder mixed with water) and Skim Milk in people with Healthy and Bone, run by York University at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Acute Bone Turnover/Cell Activity (time frame: Pre-exercise). The study lists 49 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jan 2026.