High Intensity Interval TrainingETRecNCT06043492
Recovery Following Acute Endurance Training
A study testing High Intensity Interval Training and Coninuous Running in people with High Intensity Interval Training and Continuous Running, run by University of Thessaly at 1 site in Greece.
Trial summary
Aerobic capacity is critical for many athletes, especially for endurance athletes. Althgough several training methods are implemented by coaches to improve endurance performance, recovery following acute endurance training is not adequately studied. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- High Intensity Interval Training, Continuous Running, Control Condition
- What is being tested?
- High Intensity Interval Training and Coninuous Running
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteGreece
- Study dates
- 30 Sep 2023to 15 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Middle- and long-distance runners
- Absence of musculoskeletal injuries (≥ 6 months)
- No use of drugs or ergogenic supplements (≥ 1 month)
- Absense from eccentric exercise (≥ 3 days)
- No alcohol or ergogenic drinks consumption before each training protocol
Who cannot join
- Musculoskeletal injury (< 6 months)
- Use of drugs or ergogenic supplements (< 1 month)
- Participation in eccentric exercise (< 3 days)
- Alcohol or ergogenic drinks consumption before the training protocol
Trial locations and contacts
1 site in 1 country.
Greece1 site
Department of Physical Education and Sport Science, Uninersity of Thessaly
Trikala, Thessaly, 42100
About this study
Official title: Recovery Following Different Endurance Training Protocols in Middle- and Long-Distance Runners
Aerobic capacity is critical for many athletes, especially for endurance athletes. Althgough several training methods are implemented by coaches to improve endurance performance, recovery following acute endurance training is not adequately studied. However, such information is crucial for coaches to effectively design the most favorable training program, to avoid muscle injuries and overtraining, and ultimately to improve performance of their athletes. This study aims to examine the acute effect of different continuous and HIIT training protocols on indices of metabolism, EIMD, neuromuscular fatigue and performance in middle- and long-distance runners.
Read the detailed description
Aerobic capacity is critical for many athletes, especially for endurance athletes. Endurance training leads to cardiopulmonary and musculoskeletal adaptations, which in turn lead to improvement of endurance performance. Several training methods have been established for the improvement of aerobic capacity and performance, including long distance and low speed training, and high intensity interval training (HIIT). Training methods are used depending on the kind of endurance that aim to improve, and the specific characteristics and energy demands of the event. Especially regarding middle- and long-distance runners, the energy comes mainly from the oxidative system, however, the contribution of the glycolytic pathway is equally important. Thus, improvement mainly of the low-intensity endurance, but also high-intensity endurance is important for these athletes. Additionally, both continuous endurance and HIIT are effective training methods for improving cardiorespiratory and metabolic function, and athletic performance, while evidence also exists in favor of HIIT being more effective. Thus both training methods are used by coaches to improve aerobic capacity and performance of their athletes.
Coaches should be careful regarding the frequency of HIIT training during a microcycle, to provide adequate recovery between training sessions to avoid muscle injuries and overtraining. Existing evidence suggests that endurance exercise (continuous or HIIT) may result in exercise-induced muscle damage (EIMD), inflammatory responses, oxidative stress, and performance deterioration, yet, the timeframe of recovery of physiological and biochemical indices following different endurance training protocols has not been adequately studied. However, such information is crucial for coaches to effectively design the most favorable training program for their athletes.
This study aims to examine the acute effect of different continuous and HIIT training protocols on indices of metabolism, EIMD, neuromuscular fatigue and performance in middle- and long-distance runners.
According to a preliminary power analysis (a probability error of 0.05, and a statistical power of 80%), a sample size of 8 subjects per group was considered appropriate in order to detect statistically meaningful changes between groups. Thus, 10 men and female middle- and long-distance runners, will participate in the study.
The study will be performed in a randomized, cross over, repeated measures design. During their first 1st and 2nd visit, all participants will sign an informed consent form after they will be informed about all the benefits and risks of the study and they will fill in and sign a medical history questionnaire. Fasting blood samples will be collected in order to estimate muscle damage concentration markers. Participants will be instructed by a dietitian how to record a 7-days diet recalls to ensure that they do not consume to greater extent nutrients that may affect EIMD and fatigue (e.g. antioxidants, amino acids, etc.) and to ensure that the energy intake during the trials will be the same. Assessment of body mass and body height, body composition, and aerobic capacity (VO2max), will be performed. Using a photocells system, countermovement jump will be performed to assess jump height, and 30 sec Bosco test to assess mean jump height, peak power, mean power, and fatigue index. The peak concentric, eccentric and isometric isokinetic torque of the knee flexors and extensors, in both limbs will be evaluated on an isokinetic dynamometer at 60°/sec. Maximal voluntary isometric contraction (MVIC) of the knee extensors at 65o in both limbs, as well as the fatigue rate during MVIC through the percent drop of peak torque between the first and the last three seconds of a 10-sec MVIC, will also be evaluated. Afterwards, participants will be randomly assigned into, and perform one of the three different conditions of the study design: a) Continuous running (CT) for 40 min at lactic threshold, b) High intensity interval training (HIIT): 10x2min running at vVO2max with active recovery at 40% της VO2max (interval:recovery 1:1) with a load of 10% of body weight (BW), and c) control condition, no training (measurements only). The training protocols will be matched for mean power and total duration (Tschakert and Hofmann 2013). Prior and immediately after each experimental trial, delayed onset of muscle soreness (DOMS) in the knee flexors (KF) and extensors (KE) of both limbs, as well as blood lactate will be assessed. Additionally, DOMS of KF and KE, peak concentric, eccentric and isometric isokinetic torque, CMJ height, as well as mean jump height, peak power, mean power, and fatigue index during a 30 sec Bosco test, will be assessed 24h, 48h and 72h after the end of the trial. MVIC of the knee extensors of both limbs, as well as the fatigue rate during MVIC will also be assessed at 1h, 2h and 3h, as well as 24h, 48h, and 72h after the end of the trial. Creatine kinase will be assessed at 24h, 48h, and 72h after the end of the trial. The exact above procedures will be repeated by the participants during the remaining two experimental trials. A 2-weeks wash-out period will be implemented between trials.
- Being tested
- High Intensity Interval Training, Coninuous Running, Control Trial
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High Intensity Interval TrainingOther
10 x 2 min running at vVO2max, interspersed by 2 min recovery at 40% VO2max
Coninuous RunningOther
40 min continuous running at lactate threshold
Control TrialOther
The participants will perform only the baseline and post acute-training evaluations, without performing exercise
| Study group | Role | What they receive |
|---|---|---|
| High Intensity Interval Training | Experimental | The participants will perform an acute bout of high intensity interval training Receives: Other: High Intensity Interval Training |
| Coninuous Running | Experimental | The participants will perform an acute bout of continuous running Receives: Other: Coninuous Running |
| Control Trial | Other | The participants will not perform any endurance exercise protocol Receives: Other: Control Trial |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in Creatine kinase (CK)
CK will be measured in plasma using a Clinical Chemistry Analyzer with commercially available kits.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in DOMS
DOMS of knee extensors and knee flexors of both lower extremities will be measured during palpation of the muscle belly and the distal region after performing three repetitions of a full squat.
Measured: Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in blood lactate
Lactate will be measured in capillary blood with a hand-portable analyzer.
Measured: Baseline (pre), 4 minutes post-trial
Changes in squat jump height
Squat jump height will be measured with a photocells system.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in mean jump height during a 30 sec Bosco test
Mean jump height will be measured with a photocells system.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in peak power during a 30 sec Bosco test
Peak power will be measured with a photocells system.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in mean power during a 30 sec Bosco test
Mean power will be measured with a photocells system.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in fatigue rate during a 30 sec Bosco test
Fatigue rate will be estimated through the persent drop in mean jump height between the first 5 jumps and the last 5 jumps.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in maximal voluntary isometric contraction (MVIC)
MVIC of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.
Measured: Baseline (pre), 1 hour post-, 2 hours post-, 3 hours post-, 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in peak concentric torque
Concentric torque of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Changes in peak eccentric torque
Eccentric torque of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Secondary outcomes (7)
Body weight
Body weight will be measured on a beam balance with stadiometer.
Measured: Baseline
Body height
Body height will be measured on a beam balance with stadiometer.
Measured: Baseline
Body mass index (BMI)
BMI will be calculated from the ratio of body mass/ body height squared.
Measured: Baseline
Body fat
Body fat will be measured by using Dual-emission X-ray absorptiometry.
Measured: Baseline
Lean body mass
Lean body mass will be measured by using Dual-emission X-ray absorptiometry.
Measured: Baseline
Dietary intake
Dietary intake will be assessed using 7-day diet recalls.
Measured: Baseline
Maximal oxygen consumption (VO2max)
VO2max will be measured by open circuit spirometry via breath by breath method during a graded treadmill running protocol.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Sep 2023
- Study start30 Sep 2023
- Primary completion15 Dec 2023
- Study completion15 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for High Intensity Interval TrainingStudies of the same condition, open and under way.
- More trials run by University of ThessalyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- The same participants will participate in three different conditions
- Masking
- None (open label)
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Thessaly
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Chariklia K. Deli, University of Thessaly
- Investigators
- Chariklia K Deli, PhD, Principal investigator, University of Thessaly
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06043492
- Sponsor's protocol ID
- Endurance Training - Recovery
- Acronym
- ETRec
- Status last verified
- Jan 2024
- First submitted
- 17 Sep 2023
- Last updated
- 23 Jan 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Barnes KR, Kilding AE. Strategies to improve running economy. Sports Med. 2015 Jan;45(1):37-56. doi: 10.1007/s40279-014-0246-y.
PubMed 25164465Brandao LHA, Chagas TPN, Vasconcelos ABS, de Oliveira VC, Fortes LS, de Almeida MB, Mendes Netto RS, Del-Vecchio FB, Neto EP, Chaves LMS, Jimenez-Pavon D, Da Silva-Grigoletto ME. Physiological and Performance Impacts After Field Supramaximal High-Intensity Interval Training With Different Work-Recovery Duration. Front Physiol. 2020 Oct 8;11:1075. doi: 10.3389/fphys.2020.01075. eCollection 2020.
PubMed 33162893Cipryan L. IL-6, Antioxidant Capacity and Muscle Damage Markers Following High-Intensity Interval Training Protocols. J Hum Kinet. 2017 Mar 15;56:139-148. doi: 10.1515/hukin-2017-0031. eCollection 2017 Feb.
PubMed 28469752Esfarjani F, Laursen PB. Manipulating high-intensity interval training: effects on VO2max, the lactate threshold and 3000 m running performance in moderately trained males. J Sci Med Sport. 2007 Feb;10(1):27-35. doi: 10.1016/j.jsams.2006.05.014. Epub 2006 Jul 28.
PubMed 16876479Hottenrott K, Ludyga S, Schulze S. Effects of high intensity training and continuous endurance training on aerobic capacity and body composition in recreationally active runners. J Sports Sci Med. 2012 Sep 1;11(3):483-8. eCollection 2012.
PubMed 24149357Martinez-Ferran M, Cuadrado-Penafiel V, Sanchez-Andreo JM, Villar-Lucas M, Castellanos-Montealegre M, Rubio-Martin A, Romero-Morales C, Casla-Barrio S, Pareja-Galeano H. Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial. Nutrients. 2022 Nov 3;14(21):4635. doi: 10.3390/nu14214635.
PubMed 36364898
Study at a glance
From the registry record, last updated by the sponsor on 23 Jan 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Recovery Following Different Endurance Training Protocols in Middle- and Long-Distance Runners
- ClinicalTrials.gov ID
- NCT06043492
- Acronym / sponsor ID
- ETRec / Endurance Training - Recovery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- University of ThessalyUniversity, hospital or other
- Study start
- 30 Sep 2023 (actual)
- Primary completion
- 15 Dec 2023 (actual)
- Study completion
- 15 Dec 2023 (actual)
- First posted
- 21 Sep 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aerobic capacity is critical for many athletes, especially for endurance athletes. Althgough several training methods are implemented by coaches to improve endurance performance, recovery following acute endurance training is not adequately studied. However, such information is crucial for coaches to effectively design the most favorable training program, to avoid muscle injuries and overtraining, and ultimately to improve performance of their athletes. This study aims to examine the acute effect of different continuous and HIIT training protocols on indices of metabolism, EIMD, neuromuscular fatigue and performance in middle- and long-distance runners.
Detailed description
Aerobic capacity is critical for many athletes, especially for endurance athletes. Endurance training leads to cardiopulmonary and musculoskeletal adaptations, which in turn lead to improvement of endurance performance. Several training methods have been established for the improvement of aerobic capacity and performance, including long distance and low speed training, and high intensity interval training (HIIT). Training methods are used depending on the kind of endurance that aim to improve, and the specific characteristics and energy demands of the event. Especially regarding middle- and long-distance runners, the energy comes mainly from the oxidative system, however, the contribution of the glycolytic pathway is equally important. Thus, improvement mainly of the low-intensity endurance, but also high-intensity endurance is important for these athletes. Additionally, both continuous endurance and HIIT are effective training methods for improving cardiorespiratory and metabolic function, and athletic performance, while evidence also exists in favor of HIIT being more effective. Thus both training methods are used by coaches to improve aerobic capacity and performance of their athletes.
Coaches should be careful regarding the frequency of HIIT training during a microcycle, to provide adequate recovery between training sessions to avoid muscle injuries and overtraining. Existing evidence suggests that endurance exercise (continuous or HIIT) may result in exercise-induced muscle damage (EIMD), inflammatory responses, oxidative stress, and performance deterioration, yet, the timeframe of recovery of physiological and biochemical indices following different endurance training protocols has not been adequately studied. However, such information is crucial for coaches to effectively design the most favorable training program for their athletes.
This study aims to examine the acute effect of different continuous and HIIT training protocols on indices of metabolism, EIMD, neuromuscular fatigue and performance in middle- and long-distance runners.
According to a preliminary power analysis (a probability error of 0.05, and a statistical power of 80%), a sample size of 8 subjects per group was considered appropriate in order to detect statistically meaningful changes between groups. Thus, 10 men and female middle- and long-distance runners, will participate in the study.
The study will be performed in a randomized, cross over, repeated measures design. During their first 1st and 2nd visit, all participants will sign an informed consent form after they will be informed about all the benefits and risks of the study and they will fill in and sign a medical history questionnaire. Fasting blood samples will be collected in order to estimate muscle damage concentration markers. Participants will be instructed by a dietitian how to record a 7-days diet recalls to ensure that they do not consume to greater extent nutrients that may affect EIMD and fatigue (e.g. antioxidants, amino acids, etc.) and to ensure that the energy intake during the trials will be the same. Assessment of body mass and body height, body composition, and aerobic capacity (VO2max), will be performed. Using a photocells system, countermovement jump will be performed to assess jump height, and 30 sec Bosco test to assess mean jump height, peak power, mean power, and fatigue index. The peak concentric, eccentric and isometric isokinetic torque of the knee flexors and extensors, in both limbs will be evaluated on an isokinetic dynamometer at 60°/sec. Maximal voluntary isometric contraction (MVIC) of the knee extensors at 65o in both limbs, as well as the fatigue rate during MVIC through the percent drop of peak torque between the first and the last three seconds of a 10-sec MVIC, will also be evaluated. Afterwards, participants will be randomly assigned into, and perform one of the three different conditions of the study design: a) Continuous running (CT) for 40 min at lactic threshold, b) High intensity interval training (HIIT): 10x2min running at vVO2max with active recovery at 40% της VO2max (interval:recovery 1:1) with a load of 10% of body weight (BW), and c) control condition, no training (measurements only). The training protocols will be matched for mean power and total duration (Tschakert and Hofmann 2013). Prior and immediately after each experimental trial, delayed onset of muscle soreness (DOMS) in the knee flexors (KF) and extensors (KE) of both limbs, as well as blood lactate will be assessed. Additionally, DOMS of KF and KE, peak concentric, eccentric and isometric isokinetic torque, CMJ height, as well as mean jump height, peak power, mean power, and fatigue index during a 30 sec Bosco test, will be assessed 24h, 48h and 72h after the end of the trial. MVIC of the knee extensors of both limbs, as well as the fatigue rate during MVIC will also be assessed at 1h, 2h and 3h, as well as 24h, 48h, and 72h after the end of the trial. Creatine kinase will be assessed at 24h, 48h, and 72h after the end of the trial. The exact above procedures will be repeated by the participants during the remaining two experimental trials. A 2-weeks wash-out period will be implemented between trials.
Study design
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- The same participants will participate in three different conditions
| Arm | Type | Receives |
|---|---|---|
| High Intensity Interval Training | Experimental | Other: High Intensity Interval TrainingThe participants will perform an acute bout of high intensity interval training |
| Coninuous Running | Experimental | Other: Coninuous RunningThe participants will perform an acute bout of continuous running |
| Control Trial | Other | Other: Control TrialThe participants will not perform any endurance exercise protocol |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Middle- and long-distance runners
- Absence of musculoskeletal injuries (≥ 6 months)
- No use of drugs or ergogenic supplements (≥ 1 month)
- Absense from eccentric exercise (≥ 3 days)
- No alcohol or ergogenic drinks consumption before each training protocol
Key exclusion criteria (4 listed)
- Musculoskeletal injury (< 6 months)
- Use of drugs or ergogenic supplements (< 1 month)
- Participation in eccentric exercise (< 3 days)
- Alcohol or ergogenic drinks consumption before the training protocol
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High Intensity Interval Training10 x 2 min running at vVO2max, interspersed by 2 min recovery at 40% VO2max | Other | High Intensity Interval Training |
| Coninuous Running40 min continuous running at lactate threshold | Other | Coninuous Running |
| Control TrialThe participants will perform only the baseline and post acute-training evaluations, without performing exercise | Other | Control Trial |
Primary outcome
Changes in Creatine kinase (CK)
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
CK will be measured in plasma using a Clinical Chemistry Analyzer with commercially available kits.
Changes in DOMS
Time frame: Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours post-trial
DOMS of knee extensors and knee flexors of both lower extremities will be measured during palpation of the muscle belly and the distal region after performing three repetitions of a full squat.
Changes in blood lactate
Time frame: Baseline (pre), 4 minutes post-trial
Lactate will be measured in capillary blood with a hand-portable analyzer.
Changes in squat jump height
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Squat jump height will be measured with a photocells system.
Changes in mean jump height during a 30 sec Bosco test
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Mean jump height will be measured with a photocells system.
Changes in peak power during a 30 sec Bosco test
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Peak power will be measured with a photocells system.
Changes in mean power during a 30 sec Bosco test
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Mean power will be measured with a photocells system.
Changes in fatigue rate during a 30 sec Bosco test
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Fatigue rate will be estimated through the persent drop in mean jump height between the first 5 jumps and the last 5 jumps.
Changes in maximal voluntary isometric contraction (MVIC)
Time frame: Baseline (pre), 1 hour post-, 2 hours post-, 3 hours post-, 24 hours post-, 48 hours post-, 72 hours post-trial
MVIC of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.
Changes in peak concentric torque
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Concentric torque of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.
Changes in peak eccentric torque
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial
Eccentric torque of the knee extensors and knee flexors will be measured on an isokinetic dynamometer.
7 secondary outcomes
Body weight
Time frame: Baseline
Body height
Time frame: Baseline
Body mass index (BMI)
Time frame: Baseline
Body fat
Time frame: Baseline
Lean body mass
Time frame: Baseline
Dietary intake
Time frame: Baseline
Maximal oxygen consumption (VO2max)
Time frame: Baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jan 2024.
- Background: PubMed 25164465Barnes KR, Kilding AE. Strategies to improve running economy. Sports Med. 2015 Jan;45(1):37-56. doi: 10.1007/s40279-014-0246-y.
- Background: PubMed 33162893Brandao LHA, Chagas TPN, Vasconcelos ABS, de Oliveira VC, Fortes LS, de Almeida MB, Mendes Netto RS, Del-Vecchio FB, Neto EP, Chaves LMS, Jimenez-Pavon D, Da Silva-Grigoletto ME. Physiological and Performance Impacts After Field Supramaximal High-Intensity Interval Training With Different Work-Recovery Duration. Front Physiol. 2020 Oct 8;11:1075. doi: 10.3389/fphys.2020.01075. eCollection 2020.
- Background: PubMed 28469752Cipryan L. IL-6, Antioxidant Capacity and Muscle Damage Markers Following High-Intensity Interval Training Protocols. J Hum Kinet. 2017 Mar 15;56:139-148. doi: 10.1515/hukin-2017-0031. eCollection 2017 Feb.
- Background: PubMed 16876479Esfarjani F, Laursen PB. Manipulating high-intensity interval training: effects on VO2max, the lactate threshold and 3000 m running performance in moderately trained males. J Sci Med Sport. 2007 Feb;10(1):27-35. doi: 10.1016/j.jsams.2006.05.014. Epub 2006 Jul 28.
- Background: PubMed 24149357Hottenrott K, Ludyga S, Schulze S. Effects of high intensity training and continuous endurance training on aerobic capacity and body composition in recreationally active runners. J Sports Sci Med. 2012 Sep 1;11(3):483-8. eCollection 2012.
- Background: PubMed 36364898Martinez-Ferran M, Cuadrado-Penafiel V, Sanchez-Andreo JM, Villar-Lucas M, Castellanos-Montealegre M, Rubio-Martin A, Romero-Morales C, Casla-Barrio S, Pareja-Galeano H. Effects of Acute Vitamin C plus Vitamin E Supplementation on Exercise-Induced Muscle Damage in Runners: A Double-Blind Randomized Controlled Trial. Nutrients. 2022 Nov 3;14(21):4635. doi: 10.3390/nu14214635.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Chariklia K Deli, PhD principal investigator
University of Thessaly
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High Intensity Interval Training and Coninuous Running in people with High Intensity Interval Training and Continuous Running, run by University of Thessaly at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jan 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in Creatine kinase (CK) (time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-trial). The study lists 11 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06043492, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jan 2024.