HealthyPAN-PrometNCT06045611
The Effect of Oral Intake of Animal and Plant Proteins on the Metabolism in Healthy Women
A study testing Isolated Pea Protein, Isolated Whey Protein and Isolated Faba Bean Protein in people with Healthy, run by Örebro University, Sweden at 1 site in Sweden.
Trial summary
The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control. The main questions the study aims to answer are: 1. Read more about this study
- Who is it for?
- Ages 18 to 45 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Isolated Pea Protein, Isolated Whey Protein and Isolated Faba Bean Protein
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 28 participants
- Where
- 1 siteSweden
- Study dates
- 13 Oct 2023to 24 Oct 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Females
- Age: 18-45 years
- Body mass index: 18.5 < 25 kg/m2
- Signed informed consent
Who cannot join
- Use of hormonal contraceptives
- Pregnancy or breastfeeding
- Diabetes mellitus or any other metabolic disease that might affect the results of this study
- Gastric surgery that affects digestion and uptake of protein
- Any clinically significant present or past disease/condition and medication which in the investigator's opinion could interfere with the results of the trial
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Oral Ingestion of Animal and Plant-based Proteins on the Somatotropic Axis
The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control.
The main questions the study aims to answer are:
Read more
- How do different proteins affect biological markers of the metabolism and which protein has the strongest effect?
- How are the different proteins digested and taken up from our body?
Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.
- Conditions
- Healthy
- Being tested
- Isolated Pea Protein, Isolated Whey Protein, Isolated Faba Bean Protein, Placebo
- Keywords
- Protein, Plant-based protein, Metabolism, Somatotrophic Axis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Isolated Pea ProteinDietary supplement
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Isolated Whey ProteinDietary supplement
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
Isolated Faba Bean ProteinDietary supplement
Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.
PlaceboDietary supplement
Participants will consume the placebo in an opaque mug wearing a nose clip.
| Study group | Role | What they receive |
|---|---|---|
| Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo | Experimental | * Study day 1: 0.6g isolated pea protein/kg/body weight + 400 ml water
* Study day 2: 0.6g isolated whey protein/kg/body weight + 400 ml water
* Study day 3: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
* Study day 4: 400 ml water
The fat and energy content of the drinks will be adapted using a plant based oil Receives: Dietary Supplement: Isolated Pea Protein; Dietary Supplement: Isolated Whey Protein; Dietary Supplement: Isolated Faba Bean Protein; Dietary Supplement: Placebo |
| Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein | Experimental | * Study day 1: 0.6g isolated whey protein/kg/body weight + 400 ml water
* Study day 2: 400 ml water
* Study day 3: 0.6g isolated pea protein/kg/body weight + 400 ml water
* Study day 4: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
The fat and energy content of the drinks will be adapted using a plant based oil Receives: Dietary Supplement: Isolated Pea Protein; Dietary Supplement: Isolated Whey Protein; Dietary Supplement: Isolated Faba Bean Protein; Dietary Supplement: Placebo |
| Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein | Experimental | * Study day 1: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
* Study day 2: 0.6g isolated pea protein/kg/body weight + 400 ml water
* Study day 3: 400 ml water
* Study day 4: 0.6g isolated whey protein/kg/body weight + 400 ml water
The fat and energy content of the drinks will be adapted using a plant based oil Receives: Dietary Supplement: Isolated Pea Protein; Dietary Supplement: Isolated Whey Protein; Dietary Supplement: Isolated Faba Bean Protein; Dietary Supplement: Placebo |
| Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein | Experimental | * Study day 1: 400 ml water
* Study day 2: 0.6g isolated faba bean protein/kg/body weight + 400 ml water
* Study day 3: 0.6g isolated whey protein/kg/body weight + 400 ml water
* Study day 4: 0.6g isolated pea protein/kg/body weight + 400 ml water
The fat and energy content of the drinks will be adapted using a plant based oil Receives: Dietary Supplement: Isolated Pea Protein; Dietary Supplement: Isolated Whey Protein; Dietary Supplement: Isolated Faba Bean Protein; Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Release of Growth Hormone
The primary outcome is defined as the postprandial release of growth hormone during three hours after oral ingestion of plant-protein test drinks vs. an animal-protein test drink measured as incremental area under the curve. Growth hormone will be measured in blood samples.
Measured: 0-3 hours after consumption of test drink (on all 4 study days)
Secondary outcomes (2)
Release of Hormones Related to the Somatotrophic Axis
We will measure different hormones related to the somatotrophin axis in collected blood samples and investigate if there are differences between different protein-sources.
Measured: 0-3 hours after consumption of test drink (on all 4 study days)
Kinetics of Amino Acid Uptake
We will measure amino acids in collected blood samples to investigate dynamics and kinetics of protein digestion/uptake of different protein sources.
Measured: 0-3 hours after consumption of test drink (on all 4 study days)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Sep 2023
- Study start13 Oct 2023
- Primary completion24 Oct 2024
- Study completion24 Oct 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Örebro University, Sweden
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06045611
- Sponsor's protocol ID
- Dnr 2023-03852-01
- Acronym
- PAN-Promet
- Status last verified
- Jun 2026
- First submitted
- 13 Sep 2023
- Last updated
- 23 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 23 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Oral Ingestion of Animal and Plant-based Proteins on the Somatotropic Axis
- ClinicalTrials.gov ID
- NCT06045611
- Acronym / sponsor ID
- PAN-Promet / Dnr 2023-03852-01
- Conditions
- Healthy
- Keywords
- Protein, Plant-based protein, Metabolism, Somatotrophic Axis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Örebro University, SwedenUniversity, hospital or other
- Study start
- 13 Oct 2023 (actual)
- Primary completion
- 24 Oct 2024 (actual)
- Study completion
- 24 Oct 2024 (actual)
- First posted
- 21 Sep 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control.
The main questions the study aims to answer are:
- How do different proteins affect biological markers of the metabolism and which protein has the strongest effect?
- How are the different proteins digested and taken up from our body?
Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo | Experimental | Dietary Supplement: Isolated Pea Protein, Dietary Supplement: Isolated Whey Protein, Dietary Supplement: Isolated Faba Bean Protein, Dietary Supplement: Placebo* Study day 1: 0.6g isolated pea protein/kg/body weight + 400 ml water * Study day 2: 0.6g isolated whey protein/kg/body weight + 400 ml water * Study day 3: 0.6g isolated faba bean protein/kg/body weight + 400 ml water * Study day 4: 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil |
| Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein | Experimental | Dietary Supplement: Isolated Pea Protein, Dietary Supplement: Isolated Whey Protein, Dietary Supplement: Isolated Faba Bean Protein, Dietary Supplement: Placebo* Study day 1: 0.6g isolated whey protein/kg/body weight + 400 ml water * Study day 2: 400 ml water * Study day 3: 0.6g isolated pea protein/kg/body weight + 400 ml water * Study day 4: 0.6g isolated faba bean protein/kg/body weight + 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil |
| Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein | Experimental | Dietary Supplement: Isolated Pea Protein, Dietary Supplement: Isolated Whey Protein, Dietary Supplement: Isolated Faba Bean Protein, Dietary Supplement: Placebo* Study day 1: 0.6g isolated faba bean protein/kg/body weight + 400 ml water * Study day 2: 0.6g isolated pea protein/kg/body weight + 400 ml water * Study day 3: 400 ml water * Study day 4: 0.6g isolated whey protein/kg/body weight + 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil |
| Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein | Experimental | Dietary Supplement: Isolated Pea Protein, Dietary Supplement: Isolated Whey Protein, Dietary Supplement: Isolated Faba Bean Protein, Dietary Supplement: Placebo* Study day 1: 400 ml water * Study day 2: 0.6g isolated faba bean protein/kg/body weight + 400 ml water * Study day 3: 0.6g isolated whey protein/kg/body weight + 400 ml water * Study day 4: 0.6g isolated pea protein/kg/body weight + 400 ml water The fat and energy content of the drinks will be adapted using a plant based oil |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Females
- Age: 18-45 years
- Body mass index: 18.5 < 25 kg/m2
- Signed informed consent
Key exclusion criteria (5 listed)
- Use of hormonal contraceptives
- Pregnancy or breastfeeding
- Diabetes mellitus or any other metabolic disease that might affect the results of this study
- Gastric surgery that affects digestion and uptake of protein
- Any clinically significant present or past disease/condition and medication which in the investigator's opinion could interfere with the results of the trial
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Isolated Pea ProteinParticipants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip. | Dietary supplement | Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein, Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo, Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein, Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein |
| Isolated Whey ProteinParticipants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip. | Dietary supplement | Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein, Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo, Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein, Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein |
| Isolated Faba Bean ProteinParticipants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip. | Dietary supplement | Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein, Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo, Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein, Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein |
| PlaceboParticipants will consume the placebo in an opaque mug wearing a nose clip. | Dietary supplement | Isolated Faba Bean Protein/Isolated Pea Protein/Placebo/Isolated Whey Protein, Isolated Pea Protein/Isolated Whey Protein/Isolated Faba Bean Protein/Placebo, Isolated Whey Protein/Placebo/Isolated Pea Protein/Isolated Faba Bean Protein, Placebo/Isolated Faba Bean Protein/Isolated Whey Protein/Isolated Pea Protein |
Primary outcome
Release of Growth Hormone
Time frame: 0-3 hours after consumption of test drink (on all 4 study days)
The primary outcome is defined as the postprandial release of growth hormone during three hours after oral ingestion of plant-protein test drinks vs. an animal-protein test drink measured as incremental area under the curve. Growth hormone will be measured in blood samples.
2 secondary outcomes
Release of Hormones Related to the Somatotrophic Axis
Time frame: 0-3 hours after consumption of test drink (on all 4 study days)
Kinetics of Amino Acid Uptake
Time frame: 0-3 hours after consumption of test drink (on all 4 study days)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jun 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Healthy
Recruiting
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
Brain Mapping, Healthy Volunteer
Enrolling by invitationObservational study
Connors Protocol for the Management and Use of Stored Human Specimens (Stored Human Specimens)
Healthy Volunteer Samples
Recruiting
Developing a Support Application for Food Pantries (SAFPAS) to Improve Client Access to Healthy Foods & Enhance Emergency Preparedness
Improving Healthy Food Access in Food Insecurity Populations in Normal and Emergency Situations
Not yet recruitingObservational study
Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers
Healthy
Recruiting
Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial
Healthy Volunteer
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Isolated Pea Protein, Isolated Whey Protein and Isolated Faba Bean Protein in people with Healthy, run by Örebro University, Sweden at 1 site in Sweden.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Release of Growth Hormone (time frame: 0-3 hours after consumption of test drink (on all 4 study days)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jun 2026; AzTrials last refreshed its copy on 8 Nov 2026.