HealthyNCT06053125
A Study of Adipose Tissue in Adaptive Responses to Exercise
A study testing Adipose Tissue Biopsy and Exercise in people with Healthy and Obesity, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity. Read more about this study
- Who is it for?
- Ages 18 to 85 yearsHealthy volunteers can take part
- What is being tested?
- Adipose Tissue Biopsy and Exercise
- Type of treatment
- Surgery or procedure, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 56 participants
- Where
- 1 siteUnited States
- Study dates
- 9 Nov 2023to Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults between the ages of 18-35 OR 65-85.
- BMI 18.5 kg/m2 - 40 kg/m2
- Weight stable (≥ 3 months)
- Generally healthy
Who cannot join
- Participation in ≥ 30 minutes of structured physical activity ≥ 2 days per week.
- Smoking/tobacco use.
- Alcohol/substance abuse.
- Pregnancy and breastfeeding.
- Anemia.
- Abnormal renal function.
Show all 13Show fewer
- Blood clotting disorders.
- Coronary artery disease.
- Uncontrolled thyroid disease.
- Liver disease.
- Use of medications known to influence the main outcomes of the study.
- Orthopedic problems that may be aggravated by exercise.
- Chronic disease at the discretion of the investigators.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Role of Adipose Tissue in Adaptive Responses to Exercise
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
Read the detailed description
Adipose tissue has important endocrine functions that influence metabolic health. Early evidence shows that adipose adapts to physiological stress, including exercise. The objective here is to determine how exercise-induced alterations in adipose tissue cellular composition and endocrine signaling may contribute to the beneficial adaptations to exercise in aging and obesity.
Immune cell populations and inflammatory signatures will be assessed in subcutaneous abdominal adipose tissue biopsies collected from obese and normal weight young and older adults before, immediately after, and 3 hours after a 30-min bout of cycling exercise at 70% of maximal oxygen consumption (VO2max). Mass spectrometry, Olink targeted inflammation assays, and RNA sequencing will be used for full proteomic and transcriptomic characterization of the adipose tissue secretome (the proteins and molecules secreted from the adipose tissue) and the cargo of extracellular vesicles isolated from plasma and media collected from cultured human adipose tissue explants generated from each time point.
Overall, the primary hypothesis of the proposed work is that a single bout of exercise triggers transient changes in adipose tissue paracrine/endocrine signals and immune cellular composition. The investigators propose that these responses contribute to the beneficial effects of exercise locally and in distal tissues and that the cumulative effects of acute changes in adipose tissue likely contribute to the positive alterations in adipose tissue associated with exercise training.
- Being tested
- Adipose Tissue Biopsy, Exercise
- Keywords
- exercise, adipose, cytokines
- Medical subject headings
- Obesity, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Adipose Tissue BiopsyProcedure or surgery
Fat sample collected from abdomen before exercise, immediately after exercise, and 3 hours after exercise
ExerciseBehavioural
30 minutes of exercise on a cycle ergometer exercise machine
| Study group | Role | What they receive |
|---|---|---|
| Older adults with obesity | Experimental | Participants with obesity as determined by the principal investigator and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. Receives: Procedure: Adipose Tissue Biopsy; Behavioral: Exercise |
| Older adults without obesity | Experimental | Participants with obesity as determined by the principal investigator and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. Receives: Procedure: Adipose Tissue Biopsy; Behavioral: Exercise |
| Young adults with obesity | Experimental | Participants with obesity as determined by the principal investigator and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. Receives: Procedure: Adipose Tissue Biopsy; Behavioral: Exercise |
| Young adults without obesity | Experimental | Participants with obesity as determined by the principal investigator and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. Receives: Procedure: Adipose Tissue Biopsy; Behavioral: Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Adipose lymphocyte populations
The numbers of lymphocytes in the adipose tissue will be assessed by flow cytometry.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
IL6 secreted from adipose tissue measured using the Olink Target Inflammation Panel (includes 96 inflammation-associated proteins)
The concentration of 96 IL6 will be measured using the targeted inflammation Olink proximity extension assay panel in media obtained from cultured adipose tissue explants. Adipose tissue samples will be cultured for 3 hours, and the culture media will be removed for the assessment of secreted inflammatory proteins. T
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue macrophage populations
Numbers of macrophages in the adipose tissue will be assessed by immunohistochemistry.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of interleukin (IL)-6 measured by polymerase chain reaction (PCR).
Gene expression of the inflammatory cytokine IL-6 will be measured in adipose tissue samples using real time (RT)-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of interleukin (IL)-8 measured by PCR.
Gene expression of the inflammatory cytokine IL-8 will be assessed in adipose tissue samples using real-time (RT)-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of cluster of differentiation 68 (CD68) measured by PCR.
Gene expression of the macrophage marker CD68 be assessed in adipose tissue samples using real time (RT)-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of cluster of differentiation 163 (CD163) measured by PCR.
Gene expression of the anti-inflammatory macrophage marker CD163 will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of cluster of differentiation 206 (CD206) measured by PCR.
Gene expression of the anti-inflammatory macrophage marker CD206 will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of adhesion G-protein coupled receptor E (ADGRE) measured by PCR.
Gene expression of the macrophage marker ADGRE will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of inducible nitric oxide synthase (INOS) measured by PCR.
Gene expression of the pro-inflammatory macrophage marker INOS will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of monocyte chemoattractant protein-1 (MCP1) measured by PCR.
Gene expression of the inflammatory cytokine MCP1 will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of tumor necrosis factor alpha (TNFa) measured by PCR.
Gene expression of the inflammatory cytokine TNFa will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of leptin (LEPD) measured by PCR.
Gene expression of the pro-inflammatory adipokine LEPD will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue gene expression of adiponectin (ADIPOQ) measured by PCR.
Gene expression of the anti-inflammatory adipokine ADIPOQ will be assessed in adipose tissue samples using RT-PCR.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Inflammatory proteins found in adipose tissue measured using the Olink Target Inflammation Panel (includes 96 inflammation-associated proteins)
The concentrations of 96 different inflammatory proteins (including various cytokines and adipokines) will be measured in adipose tissue lysates using the targeted inflammation Olink proximity extension assay panel. This assay measures all 96 proteins in a single assay and all are reported as normalized protein expression values.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Protein cargo of adipose extracellular vesicles measured using mass spectrometry
Adipose tissue samples will be cultured for 3 hours, and the culture media will be removed. From this media, extracellular vesicles will be isolated. In these extracellular vesicles, mass spectrometry will be performed to examine the entire proteome (all proteins) contained within these extracellular vesicles. Using the large number of proteins identified, the investigators will examine changes in categories of protein types (e.g., inflammatory proteins, metabolic proteins, transcriptional proteins).
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Secondary outcomes (3)
Adipocyte cell size
Adipocyte cell size will be determined using methylene blue staining and microscopy.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Plasma IL6 concentrations measured using the Olink Target Inflammation Panel
The concentration of IL6 will be measured in plasma samples using the targeted inflammation Olink proximity extension assay panel. This assay measures 96 proteins in a single assay and all are reported as normalized protein expression values.
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Protein cargo of plasma extracellular vesicles measured using mass spectrometry extracellular vesicles
Extracellular vesicles will be isolated from plasma samples. In these extracellular vesicles, mass spectrometry will be performed to examine the entire proteome (all proteins) contained within these extracellular vesicles. Using the large number of proteins identified, the investigators will examine changes in categories of protein types (e.g., inflammatory proteins, metabolic proteins, transcriptional proteins).
Measured: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Sep 2023
- Study start9 Nov 2023
- Primary completionOct 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hawley E. Kunz, Mayo Clinic
- Investigators
- Hawley Kunz, PhD, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06053125
- Sponsor's protocol ID
- 23-002049
- Other IDs
- K01DK134765
- Status last verified
- May 2026
- First submitted
- 7 Sep 2023
- Last updated
- 6 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Role of Adipose Tissue in Adaptive Responses to Exercise
- ClinicalTrials.gov ID
- NCT06053125
- Acronym / sponsor ID
- 23-002049
- Keywords
- exercise, adipose, cytokines
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Collaborators
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Study start
- 9 Nov 2023 (actual)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 25 Sep 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
Detailed description
Adipose tissue has important endocrine functions that influence metabolic health. Early evidence shows that adipose adapts to physiological stress, including exercise. The objective here is to determine how exercise-induced alterations in adipose tissue cellular composition and endocrine signaling may contribute to the beneficial adaptations to exercise in aging and obesity.
Immune cell populations and inflammatory signatures will be assessed in subcutaneous abdominal adipose tissue biopsies collected from obese and normal weight young and older adults before, immediately after, and 3 hours after a 30-min bout of cycling exercise at 70% of maximal oxygen consumption (VO2max). Mass spectrometry, Olink targeted inflammation assays, and RNA sequencing will be used for full proteomic and transcriptomic characterization of the adipose tissue secretome (the proteins and molecules secreted from the adipose tissue) and the cargo of extracellular vesicles isolated from plasma and media collected from cultured human adipose tissue explants generated from each time point.
Overall, the primary hypothesis of the proposed work is that a single bout of exercise triggers transient changes in adipose tissue paracrine/endocrine signals and immune cellular composition. The investigators propose that these responses contribute to the beneficial effects of exercise locally and in distal tissues and that the cumulative effects of acute changes in adipose tissue likely contribute to the positive alterations in adipose tissue associated with exercise training.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Older adults with obesity | Experimental | Procedure: Adipose Tissue Biopsy, Behavioral: ExerciseParticipants with obesity as determined by the principal investigator and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. |
| Older adults without obesity | Experimental | Procedure: Adipose Tissue Biopsy, Behavioral: ExerciseParticipants with obesity as determined by the principal investigator and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. |
| Young adults with obesity | Experimental | Procedure: Adipose Tissue Biopsy, Behavioral: ExerciseParticipants with obesity as determined by the principal investigator and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. |
| Young adults without obesity | Experimental | Procedure: Adipose Tissue Biopsy, Behavioral: ExerciseParticipants with obesity as determined by the principal investigator and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise. |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adults between the ages of 18-35 OR 65-85.
- BMI 18.5 kg/m2 - 40 kg/m2
- Weight stable (≥ 3 months)
- Generally healthy
Key exclusion criteria (13 listed)
- Participation in ≥ 30 minutes of structured physical activity ≥ 2 days per week.
- Smoking/tobacco use.
- Alcohol/substance abuse.
- Pregnancy and breastfeeding.
- Anemia.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Adipose Tissue BiopsyFat sample collected from abdomen before exercise, immediately after exercise, and 3 hours after exercise | Procedure or surgery | Older adults with obesity, Older adults without obesity, Young adults with obesity, Young adults without obesity |
| Exercise30 minutes of exercise on a cycle ergometer exercise machine | Behavioural | Older adults with obesity, Older adults without obesity, Young adults with obesity, Young adults without obesity |
Primary outcome
Adipose lymphocyte populations
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
The numbers of lymphocytes in the adipose tissue will be assessed by flow cytometry.
IL6 secreted from adipose tissue measured using the Olink Target Inflammation Panel (includes 96 inflammation-associated proteins)
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
The concentration of 96 IL6 will be measured using the targeted inflammation Olink proximity extension assay panel in media obtained from cultured adipose tissue explants. Adipose tissue samples will be cultured for 3 hours, and the culture media will be removed for the assessment of secreted inflammatory proteins. T
Adipose tissue macrophage populations
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Numbers of macrophages in the adipose tissue will be assessed by immunohistochemistry.
Adipose tissue gene expression of interleukin (IL)-6 measured by polymerase chain reaction (PCR).
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the inflammatory cytokine IL-6 will be measured in adipose tissue samples using real time (RT)-PCR.
Adipose tissue gene expression of interleukin (IL)-8 measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the inflammatory cytokine IL-8 will be assessed in adipose tissue samples using real-time (RT)-PCR.
Adipose tissue gene expression of cluster of differentiation 68 (CD68) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the macrophage marker CD68 be assessed in adipose tissue samples using real time (RT)-PCR.
Adipose tissue gene expression of cluster of differentiation 163 (CD163) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the anti-inflammatory macrophage marker CD163 will be assessed in adipose tissue samples using RT-PCR.
Adipose tissue gene expression of cluster of differentiation 206 (CD206) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the anti-inflammatory macrophage marker CD206 will be assessed in adipose tissue samples using RT-PCR.
Adipose tissue gene expression of adhesion G-protein coupled receptor E (ADGRE) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the macrophage marker ADGRE will be assessed in adipose tissue samples using RT-PCR.
Adipose tissue gene expression of inducible nitric oxide synthase (INOS) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the pro-inflammatory macrophage marker INOS will be assessed in adipose tissue samples using RT-PCR.
Adipose tissue gene expression of monocyte chemoattractant protein-1 (MCP1) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the inflammatory cytokine MCP1 will be assessed in adipose tissue samples using RT-PCR.
Adipose tissue gene expression of tumor necrosis factor alpha (TNFa) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the inflammatory cytokine TNFa will be assessed in adipose tissue samples using RT-PCR.
Adipose tissue gene expression of leptin (LEPD) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the pro-inflammatory adipokine LEPD will be assessed in adipose tissue samples using RT-PCR.
Adipose tissue gene expression of adiponectin (ADIPOQ) measured by PCR.
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Gene expression of the anti-inflammatory adipokine ADIPOQ will be assessed in adipose tissue samples using RT-PCR.
Inflammatory proteins found in adipose tissue measured using the Olink Target Inflammation Panel (includes 96 inflammation-associated proteins)
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
The concentrations of 96 different inflammatory proteins (including various cytokines and adipokines) will be measured in adipose tissue lysates using the targeted inflammation Olink proximity extension assay panel. This assay measures all 96 proteins in a single assay and all are reported as normalized protein expression values.
Protein cargo of adipose extracellular vesicles measured using mass spectrometry
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Adipose tissue samples will be cultured for 3 hours, and the culture media will be removed. From this media, extracellular vesicles will be isolated. In these extracellular vesicles, mass spectrometry will be performed to examine the entire proteome (all proteins) contained within these extracellular vesicles. Using the large number of proteins identified, the investigators will examine changes in categories of protein types (e.g., inflammatory proteins, metabolic proteins, transcriptional proteins).
3 secondary outcomes
Adipocyte cell size
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Plasma IL6 concentrations measured using the Olink Target Inflammation Panel
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Protein cargo of plasma extracellular vesicles measured using mass spectrometry extracellular vesicles
Time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 May 2026.
- Mayo Clinic Clinical TrialsLink provided by the sponsor.
- Individual participant dataSharing planned: No
Related trials for Healthy
Recruiting
THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS
Physical Activity, Body Image
Not yet recruitingPhase 1
A Phase I Study of GLR2053 Tablets in Chinese Healthy Adult Participants
Atopic Dermatitis
Recruiting
Colon-delivered Riboflavin and Gut Microbiota Composition
Microbiome Dysbiosis, Gut Health
Not yet recruiting
Neuroergonomic Analysis of a Brain-Computer Interface Device (BCI)
Healthy Volunteers - Male and Female
RecruitingPhase 1
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
Healthy Volunteer, Atopic Dermatitis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hawley Kunz, PhD principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adipose Tissue Biopsy and Exercise in people with Healthy and Obesity, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 6 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Adipose lymphocyte populations (time frame: Pre-exercise, immediately post-exercise, and 3 hours after exercise). The study lists 16 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 May 2026.