Medium Flow AnesthesiaNCT06055335
Assessing Lung Dynamics and Respiratory Functions in Minimal Flow Anesthesia: A Prospective Study
A study testing Medium flow anesthesia and Minimal flow anesthesia in people with Medium Flow Anesthesia and Minimal Flow Anesthesia, run by Ataturk University at 1 site in Turkey (Türkiye).
Trial summary
The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Medium Flow Anesthesia, Minimal Flow Anesthesia, Pulmonary Function Test
- What is being tested?
- Medium flow anesthesia and Minimal flow anesthesia
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 2 Jun 2021to 27 Apr 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- ASA I-II
- 18-65 years of age, who will undergo elective laparoscopic cholecystectomy surgery
Who cannot join
- ASA III-IV
- Smokers
- Body mass index (BMI) > 40 kg / m2,
- Patients with cardiovascular system disease
- Chronic respiratory diseases,
- Patients whose pulmonary function tests cannot be applied and who have problems with pulmonary function tests during the examination of the chest disease consultant
Trial locations and contacts
1 site in 1 country.
About this study
Official title: EVALUATION OF LUNG DYNAMICS AND RESPIRATORY FUNCTIONS IN PATIENTS APPLIED WITH MINIMAL FLOW ANESTHESIA: A PROSPECTIVE, RANDOMIZED STUDY
The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. In both groups dynamic compliance values, peak inspiratory pressure (PIP) values, total inhalation anesthetic drug consumption, total remifentanil drug consumption, duration of anesthesia, and duration of surgery were recorded. The FVC, FEV1, and FEV1/FVC values of the patients in both groups were evaluated and noted 24 hours before the operation, after the operation 2nd, 8th, and 24th hours.
- Conditions
- Medium Flow Anesthesia, Minimal Flow Anesthesia, Pulmonary Function Test, Compliance, Patient, Peak Inspiratuar Pressure
- Being tested
- Medium flow anesthesia, Minimal flow anesthesia
- Medical subject headings
- Patient Compliance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Medium flow anesthesiaOther
Group MeFA; after reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min.
Minimal flow anesthesiaOther
Group MiFA; after reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min.
| Study group | Role | What they receive |
|---|---|---|
| Medium flow anesthesia | Experimental | After reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane. Receives: Other: Medium flow anesthesia |
| Minimal flow anesthesia | Experimental | After reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane. Receives: Other: Minimal flow anesthesia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Dynamic Compliance assessment
Dynamic Compliance will be assessed 5th minutes after endotracheal intubation
Measured: 5th minutes after endotracheal intubation
Dynamic Compliance assessment
Dynamic Compliance will be assessed 5th minutes after the surgical incision
Measured: 5th minutes after surgical incision
Dynamic Compliance assessment
Dynamic Compliance will be assessed 10th minutes after the surgical incision
Measured: 10th minutes after surgical incision
Dynamic Compliance assessment
Dynamic Compliance will be assessed 30th minutes after the surgical incision
Measured: 30th minutes after surgical incision
Dynamic Compliance assessment
Dynamic Compliance will be assessed 60th minutes after the surgical incision
Measured: 60th minutes after surgical incision
Dynamic Compliance assessment
Dynamic Compliance will be assessed immediately after the end of the surgical suturing
Measured: immediately after the end of the surgical suturing
Peak inspiratory pressure assessment
Peak inspiratory pressure will be assessed 5th minutes after endotracheal intubation
Measured: 5th minutes after endotracheal intubation
Peak inspiratory pressure assessment
Peak inspiratory pressure will be assessed 5th minutes after the surgical incision
Measured: 5th minutes after the surgical incision
Peak inspiratory pressure assessment
Peak inspiratory pressure will be assessed 10th minutes after the surgical incision
Measured: 10th minutes after the surgical incision
Peak inspiratory pressure assessment
Peak inspiratory pressure will be assessed 30th minutes after the surgical incision
Measured: 30th minutes after the surgical incision
Peak inspiratory pressure assessment
Peak inspiratory pressure will be assessed 60th minutes after the surgical incision
Measured: 60th minutes after the surgical incision
Peak inspiratory pressure assessment
Peak inspiratory pressure will be assessed immediately after the end of the surgical suturing
Measured: immediately after the end of the surgical suturing
Secondary outcomes (12)
FEV1 measures assessment
FEV1 measures assessment will be assessed 24 hours before the operation
Measured: 24 hours before the operation
FEV1 measures assessment
FEV1 measures assessment will be assessed 2nd hours after the operation
Measured: 2nd hour after the operation
FEV1 measures assessmentt
FEV1 measures assessment will be assessed 8th hours after the operation
Measured: 8th hour after the operation
FEV1 measures assessment
FEV1 measures assessment will be assessed 24th hours after the operation
Measured: 24th hour after the operation
FVC measures assessment
FVC measures assessment will be assessed 24 hours before the operation
Measured: 24 hours before the operation
FVC measures assessment
FVC measures assessment will be assessed 2nd hour after the operation
Measured: 2nd hour after the operation
FVC measures assessment
FVC measures assessment will be assessed 8th hour after the operation
Measured: 8th hour after the operation
FVC measures assessment
FVC measures assessment will be assessed 24th hours after the operation
Measured: 24th hour after the operation
FEV1/FVC measures assessment
FEV1/FVC measures assessment will be assessed 24 hours before the operation
Measured: 24 hours before the operation
FEV1/FVC measures assessment
FEV1/FVC measures assessment will be assessed 2nd hour after the operation
Measured: 2nd hour after the operation
FEV1/FVC measures assessment
FEV1/FVC measures assessment will be assessed 8th hour after the operation
Measured: 8th hour after the operation
FEV1/FVC measures assessment
FEV1/FVC measures assessment will be assessed 24th hour after the operation
Measured: 24th hour after the operation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Sep 2023
- Study start2 Jun 2021
- Primary completion25 Mar 2022
- Study completion27 Apr 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Medium Flow AnesthesiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ataturk University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Erkan Cem ÇELİK, Ataturk University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06055335
- Sponsor's protocol ID
- 2/106 25.03.2021
- Status last verified
- Sep 2023
- First submitted
- 14 Sep 2023
- Last updated
- 26 Sep 2023
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Celik EC, Yayik AM, Aydin ME, Koksal ENM, Disci E, Kerget B, Doymus O, Ahiskalioglu EO, Ahiskalioglu A. Evaluation of lung dynamics and respiratory functions in patients undergoing minimal flow anesthesia: a prospective, randomized controlled trial. Med Gas Res. 2026 Jun 1;16(2):110-115. doi: 10.4103/mgr.MEDGASRES-D-25-00037. Epub 2025 Aug 18.
PubMed 40826933
Study at a glance
From the registry record, last updated by the sponsor on 26 Sep 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- EVALUATION OF LUNG DYNAMICS AND RESPIRATORY FUNCTIONS IN PATIENTS APPLIED WITH MINIMAL FLOW ANESTHESIA: A PROSPECTIVE, RANDOMIZED STUDY
- ClinicalTrials.gov ID
- NCT06055335
- Acronym / sponsor ID
- 2/106 25.03.2021
- Conditions
- Medium Flow Anesthesia, Minimal Flow Anesthesia, Pulmonary Function Test, Compliance, Patient, Peak Inspiratuar Pressure
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Ataturk UniversityUniversity, hospital or other
- Study start
- 2 Jun 2021 (actual)
- Primary completion
- 25 Mar 2022 (actual)
- Study completion
- 27 Apr 2022 (actual)
- First posted
- 26 Sep 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The patients were randomized into two groups medium flow anesthesia (MeFA) and minimal flow anesthesia (MiFA). While MeFA received medium flow anesthesia with 2 lt/min, MiFA received minimal flow anesthesia with 0.5 lt/min fresh gas flow. In both groups dynamic compliance values, peak inspiratory pressure (PIP) values, total inhalation anesthetic drug consumption, total remifentanil drug consumption, duration of anesthesia, and duration of surgery were recorded. The FVC, FEV1, and FEV1/FVC values of the patients in both groups were evaluated and noted 24 hours before the operation, after the operation 2nd, 8th, and 24th hours.
Study design
- Primary purpose
- Screening
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Medium flow anesthesia | Experimental | Other: Medium flow anesthesiaAfter reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane. |
| Minimal flow anesthesia | Experimental | Other: Minimal flow anesthesiaAfter reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- ASA I-II
- 18-65 years of age, who will undergo elective laparoscopic cholecystectomy surgery
Key exclusion criteria (6 listed)
- ASA III-IV
- Smokers
- Body mass index (BMI) > 40 kg / m2,
- Patients with cardiovascular system disease
- Chronic respiratory diseases,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Medium flow anesthesiaGroup MeFA; after reaching the MAC 1 value with 4lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, medium flow anesthesia was started with 2 lt/min 50% O2 - 50% air with MAC 1 concentration desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min. | Other | Medium flow anesthesia |
| Minimal flow anesthesiaGroup MiFA; after reaching the MAC 1 value with 4 lt/min 50% O2 - 50% air and 8% desflurane with remifentanil infusion, minimal flow anesthesia was started with 0.50 lt/min 50% O2 - 50% air with MAC 1 concentration of desflurane. The vaporizer was closed at the end of the last suture, and the flow was increased to 80% oxygen at 6 lt/min. | Other | Minimal flow anesthesia |
Primary outcome
Dynamic Compliance assessment
Time frame: 5th minutes after endotracheal intubation
Dynamic Compliance will be assessed 5th minutes after endotracheal intubation
Dynamic Compliance assessment
Time frame: 5th minutes after surgical incision
Dynamic Compliance will be assessed 5th minutes after the surgical incision
Dynamic Compliance assessment
Time frame: 10th minutes after surgical incision
Dynamic Compliance will be assessed 10th minutes after the surgical incision
Dynamic Compliance assessment
Time frame: 30th minutes after surgical incision
Dynamic Compliance will be assessed 30th minutes after the surgical incision
Dynamic Compliance assessment
Time frame: 60th minutes after surgical incision
Dynamic Compliance will be assessed 60th minutes after the surgical incision
Dynamic Compliance assessment
Time frame: immediately after the end of the surgical suturing
Dynamic Compliance will be assessed immediately after the end of the surgical suturing
Peak inspiratory pressure assessment
Time frame: 5th minutes after endotracheal intubation
Peak inspiratory pressure will be assessed 5th minutes after endotracheal intubation
Peak inspiratory pressure assessment
Time frame: 5th minutes after the surgical incision
Peak inspiratory pressure will be assessed 5th minutes after the surgical incision
Peak inspiratory pressure assessment
Time frame: 10th minutes after the surgical incision
Peak inspiratory pressure will be assessed 10th minutes after the surgical incision
Peak inspiratory pressure assessment
Time frame: 30th minutes after the surgical incision
Peak inspiratory pressure will be assessed 30th minutes after the surgical incision
Peak inspiratory pressure assessment
Time frame: 60th minutes after the surgical incision
Peak inspiratory pressure will be assessed 60th minutes after the surgical incision
Peak inspiratory pressure assessment
Time frame: immediately after the end of the surgical suturing
Peak inspiratory pressure will be assessed immediately after the end of the surgical suturing
12 secondary outcomes
FEV1 measures assessment
Time frame: 24 hours before the operation
FEV1 measures assessment
Time frame: 2nd hour after the operation
FEV1 measures assessmentt
Time frame: 8th hour after the operation
FEV1 measures assessment
Time frame: 24th hour after the operation
FVC measures assessment
Time frame: 24 hours before the operation
FVC measures assessment
Time frame: 2nd hour after the operation
FVC measures assessment
Time frame: 8th hour after the operation
FVC measures assessment
Time frame: 24th hour after the operation
FEV1/FVC measures assessment
Time frame: 24 hours before the operation
FEV1/FVC measures assessment
Time frame: 2nd hour after the operation
FEV1/FVC measures assessment
Time frame: 8th hour after the operation
FEV1/FVC measures assessment
Time frame: 24th hour after the operation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Sep 2023.
- Derived from this study: PubMed 40826933Celik EC, Yayik AM, Aydin ME, Koksal ENM, Disci E, Kerget B, Doymus O, Ahiskalioglu EO, Ahiskalioglu A. Evaluation of lung dynamics and respiratory functions in patients undergoing minimal flow anesthesia: a prospective, randomized controlled trial. Med Gas Res. 2026 Jun 1;16(2):110-115. doi: 10.4103/mgr.MEDGASRES-D-25-00037. Epub 2025 Aug 18.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Medium flow anesthesia and Minimal flow anesthesia in people with Medium Flow Anesthesia and Minimal Flow Anesthesia, run by Ataturk University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Sep 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Dynamic Compliance assessment (time frame: 5th minutes after endotracheal intubation). The study lists 12 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06055335, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Sep 2023.