Baker CystBCIVTNCT06079684
Baker Cyst Dimensions and Intermittent Vacuum Therapy in Knee Osteoarthritis (BCIVT)
A study testing Intermittent vacuum therapy in people with Baker Cyst and Knee Osteoarthritis, run by Balnear and Rehabilitation Sanatorium Techirghiol at 1 site in Romania.
Trial summary
The Baker cyst (BC), also known as the popliteal cyst or parameniscal cyst, is a fluid-filled sac that commonly develops in the posterior aspect of the knee, between the semimembranosus and medial head of the gastrocnemius. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Baker Cyst, Knee Osteoarthritis
- What is being tested?
- Intermittent vacuum therapy
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 65 participants
- Where
- 1 siteRomania
- Study dates
- 1 Nov 2022to 16 Dec 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- free consent based on explaining and understanding all related procedural steps;
- age over 18 years;
- diagnosis of knee osteoarthritis with Baker Cyst.
Who cannot join
- neurological conditions
- rheumatological conditions
- trauma
- a history of knee or lower extremity joint surgery,
- a history of hip or ankle pain
- a history of steroid injection in the previous three months,
- conditions that would be contraindicated by Intermittent Vacuum Therapy.
Trial locations and contacts
1 site in 1 country.
Romania1 site
Balneal and Rehabilitation Sanatorium Techirghiol
Techirghiol, Constanța County, 906100
About this study
Official title: Clinical Evidence Regarding The Dynamic of Baker Cyst Dimensions After Intermittent Vacuum Therapy As Rehabilitation Treatment In Patients With Knee Osteoarthritis
The Baker cyst (BC), also known as the popliteal cyst or parameniscal cyst, is a fluid-filled sac that commonly develops in the posterior aspect of the knee, between the semimembranosus and medial head of the gastrocnemius. It is a common complication of knee osteoarthritis, and can also be associated with other conditions such as rheumatoid arthritis, gout, and meniscal tears.
BCs are typically asymptomatic, but can cause pain, stiffness, and swelling in the back of the knee. In severe cases, they can rupture, leading to inflammation and pain in the calf.
Read more
Physiotherapy is a common treatment for BCs, and has been shown to be effective in reducing size and symptoms. Intermittent vacuum therapy (IVT) is a type of physiotherapy that involves applying suction to the affected area. IVT is thought to work by increasing blood flow and lymphatic drainage, which can help to reduce inflammation and swelling.
This study aims to evaluate the effectiveness of IVT in the treatment of BCs. A total of 65 patients with knee osteoarthritis and BCs will be recruited and randomized to either a control group or an IVT group. The control group will receive standard physiotherapy treatment, while the IVT group will receive IVT in addition to standard physiotherapy treatment.
All patients will be assessed at baseline and after 10 days of treatment using a variety of clinical and functional measures, including the echo volume of the BC. The results of the study will be used to determine whether IVT is an effective treatment for BCs.
This study is designed to contribute to the existing body of knowledge on the treatment of BCs. The results of the study will be of interest to clinicians, researchers, and patients.
Read the detailed description
The study was a prospective, randomized, controlled, single-blind study conducted at the Balneal and Rehabilitation Sanatorium Techirghiol (BRST) in Romania. A total of 65 patients with knee osteoarthritis (OA) and Baker's cysts (BCs) were enrolled in the study. The patients were randomly assigned to either an intermittent vacuum therapy (IVT) group or a control group.
The IVT group received IVT in addition to standard physical therapy, while the control group received standard physical therapy only. IVT was performed daily for 30 minutes using a Vacumed device. The device consists of an airtight vacuum chamber and a pump connected to a pressure control system. During vacuum treatments, participants were asked to lay themselves comfortably in a supine position. The lower body was positioned in the vacuum chamber, which was sealed around the participant's trunk with a cuff at the level of the umbilicus to allow application of negative pressure. Negative pressure cycles are created by alternating between removing air and venting the chamber to atmospheric pressure.
The standard physical therapy program consisted of a general warm mud bath (20 minutes at 38 degrees Celsius), hydrokinetotherapy in saline water from Lake Techirghiol by a certified physical therapist (20 minutes at 35 degrees Celsius), massage therapy for paravertebral muscles, shoulder and pelvis girdle, kinesio-therapy with a standard program for peripheric joints for 30 minutes.
All patients were assessed at baseline and after 10 days of treatment using a variety of clinical and functional measures, including the volume of the BC. Data on demographics and clinical conditions was gathered. The investigators collect the next features: sex, age, level of education, occupation, environment, degree of functional deficit, body mass index (BMI) and Kellgren-Lawrence classification.
Also, scores for the Knee Injury and Osteoarthritis Outcome Score (KOOS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Functional Independence measurement (FIM), the Fall Risk Score, and the Visual Analogue Scale (VAS) were recorded at baseline and after 10 days.
All patients were recruited at the BRST by a clinician blinded as to group allocation. Each study group was composed through random allocation of the total sample with a 1:1 allocation ratio that was reported to patients by a different researcher, who was neither the one who performed the treatment nor the one who performed the evaluation, through a pre-specified allocation list who was concealed in a password-protected computer file.
Of the total of 102 patients who were presented for hospitalization in the BRST between November and December 2022, only 65 completed the participation conditions, being grouped into two groups of 33 and 32, respectively. Due to the relatively small number of patients, the statistical approach was a non-parametric one: Independent Samples Mann Whitney U test, Independent Sample Median Test, Reb test Samples Wilcoxon Signed Rank test and Chi-Square test.
- Conditions
- Baker Cyst, Knee Osteoarthritis
- Being tested
- Intermittent vacuum therapy
- Keywords
- Baker Cyst, Intermittent Vacuum, Knee Osteoarthritis, Ultrasonography, Physical therapy, Mud, Rehabilitation
- Medical subject headings
- Popliteal Cyst, Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Intermittent vacuum therapyDevice
Also called General warm mud bath, Hydrokinetotherapy in saline water, Massage therapy, Kinesiotherapy
Data on demographics and clinical conditions was gathered. The investigators collect the next features: sex, age, level of education, occupation, environment, degree of functional deficit, body mass index and Kellgren-Lawrence classification.
Also, scores for the Knee Injury and Osteoarthritis Outcome Score, the Western Ontario and McMaster Universities Osteoarthritis Index, the Functional Independence measurement, the Fall Risk Score, and the Visual Analogue Scale were recorded at baseline and after 10 days.
A blinded expert used a 7-15 MHz linear probe to take ultrasonographic measurements of Baker Cyst at baseline and after 10 days.
| Study group | Role | What they receive |
|---|---|---|
| Vacuum Group | Experimental | Vacuum Group with 32 patients: for 10 consecutive days, all patients performed the same program procedures: Intermittent vacuum therapy (for 30 minutes, with a Vacumed device -the lower body was positioned in the vacuum chamber, which was sealed around the participant's trunk with a cuff at the level of the umbilicus to allow application of negative pressure), general warm mud bath (20 minutes at 38 degrees Celsius), hydrokinetotherapy in saline water from Lake Techirghiol by a certified physical therapist (20 minutes at 35 degrees Celsius), massage therapy for paravertebral muscles, shoulder and pelvis girdle and kinesiotherapy with a standard program for peripheric joints for 30 minutes Receives: Device: Intermittent vacuum therapy |
| Control Group | Active comparator | Control Group with 33 patients: for 10 consecutive days, all patients performed the same program procedures: general warm mud bath (20 minutes at 38 degrees Celsius), hydrokinetotherapy in saline water from Lake Techirghiol by a certified physical therapist (20 minutes at 35 degrees Celsius), massage therapy for paravertebral muscles, shoulder and pelvis girdle and kinesiotherapy with a standard program for peripheric joints for 30 minutes Receives: Device: Intermittent vacuum therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cyst Baker Dimensions
Ultrasonographic measurements
Measured: Two measurements, on the first day of treatment and after 10 consecutive days of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Oct 2023
- Study start1 Nov 2022
- Primary completion2 Dec 2022
- Study completion16 Dec 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (36)Papers the sponsor has linked to this study.
- Other trials for Baker CystStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 65 participants (actual)
Sponsor and investigators
- Lead sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elena-Valentina Ionescu, Balnear and Rehabilitation Sanatorium Techirghiol
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06079684
- Sponsor's protocol ID
- BalnearRehabTechirghiol
- Acronym
- BCIVT
- Status last verified
- Oct 2023
- First submitted
- 29 Sep 2023
- Last updated
- 12 Oct 2023
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Abate M, Di Carlo L, Di Iorio A, Salini V. Baker's Cyst with Knee Osteoarthritis: Clinical and Therapeutic Implications. Med Princ Pract. 2021;30(6):585-591. doi: 10.1159/000518792. Epub 2021 Aug 2.
PubMed 34348320Henricsdotter C, Ellegaard K, Klokker L, Bartholdy C, Bandak E, Bartels EM, Bliddal H, Henriksen M. Changes in ultrasound assessed markers of inflammation following intra-articular steroid injection combined with exercise in knee osteoarthritis: exploratory outcome from a randomized trial. Osteoarthritis Cartilage. 2016 May;24(5):814-21. doi: 10.1016/j.joca.2015.12.010. Epub 2015 Dec 31.
PubMed 26746147Di Sante L, Paoloni M, Ioppolo F, Dimaggio M, Di Renzo S, Santilli V. Ultrasound-guided aspiration and corticosteroid injection of Baker's cysts in knee osteoarthritis: a prospective observational study. Am J Phys Med Rehabil. 2010 Dec;89(12):970-5. doi: 10.1097/PHM.0b013e3181fc7da2.
PubMed 21403593Zhou XN, Li B, Wang JS, Bai LH. Surgical treatment of popliteal cyst: a systematic review and meta-analysis. J Orthop Surg Res. 2016 Feb 15;11:22. doi: 10.1186/s13018-016-0356-3.
PubMed 26879283Wiecha S, Jarocka M, Wisniowski P, Cieslinski M, Price S, Makaruk B, Kotowska J, Drabarek D, Cieslinski I, Sacewicz T. The efficacy of intermittent pneumatic compression and negative pressure therapy on muscle function, soreness and serum indices of muscle damage: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2021 Nov 13;13(1):144. doi: 10.1186/s13102-021-00373-2.
PubMed 34774089Parganlija D, Nieberg V, Sauer M, Rittweger J, Bloch W, Zange J. Lower body negative pressure enhances oxygen availability in the knee extensor muscles during intense resistive exercise in supine position. Eur J Appl Physiol. 2019 Jun;119(6):1289-1303. doi: 10.1007/s00421-019-04113-w. Epub 2019 Mar 26.
PubMed 30915538Dong HH, Gao BH, Zhu H, Yang ST. [The effects of lower limb intermittent negative pressure therapy on the skin microcirculation perfusion of quadriceps in male rowers]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Feb;35(2):126-129. doi: 10.12047/j.cjap.5727.2019.028. Chinese.
PubMed 31250602Yogendrakumar V, Lun R, Hutton B, Fergusson DA, Dowlatshahi D. Comparing pharmacological venous thromboembolism prophylaxis to intermittent pneumatic compression in acute intracerebral haemorrhage: protocol for a systematic review and network meta-analysis. BMJ Open. 2018 Nov 5;8(11):e024405. doi: 10.1136/bmjopen-2018-024405.
PubMed 30397010Sarman H, Muezzinoglu US, Memisoglu K, Baran T. Vacuum-assisted closure for skin necrosis after revision total knee arthroplasty. Int Wound J. 2016 Oct;13(5):843-7. doi: 10.1111/iwj.12390. Epub 2014 Dec 30.
PubMed 25597628Hageman D, Fokkenrood HJP, van Deursen BAC, Gommans LNM, Cancrinus E, Scheltinga MRM, Teijink JAW. Randomized controlled trial of vacuum therapy for intermittent claudication. J Vasc Surg. 2020 May;71(5):1692-1701.e1. doi: 10.1016/j.jvs.2019.08.239. Epub 2019 Nov 2.
PubMed 31690523Derouet H, Caspari D, Rohde V, Rommel G, Ziegler M. Treatment of erectile dysfunction with external vacuum devices. Andrologia. 1999;31 Suppl 1:89-94. doi: 10.1111/j.1439-0272.1999.tb01456.x.
PubMed 10643525Xiang J, Wu D, Li J. Clinical Efficacy of Mudpack Therapy in Treating Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Studies. Am J Phys Med Rehabil. 2016 Feb;95(2):121-31. doi: 10.1097/PHM.0000000000000354.
PubMed 26203645Sukenik S. Balneotherapy for rheumatic diseases at the Dead Sea area. Isr J Med Sci. 1996 Jul;32 Suppl:S16-9.
PubMed 8756970Vojtassak J Jr, Vojtassak J Sr. Ultrasound monitoring of the treatment of clinically significant knee osteoarthritis. Bratisl Lek Listy. 2014;115(2):86-90.
PubMed 24601702Han DY, Ryu KN, Park JS, Jin W, Park SY, Yun SJ. The prevalence of Baker cyst in relation to the arrangement pattern between the medial head of gastrocnemius tendon and the semimembranosus tendon. Eur Radiol. 2020 Mar;30(3):1544-1553. doi: 10.1007/s00330-019-06472-6. Epub 2019 Dec 6.
PubMed 31811432
Study at a glance
From the registry record, last updated by the sponsor on 12 Oct 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Evidence Regarding The Dynamic of Baker Cyst Dimensions After Intermittent Vacuum Therapy As Rehabilitation Treatment In Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT06079684
- Acronym / sponsor ID
- BCIVT / BalnearRehabTechirghiol
- Conditions
- Baker Cyst, Knee Osteoarthritis
- Keywords
- Baker Cyst, Intermittent Vacuum, Knee Osteoarthritis, Ultrasonography, Physical therapy, Mud, Rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 65 participants (actual)
- Lead sponsor
- Balnear and Rehabilitation Sanatorium TechirghiolUniversity, hospital or other
- Study start
- 1 Nov 2022 (actual)
- Primary completion
- 2 Dec 2022 (actual)
- Study completion
- 16 Dec 2022 (actual)
- First posted
- 12 Oct 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Baker cyst (BC), also known as the popliteal cyst or parameniscal cyst, is a fluid-filled sac that commonly develops in the posterior aspect of the knee, between the semimembranosus and medial head of the gastrocnemius. It is a common complication of knee osteoarthritis, and can also be associated with other conditions such as rheumatoid arthritis, gout, and meniscal tears.
BCs are typically asymptomatic, but can cause pain, stiffness, and swelling in the back of the knee. In severe cases, they can rupture, leading to inflammation and pain in the calf.
Physiotherapy is a common treatment for BCs, and has been shown to be effective in reducing size and symptoms. Intermittent vacuum therapy (IVT) is a type of physiotherapy that involves applying suction to the affected area. IVT is thought to work by increasing blood flow and lymphatic drainage, which can help to reduce inflammation and swelling.
This study aims to evaluate the effectiveness of IVT in the treatment of BCs. A total of 65 patients with knee osteoarthritis and BCs will be recruited and randomized to either a control group or an IVT group. The control group will receive standard physiotherapy treatment, while the IVT group will receive IVT in addition to standard physiotherapy treatment.
All patients will be assessed at baseline and after 10 days of treatment using a variety of clinical and functional measures, including the echo volume of the BC. The results of the study will be used to determine whether IVT is an effective treatment for BCs.
This study is designed to contribute to the existing body of knowledge on the treatment of BCs. The results of the study will be of interest to clinicians, researchers, and patients.
Detailed description
The study was a prospective, randomized, controlled, single-blind study conducted at the Balneal and Rehabilitation Sanatorium Techirghiol (BRST) in Romania. A total of 65 patients with knee osteoarthritis (OA) and Baker's cysts (BCs) were enrolled in the study. The patients were randomly assigned to either an intermittent vacuum therapy (IVT) group or a control group.
The IVT group received IVT in addition to standard physical therapy, while the control group received standard physical therapy only. IVT was performed daily for 30 minutes using a Vacumed device. The device consists of an airtight vacuum chamber and a pump connected to a pressure control system. During vacuum treatments, participants were asked to lay themselves comfortably in a supine position. The lower body was positioned in the vacuum chamber, which was sealed around the participant's trunk with a cuff at the level of the umbilicus to allow application of negative pressure. Negative pressure cycles are created by alternating between removing air and venting the chamber to atmospheric pressure.
The standard physical therapy program consisted of a general warm mud bath (20 minutes at 38 degrees Celsius), hydrokinetotherapy in saline water from Lake Techirghiol by a certified physical therapist (20 minutes at 35 degrees Celsius), massage therapy for paravertebral muscles, shoulder and pelvis girdle, kinesio-therapy with a standard program for peripheric joints for 30 minutes.
All patients were assessed at baseline and after 10 days of treatment using a variety of clinical and functional measures, including the volume of the BC. Data on demographics and clinical conditions was gathered. The investigators collect the next features: sex, age, level of education, occupation, environment, degree of functional deficit, body mass index (BMI) and Kellgren-Lawrence classification.
Also, scores for the Knee Injury and Osteoarthritis Outcome Score (KOOS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Functional Independence measurement (FIM), the Fall Risk Score, and the Visual Analogue Scale (VAS) were recorded at baseline and after 10 days.
All patients were recruited at the BRST by a clinician blinded as to group allocation. Each study group was composed through random allocation of the total sample with a 1:1 allocation ratio that was reported to patients by a different researcher, who was neither the one who performed the treatment nor the one who performed the evaluation, through a pre-specified allocation list who was concealed in a password-protected computer file.
Of the total of 102 patients who were presented for hospitalization in the BRST between November and December 2022, only 65 completed the participation conditions, being grouped into two groups of 33 and 32, respectively. Due to the relatively small number of patients, the statistical approach was a non-parametric one: Independent Samples Mann Whitney U test, Independent Sample Median Test, Reb test Samples Wilcoxon Signed Rank test and Chi-Square test.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Vacuum Group | Experimental | Device: Intermittent vacuum therapyVacuum Group with 32 patients: for 10 consecutive days, all patients performed the same program procedures: Intermittent vacuum therapy (for 30 minutes, with a Vacumed device -the lower body was positioned in the vacuum chamber, which was sealed around the participant's trunk with a cuff at the level of the umbilicus to allow application of negative pressure), general warm mud bath (20 minutes at 38 degrees Celsius), hydrokinetotherapy in saline water from Lake Techirghiol by a certified physical therapist (20 minutes at 35 degrees Celsius), massage therapy for paravertebral muscles, shoulder and pelvis girdle and kinesiotherapy with a standard program for peripheric joints for 30 minutes |
| Control Group | Active comparator | Device: Intermittent vacuum therapyControl Group with 33 patients: for 10 consecutive days, all patients performed the same program procedures: general warm mud bath (20 minutes at 38 degrees Celsius), hydrokinetotherapy in saline water from Lake Techirghiol by a certified physical therapist (20 minutes at 35 degrees Celsius), massage therapy for paravertebral muscles, shoulder and pelvis girdle and kinesiotherapy with a standard program for peripheric joints for 30 minutes |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- free consent based on explaining and understanding all related procedural steps;
- age over 18 years;
- diagnosis of knee osteoarthritis with Baker Cyst.
Key exclusion criteria (7 listed)
- neurological conditions
- rheumatological conditions
- trauma
- a history of knee or lower extremity joint surgery,
- a history of hip or ankle pain
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Intermittent vacuum therapyAlso: General warm mud bath, Hydrokinetotherapy in saline water, Massage therapy, KinesiotherapyData on demographics and clinical conditions was gathered. The investigators collect the next features: sex, age, level of education, occupation, environment, degree of functional deficit, body mass index and Kellgren-Lawrence classification. Also, scores for the Knee Injury and Osteoarthritis Outcome Score, the Western Ontario and McMaster Universities Osteoarthritis Index, the Functional Independence measurement, the Fall Risk Score, and the Visual Analogue Scale were recorded at baseline and after 10 days. A blinded expert used a 7-15 MHz linear probe to take ultrasonographic measurements of Baker Cyst at baseline and after 10 days. | Device | Control Group, Vacuum Group |
Primary outcome
Cyst Baker Dimensions
Time frame: Two measurements, on the first day of treatment and after 10 consecutive days of treatment
Ultrasonographic measurements
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Oct 2023.
- Background: PubMed 34348320Abate M, Di Carlo L, Di Iorio A, Salini V. Baker's Cyst with Knee Osteoarthritis: Clinical and Therapeutic Implications. Med Princ Pract. 2021;30(6):585-591. doi: 10.1159/000518792. Epub 2021 Aug 2.
- Background: PubMed 26746147Henricsdotter C, Ellegaard K, Klokker L, Bartholdy C, Bandak E, Bartels EM, Bliddal H, Henriksen M. Changes in ultrasound assessed markers of inflammation following intra-articular steroid injection combined with exercise in knee osteoarthritis: exploratory outcome from a randomized trial. Osteoarthritis Cartilage. 2016 May;24(5):814-21. doi: 10.1016/j.joca.2015.12.010. Epub 2015 Dec 31.
- Background: PubMed 21403593Di Sante L, Paoloni M, Ioppolo F, Dimaggio M, Di Renzo S, Santilli V. Ultrasound-guided aspiration and corticosteroid injection of Baker's cysts in knee osteoarthritis: a prospective observational study. Am J Phys Med Rehabil. 2010 Dec;89(12):970-5. doi: 10.1097/PHM.0b013e3181fc7da2.
- Background: PubMed 26879283Zhou XN, Li B, Wang JS, Bai LH. Surgical treatment of popliteal cyst: a systematic review and meta-analysis. J Orthop Surg Res. 2016 Feb 15;11:22. doi: 10.1186/s13018-016-0356-3.
- Background: PubMed 34774089Wiecha S, Jarocka M, Wisniowski P, Cieslinski M, Price S, Makaruk B, Kotowska J, Drabarek D, Cieslinski I, Sacewicz T. The efficacy of intermittent pneumatic compression and negative pressure therapy on muscle function, soreness and serum indices of muscle damage: a randomized controlled trial. BMC Sports Sci Med Rehabil. 2021 Nov 13;13(1):144. doi: 10.1186/s13102-021-00373-2.
- Background: PubMed 30915538Parganlija D, Nieberg V, Sauer M, Rittweger J, Bloch W, Zange J. Lower body negative pressure enhances oxygen availability in the knee extensor muscles during intense resistive exercise in supine position. Eur J Appl Physiol. 2019 Jun;119(6):1289-1303. doi: 10.1007/s00421-019-04113-w. Epub 2019 Mar 26.
- Background: PubMed 31250602Dong HH, Gao BH, Zhu H, Yang ST. [The effects of lower limb intermittent negative pressure therapy on the skin microcirculation perfusion of quadriceps in male rowers]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2019 Feb;35(2):126-129. doi: 10.12047/j.cjap.5727.2019.028. Chinese.
- Background: PubMed 30397010Yogendrakumar V, Lun R, Hutton B, Fergusson DA, Dowlatshahi D. Comparing pharmacological venous thromboembolism prophylaxis to intermittent pneumatic compression in acute intracerebral haemorrhage: protocol for a systematic review and network meta-analysis. BMJ Open. 2018 Nov 5;8(11):e024405. doi: 10.1136/bmjopen-2018-024405.
- Background: PubMed 25597628Sarman H, Muezzinoglu US, Memisoglu K, Baran T. Vacuum-assisted closure for skin necrosis after revision total knee arthroplasty. Int Wound J. 2016 Oct;13(5):843-7. doi: 10.1111/iwj.12390. Epub 2014 Dec 30.
- Background: PubMed 31690523Hageman D, Fokkenrood HJP, van Deursen BAC, Gommans LNM, Cancrinus E, Scheltinga MRM, Teijink JAW. Randomized controlled trial of vacuum therapy for intermittent claudication. J Vasc Surg. 2020 May;71(5):1692-1701.e1. doi: 10.1016/j.jvs.2019.08.239. Epub 2019 Nov 2.
- Background: PubMed 10643525Derouet H, Caspari D, Rohde V, Rommel G, Ziegler M. Treatment of erectile dysfunction with external vacuum devices. Andrologia. 1999;31 Suppl 1:89-94. doi: 10.1111/j.1439-0272.1999.tb01456.x.
- Background: PubMed 26203645Xiang J, Wu D, Li J. Clinical Efficacy of Mudpack Therapy in Treating Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Studies. Am J Phys Med Rehabil. 2016 Feb;95(2):121-31. doi: 10.1097/PHM.0000000000000354.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Intermittent vacuum therapy in people with Baker Cyst and Knee Osteoarthritis, run by Balnear and Rehabilitation Sanatorium Techirghiol at 1 site in Romania.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Oct 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Romania. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cyst Baker Dimensions (time frame: Two measurements, on the first day of treatment and after 10 consecutive days of treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06079684, which also lists 36 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Oct 2023.