LipoproteinsNCT06086795
Investigating Age-dependent Effects of Egg Intake on HDL and Immune Profiles
A study testing Whole eggs, Egg yolks and Egg whites in people with Lipoproteins and Inflammatory Response, run by University of Connecticut at 1 site in United States.
Trial summary
The goal of this intervention study is to determine whether consumption of different fractions of chicken eggs, including egg whites, egg yolks, and whole eggs, confer different changes in markers of HDL function and T cell profiles in younger vs. older men and women. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Lipoproteins, Inflammatory Response
- What is being tested?
- Whole eggs, Egg yolks and Egg whites
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteUnited States
- Study dates
- 23 Jan 2024to 29 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- 18-30 years old, or 50-75 years old (at time of screening)
- Body mass index (BMI) < 30 kg/m2
- Willing to consume whole eggs, egg whites, or egg yolks on a daily basis during study periods, and refrain from eating eggs during other study periods
- Do not fit any exclusion criteria
Who cannot join
- < 18 years old; 31-49 years old; > 75 years old
- BMI ≥ 30 kg/m2 or body weight < 110 pounds
- Weight changes > 10% over the last 4 weeks
- Self-reported history of diabetes, heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
- Allergy or intolerance to eggs, egg components, or egg products
- Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance
- Highly elevated fasting lipid and glucose levels (triglyceride levels higher than 500 mg/dL, fasting glucose higher than 126 mg/dL), or total cholesterol < 120 mg/dL and HDL-cholesterol < 15 mg/dL
- Currently taking lipid-lowering medications (e.g. statins, fibrates), anti-inflammatory medications (e.g., NSAIDs, corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin)
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Connecticut
Storrs, Connecticut, 06269
About this study
The goal of this intervention study is to determine whether consumption of different fractions of chicken eggs, including egg whites, egg yolks, and whole eggs, confer different changes in markers of HDL function and T cell profiles in younger vs. older men and women. The study will address the following objectives:
- Objective 1: Determine if daily consumption of egg fractions differentially alter HDL profiles across age groups.
- Objective 2: Determine if daily consumption of egg fractions differentially alter immune cell profiles across age groups.
Read more
Participants will be asked to consume egg whites, egg yolks, and whole eggs on a daily basis for 4-weeks each, and avoid eating eggs for a total of 8 weeks at different points in the study. Participants will additionally be provided guidance on following a generally healthy diet, and will be asked to complete surveys about dietary intake and physical activity, as well as provide blood samples throughout the course of the study.
Researchers will compare whether daily consumption of egg whites, egg yolks, and whole eggs differentially alter markers of HDL function and T cell profiles in younger vs. older adults.
- Conditions
- Lipoproteins, Inflammatory Response
- Being tested
- Whole eggs, Egg yolks, Egg whites
- Keywords
- Diet, Lipoproteins, T-Lymphocytes, Eggs, Aging
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Whole eggsOther
3 large whole eggs per day for 4 weeks
Egg yolksOther
3 large egg equivalent of egg yolks per day for 4 weeks
Egg whitesOther
3 large egg equivalent of egg whites per day for 4 weeks
| Study group | Role | What they receive |
|---|---|---|
| Egg whites | Active comparator | 3 large egg equivalent of liquid egg whites per day for 4 weeks Receives: Other: Egg whites |
| Egg yolks | Experimental | 3 large egg equivalent of liquid egg yolks per day for 4 weeks Receives: Other: Egg yolks |
| Whole eggs | Experimental | 3 large whole eggs per day for 4 weeks Receives: Other: Whole eggs |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in serum concentration of large HDL particles between diet periods
Measurement of serum large HDL particles (nmol/L) at the egg-free run-in period and the end of each intervention arm.
Measured: 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Oct 2023
- Study start23 Jan 2024
- Primary completion29 Dec 2025
- Study completion29 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for LipoproteinsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Connecticut
- Sponsor type
- University, hospital or other
- Collaborators
- American Egg Board
- Responsible party
- Principal investigator, Catherine Andersen, University of Connecticut
- Investigators
- Catherine J Andersen, PhD, RDN, Principal investigator, University of Connecticut
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06086795
- Sponsor's protocol ID
- H22-0174
- Other IDs
- AG221113
- Status last verified
- Apr 2026
- First submitted
- 10 Oct 2023
- Last updated
- 5 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating Age-dependent Effects of Egg Intake on HDL and Immune Profiles
- ClinicalTrials.gov ID
- NCT06086795
- Acronym / sponsor ID
- H22-0174
- Conditions
- Lipoproteins, Inflammatory Response
- Keywords
- Diet, Lipoproteins, T-Lymphocytes, Eggs, Aging
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- University of ConnecticutUniversity, hospital or other
- Collaborators
- American Egg Board
- Study start
- 23 Jan 2024 (actual)
- Primary completion
- 29 Dec 2025 (actual)
- Study completion
- 29 Dec 2025 (actual)
- First posted
- 17 Oct 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this intervention study is to determine whether consumption of different fractions of chicken eggs, including egg whites, egg yolks, and whole eggs, confer different changes in markers of HDL function and T cell profiles in younger vs. older men and women. The study will address the following objectives:
- Objective 1: Determine if daily consumption of egg fractions differentially alter HDL profiles across age groups.
- Objective 2: Determine if daily consumption of egg fractions differentially alter immune cell profiles across age groups.
Participants will be asked to consume egg whites, egg yolks, and whole eggs on a daily basis for 4-weeks each, and avoid eating eggs for a total of 8 weeks at different points in the study. Participants will additionally be provided guidance on following a generally healthy diet, and will be asked to complete surveys about dietary intake and physical activity, as well as provide blood samples throughout the course of the study.
Researchers will compare whether daily consumption of egg whites, egg yolks, and whole eggs differentially alter markers of HDL function and T cell profiles in younger vs. older adults.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Egg whites | Active comparator | Other: Egg whites3 large egg equivalent of liquid egg whites per day for 4 weeks |
| Egg yolks | Experimental | Other: Egg yolks3 large egg equivalent of liquid egg yolks per day for 4 weeks |
| Whole eggs | Experimental | Other: Whole eggs3 large whole eggs per day for 4 weeks |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- 18-30 years old, or 50-75 years old (at time of screening)
- Body mass index (BMI) < 30 kg/m2
- Willing to consume whole eggs, egg whites, or egg yolks on a daily basis during study periods, and refrain from eating eggs during other study periods
- Do not fit any exclusion criteria
Key exclusion criteria (8 listed)
- < 18 years old; 31-49 years old; > 75 years old
- BMI ≥ 30 kg/m2 or body weight < 110 pounds
- Weight changes > 10% over the last 4 weeks
- Self-reported history of diabetes, heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
- Allergy or intolerance to eggs, egg components, or egg products
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Whole eggs3 large whole eggs per day for 4 weeks | Other | Whole eggs |
| Egg yolks3 large egg equivalent of egg yolks per day for 4 weeks | Other | Egg yolks |
| Egg whites3 large egg equivalent of egg whites per day for 4 weeks | Other | Egg whites |
Primary outcome
Change in serum concentration of large HDL particles between diet periods
Time frame: 4 weeks
Measurement of serum large HDL particles (nmol/L) at the egg-free run-in period and the end of each intervention arm.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Catherine J Andersen, PhD, RDN principal investigator
University of Connecticut
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Whole eggs, Egg yolks and Egg whites in people with Lipoproteins and Inflammatory Response, run by University of Connecticut at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in serum concentration of large HDL particles between diet periods (time frame: 4 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 May 2026.