Post Operative PainNCT06088420
Analgesic Efficacy of Different Nerve Blocks in Postoperative Cesarean Section
A study testing Intrathcal Morphine Group, Quadratus Lumborum nerve block(QL) group and Erector Spinae nerve block (ESP)group in people with Post Operative Pain, run by Assiut University at 1 site in Egypt.
Trial summary
comparing analgesic efficacy of different nerve blocks on post operative cesarean sections. Read more about this study
- Who is it for?
- Ages 18 to 40 years, women only
- Conditions the study is for
- Post Operative Pain
- What is being tested?
- Intrathcal Morphine Group, Quadratus Lumborum nerve block(QL) group and Erector Spinae nerve block (ESP)group
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteEgypt
- Study dates
- 15 Oct 2023to 5 Apr 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- 18-40 years old
- more or equal 37 weeks of gestation
- ASA 1,2
- Elective cesarean delivery
Who cannot join
- Patient refusal
- inability to cooperate with or understand the study
- local infection.
- bleeding disorder
- known anaphylaxis to any drug used in the trial
- ASA physical status more than 2
Show all 10Show fewer
- emergency operations
- chronic opioid use (opioid use in the past 3 months)
- Neurologic deficit or disorder
- contraindication to regional anesthesia.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Mahmoud Mamdouh Ekram
Asyut, Manfalout
Ghada Abo Elfadl, prof, 01005802086, ghadafadl77@gmail.com
About this study
Official title: Analgesic Efficacy of Erector Spinae Block , Quadratus Lumborum Block, and Intrathecal Morphine for Postoperative Pain Relief After Cesarean Section: A Randomized Study
comparing analgesic efficacy of different nerve blocks on post operative cesarean sections.
Read the detailed description
Analgesic efficacy of Erector Spinae, Quadratus Lumborum and Intrathecal Morphine for post operative pain relief after cesarean section,
- Conditions
- Post Operative Pain
- Being tested
- Intrathcal Morphine Group, Quadratus Lumborum nerve block(QL) group, Erector Spinae nerve block (ESP)group
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Intrathcal Morphine GroupProcedure or surgery
intrathecal morphine (150 μg) in addition to standard spinal anesthetic drugs(10-12 mg 0.5% hyperbaric bupivacaine)
Quadratus Lumborum nerve block(QL) groupProcedure or surgery
intrathecal morphine (150 μg) in addition to standard spinal anesthetic drugs (10-12 mg 0.5% hyperbaric bupivacaine) + bilateral QL block by injecting 20 ml of 0.25% isobaric bupivacaine bolus with 4 mg ) dexamethasone as an adjuvant
Erector Spinae nerve block (ESP)groupProcedure or surgery
intrathecal morphine (150 μg) in addition to standard spinal anesthetic drugs (10-12 mg 0.5% hyperbaric bupivacaine) + bilateral ESP block by injecting 20 ml of 0.25% isobaric bupivacaine bolus with 4 mg ) dexamethasone as an adjuvant
| Study group | Role | What they receive |
|---|---|---|
| Intrathcal Morphine Group | Active comparator | Intrathecal morphine administration for post operative pain relief after cesarean section Receives: Procedure: Intrathcal Morphine Group |
| Quadratus Lumborum nerve block group | Active comparator | Quadratus Lumborum nerve block administration for post operative pain relief after cesarean section Receives: Procedure: Quadratus Lumborum nerve block(QL) group |
| Erector Spinae nerve block group | Active comparator | Erector Spinae nerve block administraion for post operative pain relief after cesarean section Receives: Procedure: Erector Spinae nerve block (ESP)group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Duration of analgesia until first analgesic request.
the time interval from immediate postoperative period until NRS reached 4
Measured: 24 hours .
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Oct 2023
- Study start15 Oct 2023
- Primary completion5 Apr 2025 (estimated)
- Study completion5 Apr 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Operative PainStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mahmoud Mamdouh Ekram, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06088420
- Sponsor's protocol ID
- 17101962
- Status last verified
- Apr 2025
- First submitted
- 10 Oct 2023
- Last updated
- 9 Apr 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Analgesic Efficacy of Erector Spinae Block , Quadratus Lumborum Block, and Intrathecal Morphine for Postoperative Pain Relief After Cesarean Section: A Randomized Study
- ClinicalTrials.gov ID
- NCT06088420
- Acronym / sponsor ID
- 17101962
- Conditions
- Post Operative Pain
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 15 Oct 2023 (actual)
- Primary completion
- 5 Apr 2025 (estimated)
- Study completion
- 5 Apr 2025 (estimated)
- First posted
- 18 Oct 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
comparing analgesic efficacy of different nerve blocks on post operative cesarean sections.
Detailed description
Analgesic efficacy of Erector Spinae, Quadratus Lumborum and Intrathecal Morphine for post operative pain relief after cesarean section,
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Intrathcal Morphine Group | Active comparator | Procedure: Intrathcal Morphine GroupIntrathecal morphine administration for post operative pain relief after cesarean section |
| Quadratus Lumborum nerve block group | Active comparator | Procedure: Quadratus Lumborum nerve block(QL) groupQuadratus Lumborum nerve block administration for post operative pain relief after cesarean section |
| Erector Spinae nerve block group | Active comparator | Procedure: Erector Spinae nerve block (ESP)groupErector Spinae nerve block administraion for post operative pain relief after cesarean section |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- 18-40 years old
- more or equal 37 weeks of gestation
- ASA 1,2
- Elective cesarean delivery
Key exclusion criteria (10 listed)
- Patient refusal
- inability to cooperate with or understand the study
- local infection.
- bleeding disorder
- known anaphylaxis to any drug used in the trial
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Intrathcal Morphine Groupintrathecal morphine (150 μg) in addition to standard spinal anesthetic drugs(10-12 mg 0.5% hyperbaric bupivacaine) | Procedure or surgery | Intrathcal Morphine Group |
| Quadratus Lumborum nerve block(QL) groupintrathecal morphine (150 μg) in addition to standard spinal anesthetic drugs (10-12 mg 0.5% hyperbaric bupivacaine) + bilateral QL block by injecting 20 ml of 0.25% isobaric bupivacaine bolus with 4 mg ) dexamethasone as an adjuvant | Procedure or surgery | Quadratus Lumborum nerve block group |
| Erector Spinae nerve block (ESP)groupintrathecal morphine (150 μg) in addition to standard spinal anesthetic drugs (10-12 mg 0.5% hyperbaric bupivacaine) + bilateral ESP block by injecting 20 ml of 0.25% isobaric bupivacaine bolus with 4 mg ) dexamethasone as an adjuvant | Procedure or surgery | Erector Spinae nerve block group |
Primary outcome
Duration of analgesia until first analgesic request.
Time frame: 24 hours .
the time interval from immediate postoperative period until NRS reached 4
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Apr 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Intrathcal Morphine Group, Quadratus Lumborum nerve block(QL) group and Erector Spinae nerve block (ESP)group in people with Post Operative Pain, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 9 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ghada Abo Elfadl, MD (01005802086, ghadafadl77@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Duration of analgesia until first analgesic request. (time frame: 24 hours .). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Apr 2025.