PulmonaryNCT06099483
The Effect of Exercise on Brain Functions
A study testing Action observation and motor imagery and Active breathing exercise in people with Pulmonary and EEG, run by Istanbul Medipol University Hospital at 1 site in Turkey (Türkiye).
Trial summary
Concept of action simulation; It is an internal representation of motor programs that does not involve explicit movement. Motor imagery method (MI) or movement observation (HG) method are considered two separate action simulation methods that activate motor regions in the brain. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- What is being tested?
- Action observation and motor imagery and Active breathing exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 33 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2023to 30 Sep 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Volunteering to participate in the study
- Being between the ages of 18-40
- Not using an assistive device
- Having been using the same medications for the last 4 weeks
- No additional comorbid diseases of the orthopedic, neurological or cardiac system
- Getting 30 or more points from each of the Kinesthetic and Visual Imagination Questionnaire -20 (KGIA-20) visual imagination score and kinesthetic imagination score (The purpose of this criterion is to check that the patients who will be distributed to the cognitive rehabilitation group have sufficient imagination ability and to be able to do the exercises.)
Who cannot join
- Not agreeing to participate in the study
- Patients who have used oral corticosteroid drugs in the last 4 weeks
- Participants who cannot understand verbal instructions and are visually impaired
- Have currently participated in another clinical trial within the last 30 days that may affect the results of the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Effect of Motor Imagery Exercise Combined With Movement Observation on Brain Electrical Activity and Cardioventilatory Responses in Healthy Sedentary Individuals.
Concept of action simulation; It is an internal representation of motor programs that does not involve explicit movement. Motor imagery method (MI) or movement observation (HG) method are considered two separate action simulation methods that activate motor regions in the brain. Both methods remain a popular and effective tool for improving motor learning. Research has shown that clinicians working in rehabilitation settings are aware of the needs of patients, athletes, etc. are recommended as methods that participants can use to improve their motor skills.
Motor imagery training is a dynamic mental process in which a movement is mentally visualized without any visible movement or any voluntary motor muscle activation. Movement observation training is a method that involves internal, real-time motor simulation of movements in which the observer visually perceives movements performed by another. Mirror neurons, located primarily in the rostral part of the inferior parietal lobe and the ventral premotor cortex, are activated both when an action is physically performed and when the action is observed being performed by another person. Studies using neuroimaging techniques have provided support for this theory by showing that many areas known to be active during action simulation, such as the dorsal pre-motor cortex, supplementary motor area, superior parietal lobe, and intraparietal sulcus, are indeed active during both HG and MI. There is evidence in the literature that MI and HG also trigger sympathetic nervous system activation. There may be changes in respiration, heart rate and skin temperature, as well as an increase in electrodermal activity.
Read more
EEG is an inexpensive, noninvasive, and simple examination that can be used to evaluate neurophysiological functions by measuring electrical activity. Understanding the mechanism of beta rhythms is important because they are associated with conscious thinking, logical thinking, memory and problem solving, whereas suppression of beta waves contributes to depression and cognitive decline.
This study will investigate the effectiveness of exercising or watching or imagining exercise on brain functions.
Read the detailed description
Participants in the study were divided into 3 groups. One group was shown breathing exercises and asked to imagine these exercises(Motor imagery and action observatin). The second group was made to do active exercises(The same exercises used in motor imagery and action observation were actively performed). The third group was not made to do anything. The exercises lasted 10 minutes. Watching and imagining the movement was also organized as a 10-minute program. That's why the control group was not allowed to do anything for 10 minutes. EEG recordings were taken during this 10-minute period in all three groups.
- Being tested
- Action observation and motor imagery, Active breathing exercise, Control group
- Keywords
- motor imagery; EEG; pulmonary rehabilitation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Action observation and motor imageryOther
EEG recording was taken while watching a 10-minute video recording of specified breathing exercises and imagining the exercises.
Active breathing exerciseOther
EEG recording was taken while the physiotherapist performed active breathing exercises for 10 minutes.
Control groupOther
EEG recording was taken while resting with eyes closed for 10 minutes.
| Study group | Role | What they receive |
|---|---|---|
| action observation and motor imegary | Active comparator | The motor imagery and action observation group was asked to watch a previously recorded breathing exercise video and imagine it as if they were doing it themselves. Receives: Other: Action observation and motor imagery |
| Active Breathing Exercise Group | Active comparator | Respiratory control, diaphragmatic breathing and thoracic expansion exercises were actively performed for 10 repetitions each. Receives: Other: Active breathing exercise |
| Control group | Active comparator | Participants will remain in a sitting position throughout the entire experimental group application. Participants were prevented from making physical movements and were asked to keep their minds closed by closing their eyes and not thinking about anything. Receives: Other: Control group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Acute effect on brain electrical activity
Motor imagery exercise combined with action observation has an acute effect on brain electrical activity in healthy sedentary individuals.
Measured: up to 24 weeks
Secondary outcomes (1)
Acute effect on cardioventilatory responses
Motor imagery exercise combined with action observation has an acute effect on cardioventilatory responses in healthy sedentary individuals.
Measured: up to 24 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Oct 2023
- Study start1 Aug 2023
- Primary completion30 Sep 2023
- Study completion30 Sep 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for PulmonaryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- randomized controlled double-blind study
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 33 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Medipol University Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Istanbul Gedik University
- Responsible party
- Principal investigator, ebrar atak, Istanbul Gedik University
- Investigators
- Ebrar Atak, PhD, Study director, Istanbul Gedik University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06099483
- Sponsor's protocol ID
- ebraratak1
- Status last verified
- Mar 2024
- First submitted
- 16 Oct 2023
- Last updated
- 22 Mar 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Atak E, Atac A. The Acute Effects of Motor Imagery Combined With Action Observation Breathing Exercise on Cardiorespiratory Responses, Brain Activity, and Cognition: A Randomized, Controlled Trial. Cardiovasc Ther. 2025 Feb 22;2025:6460951. doi: 10.1155/cdr/6460951. eCollection 2025.
PubMed 40026414
Study at a glance
From the registry record, last updated by the sponsor on 22 Mar 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effect of Motor Imagery Exercise Combined With Movement Observation on Brain Electrical Activity and Cardioventilatory Responses in Healthy Sedentary Individuals.
- ClinicalTrials.gov ID
- NCT06099483
- Acronym / sponsor ID
- ebraratak1
- Keywords
- motor imagery; EEG; pulmonary rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 33 participants (actual)
- Lead sponsor
- Istanbul Medipol University HospitalUniversity, hospital or other
- Collaborators
- Istanbul Gedik University
- Study start
- 1 Aug 2023 (actual)
- Primary completion
- 30 Sep 2023 (actual)
- Study completion
- 30 Sep 2023 (actual)
- First posted
- 25 Oct 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Concept of action simulation; It is an internal representation of motor programs that does not involve explicit movement. Motor imagery method (MI) or movement observation (HG) method are considered two separate action simulation methods that activate motor regions in the brain. Both methods remain a popular and effective tool for improving motor learning. Research has shown that clinicians working in rehabilitation settings are aware of the needs of patients, athletes, etc. are recommended as methods that participants can use to improve their motor skills.
Motor imagery training is a dynamic mental process in which a movement is mentally visualized without any visible movement or any voluntary motor muscle activation. Movement observation training is a method that involves internal, real-time motor simulation of movements in which the observer visually perceives movements performed by another. Mirror neurons, located primarily in the rostral part of the inferior parietal lobe and the ventral premotor cortex, are activated both when an action is physically performed and when the action is observed being performed by another person. Studies using neuroimaging techniques have provided support for this theory by showing that many areas known to be active during action simulation, such as the dorsal pre-motor cortex, supplementary motor area, superior parietal lobe, and intraparietal sulcus, are indeed active during both HG and MI. There is evidence in the literature that MI and HG also trigger sympathetic nervous system activation. There may be changes in respiration, heart rate and skin temperature, as well as an increase in electrodermal activity.
EEG is an inexpensive, noninvasive, and simple examination that can be used to evaluate neurophysiological functions by measuring electrical activity. Understanding the mechanism of beta rhythms is important because they are associated with conscious thinking, logical thinking, memory and problem solving, whereas suppression of beta waves contributes to depression and cognitive decline.
This study will investigate the effectiveness of exercising or watching or imagining exercise on brain functions.
Detailed description
Participants in the study were divided into 3 groups. One group was shown breathing exercises and asked to imagine these exercises(Motor imagery and action observatin). The second group was made to do active exercises(The same exercises used in motor imagery and action observation were actively performed). The third group was not made to do anything. The exercises lasted 10 minutes. Watching and imagining the movement was also organized as a 10-minute program. That's why the control group was not allowed to do anything for 10 minutes. EEG recordings were taken during this 10-minute period in all three groups.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- randomized controlled double-blind study
| Arm | Type | Receives |
|---|---|---|
| action observation and motor imegary | Active comparator | Other: Action observation and motor imageryThe motor imagery and action observation group was asked to watch a previously recorded breathing exercise video and imagine it as if they were doing it themselves. |
| Active Breathing Exercise Group | Active comparator | Other: Active breathing exerciseRespiratory control, diaphragmatic breathing and thoracic expansion exercises were actively performed for 10 repetitions each. |
| Control group | Active comparator | Other: Control groupParticipants will remain in a sitting position throughout the entire experimental group application. Participants were prevented from making physical movements and were asked to keep their minds closed by closing their eyes and not thinking about anything. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Volunteering to participate in the study
- Being between the ages of 18-40
- Not using an assistive device
- Having been using the same medications for the last 4 weeks
- No additional comorbid diseases of the orthopedic, neurological or cardiac system
Key exclusion criteria (4 listed)
- Not agreeing to participate in the study
- Patients who have used oral corticosteroid drugs in the last 4 weeks
- Participants who cannot understand verbal instructions and are visually impaired
- Have currently participated in another clinical trial within the last 30 days that may affect the results of the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Action observation and motor imageryEEG recording was taken while watching a 10-minute video recording of specified breathing exercises and imagining the exercises. | Other | action observation and motor imegary |
| Active breathing exerciseEEG recording was taken while the physiotherapist performed active breathing exercises for 10 minutes. | Other | Active Breathing Exercise Group |
| Control groupEEG recording was taken while resting with eyes closed for 10 minutes. | Other | Control group |
Primary outcome
Acute effect on brain electrical activity
Time frame: up to 24 weeks
Motor imagery exercise combined with action observation has an acute effect on brain electrical activity in healthy sedentary individuals.
1 secondary outcome
Acute effect on cardioventilatory responses
Time frame: up to 24 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Mar 2024.
- Derived from this study: PubMed 40026414Atak E, Atac A. The Acute Effects of Motor Imagery Combined With Action Observation Breathing Exercise on Cardiorespiratory Responses, Brain Activity, and Cognition: A Randomized, Controlled Trial. Cardiovasc Ther. 2025 Feb 22;2025:6460951. doi: 10.1155/cdr/6460951. eCollection 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ebrar Atak, PhD study director
Istanbul Gedik University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Action observation and motor imagery and Active breathing exercise in people with Pulmonary and EEG, run by Istanbul Medipol University Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Mar 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Acute effect on brain electrical activity (time frame: up to 24 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06099483, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Mar 2024.