Cognitive FunctionNCT06114550
Resistance Training on Growth Factors
A study testing High intensity resistance training and Low intensity resistance training in people with Cognitive Function, run by Air Force Military Medical University, China.
Trial summary
The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are: 1. Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Cognitive Function
- What is being tested?
- High intensity resistance training and Low intensity resistance training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- No sites listed yet
- Study dates
- 27 Feb 2024to 7 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- age between 18 to 30 years
- no experiencing musculoskeletal disorders or sports injuries
- had not participated any regular aerobic endurance or resistance training with in the previous half years
- no smoking habit or intake alcohol and other medication (e.g., steroid hormone)
- good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)
Who cannot join
- experiencing musculoskeletal disorders or sports injuries in recent 1 month
- had regular resistance training exercise
- intake any supplementary(drug and hormone)
Trial locations and contacts
No sites are listed yet.
About this study
Official title: Acute Effect of Resistance Training With Different Intensity on Circulating Levels of Neurotrophic Growth Factors and Homocysteine in Young Adults
The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:
- Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.
- whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.
Read more
Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).
Researchers will compare the training effects of two different training on these growth factors.
- Conditions
- Cognitive Function
- Being tested
- High intensity resistance training, Low intensity resistance training
- Keywords
- neurotrophic growth factors, IGF-1, BDNF, VEGF, Irisin, Hcy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High intensity resistance trainingOther
The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.
Low intensity resistance trainingOther
For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.
| Study group | Role | What they receive |
|---|---|---|
| High-intensity resistance training group (HIRT) | Experimental | All subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set. Receives: Other: High intensity resistance training |
| low-intensity resistance training group (LIRT) | Experimental | All subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order. Receives: Other: Low intensity resistance training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rata of perceived exertion
The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.
Measured: "0 minutes" "60 minutes" "90 minutes"
Blood lactate
serum blood lactate
Measured: "0 minutes" "60 minutes" "90 minutes"
BDNF
regulators of neurogenesis
Measured: "0 minutes" "60 minutes" "90 minutes"
IGF-1
regulators of neurogenesis
Measured: "0 minutes" "60 minutes" "90 minutes"
VEGF
regulators of neurogenesis
Measured: "0 minutes" "60 minutes" "90 minutes"
Irisin
regulators of neurogenesis
Measured: "0 minutes" "60 minutes" "90 minutes"
Hcy
homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction
Measured: "0 minutes" "60 minutes" "90 minutes"
Secondary outcomes (2)
Reactive time
Reaction time is the time it takes for the body to go from receiving a stimulus to responding to an action
Measured: "0 minutes" "60 minutes" "90 minutes"
Accuracy rate
Accuracy refers to the correct degree of expression or description of a thing, which is used to reflect the correct answer to the thing
Measured: "0 minutes" "60 minutes" "90 minutes"
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Nov 2023
- Study start27 Feb 2024 (estimated)
- Primary completion30 Mar 2024 (estimated)
- Study completion7 Apr 2024 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cognitive FunctionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind
- Who is masked
- Care provider, Investigator, Outcomes assessor
- Enrolment
- 12 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Air Force Military Medical University, China
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Chongwen Zuo, Air Force Military Medical University, China
- Investigators
- chongwen zuo, Doctoral, Principal investigator, Air Force Medical Center of Chinese PLA
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06114550
- Sponsor's protocol ID
- zuochongwen
- Status last verified
- Jan 2024
- First submitted
- 24 Oct 2023
- Last updated
- 1 Feb 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher. First author should be contacted if someone wants to request the data from this study.
Study at a glance
From the registry record, last updated by the sponsor on 1 Feb 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effect of Resistance Training With Different Intensity on Circulating Levels of Neurotrophic Growth Factors and Homocysteine in Young Adults
- ClinicalTrials.gov ID
- NCT06114550
- Acronym / sponsor ID
- zuochongwen
- Conditions
- Cognitive Function
- Keywords
- neurotrophic growth factors, IGF-1, BDNF, VEGF, Irisin, Hcy
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 12 participants (estimated)
- Lead sponsor
- Air Force Military Medical University, ChinaUniversity, hospital or other
- Study start
- 27 Feb 2024 (estimated)
- Primary completion
- 30 Mar 2024 (estimated)
- Study completion
- 7 Apr 2024 (estimated)
- First posted
- 2 Nov 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are:
- Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy.
- whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete.
Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets).
Researchers will compare the training effects of two different training on these growth factors.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High-intensity resistance training group (HIRT) | Experimental | Other: High intensity resistance trainingAll subjects were instructed to conduct HIRT consisted of 4-5 sets of 12 repetitions at 80%1RM, with 1-2 minutes rests between each set. |
| low-intensity resistance training group (LIRT) | Experimental | Other: Low intensity resistance trainingAll subjects were instructed to conduct LIRT consisted of 4-5 sets of 24 repetitions at 40%1RM, with same period) in random order. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- age between 18 to 30 years
- no experiencing musculoskeletal disorders or sports injuries
- had not participated any regular aerobic endurance or resistance training with in the previous half years
- no smoking habit or intake alcohol and other medication (e.g., steroid hormone)
- good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)
Key exclusion criteria (3 listed)
- experiencing musculoskeletal disorders or sports injuries in recent 1 month
- had regular resistance training exercise
- intake any supplementary(drug and hormone)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High intensity resistance trainingThe HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes. | Other | High-intensity resistance training group (HIRT) |
| Low intensity resistance trainingFor LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes. | Other | low-intensity resistance training group (LIRT) |
Primary outcome
Rata of perceived exertion
Time frame: "0 minutes" "60 minutes" "90 minutes"
The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.
Blood lactate
Time frame: "0 minutes" "60 minutes" "90 minutes"
serum blood lactate
BDNF
Time frame: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
IGF-1
Time frame: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
VEGF
Time frame: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
Irisin
Time frame: "0 minutes" "60 minutes" "90 minutes"
regulators of neurogenesis
Hcy
Time frame: "0 minutes" "60 minutes" "90 minutes"
homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction
2 secondary outcomes
Reactive time
Time frame: "0 minutes" "60 minutes" "90 minutes"
Accuracy rate
Time frame: "0 minutes" "60 minutes" "90 minutes"
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Feb 2024.
- Individual participant dataSharing planned: Yes. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher. First author should be contacted if someone wants to request the data from this study.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
chongwen zuo, Doctoral principal investigator
Air Force Medical Center of Chinese PLA
Questions about this trial
What is this clinical trial studying?
A study testing High intensity resistance training and Low intensity resistance training in people with Cognitive Function, run by Air Force Military Medical University, China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 1 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Chongwen Zuo, Doctoral (+86 18810716505, zuochongwen@cupes.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rata of perceived exertion (time frame: "0 minutes" "60 minutes" "90 minutes"). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Feb 2024.