Carcinoma, Non-Small-Cell LungPhase 3SUNRAY-01NCT06119581
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
A Phase 3 study testing LY3537982, Pembrolizumab and Cisplatin in people with Carcinoma, Non-Small-Cell Lung and Neoplasm Metastasis, run by Eli Lilly and Company at 416 sites in 29 countries.
Trial summary
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
- What is being tested?
- LY3537982, Pembrolizumab and Cisplatin
- Type of treatment
- Pill or oral medicine, Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 1,264 participants
- Where
- 416 sitesin 29 countries
- Study dates
- 21 Dec 2023to Jan 2031
- Phase
- Phase 3
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Histologically or cytologically confirmed NSCLC with Stage IIIB-IIIC or Stage IV disease, not suitable for curative intent radical surgery or radiation therapy.
- Part B and Safety Lead-In Part B: the histology of the tumor must be predominantly non-squamous (in line with pemetrexed label).
- Must have disease with evidence of KRAS G12C mutation.
- Must have known programmed death-ligand 1 (PD-L1) expression
- Part A: Greater than or equal to (≥)50 percent (%).
- Part B: 0% to 100%.
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- Part C: <50%.
- Must have measurable disease per RECIST v1.1.
- Must have an ECOG performance status of 0 or 1.
- Estimated life expectancy ≥12 weeks.
- Ability to swallow capsules.
- Must have adequate laboratory parameters.
- Contraceptive use should be consistent with local regulations for those participating in clinical studies.
- Women of childbearing potential must
- Have a negative pregnancy test.
- Not be breastfeeding during treatment
Who cannot join
- Have a documented additional validated targetable oncogenic driver mutation or alteration in genes such as epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), BRAF (V600E), human epidermal growth factor receptor 2 (HER2), MET (exon 14), ROS1, rearranged during transfection (RET), or neurotrophic tyrosine receptor kinase (NTRK)1/2/3.
- Have had any of the following prior to randomization:
- -- Prior systemic therapy (chemotherapy, immunotherapy, targeted therapy, or biological therapy) for advanced or metastatic NSCLC.
- --- 1 cycle of standard-of-care treatment prior to study enrollment will be allowed for cases where immediate treatment is clinically indicated:
- Have known active central nervous system metastases and/or carcinomatous meningitis.
- Exclusion Criteria for Participants receiving Pemetrexed and Platinum (Part B and Safety Lead-In Part B)
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- Have predominantly squamous cell histology for NSCLC
- Only for participants with mild to moderate renal insufficiency: Unable to avoid aspirin, ibuprofen, or other nonsteroidal anti-inflammatory drugs (NSAIDs) two days before (5 days for long acting NSAIDs), day of, and two days after administration of pemetrexed
- Is unable or unwilling to take folic acid or vitamin B12 supplementation.
Trial locations and contacts
416 sites in 29 countries. Contact the study team or a site near you to ask about taking part.
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or contact
Physicians interested in becoming principal investigators please contact contact
416 sites in 29 countries
United States87 sites, 86 recruiting
- Recruiting
University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, 87131
Moises Harari Turquie
- Recruiting
University of Michigan
Ann Arbor, Michigan, 48109
Angel Qin
- Recruiting
University Cancer & Blood Center, LLC
Athens, Georgia, 30607
706-353-2990
PETROS NIKOLINAKOS
- Recruiting
Emory University School of Medicine- Grady Campus
Atlanta, Georgia, 30303
404-251-5544
Ticiana Leal
- Recruiting
Winship Cancer Institute, Emory University
Atlanta, Georgia, 30322
404-251-5544
Ticiana Leal
- Recruiting
USO - Texas Oncology
Austin, Texas, 78745
James Uyeki
- Recruiting
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, 21224
Kristen Marrone
- Recruiting
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809
225-215-1185
Victor Lin
- Recruiting
Boston Medical Center
Boston, Massachusetts, 02118
617-638-7584
Umit Tapan
- Recruiting
Maimonides Cancer Center
Brooklyn, New York, 11220
718-765-2600
Julie Huang
- Recruiting
Lahey Hospital & Medical Center
Burlington, Massachusetts, 01805
781-744-8400
Andrew Piper-Vallillo
- Recruiting
The University of Vermont Medical Center Inc.
Burlington, Vermont, 05401
Rohit Singh
- Recruiting
Miami Valley Hospital South
Centerville, Ohio, 45459
tarek sabagh
- Recruiting
University of North Carolina Medical Center
Chapel Hill, North Carolina, 27599
Shetal Patel
- Recruiting
Medical University of South Carolina
Charleston, South Carolina, 29425
Mariam Alexander
- Recruiting
University of Virginia Health System
Charlottesville, Virginia, 22903
434-924-4251
Ryan Gentzler
- Recruiting
Tennessee Oncology Chattanooga
Chattanooga, Tennessee, 37404
Wade Iams
- Recruiting
University of Illinois at Chicago
Chicago, Illinois, 60612
Frank Weinberg
- Recruiting
University of Chicago Hospital
Chicago, Illinois, 60637
773-702-9901
Marina Garassino
- Recruiting
USO - Oncology Hematology Care
Cincinnati, Ohio, 45242
Patrick Ward
- Recruiting
USO - Maryland Oncology Hematology
Columbia, Maryland, 21044
Benjamin Bridges
- Recruiting
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T
Columbus, Ohio, 43210
614-293-3300
Timothy Burns
- Recruiting
Duke Cancer Institute
Durham, North Carolina, 27710
Jeffrey Clarke
- Recruiting
Swedish Cancer Institute - Edmonds
Edmonds, Washington, 98026
Siddhartha Devarakonda
- Recruiting
USO - Oncology Associates of Oregon
Eugene, Oregon, 97401
541-683-5001
James E Butrynski
- Recruiting
USO - Virginia Cancer Specialists
Fairfax, Virginia, 22031
Alexander Spira
- Recruiting
William Beaumont Army Medical Center
Fort Bliss, Texas, 79918
915-203-2268
Warren Alexander
- Recruiting
Parkview Research Center at Parkview Regional Medical Center
Fort Wayne, Indiana, 46845
patricia Rich
- Recruiting
Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234
602-521-3700
Todd Erickson
- Recruiting
The Cancer & Hematology Centers
Grand Rapids, Michigan, 49503
Eric Santos
- Recruiting
Prisma Health Cancer Institute
Greenville, South Carolina, 29605
Richard O'Neal
- Recruiting
Millennium Oncology Research Clinic
Hollywood, Florida, 33024
954-450-1808
Isaac Levy
- Recruiting
USO - Alliance Cancer Specialists, PC
Horsham, Pennsylvania, 19044
Joseph Potz
- Recruiting
Houston Methodist Hospital
Houston, Texas, 77030
713-441-9948
Jun Zhang
- Recruiting
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030
713-792-6363
Marcelo Vailati Negrao
- Recruiting
Lumi Research
Houston, Texas, 77090
David Nguyen
- Recruiting
Clearview Cancer Institute
Huntsville, Alabama, 35805
256-705-4224
Marshall Schreeder
- Recruiting
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
Gregory Durm
- Recruiting
Franciscan Health
Indianapolis, Indiana, 46237
317-859-5252
Harsha Ranganath
- Recruiting
Community Cancer Center North
Indianapolis, Indiana, 46250
317-621-3858
Natraj Ammakkanavar
- Recruiting
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
Ying Zhuo
- Recruiting
University of Tennessee Medical Center
Knoxville, Tennessee, 37920
865-305-8780
Ardy Davarifar
- Recruiting
Northwell Health/ RJ Zuckerberg Cancer Center
Lake Success, New York, 11042
Alexander Barbaro
- Recruiting
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89169
Liawaty Ho
- Recruiting
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756
Konstantin Dragnev
- Recruiting
University of Kentucky Chandler Medical Center
Lexington, Kentucky, 40536
859-257-9568
Susanne Arnold
- Recruiting
USO - Rocky Mountain Cancer Centers
Lone Tree, Colorado, 80124
303-925-0700
Robert Jotte
- Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, 90048
Kamya Sankar
- Recruiting
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical
Madison, Wisconsin, 53715
Lisa Lepeak
- Recruiting
Asante Rogue Regional Medical Center
Medford, Oregon, 97504
541-789-5003
Alison Savage
- Recruiting
Baptist Memorial Hospital-Memphis
Memphis, Tennessee, 38120
Osa Ogbeide
- Recruiting
Miami Cancer Institute at Baptist Health, Inc.
Miami, Florida, 33176
Bruna Pellini
- Recruiting
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
Mineola, New York, 11501
212-731-6363
Joshua Sabari
- Recruiting
Allina Health Cancer Institute - Abbott Northwestern Hospital
Minneapolis, Minnesota, 55407
Charlene Fares
- Recruiting
Tennessee Oncology
Nashville, Tennessee, 37203
Wade Iams
- Recruiting
USO - US Oncology Research Network
Nashville, Tennessee, 37203
SMO Sarah Cannon Research Inst.
- Recruiting
Yale University School of Medicine
New Haven, Connecticut, 06510
475-306-2658
So Yeon Kim
- Recruiting
Laura and Isaac Perlmutter Cancer Center
New York, New York, 10016
212-731-6363
Joshua Sabari
- Recruiting
Manhattan Eye, Ear and Throat Hospital
New York, New York, 10065
Alexander Barbaro
- Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
Kathryn Arbour
- Recruiting
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala
Ocala, Florida, 34474
352-732-4032
Ketan Doshi
- Recruiting
Orlando Health Cancer Institute
Orlando, Florida, 32806
Yuanbin Chen
- Recruiting
The Valley Hospital, Inc.
Paramus, New Jersey, 07652
Eli Kirshner
- Recruiting
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office
Philadelphia, Pennsylvania, 19107
Sarah Gordon
- Recruiting
Banner University Medical Center Phoenix
Phoenix, Arizona, 85006
Jiaxin Niu
- Recruiting
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232
Liza Villaruz
- Recruiting
Providence Portland Medical Center
Portland, Oregon, 97213
Rachel Sanborn
- Recruiting
Providence St. Vincent Medical Center
Portland, Oregon, 97225
Rachel Sanborn
- Recruiting
Kaiser Permanente Interstate Medical Office Central
Portland, Oregon, 97227
503-249-3315
Sandeep Mashru
- Recruiting
Lifespan Cancer Institute
Providence, Rhode Island, 02903
Christopher Azzoli
- Recruiting
VCU Health Adult Outpatient Pavillion
Richmond, Virginia, 23219
804-828-7999
Renato Martins
- Recruiting
HealthPartners Cancer Research Center
Saint Paul, Minnesota, 55101
Kurt Demel
- Recruiting
Swedish Medical Center
Seattle, Washington, 98104
Siddhartha Devarakonda
- Recruiting
VA Puget Sound Health Care System
Seattle, Washington, 98108
Daniel Wu
- Recruiting
Highlands Oncology Group
Springdale, Arkansas, 72762
479-872-8130
Eric Schaefer
- Recruiting
Springfield Clinic Main Campus
Springfield, Illinois, 62702
Preet Singh
- Recruiting
Oncology Hematology Associates
Springfield, Missouri, 65807
417-882-4880
Viran Holden
- Recruiting
Comprehensive Hematology Oncology
St. Petersburg, Florida, 33709
727-344-6569
Neeharika Makani
- Completed
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, 90502
- Recruiting
The University of Arizona Cancer Center - North Campus
Tucson, Arizona, 85719
520-626-3434
Linda Garland
- Recruiting
North Mississippi Hematology and Oncology Associates
Tupelo, Mississippi, 38801
Amit Jain
- Recruiting
USO - Northwest Cancer Specialists
Vancouver, Washington, 98684
Anthony Van Ho
- Recruiting
BASS Cancer Center
Walnut Creek, California, 94598
Jewel Johl
- Recruiting
Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016
Kristen Marrone
- Recruiting
USO - Texas Oncology
Webster, Texas, 77598
Pavel Levin
- Recruiting
Lexington Medical Center
West Columbia, South Carolina, 29169
803-794-7511
Scott Graupner
- Recruiting
The University of Kansas Cancer Center - Westwood
Westwood, Kansas, 66205
913-588-6029
Chao Huang
China33 sites, 33 recruiting
- Recruiting
Cancer Hospital Chinese Academy of Medical Science
Beijing, 100021
8615601395554
Ning Li
- Recruiting
Beijing Cancer hospital
Beijing, 100142
8613521469355
Jun Zhao
- Recruiting
Jilin Province Tumor Hospital
Changchun, 130000
Haifeng Liu
- Recruiting
Hunan Cancer Hospital
Changsha, 410013
Yongchang Zhang
- Recruiting
Hunan Cancer Hospital
Changsha, 410013
Lin Wu
- Recruiting
The First People's Hospital of Changzhou
Changzhou, 213003
Mei Ji
- Recruiting
Sichuan Cancer hospital
Chengdu, 610041
Wenxiu Yao
- Recruiting
West China Hospital, Sichuan University
Chengdu, 610041
Yan Zhang
- Recruiting
Fujian Cancer Hospital
Fuzhou, 350014
13675007687
Haipeng Xu
- Recruiting
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, 510170
Chengzhi Zhou
- Recruiting
Hainan General Hospital
Haikou, 570311
13876825536
yongxing chen
- Recruiting
The First Affiliated Hospital, Zhejiang University
Hangzhou, 310003
Jianying Zhou
- Recruiting
Sir Run Run Shaw Hospital
Hangzhou, 310016
Yong Fang
- Recruiting
Zhejiang Cancer Hospital
Hangzhou, 310022
Zhiyu Huang
- Recruiting
Harbin Medical University Cancer Hospital
Harbin, 150081
13904505825
Yan Yu
- Recruiting
Jinan Central Hospital
Jinan, 250013
Meili Sun
- Recruiting
Shandong Cancer Hospital
Jinan, 250117
Yuping Sun
- Recruiting
Taizhou Hospital of Zhejiang Province
Linhai, 317099
Dongqing LV
- Recruiting
LinYi Cancer Hospital
Linyi, 276001
15963998868
Jianhua Shi
- Recruiting
Liuzhou People's Hospital
Liuzhou, 545006
Min Li
- Recruiting
The First Affiliated Hospital of Nanchang University
Nanchang, 330006
Wei Zuo
- Recruiting
Nanjing First Hospital
Nanjing, 210012
Surong Fang
- Recruiting
Shanghai Chest Hospital
Shanghai, 200030
8613601813062
Shun Lu
- Recruiting
Tianjin Medical University Cancer Institute & Hospital
Tianjin, 300060
18622221232
Dingzhi Huang
- Recruiting
Xinjiang Medical University Cancer Hospital - Urumqi
Ürümqi, 830000
Chunling Liu
- Recruiting
Tongji Hospital Tongji Medical,Science & Technology
Wuhan, 430030
Qian Chu
- Recruiting
Wuhan Union Hospital
Wuhan, 430048
Xiaorong Dong
- Recruiting
Renmin Hospital of Wuhan University
Wuhan, 430064
Qibin Song
- Recruiting
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, 710061
Yu Yao
- Recruiting
Xiangyang Central Hospital
Xiangyang, 441021
Tienan Yi
- Recruiting
Yichang Central People's Hospital
Yichang, 443003
Xinhua Xu
- Recruiting
Affiliated Hospital of Guangdong Medical University
Zhanjiang, 524001
Shujun Li
- Recruiting
ZhuZhou Central Hospital
Zhuzhou, 412007
Yanchao Liang
Japan30 sites, 30 recruiting
- Recruiting
National Hospital Organization Asahikawa Medical Center
Asahikawa, 0708644
81120023812
Yuka Fujita
- Recruiting
Juntendo University Hospital
Bunkyō City, 113-8431
81120023812
Takehito Shukuya
- Recruiting
Tokyo Metropolitan Komagome Hospital
Bunkyō City, 113-8677
81120023812
Kageaki Watanabe
- Recruiting
National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395
81120023812
Masafumi Yamaguchi
- Recruiting
Kyushu University Hospital
Fukuoka, 812-8582
81120023812
Isamu Okamoto
- Recruiting
Saitama Medical University International Medical Center
Hidaka, 350-1298
81120023812
Hisao Imai
- Recruiting
Himeji Medical Center
Himeji, 670-8520
81120023812
Tetsuji Kawamura
- Recruiting
Kansai Medical University Hospital
Hirakata, 573-1191
81120023812
Takayasu Kurata
- Recruiting
Kanazawa University Hospital
Kanazawa, 920-8641
81120023812
Shinji Takeuchi
- Recruiting
Ibaraki Prefectural Central Hospital
Kasama, 309-1793
81120023812
Takayuki Kaburagi
- Recruiting
National Cancer Center Hospital East
Kashiwa, 277-8577
81120023812
Koichi Goto
- Recruiting
Kobe City Medical Center General Hospital
Kobe, 650-0047
81120023812
Yuki Sato
- Recruiting
Japanese Foundation for Cancer Research
Kōtō City, 135-8550
81120023812
Ryo Ariyasu
- Recruiting
University Hospital,Kyoto Prefectural University of Medicine
Kyoto, 602-8566
81120023812
Tadaaki Yamada
- Recruiting
National Hospital Organization Shikoku Cancer Center
Matsuyama, 791-0280
81120023812
Yuka Kato
- Recruiting
Shizuoka Cancer Center
Nagaizumi-cho,Sunto-gun, 411-8777
81120023812
Tateaki Naito
- Recruiting
Nagasaki University Hospital
Nagasaki, 852-8501
81120023812
Takemoto Shinnosuke
- Recruiting
Aichi Cancer Center Hospital
Nagoya, 464-8681
81120023812
Yutaka Fujiwara
- Recruiting
Miyagi Cancer Center
Natori, 981-1293
81120023812
Tatsuro Fukuhara
- Recruiting
Niigata Cancer Center Hospital
Niigata, 951-8566
81120023812
Hiroshi Tanaka
- Recruiting
Okayama University Hospital
Okayama, 700-8558
81120023812
Kadoaki Ohashi
- Recruiting
Kindai University Hospital- Osakasayama Campus
Sakai, 590-0197
81120023812
Takayuki Takahama
- Recruiting
National Hospital Organization Kinki-chuo Chest Medical Center
Sakai, 591-8555
81120023812
Kyoichi Okishio
- Recruiting
Hokkaido University Hospital
Sapporo, 060-8648
81120023812
Hidenori Kitai
- Recruiting
National Hospital Organization Yamaguchi Ube Medical Center
Ube, 755-0241
81120023812
Sho Uehara
- Recruiting
Tochigi Cancer Center
Utsunomiya, 320-0834
81120023812
Takashi Kasai
- Recruiting
Wakayama Medical University Hospital
Wakayama, 641-8510
81120023812
Eri Takase
- Recruiting
Kanagawa Cardiovascular and Respiratory Center
Yokohama, 236-0051
81120023812
Tomohisa Baba
- Recruiting
Kanagawa cancer center
Yokohama, 2418515
81120023812
Seigo Katakura
- Recruiting
Tottori University Hospital
Yonago, 683-8504
81120023812
Tomohiro Sakamoto
Brazil29 sites, 29 recruiting
- Recruiting
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, 14784400
Carlos Baston silva
- Recruiting
Hospital Tacchini
Bento Gonçalves, 95700-084
ANDRE REIRIZ
- Recruiting
Hospital São Domingos
Bequimão, 65060-645
Antonio Alencar
- Recruiting
Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul
Brasília, 70200-730
Rafaela Ribeiro
- Recruiting
Hospital Universitário Evangélico Mackenzie
Curitiba, 80730-150
+5541999744246
Fernanda Ronchi
- Recruiting
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
Fortaleza, 60430235
558532884576
Fabio Chaves
- Recruiting
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
Ijuí, 98700-000
55991592101
Fabio Franke
- Recruiting
Hospital Brasilia
Lago Sul, 71.635-610
Fernanda Amorim
- Recruiting
Hospital de Cancer de Londrina
Londrina, 86015-520
55 41 996379769
Mariana Piovesana
- Recruiting
Liga Norte Riograndense Contra o Câncer
Natal, 59062-000
55 84 40095595
Sulene Oliveira
- Recruiting
Hospital São Lucas da PUCRS
Porto Alegre, 90610-000
Ana Caroline Gelatti
- Recruiting
Oncominas
Pouso Alegre, 37554-216
553534297035
Marina Zorzetto
- Recruiting
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA
Rio de Janeiro, 20231-050
552132076564
Victor Santos
- Recruiting
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA
Rio de Janeiro, 22250-905
Tatiane Montella
- Recruiting
Instituto D'Or Pesquisa e Ensino
Rio de Janeiro, 22271-110
Clarissa Serodio da Rocha Baldotto
- Recruiting
Clinica Amo - Rio Vermelho
Salvador, 41950-640
557130218735
Aknar Calabrich
- Recruiting
Faculdade de Medicina do ABC
Santo André, 09060-650
551149935497
Claudia Vaz de Melo Sette
- Recruiting
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, 15090000
JOÃO SOLER
- Recruiting
COE Ensino e Pesquisa
São José dos Campos, 12242-660
Fabiano Costa
- Recruiting
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, 01246-000
5511999685217
Gilberto Castro
- Recruiting
Hospital Sírio Libanês
São Paulo, 01308-060
Guilherme Harada
- Recruiting
Hospital Santa Catarina - Paulista
São Paulo, 01310-000
Gregorio Soares
- Recruiting
Hospital BP
São Paulo, 01321-001
5511985883170
Marcelo Corassa
- Recruiting
Hospital Paulistano
São Paulo, 01321-001
11983591234
Cinthia Bognar
- Recruiting
Centro Paulista de Oncologia Clínica
São Paulo, 01452-000
551135056616
William Nassib William Junior
- Recruiting
Núcleo de Pesquisa Clínica da Rede São Camilo
São Paulo, 04014-002
551144500360
Felipe José Cruz
- Recruiting
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T
São Paulo, 04039-901
1150840931
Otavio Gampel
- Recruiting
Instituto D'Or de Pesquisa e Ensino (IDOR)
São Paulo, 04543-000
Milena Perez Mak
- Recruiting
CEDOES
Vitória, 29055450
Mauricio Pereira
Spain20 sites, 20 recruiting
- Recruiting
CHUAC-Hospital Teresa Herrera
A Coruña, 15006
Maria Garcia Campelo
- Recruiting
Hospital Infanta Cristina
Badajoz, 06006
924218040
Marta Gonzalez Cordero
- Recruiting
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
Barakaldo, 48903
94 60006399
Eider Azkona Uribelarrea
- Recruiting
Parc de Salut Mar - Hospital del Mar
Barcelona, 08003
34932483137
Edurne Arriola Aperribay
- Recruiting
Hospital Universitari Dexeus
Barcelona, 08028
ANDRES AGUILAR
- Recruiting
Hospital Universitari Vall d'Hebron
Barcelona, 08035
34932746085
Enriqueta Felip Font
- Recruiting
Instituto Catalan de Oncologia - Hospital Duran i Reynals
Hospitalet, 08907
932607744
Ernest Nadal Alforja
- Recruiting
Hospital Jerez de la Frontera
Jerez de la Frontera, 11407
Jesus Corral Jaime
- Recruiting
Hospital Insular de Gran Canaria
Las Palmas de Gran Canaria, 35016
34928441738
DELVYS RODRIGUEZ ABREU
- Recruiting
Complejo Asistencial Universitario de León - Hospital de León
León, 24071
Soledad Valdivieso
- Recruiting
Hospital Universitario Ramón y Cajal
Madrid, 28034
(+34) 913368263
Pilar Garrido Lopez
- Recruiting
Hospital Universitario 12 de Octubre
Madrid, 28041
0034913908000
Luis Paz-Ares Rodriguez
- Recruiting
H.R.U Málaga - Hospital General
Málaga, 29011
34951308130
María Vanesa Gutierrez Calderon
- Recruiting
Hospital Universitari Son Espases
Palma, 07120
Aitor Azkarate Martinez
- Recruiting
Complejo Hospitalario de Navarra
Pamplona, 31009
Maite Martinez Aguillo
- Recruiting
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, 28223
34914521987
Belen Rubio Viqueira
- Recruiting
CHUS - Hospital Clinico Universitario
Santiago de Compostela, 15706
981950511
Luis Leon Mateos
- Recruiting
Hospital Universitario Virgen Del Rocio
Seville, 41013
955013068
Reyes Bernabe Caro
- Recruiting
Hospital Clinico de Valencia
Valencia, 46010
961973500
Amelia Insa Molla
- Recruiting
Hospital Clínico Universitario Lozano Blesa
Zaragoza, 50009
+34976765746
Dolores Isla Casado
France18 sites, 18 recruiting
- Recruiting
Sainte Catherine Institut du Cancer Avignon Provence
Avignon, 84918
Hachmi AIT MOHAND SAID
- Recruiting
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, 69677
Michael Duruisseaux
- Recruiting
CHU Lille - Institut Coeur Poumon
Lille, 59037
0320444998
Alexis Cortot
- Recruiting
Centre Leon Berard
Lyon Cedex08, 69373
33426556761
Maurice Perol
- Recruiting
Centre Antoine-Lacassagne
Nice, 06189
0492031324
Victoria ferrari
- Recruiting
Institut Curie
Paris, 75248
33624456290
nicolas girard
- Recruiting
CHU Bordeaux Haut-Leveque
Pessac, 33600
Remi Veillon
- Recruiting
Centre Hospitalier Universitaire de Poitiers
Poitiers, 86021
Clotilde Deldycke
- Recruiting
Institut Jean Godinot
Reims, 51726
Amélie Lemoine
- Recruiting
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
Rennes, 35033
Herve Lena
- Recruiting
Institut de Cancérologie de l'Ouest
Saint-Herblain, 44805
33240679978
Sandrine Hiret
- Recruiting
Nouvel Hôpital Civil (NHC)
Strasbourg, 67091
Celine Mascaux
- Recruiting
Hôpital Foch
Suresnes, 92151
33 1 46 25 24 63
Jaafar Bennouna
- Recruiting
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer
Toulon, 83100
Clotilde Fournier
- Recruiting
CHU de Toulouse - Hopital Larrey
Toulouse, 31059
335677718
Julien Mazieres
- Recruiting
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
Vandœuvre-lès-Nancy, 54511
Bertrand Mennecier
- Recruiting
Hôpital Robert Schuman
Vantoux, 57070
Julie Perrin
- Recruiting
Gustave Roussy
Villejuif, 94800
Fabrice Barlesi
Germany18 sites, 18 recruiting
- Recruiting
Evangelische Lungenklinik Berlin
Berlin, 13125
Christian Grohe
- Recruiting
Charité Campus Virchow-Klinikum
Berlin, 13353
004930450553044
Nikolaj Frost
- Recruiting
Helios Klinikum Emil von Behring Berlin-Zehlendorf
Berlin, 14165
Jens Kollmeier
- Recruiting
Klinikum Chemnitz
Chemnitz, 09116
4937133343550
Stefan Hammerschmidt
- Recruiting
MV-Zentrum für Onkologie und Hämatologie
Cologne, 50677
Jan-Phillip Weber
- Recruiting
Onkologiezentrum Donauwörth
Donauwörth, 86609
49990629993911
Bastian Fleischmann
- Recruiting
HELIOS Klinikum Erfurt
Erfurt, 99089
03617812586
Eva-Maria Barkowsky
- Recruiting
Universitaetsklinikum Freiburg
Freiburg im Breisgau, 79106
0049 761 27036630
Justyna Rawluk
- Recruiting
Asklepios Fachkliniken München-Gauting
Gauting, 82131
004989857914001
Niels Reinmuth
- Recruiting
Franziskus-Hospital Harderberg
Georgsmarienhütte, 49124
Petra Hoffknecht
- Recruiting
LungenClinic Grosshansdorf
Großhansdorf, 22927
Martin Reck
- Recruiting
Krankenhaus Martha-Maria Halle-Dölau
Halle, 06120
Miriam Moeller
- Recruiting
Hämato-Onkologie Hamburg, Prof. Laack und Partner
Hamburg, 20251
4940280065620
Eckart Laack
- Recruiting
Asklepios Klinik Harburg
Hamburg, 21075
Claas Wesseler
- Recruiting
Thoraxklinik-Heidelberg gGmbH
Heidelberg, 69126
49 6221 3968304
Helge Bischoff
- Recruiting
Universitätsklinikum Münster - Albert Schweitzer Campus
Münster, 48149
492518352712
Annalen Bleckmann
- Recruiting
Klinikum Nürnberg Nord
Nuremberg, 90419
0911398114963
Markus Horneber
- Recruiting
Universitaetsklinikum Tuebingen
Tübingen, 72076
4970712982711
Thorben Gross
India18 sites, 18 recruiting
- Recruiting
Hemato Oncology Clinic
Ahmedabad, 380054
09824047561
Chirag Desai
- Recruiting
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, 590010
09448111913
Rohan Bhise
- Recruiting
SRV Hospitals
Bengaluru, 560027
Lokesh K.N
- Recruiting
All India Institute of Medical Sciences
Bhubaneswar, 751019
7008651823
Sourav Mishra
- Recruiting
Ashwin Hospital
Coimbatore, 641012
9884457106
Prabagar Manickam
- Recruiting
Nizam's Institute of Medical Sciences
Hyderabad, 500082
+919440911865
Sadashivudu Gundeti
- Recruiting
Krishna Institute of Medical Sciences - Karad
Karad, 415539
Rashmi Gudur
- Recruiting
Kolhapur Cancer Centre Private Limited
Kolhāpur, 416234
Praveen Adusumilli
- Recruiting
HCG Manavata Cancer Centre
Nashik, 422001
Dr. Aman Sondoule
- Recruiting
Advanced Centre for Treatment Research and Education in Cancer
Navi Mumbai, 410210
9769331525
Amit Joshi
- Recruiting
Jawaharlal Institute Of Postgraduate Medical Education And Research
Puducherry, 605006
Prasanth Ganesan
- Recruiting
Grant Medical Foundation - Ruby Hall Clinic
Pune, 411001
02066455495
Minish Jain
- Recruiting
Sahyadri Super Speciality Hospital
Pune, 411004
Tushar Patil
- Recruiting
Lifepoint Multispeciality Hospital
Pune, 411057
02066434366
Ashwin Rajbhoj
- Recruiting
Regional Cancer Centre - Thiruvananthapuram
Thiruvananthapuram, 695011
Anoop Manoharan
- Recruiting
Pacific Medical College & Hospital
Udaipur, 313001
Manoj Mahajan
- Recruiting
Tata Memorial Centre - Homi Bhabha Cancer Hospital
Varanasi, 221002
0542 2517699 ext 1001
Akhil Kapoor
- Recruiting
Mahatma Gandhi Cancer Hospital and Research Institute
Visakhapatnam, 530017
9640953911
YEDLA PRIYA
Taiwan17 sites, 17 recruiting
- Recruiting
Changhua Christian Hospital
Changhua County, 50006
+886-4-7238595 ext.3934
Sheng-Hao Lin
- Recruiting
Buddhist Dalin Tzu Chi General Hospital
Chiayi City, 622
Chun-Liang Lai
- Recruiting
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
Douliu, 640
You-Yi Chen
- Recruiting
Hualien Tzu Chi Medical Center
Hualien City, 970
Chih-Bin Lin
- Recruiting
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
88673121101-5651
Jen-Yu Hung
- Recruiting
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, 83301
+886-7-7317123 ext. 8199
Chin-Chou Wang
- Recruiting
New Taipei Municipal TuCheng Hospital
New Taipei City, 236
0975366098
Chiao-En Wu
- Recruiting
Chung Shan Medical University Hospital
Taichung, 402
0424739595
Gee-Chen Chang
- Recruiting
Taichung Veterans General Hospital
Taichung, 407
886-23592525(3259)
Tsung-Ying Yang
- Recruiting
National Cheng Kung University Hospital
Tainan, 704
Chien-Chung Lin
- Recruiting
Chi Mei Medical Center
Tainan, 71004
Yu-Hsuan Kuo
- Recruiting
Chi Mei Hospital - Liouying Branch
Tainan, 73657
Wen-Tsung Huang
- Recruiting
National Taiwan University Hospital
Taipei, 10002
886-2-2312-3456
Chia-Chi Lin
- Recruiting
National Taiwan University Cancer Center (NTUCC)
Taipei, 106
886-2-23123456
Chih-Hsin Yang
- Recruiting
Taipei Veterans General Hospital
Taipei, 11217
Chi-Lu Chiang
- Recruiting
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333
Cheng-Ta Yang
- Recruiting
National Taiwan University Hospital - Hsinchu branch
Zhubei, 302
886-3-5326151 ext 34502
Jih-Hsiang Lee
Turkey (Türkiye)17 sites, 17 recruiting
- Recruiting
Adana Medical Park Seyhan Hastanesi
Adana, 01140
905333616939
Ahmet Sezer
- Recruiting
Adana City Hospital
Adana, 01370
90538 609 92 02
Timucin Cil
- Recruiting
Ankara Etlik City Hospital
Ankara, 06170
05055718475
Berna Oksuzoglu
- Recruiting
Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital
Ankara, 06200
Cengiz Karacin
- Recruiting
Ankara Bilkent Şehir Hastanesi
Ankara, 06800
905555306271
Mehmet Ali Nahit Sendur
- Recruiting
Akdeniz Universitesi Hastanesi
Antalya, 07059
05052312377
Sema Sezgin Goksu
- Recruiting
Memorial Antalya Hospital
Antalya, 07090
Mustafa Ozdogan
- Recruiting
Antalya Egitim ve Arastırma Hastanesi
Antalya, 07100
905336488217
Derya KIVRAK SALIM
- Recruiting
Uludag Universitesi
Bursa, 16059
905336460546
Turkkan Evrensel
- Recruiting
Dicle Üniversitesi
Diyarbakır, 21200
90 5337677131
Muhammet kaplan
- Recruiting
Bezmialem Vakf Üniversitesi
Istanbul, 34093
05344299253
Haci Mehmet Turk
- Recruiting
İ.A.Ü VM Medical Park Florya Hastanesi
Istanbul, 34295
905322480988
Irfan Cicin
- Recruiting
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, 34722
Mahmut Gumus
- Recruiting
Ege Universitesi Hastanesi
Izmir, 35100
05322202675
Tuncay Goksel
- Recruiting
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi
Izmir, 35360
905324078648
Ahmet Alacacioglu
- Recruiting
Kocaeli Üniversitesi
Kocaeli, 41380
+905327650185
Devrim Cabuk
- Recruiting
Ondokuz Mayıs Universitesi
Samsun, 55270
90 532 599 28 25
Bahiddin Yilmaz
South Korea15 sites, 15 recruiting
- Recruiting
Chungbuk National University Hospital
Cheongju-si, 28644
Ki Hyeong Lee
- Recruiting
Keimyung University Dongsan Hospital
Daegu, 42601
01063522096
Sun Hyo Park
- Recruiting
Kyungpook National University Chilgok Hospital
Deagu, 41404
Shin Yup Lee
- Recruiting
Gangnam Severance Hospital, Yonsei University Health System
Gangnam-gu, 06273
Yoon Soo Chang
- Recruiting
National Cancer Center
Goyang-si, 10408
82319201154
Ji-Youn Han
- Recruiting
Chonnam National University Hwasun Hospital
Hwasun, 58128
Young-Chul Kim
- Recruiting
Korea University Anam Hospital
Seoul, 02841
82-2-920-6267
Yoon Ji Choi
- Recruiting
Severance Hospital, Yonsei University Health System
Seoul, 03722
82222284190
Hye Ryun Kim
- Recruiting
Hanyang University Seoul Hospital
Seoul, 04763
Dong-Woo Han
- Recruiting
Asan Medical Center
Seoul, 05505
Chang Min Choi
- Recruiting
Samsung Medical Center
Seoul, 06351
Se-Hoon Lee
- Recruiting
The Catholic University of Korea, Yeouido St. Mary's Hospital
Seoul, 07345
Chankwon Park
- Recruiting
Korea University Guro Hospital
Seoul, 08308
Sung Yong Lee
- Recruiting
The Catholic University Of Korea St. Vincent's Hospital
Suwon, 16247
82-31-881-8906
Byoung Yong Shim
- Recruiting
Pusan National University Yangsan Hospital
Yangsan, 50612
Seong Hoon Yoon
Mexico14 sites, 14 recruiting
- Recruiting
CIO - Centro de Inmuno-Oncología de Occidente
Guadalajara, 44630
+523330447001
Noel Luna-Romero
- Recruiting
PanAmerican Clinical Research - Guadalajara
Guadalajara, 44670
Emilio Murillo
- Recruiting
Actualidad Basada en la Investigación del Cáncer
Guadalajara, 44680
3316395372
Emmanuel de la Mora Jimenez
- Recruiting
Renati Innovation
Guadalajara, 44680
Carlos Zuloaga Fernandez del Valle
- Recruiting
Health Pharma Querétaro
Juriquilla, 76230
Jordi Guzmán Casta
- Recruiting
Preparaciones Oncológicas S.C.
León, 37178
4776439745
Jose Gonzalez Trujillo
- Recruiting
Health Pharma Professional Research S.A. de C.V:
Mexico City, 03100
+5215529002732
Jorge Alatorre Alexander
- Recruiting
Higiea Oncologia
Mexico City, 11819
525552731712
Manuel Magallanes Maciel
- Recruiting
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, 64460
Victor Oyervides Juarez
- Recruiting
Avix Investigación Clinica, S.C.
Monterrey, 64623
528181431112
Julia Saenz Frias
- Recruiting
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, 68020
+529516035559
Yolanda Bautista Aragon
- Recruiting
Clinica Integral Internacional de Oncología
Puebla City, 72530
Iván González Espinoza
- Not yet recruiting
Oncare - Unidad Valle
San Pedro Garza García, 66220
82188555
Luis Cancel
- Recruiting
Arké SMO S.A de C.V
Veracruz, 91900
2299314102
Pedro Arredondo Ruiz
Australia11 sites, 11 recruiting
- Recruiting
Royal Adelaide Hospital
Adelaide, 5000
Harminder Takhar
- Recruiting
Icon Cancer Centre Wesley
Auchenflower, 4066
Adam Stirling
- Recruiting
Ballarat Health Services
Ballarat Central, 3350
61-03-53208500
Wasek Faisal
- Recruiting
Sunshine Coast University Hospital
Birtinya, 4575
07 5202 0000
Bryan Chan
- Recruiting
Gosford Hospital
Gosford, 2250
Matthew Ho Fai Wong
- Recruiting
Mackay Base Hospital
Mackay, 4740
Nimisha Kumari
- Recruiting
St Vincent's Hospital
Melbourne, 3065
61392313155
Melissa Moore
- Recruiting
Sir Charles Gairdner Hospital
Perth, 6009
samantha bowyer
- Recruiting
Goulburn Valley Health
Shepparton, 3630
61358323777
Myron Klevansky
- Recruiting
Gold Coast University Hospital
Southport, 4215
6175687000
Robert Mason
- Recruiting
The Townsville Hospital
Townsville, 4814
Abhishek Joshi
Belgium10 sites, 10 recruiting
- Recruiting
ZNA Middelheim
Antwerp, 2020
032803575
Kim De Muynck
- Recruiting
CHIREC - site delta
Auderghem, 1160
0032 2 434 81 13
Christophe Compère
- Recruiting
AZ Sint-Jan Brugge-Oostende AV
Bruges, 8000
Lander Van Acker
- Recruiting
UZ Gent
Ghent, 9000
Veerle Surmont
- Recruiting
AZ Groeninge Campus Kennedylaan
Kortrijk, 8500
056633340
Katrien Ghysen
- Recruiting
UZ Leuven
Leuven, 3000
32 16 34 68 02
christophe Dooms
- Recruiting
AZ Sint-Maarten
Mechelen, 2800
+3215892040
Marc Lambrechts
- Recruiting
Clinique Saint Pierre
Ottignies, 1340
0032 10 437 298
Luciano Carestia
- Recruiting
AZ Glorieux Ronse
Ronse, 9600
3255233668
Patrick Alexander
- Recruiting
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne
Yvoir, 5530
081423351
Sebahat Ocak
Italy10 sites, 10 recruiting
- Recruiting
Instituto Tumori Giovanni Paolo II
Bari, 70124
39 080 5555442
Domenico Galetta
- Recruiting
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, 40138
390512142204
Andrea Ardizzoni
- Recruiting
Policlinico "G. Rodolico"
Catania, 95123
390953781496
HECTOR SOTO PARRA
- Recruiting
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133
390223903829
Giuseppe Lo Russo
- Recruiting
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, 80131
390817770291
Alessandro Morabito
- Recruiting
Istituto Oncologico Veneto IRCCS
Padova, 35128
00390498215608
Giulia Pasello
- Recruiting
Fondazione Policlinico Universitario Agostino Gemelli
Roma, 00168
Emilio Bria
- Recruiting
Istituto Nazionale Tumori Regina Elena
Rome, 00144
390652665698
Federico Cappuzzo
- Recruiting
Ospedale di Circolo e Fondazione Macchi Varese
Varese, 21100
+39 0332278558
Veronica Crespi
- Recruiting
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
Verona, 37126
3904518123515
SARA PILOTTO
Greece9 sites, 9 recruiting
- Recruiting
Agios Savvas Regional Cancer Hospital
Athens, 115 22
ANASTASIOS GRIVAS
- Recruiting
Errikos Dunant Hospital Center
Athens, 115 26
IOANNIS MOUNTZIOS
- Recruiting
Sotiria Thoracic Diseases Hospital of Athens
Athens, 11527
302107700220
Konstantinos Syrigos
- Recruiting
Attikon General University Hospital
Chaïdári, 12462
302105831265
Amanda Psyrri
- Recruiting
University General Hospital of Heraklion
Heraklion, 715 00
2810-392750
Dimitrios Mavroudis
- Recruiting
University Hospital of Patras
Pátrai, 26504
302610999791
Angelos Koutras
- Recruiting
"Theagenio" Cancer Hospital of Thessaloniki
Thessaloniki, 540 07
302310898607
Grigorios Rallis
- Recruiting
European Interbalkan Medical Center
Thessaloniki, 570 01
Sofia Baka
- Recruiting
G. Papanikolaou General Hospital
Thessaloniki, 570 10
302312307278
Dionisios Spyratos
Netherlands9 sites, 9 recruiting
- Recruiting
Jeroen Bosch Hospital
's-Hertogenbosch, 5223 GZ
0031735532463
Bianca Veggel
- Recruiting
Medisch Spectrum Twente
Enschede, 7512 KZ
0534872610
Albert Polman
- Recruiting
Ziekenhuis St. Jansdal
Harderwijk, 3844 DG
0031 341 463504
L.N. Boom
- Recruiting
Tergooiziekenhuizen, locatie Hilversum
Hilversum, 1213 XZ
0887531753
Jan Maarten van Haarst
- Recruiting
Frisius Medisch Centrum
Leeuwarden, 8934 AD
0031582863103
Rolof Gijtenbeek
- Recruiting
Leids Universitair Medisch Centrum
Leiden, 2333 ZA
31715262950
Egbert Smit
- Recruiting
Erasmus Medisch Centrum
Rotterdam, 3015 GD
31107040704
Anne Marie C. Dingemans
- Recruiting
ETZ Elisabeth
Tilburg, 5022 GC
31132213101
Mart Schiefer
- Recruiting
St. Antonius Ziekenhuis, locatie Utrecht
Utrecht, 3543 AZ
31883201410
Lisanne Kastelijn
Romania8 sites, 8 recruiting
- Recruiting
Lotus-Med
Bucharest, 012292
40751110005
Anca Zgura
- Recruiting
SC Memorial Healthcare International SRL
Bucharest, 013812
40721298677
Ingrid Iordan
- Recruiting
Gral Medical Diagnostic Center
Bucharest, 031422
40726273762
Cristina Tiut
- Recruiting
Institutul Oncologic
Cluj-Napoca, 400015
Tudor Ciuleanu
- Recruiting
Centrul de Oncologie "Sfântul Nectarie"
Craiova, 200542
40727774974
Michael Schenker
- Recruiting
Ovidius Clinical Hospital OCH
Ovidiu, 905900
0724877013
Laura Mazilu
- Recruiting
S C Oncocenter Oncologie Clinica S R L
Timișoara, 300166
0040745146020
Roxana Scheusan
- Recruiting
Cabinet Medical Oncomed
Timișoara, 300239
40723401453
Mihaela Pasca-Fenesan
United Kingdom8 sites, 8 recruiting
- Recruiting
Aberdeen Royal Infirmary
Aberdeen, AB25 2ZN
Andrew Duncan
- Recruiting
Ninewells Hospital and Medical School
Dundee, DD1 9SY
Hannah Lord
- Recruiting
Huddersfield Royal Infirmary
Huddersfield, HD3 3EA
Emma Rathbone
- Recruiting
St James's University Hospital
Leeds, LS9 7TF
Katy Clarke
- Recruiting
The Christie NHS Foundation Trust
Manchester, M20 4BX
Colin Lindsay
- Recruiting
Mount Vernon Hospital
Northwood, HA6 2RN
02038262058
Andreas Polychronis
- Recruiting
Weston Park Hospital
Sheffield, S10 2SJ
Tathagata Das
- Recruiting
New Cross Hospital
Wolverhampton, WV10 0QP
Talha Hafeez
Norway7 sites, 7 recruiting
- Recruiting
Haukeland Universitetssjukehus
Bergen, 5021
4755970762
Christina Aamelfot
- Recruiting
Drammen Sykehus, Vestre Viken HF
Drammen, 3004
4732000240
Odd Terje Brustugun
- Recruiting
Sykehuset Innlandet HF Gjøvik
Gjøvik, 2819
4791395554
Daniel Heinrich
- Recruiting
Akershus Universitetssykehus
Lørenskog, 1478
0047 679 66 079
Kirill Neumann
- Recruiting
Oslo universitetssykehus, Radiumhospitalet
Oslo, 0379
47 02770
Vilde Haakensen
- Recruiting
Stavanger Universitetssykehus
Stavanger, 4021
Edie Gina Barrera
- Recruiting
St. Olavs Hospital
Trondheim, 7030
Bjørn Grønberg
Portugal7 sites, 7 recruiting
- Recruiting
Centro Hospitalar E Universitário De Coimbra
Coimbra, 3004-561
Ana Figueiredo
- Recruiting
Champalimaud Foundation
Lisbon, 1400-038
Susana Simoes
- Recruiting
Hospital da Luz Lisboa
Lisbon, 1500-650
Joao Moreira Pinto
- Recruiting
Hospital Pulido Valente
Lisbon, 1769-001
Paula Alves
- Recruiting
Centro Hospitalar do Porto - Hospital de Santo António
Porto, 4099-001
222077500
Antonio Araujo
- Recruiting
Hospital CUF Porto
Porto, 4100-180
220039029
Venceslau Hespanhol
- Recruiting
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
Porto, 4200-072
Cristina Oliveira
Hungary5 sites, 5 recruiting
- Recruiting
Országos Korányi Pulmonológiai Intézet
Budapest, 1121
Szabolcs Soter
- Recruiting
Országos Onkológiai Intézet
Budapest, 1122
Tunde Nagy
- Recruiting
Budapesti Uzsoki Utcai Kórház
Budapest, 1145
+3614673852
Csaba Mathe
- Recruiting
Farkasgyepui Tudogyogyintezet
Farkasgyepű, 8582
Zsolt Kiraly
- Recruiting
Bacs-Kiskun Megyei Korhaz
Kecskemét, 6000
3676516719
Zsolt Horvath
Austria3 sites, 3 recruiting
- Recruiting
Landeskrankenhaus Feldkirch
Feldkirch, 6800
4355223032681
Thomas Winder
- Recruiting
Ordensklinikum Linz GmbH Elisabethinen
Linz, 4020
Michael Schumacher
- Recruiting
Klinik Floridsdorf
Vienna, 1210
43 1 27700 2212
Maximilian Hochmair
Canada3 sites, 3 recruiting
- Recruiting
BC Cancer Abbotsford
Abbotsford British Columbia, V2S 0C2
David Fenton
- Recruiting
CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, G7H 5H6
4185411000
Jose Luiz Guimaraes
- Recruiting
BC Cancer Vancouver
Vancouver, V5Z 4E6
Jamie Feng
Poland3 sites, 3 recruiting
- Recruiting
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej
Kielce, 25-734
48 41 3674809
Kinga Szydziak-Zwierzynska
- Recruiting
One Day Med
Szczecin, 70-419
48914427209
Piotr Serwatowski
- Recruiting
MICS Centrum Medyczne Torun
Torun, 87-100
48563004384
Justyna Wietrzynska
Czechia2 sites, 2 recruiting
- Recruiting
Nemocnice AGEL Ostrava - Vitkovice a.s.
Ostrava, 703 84
Jaromir Roubec
- Recruiting
Fakultni nemocnice Bulovka
Prague, 180 81
420607533688
Jana Krejci
Sweden2 sites, 2 recruiting
- Recruiting
Mälarsjukhuset
Eskilstuna, 631 88
0046700599120
Andreas Nearchou
- Recruiting
Västmanlands Sjukhus Västerås
Västerås, 721 89
David Sterner
Switzerland2 sites, 2 recruiting
- Recruiting
CHUV (centre hospitalier universitaire vaudois)
Lausanne, 1011
Karim Abdelhamid
- Recruiting
Kantonsspital Winterthur
Winterthur, 8401
41522662373
Laetitia Mauti
Denmark1 site, 1 recruiting
- Recruiting
Roskilde University Hospital
Roskilde, 4000
Vladimira Horvat
About this study
Official title: SUNRAY-01, A Global Pivotal Study in Participants With KRAS G12C-Mutant, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Comparing First-Line Treatment of LY3537982 and Pembrolizumab vs Placebo and Pembrolizumab in Those With PD-L1 Expression ≥50% or LY3537982 and Pembrolizumab, Pemetrexed, Platinum vs Placebo and Pembrolizumab, Pemetrexed, Platinum Regardless of PD-L1 Expression
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing.
Read the detailed description
Dose Optimization, Part A, and Part B are randomized. Safety Lead-In for Part B is single arm, non-randomized. Part C is non-randomized.
- Being tested
- LY3537982, Pembrolizumab, Placebo, Cisplatin, Carboplatin
- Keywords
- Advanced Non-Small Cell Lung Cancer, KRAS G12 Lung Cancer, Advanced Lung Cancer, Metastatic Lung Cancer, KRAS G12C inhibitor, KRAS G12C Positive, KRAS Mutation, KRAS G12 Mutation, Lung Cancer Mutation, Olomorasib, Lung Diseases, Neoplastic Processes, Pathologic Processes, Neoplasm Metastasis, Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer (NSCLC), Antineoplastic Agents, Respiratory Tract Neoplasms, Thoracic Neoplasms, Neoplasms by Site
- Medical subject headings
- Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Lung Neoplasms, Lung Diseases, Neoplastic Processes, Pathologic Processes, Respiratory Tract Neoplasms, Thoracic Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
LY3537982Drug
Also called Olomorasib
Administered orally.
PembrolizumabDrug
Administered IV.
PlaceboDrug
Administered orally.
CisplatinDrug
Administered IV.
CarboplatinDrug
Administered IV.
PemetrexedDrug
Administered IV.
| Study group | Role | What they receive |
|---|---|---|
| Dose Optimization: LY3537982 Dose Level 1 plus Pembrolizumab | Experimental | LY3537982 Dose level 1 administered orally in combination with pembrolizumab administered intravenously (IV) in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: LY3537982; Drug: Pembrolizumab |
| Dose Optimization: LY3537982 Dose Level 2 plus Pembrolizumab | Experimental | LY3537982 Dose level 2 administered orally in combination with pembrolizumab administered IV in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: LY3537982; Drug: Pembrolizumab |
| Safety Lead In: LY3537982 plus Pembrolizumab, Pemetrexed and Platinum | Experimental | LY3537982 administered orally in combination with pembrolizumab, pemetrexed, and platinum (cisplatin or carboplatin) administered IV in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: LY3537982; Drug: Pembrolizumab; Drug: Cisplatin; Drug: Carboplatin; Drug: Pemetrexed |
| Part A: LY3537982 plus Pembrolizumab | Experimental | LY3537982 administered orally in combination with pembrolizumab administered IV in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: LY3537982; Drug: Pembrolizumab |
| Part A: Placebo plus Pembrolizumab | Placebo comparator | Placebo administered orally in combination with pembrolizumab administered IV in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: Pembrolizumab; Drug: Placebo |
| Part B: LY3537982 plus Pembrolizumab, Pemetrexed, and Platinum | Experimental | LY3537982 administered orally in combination with pembrolizumab, pemetrexed, and platinum (cisplatin or carboplatin) administered IV in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: LY3537982; Drug: Pembrolizumab; Drug: Cisplatin; Drug: Carboplatin; Drug: Pemetrexed |
| Part B: Placebo plus Pembrolizumab, Pemetrexed, and Platinum | Placebo comparator | Placebo administered orally in combination with pembrolizumab, pemetrexed, and platinum (cisplatin or carboplatin) administered IV in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: Pembrolizumab; Drug: Placebo; Drug: Cisplatin; Drug: Carboplatin; Drug: Pemetrexed |
| Part C: LY3537982 plus Pembrolizumab | Experimental | LY3537982 administered orally in combination with pembrolizumab administered IV in 21-day cycles. Participants may continue to receive treatment until discontinuation criteria are met. Receives: Drug: LY3537982; Drug: Pembrolizumab |
What is being measured
The primary outcome is the main question the study is designed to answer.
Dose Optimization and Safety Lead-In Part B: Number of Participants with a Treatment Emergent Adverse Event(s) (TEAE)
Dose Optimization and Safety Lead-In Part B: Number of Participants with a TEAE
Measured: Randomization to first documented progression of disease or death from any cause. (Estimated as approximately 1 year)
Part A and Part B: Progression-Free Survival (PFS)
PFS per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by blinded independent central review (BICR)
Measured: Randomization to first documented progression of disease or death from any cause. (Estimated as approximately 1 year)
Secondary outcomes (15)
Part A and Part B: Overall Survival (OS)
Part A and Part B: OS
Measured: Randomization to date of death from any cause. (Estimated as up to 3 years)
Part A and Part B: PFS
PFS per RECIST v1.1 by investigator
Measured: Randomization to first documented progression of disease or death from any cause. (Estimated as approximately 1 year)
Part A and Part B: Overall Response Rate (ORR): Percentage of Participants who Achieve a Best Overall Response (BOR) of Complete Response (CR) or Partial Response (PR)
ORR per RECIST v1.1 by BICR and Investigator
Measured: Randomization to disease progression or death. (Estimated as approximately 1 year)
Part A and Part B: Duration of Response (DOR)
DOR per RECIST v1.1 by BICR and Investigator
Measured: Date of first evidence of CR or PR to date of disease progression or death from any cause. (Estimated as approximately 1 year)
Part A and Part B: Disease Control Rate (DCR): Percentage of Participants who Achieve a BOR of CR, PR, or Stable Disease (SD)
DCR per RECIST v1.1 by BICR and Investigator
Measured: Randomization to disease progression or death from any cause. (Estimated as approximately 1 year)
Part A and Part B: Time to Response (TTR)
TTR per RECIST v1.1 by BICR and Investigator
Measured: Time from randomization until the date that measurement criteria for CR or PR (whichever is first recorded) are first met (Estimated as approximately 1 year)
Part A and Part B: Intracranial Overall Response Rate (ORR)
Intracranial ORR per Modified RECIST (mRECIST) by BICR
Measured: Randomization to intracranial disease progression or death. (Estimated as approximately 1 year)
Part A and Part B: Intracranial Duration of Response (DoR)
Intracranial DoR per mRECIST by BICR
Measured: Date of first evidence of CR or PR to date of intracranial disease progression or death from any cause. (Estimated as approximately 1 year)
Part A and Part B: PFS2
Part A and Part B: PFS2 by Investigator
Measured: Randomization to disease progression on next line of treatment or death from any cause (Estimated as approximately 1 year
Part A and Part B: Changes in NSCLC-related symptoms as measured by NSCLC-SAQ
NSCLC-related symptoms are assessed by the NSCLC-SAQ total score, which is computed as the sum of the 5 domains (7 questions) and ranges from 0 to 20. The total score will be calculated if all 7 questions are completed. Higher scores indicate more severe symptomatology.
Measured: Randomization through end of treatment (Estimated as approximately 1 year)]
Part A and Part B: Time to Worsening of NSCLC-related Symptoms as Measured by NSCLC Symptom Assessment Questionnaire (NSCLC-SAQ)
NSCLC symptoms will be assessed using the 7-item NSCLC-SAQ. The NSCLC-SAQ measures overall symptom severity of NSCLC, including cough, pain, dyspnea, fatigue, and poor appetite. Response options range from 0) "Not at all" to 4) "Always" or from 0) "Never" to 4) "Always." The total score ranges from 0-20. Higher scores represent worse symptoms.
Measured: Randomization through end of treatment (Estimated as approximately 1 year)
Part A and Part B: Changes in physical function, as measured by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30) Physical Functioning subscale and IL19
Physical function is assessed by EORTC-QLQ-C30 Physical Functioning scale or IL19. The physical function score is calculated by generating the raw score: (Q1+Q2+Q3+Q4+Q5)/5; and then generating the transformed score: (1-((raw score-1)/3)) x 100. The score ranges from 0 to 100. Higher scores indicate better physical function.
Measured: Randomization through end of treatment (Estimated as approximately 1 year)
Part A and Part B: Time to Deterioration in Physical Function, as Measured by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (EORTC QLQ-C30) Physical Functioning Subscale and IL19
The EORTC QLQ-C30 is a 30-question patient-reported instrument used to assess multidimensional health-related quality of life (HRQoL) in cancer patients. Physical functioning is measured by the EORTC-QLQ-30 Physical Function Scale (five items). Response options range from 1) "Not at all" to 4) "Very much." The sum score is linearly transformed to the range 0 - 100. Higher scores represent better physical function.
Measured: Randomization through end of treatment (Estimated as approximately 1 year)
Part A and Part B: Proportion of Time with High Side-Effect Burden, as Measured by Functional Assessment of Cancer Therapy - General Item 5 (FACT-GP5)
FACT-GP5 is a single-item, patient-reported instrument for assessing overall treatment side-effect burden. Response options range from 0) "Not at all" to 4) "Very much." Higher scores represent higher symptom burden.
Measured: Randomization through end of treatment (Estimated as approximately 1 year)
Part A and Part B: Change from Baseline in Overall Health-related Quality of Life, as Measured by the EORTC QLQ-C30 Global Health Status/Quality of Life Subscale
The EORTC QLQ-C30 is a 30-question patient-reported instrument used to assess multidimensional HRQoL in cancer patients. Overall HRQoL is measured by the EORTC QLQ-30 Global Health Status/Quality of Life Subscale (two items). Response options range from 1) "very poor" to 7) "excellent." Scores are linearly transformed to the range 0 - 100. Higher scores represent better overall HRQoL.
Measured: Randomization through end of treatment (Estimated as approximately 1 year)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Nov 2023
- Study start21 Dec 2023
- Primary completionNov 2027 (estimated)
- Study completionJan 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Carcinoma, Non-Small-Cell LungStudies of the same condition, open and under way.
- More trials run by Eli Lilly and CompanyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 1,264 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Eli Lilly and Company
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Study director, Eli Lilly and Company
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06119581
- Sponsor's protocol ID
- 18612
- Other IDs
- J3M-MC-JZQB, U1111-1288-0565, 2023-503412-33-00, 2023
- Acronym
- SUNRAY-01
- Status last verified
- Oct 2026
- First submitted
- 1 Nov 2023
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.
Publications
Peters S, Hochmair M, Arbour KC, Rodriguez LP, Reck M, Leal T, R Lindsay C, Shun L, William WN, Spira AI, Sabari JK, Henning Gronberg B, Nishio M, Burns TF, Girard N, Capuzzo F, Merced A, Fasnacht N, Visseren-Grul C, Negrao MV. SUNRAY-01 trial protocol: an innovative study design of olomorasib and pembrolizumab with or without chemotherapy in KRAS G12C NSCLC. Future Oncol. 2026 Apr;22(9):1073-1082. doi: 10.1080/14796694.2026.2651961. Epub 2026 Apr 6.
PubMed 41940628