Cystic FibrosisYOGA-CFNCT06120465
YOGA-CF (Yoga Outcomes Get Assessed in Cystic Fibrosis)
A study testing Yoga in people with Cystic Fibrosis, run by Royal Brompton & Harefield NHS Foundation Trust at 1 site in United Kingdom.
Trial summary
The goal of this clinical trial is to investigate the effects of yoga participation for adults with cystic fibrosis. The main question it aims to answer is: does participation in yoga affect health-related quality of life for adults with cystic fibrosis? Researchers will compare a group completing a 12-week yoga… Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Cystic Fibrosis
- What is being tested?
- Yoga
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 314 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 22 Apr 2024to 31 Jan 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Diagnosis of CF (confirmed by standard criteria; (Farrell et al. 2017))
- Sixteen years of age or over
- Home internet access
- Ability to complete questionnaires in English
- Stable CF disease as judged by the investigator, a senior CF clinician
Who cannot join
- Inability to consent for treatment or measurement
- Current participation in another interventional study of a medicinal product
- Current haemoptysis (greater than streaking in the sputum)
- Known pregnancy at time of recruitment
- Forced expiratory volume in 1 second (FEV1) below 30% predicted at baseline
- Use of ambulatory oxygen therapy, long-term oxygen therapy (LTOT) or non-invasive ventilation
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- Current regular participation in yoga practice
- Current neurological or musculoskeletal injury which would prevent completion of yoga
- Diagnosis of osteoporosis (bone density Z score <-2.5) or history of spontaneous spinal fractures
- Uncontrolled gastroesophageal reflux
- Acute pulmonary exacerbation within 28 days of screening
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site
The Royal Brompton Hospital
London, Greater London, SW3 6NP
About this study
Official title: Yoga Outcomes Get Assessed in Cystic Fibrosis
The goal of this clinical trial is to investigate the effects of yoga participation for adults with cystic fibrosis.
The main question it aims to answer is: does participation in yoga affect health-related quality of life for adults with cystic fibrosis?
Researchers will compare a group completing a 12-week yoga programme alongside usual cystic fibrosis care, to a group completing usual care alone to see if the addition of yoga effects health-related quality of life.
- Conditions
- Cystic Fibrosis
- Being tested
- Yoga
- Keywords
- Yoga
- Medical subject headings
- Cystic Fibrosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
YogaOther
Yoga classes
| Study group | Role | What they receive |
|---|---|---|
| Yoga intervention group | Active comparator | 12 week programme of yoga - encouraged to complete 1 live class and one pre-recorded class a week. Participants will continue with usual cystic fibrosis care. Receives: Other: Yoga |
| Control group | No intervention | Usual cystic fibrosis care. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Respiratory Health- related quality of life - measured by the respiratory domain of the Cystic Fibrosis Questionnaire - Revised.
Cystic Fibrosis Questionnaire - Revised (CFQ-R) respiratory domain.Scores range from 0 to 100, with higher scores indicating better health.
Measured: Baseline, 12 and 24-weeks
Secondary outcomes (4)
Other Health-related quality of life domains - captured on the Cystic Fibrosis Questionnaire - Revised (CFQ-R)
Cystic Fibrosis Questionnaire - Revised (CFQ-R) other eleven domains. Scores range from 0 to 100, with higher scores indicating better health.
Measured: Baseline, 12 and 24-weeks
One Minute Sit to Stand Test
Participant stands up and sits down from a chair for one minute and the number of completed sit-to-stands is recorded.
Measured: Baseline, 12 and 24-weeks
Forced Expiratory Volume in 1 second
Forced expiratory volume in 1 second (FEV1) obtained through spirometry. Measured in litres and percentage predicted (using Global Lung Index equations)
Measured: Baseline, 12 and 24-weeks
Forced vital capacity (FVC)
Forced vital capacity obtained through spirometry. Measured in litres and percentage predicted (using Global Lung Index equations)
Measured: Baseline, 12 and 24-weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Nov 2023
- Study start22 Apr 2024
- Primary completion31 Jan 2026 (estimated)
- Study completion31 Jan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cystic FibrosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 314 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Royal Brompton & Harefield NHS Foundation Trust
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Nicholas Simmonds, Principal investigator, Royal Brompton Hospital, Guys and St Thomas's Foundation Trust
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06120465
- Sponsor's protocol ID
- YOGA-CF
- Acronym
- YOGA-CF
- Status last verified
- Jul 2025
- First submitted
- 19 Sep 2023
- Last updated
- 29 Jul 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Stanford GE, Scarborough P, Charman SC, Cameron RA, Wagner AP, Simmonds NJ. Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF): protocol of a multicentre interventional randomised controlled clinical trial-investigating effects of a 12-week yoga intervention for adults with cystic fibrosis. BMJ Open Respir Res. 2026 Jan 6;13(1):e003405. doi: 10.1136/bmjresp-2025-003405.
PubMed 41494700
Study at a glance
From the registry record, last updated by the sponsor on 29 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Yoga Outcomes Get Assessed in Cystic Fibrosis
- ClinicalTrials.gov ID
- NCT06120465
- Acronym / sponsor ID
- YOGA-CF / YOGA-CF
- Conditions
- Cystic Fibrosis
- Keywords
- Yoga
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 314 participants (estimated)
- Lead sponsor
- Royal Brompton & Harefield NHS Foundation TrustUniversity, hospital or other
- Study start
- 22 Apr 2024 (actual)
- Primary completion
- 31 Jan 2026 (estimated)
- Study completion
- 31 Jan 2026 (estimated)
- First posted
- 7 Nov 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to investigate the effects of yoga participation for adults with cystic fibrosis.
The main question it aims to answer is: does participation in yoga affect health-related quality of life for adults with cystic fibrosis?
Researchers will compare a group completing a 12-week yoga programme alongside usual cystic fibrosis care, to a group completing usual care alone to see if the addition of yoga effects health-related quality of life.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Yoga intervention group | Active comparator | Other: Yoga12 week programme of yoga - encouraged to complete 1 live class and one pre-recorded class a week. Participants will continue with usual cystic fibrosis care. |
| Control group | No intervention | –Usual cystic fibrosis care. |
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Diagnosis of CF (confirmed by standard criteria; (Farrell et al. 2017))
- Sixteen years of age or over
- Home internet access
- Ability to complete questionnaires in English
- Stable CF disease as judged by the investigator, a senior CF clinician
Key exclusion criteria (11 listed)
- Inability to consent for treatment or measurement
- Current participation in another interventional study of a medicinal product
- Current haemoptysis (greater than streaking in the sputum)
- Known pregnancy at time of recruitment
- Forced expiratory volume in 1 second (FEV1) below 30% predicted at baseline
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| YogaYoga classes | Other | Yoga intervention group |
Primary outcome
Respiratory Health- related quality of life - measured by the respiratory domain of the Cystic Fibrosis Questionnaire - Revised.
Time frame: Baseline, 12 and 24-weeks
Cystic Fibrosis Questionnaire - Revised (CFQ-R) respiratory domain.Scores range from 0 to 100, with higher scores indicating better health.
4 secondary outcomes
Other Health-related quality of life domains - captured on the Cystic Fibrosis Questionnaire - Revised (CFQ-R)
Time frame: Baseline, 12 and 24-weeks
One Minute Sit to Stand Test
Time frame: Baseline, 12 and 24-weeks
Forced Expiratory Volume in 1 second
Time frame: Baseline, 12 and 24-weeks
Forced vital capacity (FVC)
Time frame: Baseline, 12 and 24-weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Jul 2025.
- Derived from this study: PubMed 41494700Stanford GE, Scarborough P, Charman SC, Cameron RA, Wagner AP, Simmonds NJ. Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF): protocol of a multicentre interventional randomised controlled clinical trial-investigating effects of a 12-week yoga intervention for adults with cystic fibrosis. BMJ Open Respir Res. 2026 Jan 6;13(1):e003405. doi: 10.1136/bmjresp-2025-003405.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nicholas Simmonds principal investigator
Royal Brompton Hospital, Guys and St Thomas's Foundation Trust
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Yoga in people with Cystic Fibrosis, run by Royal Brompton & Harefield NHS Foundation Trust at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 29 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Respiratory Health- related quality of life - measured by the respiratory domain of the Cystic Fibrosis Questionnaire - Revised. (time frame: Baseline, 12 and 24-weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06120465, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Jul 2025.