Muscle MetabolismNCT06129513
The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis
A study testing Bilateral resistance exercise, Whey protein and Plant-blend protein in people with Muscle Metabolism, run by University of Exeter at 1 site in United Kingdom.
Trial summary
Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and… Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Metabolism
- What is being tested?
- Bilateral resistance exercise, Whey protein and Plant-blend protein
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 24 Feb 2022to 31 Oct 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- BMI between 18 - 30
- Resistance trained (>3 times per week structured resistance exercise training for at least 3 months)
Who cannot join
- Any metabolic impairment
- Any cardiovascular impairment
- Smoking
- Lactose intolerance
- Allergies to products containing dairy, meat or nuts
- Prescribed intake of over the counter pharmaceuticals
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of a Novel Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis When Compared to Whey Protein in Healthy Young Adults
Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.
- Conditions
- Muscle Metabolism
- Being tested
- Bilateral resistance exercise, Whey protein, Plant-blend protein
- Keywords
- Myofibrillar Protein Synthesis, Resistance Exercise, Plant Protein, Stable Isotopes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Bilateral resistance exerciseBehavioural
A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension
Whey proteinDietary supplement
Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate
Plant-blend proteinDietary supplement
Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate
| Study group | Role | What they receive |
|---|---|---|
| Whey protein isolate | Active comparator | Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate Receives: Behavioral: Bilateral resistance exercise; Dietary Supplement: Whey protein |
| Plant-blend isolate | Experimental | Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from a novel plant-blend protein isolate Receives: Behavioral: Bilateral resistance exercise; Dietary Supplement: Plant-blend protein |
What is being measured
The primary outcome is the main question the study is designed to answer.
Post-exercise myofibrillar protein synthesis following protein ingestion
The fractional synthetic rate of myofibrillar proteins
Measured: 4 hours
Secondary outcomes (4)
Post-exercise myofibrillar protein synthesis during the early postprandial period
The fractional synthetic rate of myofibrillar proteins
Measured: 2 hours
Post-exercise myofibrillar protein synthesis during the late postprandial period
The fractional synthetic rate of myofibrillar proteins
Measured: 2 hours
Plasma amino acid response
Post-exercise and postprandial change in plasma amino acid concentrations and availability
Measured: 4 hours
Serum insulin response
Post-exercise and postprandial change in serum insulin concentrations
Measured: 4 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Nov 2023
- Study start24 Feb 2022
- Primary completion31 Oct 2022
- Study completion31 Oct 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Muscle MetabolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Exeter
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06129513
- Sponsor's protocol ID
- 22-02-02-B-02
- Status last verified
- Nov 2023
- First submitted
- 20 Sep 2023
- Last updated
- 13 Nov 2023
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
VAN DER Heijden I, Monteyne AJ, West S, Morton JP, Langan-Evans C, Hearris MA, Abdelrahman DR, Murton AJ, Stephens FB, Wall BT. Plant Protein Blend Ingestion Stimulates Postexercise Myofibrillar Protein Synthesis Rates Equivalently to Whey in Resistance-Trained Adults. Med Sci Sports Exerc. 2024 Aug 1;56(8):1467-1479. doi: 10.1249/MSS.0000000000003432. Epub 2024 Mar 23.
PubMed 38537270
Study at a glance
From the registry record, last updated by the sponsor on 13 Nov 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of a Novel Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis When Compared to Whey Protein in Healthy Young Adults
- ClinicalTrials.gov ID
- NCT06129513
- Acronym / sponsor ID
- 22-02-02-B-02
- Conditions
- Muscle Metabolism
- Keywords
- Myofibrillar Protein Synthesis, Resistance Exercise, Plant Protein, Stable Isotopes
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- University of ExeterUniversity, hospital or other
- Study start
- 24 Feb 2022 (actual)
- Primary completion
- 31 Oct 2022 (actual)
- Study completion
- 31 Oct 2022 (actual)
- First posted
- 13 Nov 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Whey protein isolate | Active comparator | Behavioral: Bilateral resistance exercise, Dietary Supplement: Whey proteinFollowing a bout of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate |
| Plant-blend isolate | Experimental | Behavioral: Bilateral resistance exercise, Dietary Supplement: Plant-blend proteinFollowing a bout of bilateral resistance exercise, participants will ingest 32 g protein from a novel plant-blend protein isolate |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- BMI between 18 - 30
- Resistance trained (>3 times per week structured resistance exercise training for at least 3 months)
Key exclusion criteria (6 listed)
- Any metabolic impairment
- Any cardiovascular impairment
- Smoking
- Lactose intolerance
- Allergies to products containing dairy, meat or nuts
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Bilateral resistance exerciseA bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension | Behavioural | Plant-blend isolate, Whey protein isolate |
| Whey proteinFollowing execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate | Dietary supplement | Whey protein isolate |
| Plant-blend proteinFollowing execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate | Dietary supplement | Plant-blend isolate |
Primary outcome
Post-exercise myofibrillar protein synthesis following protein ingestion
Time frame: 4 hours
The fractional synthetic rate of myofibrillar proteins
4 secondary outcomes
Post-exercise myofibrillar protein synthesis during the early postprandial period
Time frame: 2 hours
Post-exercise myofibrillar protein synthesis during the late postprandial period
Time frame: 2 hours
Plasma amino acid response
Time frame: 4 hours
Serum insulin response
Time frame: 4 hours
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Nov 2023.
- Derived from this study: PubMed 38537270VAN DER Heijden I, Monteyne AJ, West S, Morton JP, Langan-Evans C, Hearris MA, Abdelrahman DR, Murton AJ, Stephens FB, Wall BT. Plant Protein Blend Ingestion Stimulates Postexercise Myofibrillar Protein Synthesis Rates Equivalently to Whey in Resistance-Trained Adults. Med Sci Sports Exerc. 2024 Aug 1;56(8):1467-1479. doi: 10.1249/MSS.0000000000003432. Epub 2024 Mar 23.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Bilateral resistance exercise, Whey protein and Plant-blend protein in people with Muscle Metabolism, run by University of Exeter at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Nov 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Post-exercise myofibrillar protein synthesis following protein ingestion (time frame: 4 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06129513, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Nov 2023.