Overtraining SyndromeCHIPYANCT06150105
Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes.
An observational study of Overtraining Syndrome, run by Poznan University of Physical Education at 1 site in Poland.
Trial summary
One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events. During sports camps, due to the accumulation of a large number of training units, including high-intensity exercises, athletes react with… Read more about this study
- Who is it for?
- Ages 15 to 17 yearsHealthy volunteers can take part
- Conditions the study is for
- Overtraining Syndrome
- What is being tested?
- Exercise training
- How many people
- 24 participants
- Where
- 1 sitePoland
- Study dates
- 16 Feb 2018to 10 Dec 2018
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 17 years
- All sexes
- Healthy volunteers accepted
- Child
Study population: Twenty-four young male and female athletes, students at Sports Championship School, future representatives of the Polish National Team, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study.
Who may be able to join
- age 15-17 years,
- minimum of 3 years of training experience,
- specialization in anaerobic and aerobic disciplines.
Who cannot join
- presence of acute or chronic inflammation
- fever, infections, injuries
- se of any anti-inflammatory drugs.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes Following a Sports Camp
One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events. During sports camps, due to the accumulation of a large number of training units, including high-intensity exercises, athletes react with post-exercise overload, acute fatigue, and overreaching which can become a chronic overtraining syndrome. Overtraining syndrome is a very specific and severe condition where overtraining without adequate rest and recovery leads to performance decrements lasting more than 2-3 months, coupled with a mood disturbance. The exact etiology and pathogenesis are unknown and actively being investigated.
During training camps the balance between training volumes and recovery is often a delicate one and, the accumulation of exercise-induced stress may exceed the capacity of both neuroendocrine and immune adaptation leading to an alteration of physiological functions, decreasing adaptation to performance, impairment of psychological processing, immunological dysfunction, and biochemical abnormalities. Moreover, there is currently a lack of biomarkers accessible to assist in diagnosing and, what's even more important - help to prevent the overtraining syndrome, except for the continued presence of unexplained underperformance despite athletes' adequate rest and recovery.
Read more
Thus, this study aims to explain how long and intensive training for endurance affects the hormonal and immune systems of young athletes.
The main questions it aims to answer are:
- How does intense training influence hormonal and immune responses in young, trained athletes?
- Does training specialization affect the hormonal and immune response to intense training?
Read the detailed description
Twenty-four young male and female athletes, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study. Investigation was held during 9 days of the training camp (preparatory period, general preparation sub-period), which was aimed at increasing the endurance and flexibility of athletes. During the training camp, all subjects occupied the same accommodations and followed the same training plan and diet schedules. The camp regime included 2 training sessions per day, lasting 4 hours per day, and a total of 21 hours per 9 days. Blood samples were taken always in the same conditions, from the antecubital veins. Participants were seated in a recumbent position for a minimum of 10 minutes before blood draws to stabilize the hydrostatic condition. Before collection of the first sample (rested baseline), participants were asked to avoid any intense exercise at least 24 hours before sampling. Next samples were taken after 4 days and after another 5 days of training camp (in total after 9 days). The concentration of catecholamines: epinephrine and norepinephrine in serum was measured as well and the responsiveness of the adrenal medulla to the sympathetic nervous activity was estimated by the ratio E/NE calculated. Also, concentrations of cortisol, hs-CRP, and myoglobin were measured and changes in blood morphology were estimated.
- Conditions
- Overtraining Syndrome
- Being tested
- Exercise training
- Keywords
- epinephrine, norepinephrine, cortisol, athletes, fatigue
- Medical subject headings
- Overtraining Syndrome, Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise trainingOther
Intense endurance training
| Study group | Role | What they receive |
|---|---|---|
| sprint-trained | Sprint-trained athletes: 6 male and 6 female, aged average 15 y., Receives: Other: Exercise training | |
| endurance-trained | Endurance-trained athletes: 6 male and 6 female, aged average 15 y., Receives: Other: Exercise training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in epinephrine serum level.
marker of HPA axis functioning, stress hormone.
Measured: at rest baseline (before training), after 4 - and after another 5 days of training.
Changes in norepinephrine serum level.
marker of HPA axis functioning, stress hormone.
Measured: at rested baseline (before training), after 4 - and after another 5 days of training.
Changes in cortisol serum level.
marker of HPA axis functioning, stress hormone
Measured: at rested baseline (before training), after 4 - and after another 5 days of training.
Changes in hs-CRP serum level.
marker of inflammatory response.
Measured: at rested baseline (before training), after 4 - and after another 5 days of training.
Changes in Myoglobin serum level.
marker of muscle damage
Measured: at rested baseline (before training), after 4 - and after another 5 days of training.
Secondary outcomes (2)
Changes in blood morphology.
Morphometric measurements of blood cell.
Measured: sat rested baseline (before training), after 4 - and after another 5 days of training.
Changes in epinephrine/norepinephrine ratio.
marker of responsiveness of the adrenal medulla to sympathetic nervous activity.
Measured: at rested baseline (before training), after 4 - and after another 5 days of training.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Nov 2023
- Study start16 Feb 2018
- Primary completion24 Feb 2018
- Study completion10 Dec 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Overtraining SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Poznan University of Physical Education
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Joanna Ostapiuk-Karolczuk, Ph.D., Principal investigator, Poznan University of Physical Education
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06150105
- Sponsor's protocol ID
- 530/18
- Acronym
- CHIPYA
- Status last verified
- Nov 2023
- First submitted
- 13 Nov 2023
- Last updated
- 6 Dec 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ostapiuk-Karolczuk J, Kasperska A, Dziewiecka H, Cieslicka M, Zawadka-Kunikowska M, Zaleska-Posmyk I. Changes in the hormonal and inflammatory profile of young sprint- and endurance-trained athletes following a sports camp: a nonrandomized pretest-posttest study. BMC Sports Sci Med Rehabil. 2024 Jun 20;16(1):136. doi: 10.1186/s13102-024-00924-3.
PubMed 38898468
Study at a glance
From the registry record, last updated by the sponsor on 6 Dec 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes Following a Sports Camp
- ClinicalTrials.gov ID
- NCT06150105
- Acronym / sponsor ID
- CHIPYA / 530/18
- Conditions
- Overtraining Syndrome
- Keywords
- epinephrine, norepinephrine, cortisol, athletes, fatigue
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Poznan University of Physical EducationUniversity, hospital or other
- Study start
- 16 Feb 2018 (actual)
- Primary completion
- 24 Feb 2018 (actual)
- Study completion
- 10 Dec 2018 (actual)
- First posted
- 29 Nov 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events. During sports camps, due to the accumulation of a large number of training units, including high-intensity exercises, athletes react with post-exercise overload, acute fatigue, and overreaching which can become a chronic overtraining syndrome. Overtraining syndrome is a very specific and severe condition where overtraining without adequate rest and recovery leads to performance decrements lasting more than 2-3 months, coupled with a mood disturbance. The exact etiology and pathogenesis are unknown and actively being investigated.
During training camps the balance between training volumes and recovery is often a delicate one and, the accumulation of exercise-induced stress may exceed the capacity of both neuroendocrine and immune adaptation leading to an alteration of physiological functions, decreasing adaptation to performance, impairment of psychological processing, immunological dysfunction, and biochemical abnormalities. Moreover, there is currently a lack of biomarkers accessible to assist in diagnosing and, what's even more important - help to prevent the overtraining syndrome, except for the continued presence of unexplained underperformance despite athletes' adequate rest and recovery.
Thus, this study aims to explain how long and intensive training for endurance affects the hormonal and immune systems of young athletes.
The main questions it aims to answer are:
- How does intense training influence hormonal and immune responses in young, trained athletes?
- Does training specialization affect the hormonal and immune response to intense training?
Detailed description
Twenty-four young male and female athletes, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study. Investigation was held during 9 days of the training camp (preparatory period, general preparation sub-period), which was aimed at increasing the endurance and flexibility of athletes. During the training camp, all subjects occupied the same accommodations and followed the same training plan and diet schedules. The camp regime included 2 training sessions per day, lasting 4 hours per day, and a total of 21 hours per 9 days. Blood samples were taken always in the same conditions, from the antecubital veins. Participants were seated in a recumbent position for a minimum of 10 minutes before blood draws to stabilize the hydrostatic condition. Before collection of the first sample (rested baseline), participants were asked to avoid any intense exercise at least 24 hours before sampling. Next samples were taken after 4 days and after another 5 days of training camp (in total after 9 days). The concentration of catecholamines: epinephrine and norepinephrine in serum was measured as well and the responsiveness of the adrenal medulla to the sympathetic nervous activity was estimated by the ratio E/NE calculated. Also, concentrations of cortisol, hs-CRP, and myoglobin were measured and changes in blood morphology were estimated.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| sprint-trained | – | Other: Exercise trainingSprint-trained athletes: 6 male and 6 female, aged average 15 y., |
| endurance-trained | – | Other: Exercise trainingEndurance-trained athletes: 6 male and 6 female, aged average 15 y., |
Who may qualify
- Ages
- 15 to 17 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
- Study population
- Twenty-four young male and female athletes, students at Sports Championship School, future representatives of the Polish National Team, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study.
Key inclusion criteria (3 listed)
- age 15-17 years,
- minimum of 3 years of training experience,
- specialization in anaerobic and aerobic disciplines.
Key exclusion criteria (3 listed)
- presence of acute or chronic inflammation
- fever, infections, injuries
- se of any anti-inflammatory drugs.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise trainingIntense endurance training | Other | endurance-trained, sprint-trained |
Primary outcome
Changes in epinephrine serum level.
Time frame: at rest baseline (before training), after 4 - and after another 5 days of training.
marker of HPA axis functioning, stress hormone.
Changes in norepinephrine serum level.
Time frame: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of HPA axis functioning, stress hormone.
Changes in cortisol serum level.
Time frame: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of HPA axis functioning, stress hormone
Changes in hs-CRP serum level.
Time frame: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of inflammatory response.
Changes in Myoglobin serum level.
Time frame: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of muscle damage
2 secondary outcomes
Changes in blood morphology.
Time frame: sat rested baseline (before training), after 4 - and after another 5 days of training.
Changes in epinephrine/norepinephrine ratio.
Time frame: at rested baseline (before training), after 4 - and after another 5 days of training.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Dec 2023.
- Derived from this study: PubMed 38898468Ostapiuk-Karolczuk J, Kasperska A, Dziewiecka H, Cieslicka M, Zawadka-Kunikowska M, Zaleska-Posmyk I. Changes in the hormonal and inflammatory profile of young sprint- and endurance-trained athletes following a sports camp: a nonrandomized pretest-posttest study. BMC Sports Sci Med Rehabil. 2024 Jun 20;16(1):136. doi: 10.1186/s13102-024-00924-3.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Joanna Ostapiuk-Karolczuk, Ph.D. principal investigator
Poznan University of Physical Education
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Overtraining Syndrome, run by Poznan University of Physical Education at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Dec 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in epinephrine serum level. (time frame: at rest baseline (before training), after 4 - and after another 5 days of training.). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06150105, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Dec 2023.