HypertrophyQUADRATURENCT06164249
Quantification of Internal Training Load
A study testing strength training in people with Hypertrophy and Resistance Training, run by Université de Nantes.
Trial summary
The aim of this study is to determine whether the distribution of internal load predicts the distribution of muscle hypertrophy among hamstring heads after a 10-week resistance exercise program. Read more about this study
- Who is it for?
- Ages 18 to 25 yearsHealthy volunteers can take part
- Conditions the study is for
- Hypertrophy, Resistance Training, Muscle
- What is being tested?
- strength training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- No sites listed yet
- Study dates
- 29 Jan 2024to 19 May 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- No history of lower limb injury
- No chronic pathology associated with a long term care
Who cannot join
- Individual enrolled in a research study
Trial locations and contacts
No sites are listed yet.
About this study
Official title: Quantification of Internal Training Load: Toward the Prediction of the Distribution of Hypertrophy
The aim of this study is to determine whether the distribution of internal load predicts the distribution of muscle hypertrophy among hamstring heads after a 10-week resistance exercise program. The hypothesis is that the distribution of internal muscle load among the hamstring is related to the distribution of muscle hypertrophy.
Read the detailed description
It is well accepted that muscle stress (mechanical and/or metabolic) is the major way to induce muscle hypertrophy. While this link between muscle stress and hypertrophy is pivotal is sport training, prevention and rehabilitation, it remains poorly understood. To date, the only indirect evidence of relationship of muscle stress and muscle hypertrophy is the similar patterns (from independent studies) between muscle damage and hypertrophy within quadriceps (i.e., rectus femoris (RF) > vastus (VL) = vastus medialis VM), hamstring, and triceps surae. However, muscle damage is an indirect proof of muscle mechanical stress. With the quantification of internal muscle load, it is interesting to determine whether the muscle that receives the larger stress exhibits the larger hypertrophy.
- Conditions
- Hypertrophy, Resistance Training, Muscle
- Being tested
- strength training
- Keywords
- Muscle activation, Muscle volume, Muscle stress, Muscle mass
- Medical subject headings
- Hypertrophy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
strength trainingOther
Strength training, three times a week, during nine weeks.
| Study group | Role | What they receive |
|---|---|---|
| Nordic | Experimental | Training regimens composed of nordic exercise Receives: Other: strength training |
| Deadlift | Experimental | Training regimens composed of deadlift exercise Receives: Other: strength training |
| Control | No intervention | Training regimens composed of no exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle volume
Hypertrophy
Measured: 10 weeks
Internal training load
Magnitude and onset/offset of muscle activation
Measured: 10 weeks
Secondary outcomes (2)
Maximal strength Nordic
Maximal strength during the Nordic exercise
Measured: 10 weeks
Maximal strength Deadlift
Maximal strength during the Deadlift exercise
Measured: 10 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Dec 2023
- Study start29 Jan 2024 (estimated)
- Primary completion2 Apr 2024 (estimated)
- Study completion19 May 2024 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HypertrophyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Three independent groups : * Control (no strengthening) * Nordic (strengthening in Nordic Hamstring exercise) * Deadlift (strengthening in Deadlift exercise)
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 36 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Université de Nantes
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lilian Lacourpaille, Université de Nantes
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06164249
- Sponsor's protocol ID
- EM_LL_2024
- Acronym
- QUADRATURE
- Status last verified
- Dec 2023
- First submitted
- 30 Nov 2023
- Last updated
- 11 Dec 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Data will be available from a Dryad Digital Repository
Study at a glance
From the registry record, last updated by the sponsor on 11 Dec 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Quantification of Internal Training Load: Toward the Prediction of the Distribution of Hypertrophy
- ClinicalTrials.gov ID
- NCT06164249
- Acronym / sponsor ID
- QUADRATURE / EM_LL_2024
- Conditions
- Hypertrophy, Resistance Training, Muscle
- Keywords
- Muscle activation, Muscle volume, Muscle stress, Muscle mass
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 36 participants (estimated)
- Lead sponsor
- Université de NantesUniversity, hospital or other
- Study start
- 29 Jan 2024 (estimated)
- Primary completion
- 2 Apr 2024 (estimated)
- Study completion
- 19 May 2024 (estimated)
- First posted
- 11 Dec 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to determine whether the distribution of internal load predicts the distribution of muscle hypertrophy among hamstring heads after a 10-week resistance exercise program. The hypothesis is that the distribution of internal muscle load among the hamstring is related to the distribution of muscle hypertrophy.
Detailed description
It is well accepted that muscle stress (mechanical and/or metabolic) is the major way to induce muscle hypertrophy. While this link between muscle stress and hypertrophy is pivotal is sport training, prevention and rehabilitation, it remains poorly understood. To date, the only indirect evidence of relationship of muscle stress and muscle hypertrophy is the similar patterns (from independent studies) between muscle damage and hypertrophy within quadriceps (i.e., rectus femoris (RF) > vastus (VL) = vastus medialis VM), hamstring, and triceps surae. However, muscle damage is an indirect proof of muscle mechanical stress. With the quantification of internal muscle load, it is interesting to determine whether the muscle that receives the larger stress exhibits the larger hypertrophy.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- Three independent groups : * Control (no strengthening) * Nordic (strengthening in Nordic Hamstring exercise) * Deadlift (strengthening in Deadlift exercise)
| Arm | Type | Receives |
|---|---|---|
| Nordic | Experimental | Other: strength trainingTraining regimens composed of nordic exercise |
| Deadlift | Experimental | Other: strength trainingTraining regimens composed of deadlift exercise |
| Control | No intervention | –Training regimens composed of no exercise |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- No history of lower limb injury
- No chronic pathology associated with a long term care
Key exclusion criteria (1 listed)
- Individual enrolled in a research study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| strength trainingStrength training, three times a week, during nine weeks. | Other | Deadlift, Nordic |
Primary outcome
Muscle volume
Time frame: 10 weeks
Hypertrophy
Internal training load
Time frame: 10 weeks
Magnitude and onset/offset of muscle activation
2 secondary outcomes
Maximal strength Nordic
Time frame: 10 weeks
Maximal strength Deadlift
Time frame: 10 weeks
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Dec 2023.
- Individual participant dataSharing planned: Undecided. Data will be available from a Dryad Digital Repository
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Questions about this trial
What is this clinical trial studying?
A study testing strength training in people with Hypertrophy and Resistance Training, run by Université de Nantes.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 11 Dec 2023. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Lilian LACOURPAILLE, Doctor (+33670807473, lilian.lacourpaille@univ-nantes.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle volume (time frame: 10 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Dec 2023.