Post-Acute COVID-19 SyndromeRecoveryNCT06168006
Exercise Training Using an App on Physical Cardiovascular Function Individuals With Post-covid-19 Syndrome
A study testing Exercise in people with Post-Acute COVID-19 Syndrome, run by University of Nove de Julho at 1 site in Brazil.
Trial summary
The aim of this study is to assess the effect of a physical exercise program via a mobile application on functional parameters in individuals with post-COVID-19 syndrome. This is a clinical trial involving 60 individuals with post-COVID syndrome who will be randomly assigned to either a control group (physical… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Post-Acute COVID-19 Syndrome
- What is being tested?
- Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 60 participants
- Where
- 1 siteBrazil
- Study dates
- 1 Mar 2024to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Laboratory diagnosis of COVID-19
- Fatigue ≥ 8 points on the Chalder Scale and/or dyspnea 2-4 on the Modified Medical Research Council
- Have access to a smartphone
- Have no contraindications for exercise practice
- Have ability to sit and stand and maintain balance while standing
- Have preserved cognitive function
- Have no risk of falls according to the Morse Fall Scale
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Brazil1 site, 1 recruiting
- Recruiting
Universidade Nove de Julho
São Paulo, São Paulo, 01504-001
Raphael Dias
About this study
Official title: Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial
The aim of this study is to assess the effect of a physical exercise program via a mobile application on functional parameters in individuals with post-COVID-19 syndrome. This is a clinical trial involving 60 individuals with post-COVID syndrome who will be randomly assigned to either a control group (physical activity guideline) or an experimental group (app-based training).
- Conditions
- Post-Acute COVID-19 Syndrome
- Being tested
- Exercise, Control
- Keywords
- exercise, mobile app, physical function, cardiovascular function
- Medical subject headings
- Post-Acute COVID-19 Syndrome, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ExerciseBehavioural
Also called Rehabilitation, Physical activity, Endurance, Resistance exercises
The experimental group will undergo an exercise program using the Recovery App. Participants will receive guidance from researchers about the functionality of the app. The Recovery App includes flexibility, strength, and aerobic training exercises, aiming for a progressive intensity and volume over the weeks.
ControlBehavioural
They will receive an exercise booklet based on the Brazilian Physical Activity Recommendations (MINISTRY OF HEALTH, 2021), which recommend 150 minutes of physical activity for adults and seniors.
| Study group | Role | What they receive |
|---|---|---|
| Exercise intervention | Experimental | The subjects randomized to this group will perform three app-based training sessions per week for 12 weeks, each session lasting a maximum of 40 minutes. Receives: Behavioral: Exercise |
| Control intervention | Sham comparator | This group will receive a booklet with exercise instructions, and will be recommended the same frequency and duration of exercise as the experimental group Receives: Behavioral: Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from baseline in 6 min-walk test distance at 12 weeks
The 6-minute walk test performed in a 30-meter corridor, measured in meters
Measured: Baseline and 12 weeks
Change from baseline in Glittre test at 12 weeks
The test consists in rise from a chair, carry a weighted backpack, walk 10 meters, climb stairs, move objects between shelves (1 kg each), and return. They perform tasks sequentially, transferring items up and down shelves. The route is retraced, ending by sitting back in the initial chair, measured in seconds
Measured: Baseline and 12 weeks
Change from baseline in sit and stand test at 12 weeks
The test consists in rising from a chair as many times as possible within 30 seconds, measured in number of repetitions
Measured: Baseline and 12 weeks
Change from baseline in Post-Covid Functional Scale at 12 weeks
The Post-COVID-19 Functional Status Scale assesses limitations following SARS-CoV-2 infection, measured as a score
Measured: Baseline and 12 weeks
Secondary outcomes (16)
Change from baseline in Patient Functional Scale at 12 weeks
The Patient Functional Scale allows individuals to identify 3 to 5 important activities they consider themselves unable to perform or are having difficulty with due to their condition, measured in a score
Measured: Baseline and 12 weeks
Change from baseline in Motor Evoked Potential at 12 weeks
The cortical excitability of the quadriceps motor area will be measured using Motor Evoked Potential results in microvolts (µV) using the Transcranial Magnetic Stimulation equipment model MagPro R20 (MagVenture, Denmark) with the parabolic coil model MMC-140-II, measured in kgf
Measured: Baseline and 12 weeks
Change from baseline in Modified Medical Research Dyspnea Scale at 12 weeks
This scale comprises five items, allowing the patient to select the item that corresponds to how much their dyspnea limits their daily life activities, measured as a score
Measured: Baseline and 12 weeks
Change from baseline in Chalder Physical Fatigue Scale at 12 weeks
Comprising eight specific statements about physical fatigue to confirm its presence or absence, measured as a score
Measured: Baseline and 12 weeks
Change from baseline in De Paul Symptom Questionnaire at 12 weeks
The questionnaire evaluate the symptoms of fatigue in different conditions, measured as a score
Measured: Baseline and 12 weeks
Change from baseline in Quality of Life at 12 weeks
To assess quality of life, the 12-Item Short-Form Health Survey will be used, consisting of twelve items that evaluate eight different dimensions influencing quality of life, measured as a score
Measured: Baseline and 12 weeks
Change from baseline in Frailty and Sarcopenia at 12 weeks
Frailty will be assessed using the Tilburg Frailty Indicator, while sarcopenia will be evaluated through the Sarcopenia Form questionnaire, both measured as a score
Measured: Baseline and 12 weeks
Change from baseline in Anxiety and Depressive Symptoms at 12 weeks
Levels of anxiety and depression will be assessed using the Hospital Anxiety and Depression Scale, measured as a score
Measured: Baseline and 12 weeks
Change from baseline in Pain at 12 weeks
Assessed using the Numeric Pain Rating Scale, measured as a score
Measured: Baseline and 12 weeks
Change from baseline in Movement Behavior at 12 weeks
Movement behavior will be quantified through a motion sensor, measured in minutes
Measured: Baseline and 12 weeks
Change from baseline in Barriers to Physical activity at 12 weeks
Specific questionnaire to assess the most prevalent environmental barriers to physical activity, measured as presence or absence
Measured: Baseline and 12 weeks
Post assessment of Exercise Adherence Assessment Scale
Adherence to exercise interventions will be obtained with the Adherence Assessment Scale
Measured: 12 weeks
Change from baseline in Blood Pressure at 12 weeks
The clinical resting blood pressure will be assessed using automatic blood pressure monitoring equipment (HEM-7113, OMRON®, Brazil), measured in mmHg
Measured: Baseline and 12 weeks
Change from baseline in Cardiac Autonomic Modulation at 12 weeks
Cardiac autonomic modulation will be assessed through heart rate variability using a heart rate monitor, measured in RR intervals
Measured: Baseline and 12 weeks
Change from baseline in Blood Flow and Flow-mediated Dilation at 12 weeks
The measurements of basal blood flow and flow-mediated vasodilation will be obtained through ultrasonography in brachial artery, measured in ml/min or %
Measured: Baseline and 12 weeks
Change in Spirometry parameters at 12 weeks
Changes in Forced vital capacity, forced expiratory volume in the first second, Peak expiratory flow, forced expiratory flow 25-75% and FEV 1 /FVC ratio
Measured: Baseline and 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Dec 2023
- Study start1 Mar 2024
- Primary completion30 Jun 2026 (estimated)
- Study completion30 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post-Acute COVID-19 SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Nove de Julho
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Raphael Mendes Ritti Dias, University of Nove de Julho
- Investigators
- Fernanda Corrêa, PhD, Principal investigator, University of Nove de Julho
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06168006
- Sponsor's protocol ID
- Recovery Long Covid
- Acronym
- Recovery
- Status last verified
- Feb 2026
- First submitted
- 12 Dec 2023
- Last updated
- 17 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available after the completion of the study and the finalization of the main articles of this projects
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT06168006
- Acronym / sponsor ID
- Recovery / Recovery Long Covid
- Conditions
- Post-Acute COVID-19 Syndrome
- Keywords
- exercise, mobile app, physical function, cardiovascular function
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- University of Nove de JulhoUniversity, hospital or other
- Study start
- 1 Mar 2024 (actual)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 30 Jun 2026 (estimated)
- First posted
- 13 Dec 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to assess the effect of a physical exercise program via a mobile application on functional parameters in individuals with post-COVID-19 syndrome. This is a clinical trial involving 60 individuals with post-COVID syndrome who will be randomly assigned to either a control group (physical activity guideline) or an experimental group (app-based training).
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Exercise intervention | Experimental | Behavioral: ExerciseThe subjects randomized to this group will perform three app-based training sessions per week for 12 weeks, each session lasting a maximum of 40 minutes. |
| Control intervention | Sham comparator | Behavioral: ControlThis group will receive a booklet with exercise instructions, and will be recommended the same frequency and duration of exercise as the experimental group |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Laboratory diagnosis of COVID-19
- Fatigue ≥ 8 points on the Chalder Scale and/or dyspnea 2-4 on the Modified Medical Research Council
- Have access to a smartphone
- Have no contraindications for exercise practice
- Have ability to sit and stand and maintain balance while standing
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ExerciseAlso: Rehabilitation, Physical activity, Endurance, Resistance exercisesThe experimental group will undergo an exercise program using the Recovery App. Participants will receive guidance from researchers about the functionality of the app. The Recovery App includes flexibility, strength, and aerobic training exercises, aiming for a progressive intensity and volume over the weeks. | Behavioural | Exercise intervention |
| ControlThey will receive an exercise booklet based on the Brazilian Physical Activity Recommendations (MINISTRY OF HEALTH, 2021), which recommend 150 minutes of physical activity for adults and seniors. | Behavioural | Control intervention |
Primary outcome
Change from baseline in 6 min-walk test distance at 12 weeks
Time frame: Baseline and 12 weeks
The 6-minute walk test performed in a 30-meter corridor, measured in meters
Change from baseline in Glittre test at 12 weeks
Time frame: Baseline and 12 weeks
The test consists in rise from a chair, carry a weighted backpack, walk 10 meters, climb stairs, move objects between shelves (1 kg each), and return. They perform tasks sequentially, transferring items up and down shelves. The route is retraced, ending by sitting back in the initial chair, measured in seconds
Change from baseline in sit and stand test at 12 weeks
Time frame: Baseline and 12 weeks
The test consists in rising from a chair as many times as possible within 30 seconds, measured in number of repetitions
Change from baseline in Post-Covid Functional Scale at 12 weeks
Time frame: Baseline and 12 weeks
The Post-COVID-19 Functional Status Scale assesses limitations following SARS-CoV-2 infection, measured as a score
16 secondary outcomes
Change from baseline in Patient Functional Scale at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Motor Evoked Potential at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Modified Medical Research Dyspnea Scale at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Chalder Physical Fatigue Scale at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in De Paul Symptom Questionnaire at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Quality of Life at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Frailty and Sarcopenia at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Anxiety and Depressive Symptoms at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Pain at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Movement Behavior at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Barriers to Physical activity at 12 weeks
Time frame: Baseline and 12 weeks
Post assessment of Exercise Adherence Assessment Scale
Time frame: 12 weeks
Change from baseline in Blood Pressure at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Cardiac Autonomic Modulation at 12 weeks
Time frame: Baseline and 12 weeks
Change from baseline in Blood Flow and Flow-mediated Dilation at 12 weeks
Time frame: Baseline and 12 weeks
Change in Spirometry parameters at 12 weeks
Time frame: Baseline and 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2026.
- Individual participant dataSharing planned: Yes. The data will be available after the completion of the study and the finalization of the main articles of this projects
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Fernanda Corrêa, PhD principal investigator
University of Nove de Julho
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise in people with Post-Acute COVID-19 Syndrome, run by University of Nove de Julho at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Raphael Ritti-Dias, PhD (+55 19 99940 6878, raphaelritti@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from baseline in 6 min-walk test distance at 12 weeks (time frame: Baseline and 12 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2026.