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HypoxemiaMOXY-HSPNCT06169514

Health Systems and Policy Contexts of Medical Oxygen

An observational study of Hypoxemia and Morality, run by Murdoch Childrens Research Institute at 6 sites in 6 countries.

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Sites and contacts
Official record

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Trial summary

This is a mixed-methods program evaluation from a health systems and policy perspective, involving (i) stakeholder analysis, (ii) policy-implementation gap analysis, and (iii) comparative country case studies. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Hypoxemia, Morality, Pneumonia
How many people
1 participants
Where
6 sitesin 6 countries
Study dates
31 Jul 2024to Dec 2027
Phase
Observational

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: This study will be conducted in 6 of the 9 countries participating in the CHAI-led MOXY program (Uganda, Nigeria, Rwanda, Liberia, Lao PDR, Cambodia).

Key informants will be selected representing government, non-governmental agencies, professional associations, private sector, and civil society.

Trial locations and contacts

6 sites in 6 countries. Contact the study team or a site near you to ask about taking part.

Rami Subhi, MBBS, FRACS, MD (Res) contact

+61403151186

rami.subhi@mcri.edu.au

Hamish Graham, PhD contact

+61403456262

hamish.graham@rch.org.au

6 sites in 6 countries

Cambodia1 site, 1 recruiting
  • Cambodia

    Phnom Penh

    Siyan Yi, PhD, siyan@nus.edu.sg

    Recruiting

Other trials in Cambodia

Laos1 site, 1 recruiting
  • Lao PDR

    Vientiane

    Mayfong Mayxay, PhD

    Recruiting

Other trials in Laos

Liberia1 site, 1 recruiting
  • Liberia

    Monrovia

    Readon Ideh, MD, rideh1010@gmail.com

    Recruiting

Other trials in Liberia

Nigeria1 site, 1 recruiting
  • Nigeria

    Ibadan

    Ayobami Bakare, MD, aadebayobakare@gmail.com

    Recruiting

Other trials in Nigeria

Rwanda1 site, 1 recruiting
  • Rwanda

    Kigali

    Corneille Killy Ntihabose, MD, ckntihabose@gmail.com

    Recruiting

Other trials in Rwanda

Uganda1 site, 1 recruiting
  • Uganda

    Kampala

    Freddy Kitutu, PhD, 256 705 79177, kitutufred@gmail.com

    Recruiting

Other trials in Uganda

About this study

Official title: Understanding the Health Systems and Policy Contexts of Medical Oxygen in Africa and Asia (MOXY-HSP)

This is a mixed-methods program evaluation from a health systems and policy perspective, involving (i) stakeholder analysis, (ii) policy-implementation gap analysis, and (iii) comparative country case studies. This study aims to understand how national oxygen strategies achieve impact at national, and subnational level, across country contexts, at what cost.

The the investigators seek to:

Read more
  1. Involve policymakers, implementers (including private sector), and medical oxygen users in identifying challenges and understanding potential solutions to medical oxygen access;
  2. Generate new data on how medical oxygen systems work and can be improved from multiple perspectives;
  3. Draw lessons on medical oxygen that can directly inform national and global practice and policy.

This study will be conducted in 6 of the 9 countries participating in the Clinton Health Access Initiative (CHAI) led Medical Oxygen Implementation (MOXY) program (Uganda, Nigeria, Rwanda, Liberia, Lao PDR, Cambodia).

Key informants will be selected representing government, non-governmental agencies, professional associations, private sector, and civil society. This study will be completed over 4 years, with timelines varying between country study sites.

Read the detailed description

The investigators will use a concurrent mixed-methods design, with an overarching comparative case study methodology. The investigators will adopt an iterative approach, using co-design to adapt the study methodology to the specific context of each country and annual learning team meetings with stakeholders to refine the final case study topics (sub-study 3) and methodology.

Three embedded sub-studies are planned:

Sub-study 1 (Stakeholder Analysis) aims to understand the policy environment for medical oxygen services across different country contexts. This will be informed by the MOXY baseline survey, which includes data on oxygen-related facility readiness and clinical practices across the MOXY program areas. Data sources will include stakeholder interviews with participants from different levels (national, provincial, local) and policy perspectives (government, implementing/advising partners, practitioners, beneficiaries). Results will inform sub-study 2 and MOXY program implementation.

Sub-study 2 (Policy-Implementation Gap Analysis) aims to critically analyse the gap between policy intentions and actual implementation. This will be informed by the baseline facility readiness and clinical practice data. Data sources will include a desk review of oxygen-related policies, stakeholder in-depth interviews, and program administrative data. Results will inform implementation of country oxygen strategies and feed into prioritization of focus areas for sub-study 3.

Sub-study 3 (Comparative Country Case Studies) aims to compare oxygen programs across countries, focusing on particular challenges or unique solutions identified in sub-study 1 and 2. Data sources will include repeated desk review of oxygen-related policies and program administrative data, follow-up stakeholder interviews, and triangulation with quantitative survey results on facility readiness and clinical practices.

This research will also draw on national stakeholder dialogues - both to review, refine, and validate preliminary findings of the study team and to draw out feasible solutions/alternatives for both policy and practice and oxygen eco-system. In year 1 the investigators will generate key evidence about how the current strategies and polices are being translated into action, identifying key opportunities for implementing partners to focus support. Over years 2 and 3, the investigators will learn how these activities have affected medical oxygen service coverage, drawing lessons across country contexts and across different implementation approaches.

Being tested
No intervention
Keywords
Health system, Oxygen, Oxygen systems, Oxygen access, Pulse oximetry
Medical subject headings
Hypoxia, Pneumonia

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • No interventionOther

    No intervention

Study groups in NCT06169514
Study groupRoleWhat they receive
Policy and stakeholder analysis across 6 countriesPolicy and stakeholder analysis across 6 countries
Receives: Other: No intervention

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. In-depth stakeholder interviews on national medical oxygen strategies

    In depth stakeholder interviews covering perspectives on policies, oversight, implementation, and related support towards the particular domain (e.g. measurement and indicators, health workforce capacity building, etc.)

    Measured: 4 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Dec 2023
  2. Study start31 Jul 2024
  3. Primary completionDec 2027 (estimated)
  4. Study completionDec 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Other
Time perspective
Other
Enrolment
1 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06169514
Sponsor's protocol ID
HREC 100143
Acronym
MOXY-HSP
Status last verified
Nov 2025
First submitted
29 Oct 2023
Last updated
6 Feb 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

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