CancerNCT06173843
Occupational Exposures Among Firefighters
An observational study of Cancer, run by Vincere Cancer Center at 1 site in United States.
Trial summary
This study aims to understand the effect of occupational exposures, including PFAS exposures, among firefighters. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cancer
- What is being tested?
- PFAS / heavy metal testing, exposures
- How many people
- 2,000 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Dec 2023to 31 Dec 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Actively working or retired firefighters of any adult age, any gender and any demographic group are eligible, with no limitations regarding general health status other than those specified in the protocol Eligibility Criteria.
Who may be able to join
- 18 years of age or older; any gender
- Currently (or previously) employed as a firefighter, full-time or part-time, participating in Vincere's First Responder Cancer Screening Program
- Willing to provide a blood, urine, and/or tissue sample
- Able to provide informed consent to participate in the study
- (A small group of non-firefighters will be enrolled to act as a comparison group)
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Vincere Cancer Center
Scottsdale, Arizona, 85260
Christine Lau, MD, 480-306-5390, drlau@vincerecancer.com
Vershalee Shukla, MD
About this study
Official title: Effect of Occupational Exposures on Cancer Pathophysiology Among Firefighters
This study aims to understand the effect of occupational exposures, including PFAS exposures, among firefighters.
- Conditions
- Cancer
- Being tested
- PFAS / heavy metal testing, exposures
- Keywords
- Cancer, Occupational exposure
- Medical subject headings
- Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PFAS / heavy metal testing, exposuresOther
PFAS / heavy metal concentrations, exposure survey
| Study group | Role | What they receive |
|---|---|---|
| Firefighters | Not described Receives: Other: PFAS / heavy metal testing, exposures | |
| Non-Firefighters | Not described Receives: Other: PFAS / heavy metal testing, exposures |
What is being measured
The primary outcome is the main question the study is designed to answer.
Exposures associated with elevated PFAS
Measured: 5 years
Secondary outcomes (1)
Cancer rates
Measured: 5 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Dec 2023
- Study start6 Dec 2023
- Primary completion31 Dec 2028 (estimated)
- Study completion31 Dec 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 2,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Vincere Cancer Center
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06173843
- Sponsor's protocol ID
- VCC-PFAS-001
- Status last verified
- Nov 2024
- First submitted
- 7 Dec 2023
- Last updated
- 14 Nov 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Nov 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Occupational Exposures on Cancer Pathophysiology Among Firefighters
- ClinicalTrials.gov ID
- NCT06173843
- Acronym / sponsor ID
- VCC-PFAS-001
- Conditions
- Cancer
- Keywords
- Cancer, Occupational exposure
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 2,000 participants (estimated)
- Lead sponsor
- Vincere Cancer CenterUniversity, hospital or other
- Study start
- 6 Dec 2023 (actual)
- Primary completion
- 31 Dec 2028 (estimated)
- Study completion
- 31 Dec 2029 (estimated)
- First posted
- 18 Dec 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to understand the effect of occupational exposures, including PFAS exposures, among firefighters.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Firefighters | – | Other: PFAS / heavy metal testing, exposures |
| Non-Firefighters | – | Other: PFAS / heavy metal testing, exposures |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Actively working or retired firefighters of any adult age, any gender and any demographic group are eligible, with no limitations regarding general health status other than those specified in the protocol Eligibility Criteria.
Key inclusion criteria (5 listed)
- 18 years of age or older; any gender
- Currently (or previously) employed as a firefighter, full-time or part-time, participating in Vincere's First Responder Cancer Screening Program
- Willing to provide a blood, urine, and/or tissue sample
- Able to provide informed consent to participate in the study
- (A small group of non-firefighters will be enrolled to act as a comparison group)
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PFAS / heavy metal testing, exposuresPFAS / heavy metal concentrations, exposure survey | Other | Firefighters, Non-Firefighters |
Primary outcome
Exposures associated with elevated PFAS
Time frame: 5 years
1 secondary outcome
Cancer rates
Time frame: 5 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Nov 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cancer, run by Vincere Cancer Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 14 Nov 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Christine Lau, MD (480-306-5390, drlau@vincerecancer.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Exposures associated with elevated PFAS (time frame: 5 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Nov 2024.