Chronic Venous Disease (CVD), Vein Compliance, Venous Clinical Severity Score (VCSS)NCT06175481
Correlation Between Popliteal Vein Compliance and Venous Clinical Severity Score
An observational study of Chronic Venous Disease (CVD), Vein Compliance, Venous Clinical Severity Score (VCSS), run by Hao Liu at 1 site in China.
Trial summary
When the liquid flow increases, the luminal caliber's stretching amplitude decreases, leading to a higher hydraulic pressure according to Poiseuille's law. In this study, investigators measured the caliber change of the popliteal vein under a rated pressure gradient and evaluated the relationship between popliteal… Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Chronic Venous Disease (CVD), Vein Compliance, Venous Clinical Severity Score (VCSS)
- What is being tested?
- Popliteal Vein Compliance
- How many people
- 173 participants
- Where
- 1 siteChina
- Study dates
- 1 Jun 2023to 1 Oct 2023
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: Patients were prospectively enrolled in Guangdong Second Provincial General Hospital from May 2023 to October 2023. All participants gave their voluntary consent.
Who may be able to join
- C1 to C6 disease using the CEAP (clinical, etiologic, anatomic, pathophysiologic) classification.
Who cannot join
- acute or chronic thrombosis of deep veins, previously received intravenous surgery or injection sclerotherapy, ankle brachial index<0.90, and concomitant cardiovascular, pulmonary, renal, or metabolic diseases.
Trial locations and contacts
1 site in 1 country.
About this study
When the liquid flow increases, the luminal caliber's stretching amplitude decreases, leading to a higher hydraulic pressure according to Poiseuille's law. In this study, investigators measured the caliber change of the popliteal vein under a rated pressure gradient and evaluated the relationship between popliteal vein compliance and venous clinical severity score (VCSS).
- Being tested
- Popliteal Vein Compliance
- Medical subject headings
- Cardiovascular Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Popliteal Vein ComplianceOther
Compliance of the popliteal vein is calculated as the distensibility, with the ratio of functional caliber/native caliber/cuff pressure value ( mmHg-1 ).
| Study group | Role | What they receive |
|---|---|---|
| control group | Not described Receives: Other: Popliteal Vein Compliance | |
| experimental group | Not described Receives: Other: Popliteal Vein Compliance |
What is being measured
The primary outcome is the main question the study is designed to answer.
Compliance of the popliteal vein
Compliance of the popliteal vein is calculated as the distensibility, with the ratio of functional caliber/native caliber/cuff pressure value
Measured: May 2023 to October 2023
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Dec 2023
- Study start1 Jun 2023
- Primary completion1 Oct 2023
- Study completion1 Oct 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Chronic Venous Disease (CVD), Vein Compliance, Venous Clinical Severity Score (VCSS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 173 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hao Liu
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Hao Liu, Guangdong Second Provincial General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06175481
- Sponsor's protocol ID
- HaoLiu
- Status last verified
- Oct 2023
- First submitted
- 28 Nov 2023
- Last updated
- 19 Dec 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Liu H, Li L, Wei W, Tang Y, Liu L, Xiao C. Correlation between popliteal vein functional diameter and the severity of chronic venous disease. Phlebology. 2025 Jul;40(6):415-419. doi: 10.1177/02683555241310531. Epub 2024 Dec 21.
PubMed 39708049
Study at a glance
From the registry record, last updated by the sponsor on 19 Dec 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Correlation Between Popliteal Vein Compliance and Venous Clinical Severity Score
- ClinicalTrials.gov ID
- NCT06175481
- Acronym / sponsor ID
- HaoLiu
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 173 participants (actual)
- Lead sponsor
- Hao LiuUniversity, hospital or other
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 1 Oct 2023 (actual)
- Study completion
- 1 Oct 2023 (actual)
- First posted
- 19 Dec 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
When the liquid flow increases, the luminal caliber's stretching amplitude decreases, leading to a higher hydraulic pressure according to Poiseuille's law. In this study, investigators measured the caliber change of the popliteal vein under a rated pressure gradient and evaluated the relationship between popliteal vein compliance and venous clinical severity score (VCSS).
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| control group | – | Other: Popliteal Vein Compliance |
| experimental group | – | Other: Popliteal Vein Compliance |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients were prospectively enrolled in Guangdong Second Provincial General Hospital from May 2023 to October 2023. All participants gave their voluntary consent.
Key inclusion criteria (1 listed)
- C1 to C6 disease using the CEAP (clinical, etiologic, anatomic, pathophysiologic) classification.
Key exclusion criteria (1 listed)
- acute or chronic thrombosis of deep veins, previously received intravenous surgery or injection sclerotherapy, ankle brachial index<0.90, and concomitant cardiovascular, pulmonary, renal, or metabolic diseases.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Popliteal Vein ComplianceCompliance of the popliteal vein is calculated as the distensibility, with the ratio of functional caliber/native caliber/cuff pressure value ( mmHg-1 ). | Other | control group, experimental group |
Primary outcome
Compliance of the popliteal vein
Time frame: May 2023 to October 2023
Compliance of the popliteal vein is calculated as the distensibility, with the ratio of functional caliber/native caliber/cuff pressure value
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Dec 2023.
- Derived from this study: PubMed 39708049Liu H, Li L, Wei W, Tang Y, Liu L, Xiao C. Correlation between popliteal vein functional diameter and the severity of chronic venous disease. Phlebology. 2025 Jul;40(6):415-419. doi: 10.1177/02683555241310531. Epub 2024 Dec 21.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Venous Disease (CVD), Vein Compliance, Venous Clinical Severity Score (VCSS), run by Hao Liu at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Dec 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Compliance of the popliteal vein (time frame: May 2023 to October 2023). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06175481, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Dec 2023.