Mild Cognitive ImpairmentTRAIN4BRAINNCT06185010
Resistance Training to Individuals for Cognitive Impairment With Dementia
A study testing One Resistance Training Set (Single Session), Three Resistance Training Sets (Single Session) and One Resistance Training Set (8 Weeks) in people with Mild Cognitive Impairment and Mild Dementia, run by University of Beira Interior at 1 site in Portugal.
Trial summary
This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. Read more about this study
- Who is it for?
- Ages 50 years and olderHealthy volunteers can take part
- Conditions the study is for
- Mild Cognitive Impairment, Mild Dementia
- What is being tested?
- One Resistance Training Set (Single Session), Three Resistance Training Sets (Single Session) and One Resistance Training Set (8 Weeks)
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 sitePortugal
- Study dates
- 1 Dec 2023to 31 Dec 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Clinical diagnosis of mild cognitive impairment
- SPPB score ≥ 3 points
- Willingness to participate in the interventions and collaborate with the research team
- Must be able to provide informed consent (oral or written)
Who cannot join
- Severe dementia
- Severe comorbidity that negatively influences participation in the intervention
- Color blindness
- Fractures in the last three months
Trial locations and contacts
1 site in 1 country.
Portugal1 site, 1 recruiting
- Recruiting
University of Beira Interior
Covilha
Nuno Fonseca
About this study
Official title: Effects of Different Resistance Training Volumes on Cognitive Function, Oxidative Stress, Immunological Response, Lipid Profile, Glycemic Status, Liver Function, Muscle Function, Hemodynamic Response, and Physical Performance in Individuals With Mild Cognitive Impairment
This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. First the investigators will analyze the effects of a single resistance training session (acute effects) with one and three sets on hemodynamic and physical performance in individuals with mild cognitive impairment. After, the investigators will analyze the effects of an 8-week resistance training program with one or three sets on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. The investigators hypothesize that a single resistance training session of one or three sets will increase the acute hemodynamic and physical performance stress in individuals with mild cognitive impairment, although with a higher magnitude in the session with three sets. Furthermore, we hypothesize that eight weeks of resistance training with one or three sets will induce similar improvements in cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment.
Read the detailed description
Following specific inclusion and exclusion criteria (see Eligibility Criteria), participants will be recruited from residential care facilities or day centers. For the acute effects study (cross-over study), participants will randomly perform two resistance training sessions separated by one week of rest: i) one session with one set and ii) another session of three sets. The intensity of the exercises, number of repetitions, type and order of exercises, movement velocity, and rest time between exercises will be the same in both groups. Before, immediately after, and 72 hours after the sessions, a battery of tests will be applied to evaluate the changes in blood pressure, heart rate, tympanic temperature, medicine ball throw distance, five-repetition sit-to-stand time, and handgrip strength. Afterward, participants will be randomly assigned into a one-set or three-set group to perform an eight-week resistance training intervention. As for the acute effects study, the prescription of the other acute training variables will be the same for both groups. A control group (without any form of physical exercise), recruited at the beginning of the research project, will also be part of the study. Before and after the intervention, a battery of tests will be applied to determine the training program's impact on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment.
- Conditions
- Mild Cognitive Impairment, Mild Dementia
- Being tested
- One Resistance Training Set (Single Session), Three Resistance Training Sets (Single Session), One Resistance Training Set (8 Weeks), Three Resistance Training Sets (8 Weeks), Control (8 Weeks)
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
One Resistance Training Set (Single Session)Other
The participants will perform a resistance training session with one set per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 1 set of 10 repetitions at 60% of one-repetition maximum (1RM) in the leg press, iii) 1 set of 10 repetitions at 55% 1RM in the chest press, iv) 1 set of 10 repetitions in the sit-to-stand exercise, v) 1 set of 10 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
Three Resistance Training Sets (Single Session)Other
The participants will perform a resistance training session with three sets per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 3 sets of 10 repetitions at 60% of one-repetition maximum (1RM) in the leg press, iii) 3 sets of 10 repetitions at 55% 1RM in the chest press, iv) 3 sets of 10 repetitions in the sit-to-stand exercise, v) 3 sets of 10 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
One Resistance Training Set (8 Weeks)Other
The participants will perform eight weeks of resistance training with one set per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 1 set of 10 repetitions between 50-70% of one-repetition maximum (1RM) in the leg press, iii) 1 set of 10 repetitions between 40-60% 1RM in the chest press, iv) 1 set of 6-12 repetitions in the sit-to-stand exercise, v) 1 set of 6-12 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
Three Resistance Training Sets (8 Weeks)Other
The participants will perform eight weeks of resistance training with three sets per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 3 sets of 10 repetitions between 50-70% of one-repetition maximum (1RM) in the leg press, iii) 3 sets of 10 repetitions between 40-60% 1RM in the chest press, iv) 3 sets of 6-12 repetitions in the sit-to-stand exercise, v) 3 sets of 6-12 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity.
Control (8 Weeks)Other
The participants in the control group will maintain their regular daily activities without performing any form of physical exercise.
| Study group | Role | What they receive |
|---|---|---|
| One Resistance Training Set (Single Session) | Experimental | The participants will perform one resistance training session with one set. Receives: Other: One Resistance Training Set (Single Session) |
| Three Resistance Training Sets (Single Session) | Experimental | The participants will perform one resistance training session with three sets. Receives: Other: Three Resistance Training Sets (Single Session) |
| One Resistance Training Set (8 Weeks) | Experimental | The participants will perform eight weeks of resistance training (two sessions per week, separated by 72 hours of rest) with one set. Receives: Other: One Resistance Training Set (8 Weeks) |
| Three Resistance Training Sets (8 Weeks) | Experimental | The participants will perform eight weeks of resistance training (two sessions per week, separated by 72 hours of rest) with three sets. Receives: Other: Three Resistance Training Sets (8 Weeks) |
| Control (8 Weeks) | Experimental | The participants will not perform any form of physical exercise during the intervention period of eight weeks. Receives: Other: Control (8 Weeks) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Systolic blood pressure (SBP)
In the cross-over study (acute effects), the SBP will be assessed through a blood pressure device.
Measured: Change from baseline to 0 minutes and 72 hours after the sessions
Handgrip strength (HGS)
In the cross-over study (acute effects), the HGS will be assessed through an analogic dynamometer.
Measured: Change from baseline to 0 minutes and 72 hours after the sessions
Dementia Rating Scale-2 (DRS-2)
In the eight-week study, the DRS-2 questionnaire will be applied to analyze the overall level of cognitive function through five subscales: attention, initiation/perseveration, construction, conceptualization, and memory.
Measured: Change from baseline to week 8
Brain-Derived Neurotrophic Factor (BDNF)
In the eight-week study, the BDNF protein levels will be analyzed through specific blood testing kits.
Measured: Change from baseline to week 8
Short Physical Performance Battery (SPPB)
In the eight-week study, the SPPB will determine the overall level of functional performance through three tests: balance (feet side by side, semi tandem, tandem), 4-meter walking, and 5-repetition sit-to-stand.
Measured: Change from baseline until week 8
Secondary outcomes (16)
Diastolic blood pressure (DBP)
In the cross-over study (acute effects), the DBP will be assessed through a blood pressure device.
Measured: Change from baseline to 0 minutes and 72 hours after the sessions
Heart rate (HR)
In the cross-over study (acute effects), the HR will be assessed through a blood pressure device.
Measured: Change from baseline to 0 minutes and 72 hours after the sessions
Tympanic temperature (TT)
In the cross-over study (acute effects), the TT will be assessed through a tympanic thermometer.
Measured: Change from baseline to 0 minutes and 72 hours after the sessions
Five-repetition sit-to-stand (5STS)
In the cross-over study (acute effects), the 5STS time will be recorded through a chronometer.
Measured: Change from baseline to 0 minutes and 72 hours after the sessions
1-kg Medicine Ball Throw (MBT)
In the cross-over study (acute effects), the MBT distance will be recorded with a tape measure.
Measured: Change from baseline to 0 minutes and 72 hours after the sessions
Inflammatory markers
In the eight-week study, inflammatory markers (IL-6, TNF-α, and IL-10) will be analyzed through specific blood testing kits.
Measured: Change from baseline to week 8
Oxidative stress
In the eight-week study, oxidative stress markers (carbonylated proteins) will be analyzed through specific blood testing kits.
Measured: Change from baseline to week 8
Lipid Profile
In the eight-week study, the lipid profile (LDL, HDL, total cholesterol, triglycerides) will be analyzed through specific blood testing kits.
Measured: Change from baseline to week 8
HbA1c
In the eight-week study, the HbA1c will be analyzed through specific blood testing kits.
Measured: Change from baseline to week 8
Muscle Damage
In the eight-week study, the muscle damage (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase) will be analyzed through specific blood testing kits.
Measured: Change from baseline to week 8
One-repetition maximum (1RM)
In the eight-week study, a progressive loading test until reaching the 1RM will be applied in the horizontal leg press and seated chest press machines.
Measured: Change from baseline to week 8
Load-velocity profiles
In the eight-week study, the load-velocity profiles will be analyzed using the velocity values (recorded with a linear velocity transducer) associated with the absolute loads used during the progressive loading tests in the horizontal leg press and seated chest press machines.
Measured: Change from baseline to week 8
Ten-meters walking
In the eight-week study, the 10-meter walking time will be measured through a chronometer.
Measured: Change from baseline to week 8
1-kg Medicine Ball Throw (MBT)
In the eight-week study, the MBT distance will be recorded with a tape measure.
Measured: Change from baseline to week 8
Handgrip strength (HGS)
In the eight-week study, the HGS will be assessed through an analogic dynamometer.
Measured: Change from baseline to week 8
6-Minute Walk Test (6MWT)
In the eight-week study, the 6MWT distance will be assessed by multiplying the number of total laps by the lap distance (e.g., 10 laps x 10 meters).
Measured: Change from baseline to week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Dec 2023
- Study start1 Dec 2023
- Primary completion30 Nov 2024 (estimated)
- Study completion31 Dec 2024 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Mild Cognitive ImpairmentStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Beira Interior
- Sponsor type
- University, hospital or other
- Collaborators
- Research Center in Sports Sciences, Health Sciences and Human Development
- Responsible party
- Principal investigator, Nuno Miguel Pintassilgo da Silva Fonseca, University of Beira Interior
- Investigators
- Mário C Marques, PhD, Principal investigator, University of Beira InteriorDulce Esteves, PhD, Principal investigator, University of Beira InteriorMikel Izquierdo, PhD, Principal investigator, Universidad Pública de Navarra
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06185010
- Sponsor's protocol ID
- University of Beira Interior
- Acronym
- TRAIN4BRAIN
- Status last verified
- Aug 2024
- First submitted
- 14 Dec 2023
- Last updated
- 6 Aug 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Fonseca NM, Esteves D, Marques DL, Fonseca CP, Costa J, Sousa T, Sousa AC, Neiva HP, Izquierdo M, Marques MC. Effects of Resistance Training Sets on Cognition and Brain-Derived Neurotrophic Factor in Cognitively Impaired Individuals: A Quasi-Experimental Study. J Gerontol A Biol Sci Med Sci. 2026 Sep 1:glag216. doi: 10.1093/gerona/glag216. Online ahead of print.
PubMed 42678372Fonseca N, Esteves D, Marques DL, Fail LB, Sousa T, Pinto MP, Neiva HP, Izquierdo M, Marques MC. Acute and time-course changes in hemodynamic and physical performance parameters following single and multiple resistance training sets in cognitively impaired individuals: A randomized crossover study. Exp Gerontol. 2025 Mar;201:112688. doi: 10.1016/j.exger.2025.112688. Epub 2025 Jan 23.
PubMed 39854950
Study at a glance
From the registry record, last updated by the sponsor on 6 Aug 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Different Resistance Training Volumes on Cognitive Function, Oxidative Stress, Immunological Response, Lipid Profile, Glycemic Status, Liver Function, Muscle Function, Hemodynamic Response, and Physical Performance in Individuals With Mild Cognitive Impairment
- ClinicalTrials.gov ID
- NCT06185010
- Acronym / sponsor ID
- TRAIN4BRAIN / University of Beira Interior
- Conditions
- Mild Cognitive Impairment, Mild Dementia
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- University of Beira InteriorUniversity, hospital or other
- Collaborators
- Research Center in Sports Sciences, Health Sciences and Human Development
- Study start
- 1 Dec 2023 (actual)
- Primary completion
- 30 Nov 2024 (estimated)
- Study completion
- 31 Dec 2024 (estimated)
- First posted
- 29 Dec 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This research project aims to analyze the effects of different resistance training volumes on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. First the investigators will analyze the effects of a single resistance training session (acute effects) with one and three sets on hemodynamic and physical performance in individuals with mild cognitive impairment. After, the investigators will analyze the effects of an 8-week resistance training program with one or three sets on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment. The investigators hypothesize that a single resistance training session of one or three sets will increase the acute hemodynamic and physical performance stress in individuals with mild cognitive impairment, although with a higher magnitude in the session with three sets. Furthermore, we hypothesize that eight weeks of resistance training with one or three sets will induce similar improvements in cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment.
Detailed description
Following specific inclusion and exclusion criteria (see Eligibility Criteria), participants will be recruited from residential care facilities or day centers. For the acute effects study (cross-over study), participants will randomly perform two resistance training sessions separated by one week of rest: i) one session with one set and ii) another session of three sets. The intensity of the exercises, number of repetitions, type and order of exercises, movement velocity, and rest time between exercises will be the same in both groups. Before, immediately after, and 72 hours after the sessions, a battery of tests will be applied to evaluate the changes in blood pressure, heart rate, tympanic temperature, medicine ball throw distance, five-repetition sit-to-stand time, and handgrip strength. Afterward, participants will be randomly assigned into a one-set or three-set group to perform an eight-week resistance training intervention. As for the acute effects study, the prescription of the other acute training variables will be the same for both groups. A control group (without any form of physical exercise), recruited at the beginning of the research project, will also be part of the study. Before and after the intervention, a battery of tests will be applied to determine the training program's impact on cognitive function, oxidative stress, immunological response, lipid profile, glycemic status, liver function, muscle function, hemodynamic response, and physical performance in individuals with mild cognitive impairment.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| One Resistance Training Set (Single Session) | Experimental | Other: One Resistance Training Set (Single Session)The participants will perform one resistance training session with one set. |
| Three Resistance Training Sets (Single Session) | Experimental | Other: Three Resistance Training Sets (Single Session)The participants will perform one resistance training session with three sets. |
| One Resistance Training Set (8 Weeks) | Experimental | Other: One Resistance Training Set (8 Weeks)The participants will perform eight weeks of resistance training (two sessions per week, separated by 72 hours of rest) with one set. |
| Three Resistance Training Sets (8 Weeks) | Experimental | Other: Three Resistance Training Sets (8 Weeks)The participants will perform eight weeks of resistance training (two sessions per week, separated by 72 hours of rest) with three sets. |
| Control (8 Weeks) | Experimental | Other: Control (8 Weeks)The participants will not perform any form of physical exercise during the intervention period of eight weeks. |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Clinical diagnosis of mild cognitive impairment
- SPPB score ≥ 3 points
- Willingness to participate in the interventions and collaborate with the research team
- Must be able to provide informed consent (oral or written)
Key exclusion criteria (4 listed)
- Severe dementia
- Severe comorbidity that negatively influences participation in the intervention
- Color blindness
- Fractures in the last three months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| One Resistance Training Set (Single Session)The participants will perform a resistance training session with one set per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 1 set of 10 repetitions at 60% of one-repetition maximum (1RM) in the leg press, iii) 1 set of 10 repetitions at 55% 1RM in the chest press, iv) 1 set of 10 repetitions in the sit-to-stand exercise, v) 1 set of 10 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity. | Other | One Resistance Training Set (Single Session) |
| Three Resistance Training Sets (Single Session)The participants will perform a resistance training session with three sets per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 3 sets of 10 repetitions at 60% of one-repetition maximum (1RM) in the leg press, iii) 3 sets of 10 repetitions at 55% 1RM in the chest press, iv) 3 sets of 10 repetitions in the sit-to-stand exercise, v) 3 sets of 10 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity. | Other | Three Resistance Training Sets (Single Session) |
| One Resistance Training Set (8 Weeks)The participants will perform eight weeks of resistance training with one set per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 1 set of 10 repetitions between 50-70% of one-repetition maximum (1RM) in the leg press, iii) 1 set of 10 repetitions between 40-60% 1RM in the chest press, iv) 1 set of 6-12 repetitions in the sit-to-stand exercise, v) 1 set of 6-12 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity. | Other | One Resistance Training Set (8 Weeks) |
| Three Resistance Training Sets (8 Weeks)The participants will perform eight weeks of resistance training with three sets per exercise. The training sequence will be the following: i) 10 minutes of warm-up walking on the treadmill at 50% of maximal walking velocity, ii) 3 sets of 10 repetitions between 50-70% of one-repetition maximum (1RM) in the leg press, iii) 3 sets of 10 repetitions between 40-60% 1RM in the chest press, iv) 3 sets of 6-12 repetitions in the sit-to-stand exercise, v) 3 sets of 6-12 repetitions in the 1-kg medicine ball throw exercise, and vi) 5 minutes walking on the treadmill at 60% of maximal walking velocity. | Other | Three Resistance Training Sets (8 Weeks) |
| Control (8 Weeks)The participants in the control group will maintain their regular daily activities without performing any form of physical exercise. | Other | Control (8 Weeks) |
Primary outcome
Systolic blood pressure (SBP)
Time frame: Change from baseline to 0 minutes and 72 hours after the sessions
In the cross-over study (acute effects), the SBP will be assessed through a blood pressure device.
Handgrip strength (HGS)
Time frame: Change from baseline to 0 minutes and 72 hours after the sessions
In the cross-over study (acute effects), the HGS will be assessed through an analogic dynamometer.
Dementia Rating Scale-2 (DRS-2)
Time frame: Change from baseline to week 8
In the eight-week study, the DRS-2 questionnaire will be applied to analyze the overall level of cognitive function through five subscales: attention, initiation/perseveration, construction, conceptualization, and memory.
Brain-Derived Neurotrophic Factor (BDNF)
Time frame: Change from baseline to week 8
In the eight-week study, the BDNF protein levels will be analyzed through specific blood testing kits.
Short Physical Performance Battery (SPPB)
Time frame: Change from baseline until week 8
In the eight-week study, the SPPB will determine the overall level of functional performance through three tests: balance (feet side by side, semi tandem, tandem), 4-meter walking, and 5-repetition sit-to-stand.
16 secondary outcomes
Diastolic blood pressure (DBP)
Time frame: Change from baseline to 0 minutes and 72 hours after the sessions
Heart rate (HR)
Time frame: Change from baseline to 0 minutes and 72 hours after the sessions
Tympanic temperature (TT)
Time frame: Change from baseline to 0 minutes and 72 hours after the sessions
Five-repetition sit-to-stand (5STS)
Time frame: Change from baseline to 0 minutes and 72 hours after the sessions
1-kg Medicine Ball Throw (MBT)
Time frame: Change from baseline to 0 minutes and 72 hours after the sessions
Inflammatory markers
Time frame: Change from baseline to week 8
Oxidative stress
Time frame: Change from baseline to week 8
Lipid Profile
Time frame: Change from baseline to week 8
HbA1c
Time frame: Change from baseline to week 8
Muscle Damage
Time frame: Change from baseline to week 8
One-repetition maximum (1RM)
Time frame: Change from baseline to week 8
Load-velocity profiles
Time frame: Change from baseline to week 8
Ten-meters walking
Time frame: Change from baseline to week 8
1-kg Medicine Ball Throw (MBT)
Time frame: Change from baseline to week 8
Handgrip strength (HGS)
Time frame: Change from baseline to week 8
6-Minute Walk Test (6MWT)
Time frame: Change from baseline to week 8
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Aug 2024.
- Derived from this study: PubMed 42678372Fonseca NM, Esteves D, Marques DL, Fonseca CP, Costa J, Sousa T, Sousa AC, Neiva HP, Izquierdo M, Marques MC. Effects of Resistance Training Sets on Cognition and Brain-Derived Neurotrophic Factor in Cognitively Impaired Individuals: A Quasi-Experimental Study. J Gerontol A Biol Sci Med Sci. 2026 Sep 1:glag216. doi: 10.1093/gerona/glag216. Online ahead of print.
- Derived from this study: PubMed 39854950Fonseca N, Esteves D, Marques DL, Fail LB, Sousa T, Pinto MP, Neiva HP, Izquierdo M, Marques MC. Acute and time-course changes in hemodynamic and physical performance parameters following single and multiple resistance training sets in cognitively impaired individuals: A randomized crossover study. Exp Gerontol. 2025 Mar;201:112688. doi: 10.1016/j.exger.2025.112688. Epub 2025 Jan 23.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mário C Marques, PhD principal investigator
University of Beira Interior
Dulce Esteves, PhD principal investigator
University of Beira Interior
Mikel Izquierdo, PhD principal investigator
Universidad Pública de Navarra
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing One Resistance Training Set (Single Session), Three Resistance Training Sets (Single Session) and One Resistance Training Set (8 Weeks) in people with Mild Cognitive Impairment and Mild Dementia, run by University of Beira Interior at 1 site in Portugal.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 6 Aug 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Portugal. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Nuno Fonseca, Master's (918241354 ext. +351, nuno1977fonseca@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Systolic blood pressure (SBP) (time frame: Change from baseline to 0 minutes and 72 hours after the sessions). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06185010, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Aug 2024.