E Cigarette UseNCT06196489
Adapting an Intervention for Vaping in Young Veterans
A study testing adapted vaping cessation intervention in people with E Cigarette Use, run by Veterans Medical Research Foundation at 1 site in United States.
Trial summary
The objective of this proposal is to adapt an evidence-based combustible tobacco counseling intervention following an evidence-based process to include e-cigarette use and update its components for emerging adults (EA). 1. Read more about this study
- Who is it for?
- Ages 18 to 30 years
- Conditions the study is for
- E Cigarette Use
- What is being tested?
- adapted vaping cessation intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jan 2024to Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- daily e-cigarette user for at least the past 6 months
- 18-30 years old
- willing to enroll in a program to quit nicotine use within 30 days
- owns smartphone or computer/tablet with camera and internet connectivity
- English speaker
Who cannot join
- ICD-10 diagnosis of dementia
- current use of combustible tobacco products at least weekly
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Veterans Medical Research Foundation
San Diego, California, 92161
Neal Doran, 858-552-8585, neal.doran@va.gov
Neal M Doran, PhD
About this study
Official title: Nicotine Cessation: Adapting a Counseling Program for Emerging Adults
The objective of this proposal is to adapt an evidence-based combustible tobacco counseling intervention following an evidence-based process to include e-cigarette use and update its components for emerging adults (EA).
- Examine factors related to e-cigarette use, barriers to cessation, and facilitators of use of cessation services among an EA population.
- Beta-test an initial version of the intervention, delivered via video telehealth and telephone, to examine usability and acceptability.
Read the detailed description
Use of electronic nicotine products (ENDS) has increased dramatically especially among young adults (EA- aged 18-30) and has been found to lead to immediate harmful health effects and increased addiction to combustible cigarette use. To date no research-tested interventions have been developed for helping people stop use of electronic nicotine products. Emerging adulthood is a developmental period that can lead to adoption of health risk behaviors.
This proposal aims to address nicotine addiction by adapting an evidence-based counseling cessation intervention developed by the American Cancer Society (ACS) for a general population of combustible tobacco smokers, but found to be effective in EA. We will test two methods of providing counseling to participants: video telehealth or telephone. Primary outcome: Compared to self-help guide only, at 3 month follow-up, we hypothesize that participants in either counseling arm will have higher rates as compared to self-help only control of 7-day abstinence from using any nicotine product.
This study fills a critical gap in ENDS research and will provide a model for further research into all-nicotine cessation in this vulnerable population.
- Conditions
- E Cigarette Use
- Being tested
- adapted vaping cessation intervention
- Keywords
- Veteran, e-cigarette, vaping, young adult
- Medical subject headings
- Vaping
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
adapted vaping cessation interventionBehavioural
Behavioral intervention for vaping cessation
| Study group | Role | What they receive |
|---|---|---|
| telephone | Experimental | Participants assigned to this group will receive the adapted intervention by telephone. Receives: Behavioral: adapted vaping cessation intervention |
| Video | Experimental | Participants assigned to this group will receive the adapted intervention by video telehealth. Receives: Behavioral: adapted vaping cessation intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
e-cigarette use frequency
number of days using e-cigarettes in the past 7 days at the time of assessment
Measured: end of treatment (8 weeks post-baseline) and 30 days thereafter
e-cigarette use quantity
number of e-cigarette uses per day
Measured: end of treatment (8 weeks post-baseline) and 30 days thereafter
Client Satisfaction Questionnaire (CSQ-8)
Participant satisfaction ratings; higher scores indicate greater satisfaction with the intervention
Measured: end of treatment (8 weeks post-baseline) and 30 days thereafter
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Jan 2024
- Study start1 Jan 2024
- Primary completionJun 2026 (estimated)
- Study completionJun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for E Cigarette UseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Veterans Medical Research Foundation
- Sponsor type
- University, hospital or other
- Collaborators
- University of California
- Responsible party
- Sponsor
- Investigators
- Neal M Doran, PhD, Principal investigator, Veterans Medical Research Foundation
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06196489
- Sponsor's protocol ID
- VeteransMRF
- Other IDs
- T31P1525
- Status last verified
- Sep 2025
- First submitted
- 13 Dec 2023
- Last updated
- 8 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Sample size is sufficiently small that sharing could threaten confidentiality.
Publications
Palmer AM, Tomko RL, Squeglia LM, Gray KM, Carpenter MJ, Smith TT, Dahne J, Toll BA, McClure EA. A pilot feasibility study of a behavioral intervention for nicotine vaping cessation among young adults delivered via telehealth. Drug Alcohol Depend. 2022 Mar 1;232:109311. doi: 10.1016/j.drugalcdep.2022.109311. Epub 2022 Jan 19.
PubMed 35123362Kinouani S, Leflot C, Vanderkam P, Auriacombe M, Langlois E, Tzourio C. Motivations for using electronic cigarettes in young adults: A systematic review. Subst Abus. 2020;41(3):315-322. doi: 10.1080/08897077.2019.1671937. Epub 2019 Oct 22.
PubMed 31638872Harrell PT, Brandon TH, Stark SE, Simmons VN, Barnett TE, Quinn GP, Chun S. Measuring vaping-related expectancies in young adults: Psychometric evaluation of the Electronic Nicotine Vaping Outcomes (ENVO) scale. Drug Alcohol Depend. 2023 May 1;246:109861. doi: 10.1016/j.drugalcdep.2023.109861. Epub 2023 Mar 29.
PubMed 37028105Cuccia AF, Patel M, Amato MS, Stephens DK, Yoon SN, Vallone DM. Quitting e-cigarettes: Quit attempts and quit intentions among youth and young adults. Prev Med Rep. 2021 Jan 5;21:101287. doi: 10.1016/j.pmedr.2020.101287. eCollection 2021 Mar.
PubMed 33489721Buu A, Hu YH, Wong SW, Lin HC. Comparing American college and noncollege young adults on e-cigarette use patterns including polysubstance use and reasons for using e-cigarettes. J Am Coll Health. 2020 Aug-Sep;68(6):610-616. doi: 10.1080/07448481.2019.1583662. Epub 2019 Mar 25.
PubMed 30908151Bandi P, Star J, Minihan AK, Patel M, Nargis N, Jemal A. Changes in E-Cigarette Use Among U.S. Adults, 2019-2021. Am J Prev Med. 2023 Aug;65(2):322-326. doi: 10.1016/j.amepre.2023.02.026. Epub 2023 Apr 18.
PubMed 37479423
Study at a glance
From the registry record, last updated by the sponsor on 8 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Nicotine Cessation: Adapting a Counseling Program for Emerging Adults
- ClinicalTrials.gov ID
- NCT06196489
- Acronym / sponsor ID
- VeteransMRF
- Conditions
- E Cigarette Use
- Keywords
- Veteran, e-cigarette, vaping, young adult
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Veterans Medical Research FoundationUniversity, hospital or other
- Collaborators
- University of California
- Study start
- 1 Jan 2024 (actual)
- Primary completion
- Jun 2026 (estimated)
- Study completion
- Jun 2026 (estimated)
- First posted
- 9 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this proposal is to adapt an evidence-based combustible tobacco counseling intervention following an evidence-based process to include e-cigarette use and update its components for emerging adults (EA).
- Examine factors related to e-cigarette use, barriers to cessation, and facilitators of use of cessation services among an EA population.
- Beta-test an initial version of the intervention, delivered via video telehealth and telephone, to examine usability and acceptability.
Detailed description
Use of electronic nicotine products (ENDS) has increased dramatically especially among young adults (EA- aged 18-30) and has been found to lead to immediate harmful health effects and increased addiction to combustible cigarette use. To date no research-tested interventions have been developed for helping people stop use of electronic nicotine products. Emerging adulthood is a developmental period that can lead to adoption of health risk behaviors.
This proposal aims to address nicotine addiction by adapting an evidence-based counseling cessation intervention developed by the American Cancer Society (ACS) for a general population of combustible tobacco smokers, but found to be effective in EA. We will test two methods of providing counseling to participants: video telehealth or telephone. Primary outcome: Compared to self-help guide only, at 3 month follow-up, we hypothesize that participants in either counseling arm will have higher rates as compared to self-help only control of 7-day abstinence from using any nicotine product.
This study fills a critical gap in ENDS research and will provide a model for further research into all-nicotine cessation in this vulnerable population.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| telephone | Experimental | Behavioral: adapted vaping cessation interventionParticipants assigned to this group will receive the adapted intervention by telephone. |
| Video | Experimental | Behavioral: adapted vaping cessation interventionParticipants assigned to this group will receive the adapted intervention by video telehealth. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- daily e-cigarette user for at least the past 6 months
- 18-30 years old
- willing to enroll in a program to quit nicotine use within 30 days
- owns smartphone or computer/tablet with camera and internet connectivity
- English speaker
Key exclusion criteria (2 listed)
- ICD-10 diagnosis of dementia
- current use of combustible tobacco products at least weekly
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| adapted vaping cessation interventionBehavioral intervention for vaping cessation | Behavioural | Video, telephone |
Primary outcome
e-cigarette use frequency
Time frame: end of treatment (8 weeks post-baseline) and 30 days thereafter
number of days using e-cigarettes in the past 7 days at the time of assessment
e-cigarette use quantity
Time frame: end of treatment (8 weeks post-baseline) and 30 days thereafter
number of e-cigarette uses per day
Client Satisfaction Questionnaire (CSQ-8)
Time frame: end of treatment (8 weeks post-baseline) and 30 days thereafter
Participant satisfaction ratings; higher scores indicate greater satisfaction with the intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jan 2026.
- Background: PubMed 35123362Palmer AM, Tomko RL, Squeglia LM, Gray KM, Carpenter MJ, Smith TT, Dahne J, Toll BA, McClure EA. A pilot feasibility study of a behavioral intervention for nicotine vaping cessation among young adults delivered via telehealth. Drug Alcohol Depend. 2022 Mar 1;232:109311. doi: 10.1016/j.drugalcdep.2022.109311. Epub 2022 Jan 19.
- Background: PubMed 31638872Kinouani S, Leflot C, Vanderkam P, Auriacombe M, Langlois E, Tzourio C. Motivations for using electronic cigarettes in young adults: A systematic review. Subst Abus. 2020;41(3):315-322. doi: 10.1080/08897077.2019.1671937. Epub 2019 Oct 22.
- Background: PubMed 37028105Harrell PT, Brandon TH, Stark SE, Simmons VN, Barnett TE, Quinn GP, Chun S. Measuring vaping-related expectancies in young adults: Psychometric evaluation of the Electronic Nicotine Vaping Outcomes (ENVO) scale. Drug Alcohol Depend. 2023 May 1;246:109861. doi: 10.1016/j.drugalcdep.2023.109861. Epub 2023 Mar 29.
- Background: PubMed 33489721Cuccia AF, Patel M, Amato MS, Stephens DK, Yoon SN, Vallone DM. Quitting e-cigarettes: Quit attempts and quit intentions among youth and young adults. Prev Med Rep. 2021 Jan 5;21:101287. doi: 10.1016/j.pmedr.2020.101287. eCollection 2021 Mar.
- Background: PubMed 30908151Buu A, Hu YH, Wong SW, Lin HC. Comparing American college and noncollege young adults on e-cigarette use patterns including polysubstance use and reasons for using e-cigarettes. J Am Coll Health. 2020 Aug-Sep;68(6):610-616. doi: 10.1080/07448481.2019.1583662. Epub 2019 Mar 25.
- Background: PubMed 37479423Bandi P, Star J, Minihan AK, Patel M, Nargis N, Jemal A. Changes in E-Cigarette Use Among U.S. Adults, 2019-2021. Am J Prev Med. 2023 Aug;65(2):322-326. doi: 10.1016/j.amepre.2023.02.026. Epub 2023 Apr 18.
- Individual participant dataSharing planned: No. Sample size is sufficiently small that sharing could threaten confidentiality.
Related trials for E Cigarette Use
RecruitingEarly Phase 1
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
Electronic Cigarette Use, Endothelial Dysfunction
Recruiting
Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study
Vaping Teens, Vaping Behaviors
Not yet recruiting
Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial
Tobacco Cessation, Electronic Nicotine Delivery Systems
Recruiting
A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System
Smoking, Tobacco
Recruiting
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
Tobacco Use, Substance Use Disorders
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Neal M Doran, PhD principal investigator
Veterans Medical Research Foundation
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing adapted vaping cessation intervention in people with E Cigarette Use, run by Veterans Medical Research Foundation at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Neal M Doran, PhD (858-552-8585, neal.doran@va.gov), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
e-cigarette use frequency (time frame: end of treatment (8 weeks post-baseline) and 30 days thereafter). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06196489, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jan 2026.