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Glycemic ControlNCT06217679

Comparing the Effects of Different Types of Exercise on Glucose Handling

A study testing Mixed Exercise in people with Glycemic Control and Insulin Sensitivity, run by University of Waterloo at 1 site in Canada.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The purpose of the proposed study is to compare the acute effects of different types of exercise modalities on glucose handling in young, healthy males and females. The exercise modalities that will be compared include: a high intensity interval exercise (HIIE) protocol, a moderate intensity continuous exercise (MICE)… Read more about this study

Who is it for?
Ages 18 to 30 yearsHealthy volunteers can take part
What is being tested?
Mixed Exercise
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
24 participants
Where
1 siteCanada
Study dates
1 May 2018to 31 Oct 2019
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 30 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • In order to participate in this study, participants must be a healthy man or woman between the ages of 18 and 30 years.

Who cannot join

  • Presence of chronic health condition(s) [i.e. metabolic (i.e. Type 1 or type 2 diabetes), cardiovascular (i.e hypertension), respiratory (i.e. chronic pulmonary obstructive disorder) or digestive (i.e. ulcerative colitis) disorders.
  • Are pregnant, or suspect that they may be pregnant, or nursing
  • Inability to complete the single exercise sessions.
  • Regularly participate in cardiovascular (>3 sessions/week) or resistance training (>2 sessions/week) exercise.
  • Have an allergy to local anesthetic (or family history of allergy)
  • Have undergone a barium swallow or an infusion of a contrast agent in the past 3 weeks
Show all 9Show fewer
  • Are taking prescription anti-coagulant or anti-platelet medications (e.g., warfarin, heparin, clopidogrel)
  • Inability to exercise as suggested by the get active questionnaire (GAQ)
  • BMI > 27 kg/m2

Trial locations and contacts

1 site in 1 country.

Canada1 site

  • University of Waterloo

    Waterloo, Ontario, N2L 3G1

Other trials in Canada

About this study

Official title: Comparing the Effects of Different Types of Exercise on Glucose Handling and Muscle Metabolism in Young Males and Females

The purpose of the proposed study is to compare the acute effects of different types of exercise modalities on glucose handling in young, healthy males and females. The exercise modalities that will be compared include: a high intensity interval exercise (HIIE) protocol, a moderate intensity continuous exercise (MICE) protocol and a low-load, high-repetition (LL-HR) resistance exercise protocol.

Read the detailed description

The purpose of this study is to compare the effects of different exercise modalities (High intensity interval exercise, Moderate intensity continuous exercise, and Low-load-high repetition resistance exercise) on blood sugar control in young healthy, males and females. To test this theory, a sugar challenge (oral glucose tolerance test - OGTT) will be performed during the pre-testing visit to determine the baseline blood sugar response. An OGTT will also be performed 2 hours after each single exercise session to determine how each type of exercise affects the blood sugar response. Investigators will take multiple blood samples throughout the trial to allow us to measure blood sugar, insulin and concentrations and oxidative stress. Muscle biopsies will be taken before and after each exercise bout so that investigators can examine the underlying mechanisms that contribute to the effectiveness of the different types of exercise on blood sugar control. Investigators will also use an ultrasound to measure factors related to of cardiovascular health such as artery stress and vascular conductance during the exercise bouts. Direct benefits of this study include characterizing sex differences of blood sugar handling after single exercise sessions. This study could have direct benefits on deterring the effectiveness of different forms of exercise on blood sugar levels.

Being tested
Control Oral Glucose Tolerance Test, Mixed Exercise
Medical subject headings
Insulin Resistance

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Control Oral Glucose Tolerance TestOther

    control oral glucose tolerance test

  • Mixed ExerciseOther

    exercise performed in randomized order

Study groups in NCT06217679
Study groupRoleWhat they receive
Control Oral Glucose Tolerance TestExperimentalThis visit will include a baseline OGTT to be used as a pre-exercise baseline measure for each of the arms. Participants will then consume a 75g glucose beverage (Trutol, Thermo Scientific) and blood samples will be drawn at 0, 10, 20, 30, 45, 60, 75, 90 and 120 minutes post consumption.
Receives: Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise
High intensity interval exercise (HIIE)ExperimentalParticipants performed a High intensity interval exercise (HIIE) bout which includes 10 x 1 min at 90% maximum heart rate (HRmax) with 5 min warm up and 5 min cool down at 50watts (low state steady cycling). 90mins following the exercise bout participants will undergo another oral glucose tolerance test.
Receives: Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise
Moderate intensity continuous exercise (MICE)ExperimentalParticipants performed a Moderate intensity continuous exercise (MICE) bout which includes 30 min at 65% maximal aerobic capacity (VO2max). 90mins following the exercise bout participants will undergo another oral glucose tolerance test.
Receives: Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise
Low-load, high-repetition resistance exercise (LL-HR)ExperimentalParticipants performed a Low-load, high-rep resistance exercise (LL-HR) bout which includes a whole body resistance exercise bout, 3 sets at 30% maximum strength (1RM) for leg press, knee extension, hamstring curl, lat pulldown, shoulder press, chest press, 20-25 reps, last set to failure. 90mins following the exercise bout participants will undergo another oral glucose tolerance test.
Receives: Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Blood insulin change

    To assess the effect of sex and exercise on basal and post-exercise blood insulin

    Measured: 120mins

  2. Blood glucose change

    To assess the effect of sex and exercise on basal and post-exercise blood glucose.

    Measured: 120mins

  3. Blood c-peptide change

    To assess the effect of sex and exercise on basal and post-exercise blood c-peptide.

    Measured: 120mins

  4. Insulin sensitivity change

    Assess the changes in insulin sensitivity pre to post exercise

    Measured: 120mins

Secondary outcomes (7)

  1. TBC1 domain family member 4 change (TBC1D4)

    examine protein content changes from pre to post exercise

    Measured: 35mins

  2. TBC1 domain family member 1 change (TBC1D1)

    examine protein content changes from pre to post exercise

    Measured: 35mins

  3. protein kinase B change

    examine protein content changes from pre to post exercise

    Measured: 35mins

  4. 5' adenosine monophosphate-activated protein kinase change

    examine protein content changes from pre to post exercise

    Measured: 35mins

  5. glucose transporter 4 change (GLUT4)

    examine protein content changes from pre to post exercise

    Measured: 35mins

  6. estrogen concentration

    to assess the differences in estrogen concentration between males and females

    Measured: 30mins

  7. progesterone concentration

    to assess the differences in progesterone concentration between males and females

    Measured: 30mins

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted22 Jan 2024
  2. Study start1 May 2018
  3. Primary completion31 Oct 2019
  4. Study completion31 Oct 2019

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Randomised
Intervention model
Crossover
Masking
None (open label)
Enrolment
24 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06217679
Sponsor's protocol ID
ORE #22477
Status last verified
Jan 2024
First submitted
8 Jan 2024
Last updated
6 Feb 2024
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Beaudry KM, Surdi JC, Pancevski K, Tremblay C, Devries MC. Greater glycemic control following low-load, high-repetition resistance exercise compared with moderate-intensity continuous exercise in males and females: a randomized control trial. Appl Physiol Nutr Metab. 2024 Jul 1;49(7):943-955. doi: 10.1139/apnm-2023-0353. Epub 2024 Mar 22.

    PubMed 38518263

Questions about this trial

What is this clinical trial studying?

A study testing Mixed Exercise in people with Glycemic Control and Insulin Sensitivity, run by University of Waterloo at 1 site in Canada.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 6 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Blood insulin change (time frame: 120mins). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06217679, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Feb 2024.

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