HealthyCAMERANCT06220396
CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
A study testing Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, Magnetic Resonance Imaging (MRI) and Dual X-ray absorptiometry (DEXA) scan in people with Healthy, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum. Read more about this study
- Who is it for?
- Ages 30 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, Magnetic Resonance Imaging (MRI) and Dual X-ray absorptiometry (DEXA) scan
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteUnited States
- Study dates
- 22 Jan 2026to Jan 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure.
- Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
- Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
- Informed consent were obtained.
- No history of heart failure.
- Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments.
Who cannot join
- Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators.
- Any diagnosis of heart failure
- Symptomatic coronary artery disease (e.g., patients with chronic angina)
- Symptomatic valvular heart disease
- Pulmonary hypertension
- Cardiomyopathies
Show all 13Show fewer
- High output heart failure
- Pericardial disease
- Clinically significant chronic lung disease in the opinion of the investigators
- Anemia (hemoglobin <12 gm/dL in women and <13 gm/dL in men)
- Estimated glomerular filtration rate ≤30mL/min
- Pregnant women
- Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Barry Borlaug, MD contact
United States1 site, 1 recruiting
- Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Dr. Borlaug's Research Team, (507) 255-2200
Barry Borlaug, MD, (507) 255-1051, Borlaug.Barry@mayo.edu
About this study
The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum.
- Conditions
- Healthy
- Being tested
- Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, Magnetic Resonance Imaging (MRI), Dual X-ray absorptiometry (DEXA) scan
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Right Heart Catheterization with Hemodynamics and Limited EchocardiogramProcedure or surgery
Right Heart Catheterization (RHC) with Hemodynamics and Limited Echocardiogram is an invasive procedure that involves insertion of a catheter through a blood vessel in the neck, groin, or arm to the right side of the heart. Hemodynamic measurements such as the blood pressure inside the veins, heart, and arteries as well as measurements of blood flow and how much oxygen is in the blood will be completed during the catheterization procedure. It is a way to see how well the heart is working during your procedure. During the RHC procedure a limited echocardiogram, using ultrasound waves, will be collected to evaluate the structure and function of the heart.
All measurements will be conducted at rest and during exercise using a supine cycle ergometer
Magnetic Resonance Imaging (MRI)Procedure or surgery
Also called CMR Imaging
MRI is a medical imaging technique that uses a magnetic field and computer-generated radio waves to create detailed images of the organs and tissues in your body. CMR Imaging will assess myocardial structure, function, and fat content.
An additional limited MRI sequence of the the abdomen and one sequence in the thigh will be used to evaluate for visceral adipose tissue (VAT) as a measurement of body composition.
Dual X-ray absorptiometry (DEXA) scanProcedure or surgery
A DEXA scan measures the amount of fat in the body using an x-ray that measures bone, calcium and fat.
| Study group | Role | What they receive |
|---|---|---|
| Healthy Volunteers | Experimental | Healthy volunteers with no history of Heart Failure (HF) will undergo a Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, MRI, and DEXA scan. Receives: Procedure: Right Heart Catheterization with Hemodynamics and Limited Echocardiogram; Procedure: Magnetic Resonance Imaging (MRI); Procedure: Dual X-ray absorptiometry (DEXA) scan |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pulmonary Capillary Wedge Pressure (PCWP) at rest
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter at rest.
Measured: Baseline
Pulmonary Capillary Wedge Pressure (PCWP) during exercise
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during exercise.
Measured: Baseline
Secondary outcomes (20)
Trans-cardiac uptake of free fatty acids (FFA) at rest
Trans-cardiac uptake of FFA will be measured using arterial and coronary sinus blood samples collected at rest during cardiac catheterization procedure.
Measured: Baseline
Trans-cardiac uptake of free fatty acids (FFA) during exercise
Trans-cardiac uptake of FFA will be measured using arterial and coronary sinus blood samples collected during the exercise portion of the cardiac catheterization procedure.
Measured: Baseline
Trans-cardiac uptake of glucose at rest
Trans-cardiac uptake of glucose will be measured using arterial and coronary sinus blood samples collected at rest during the cardiac catheterization procedure.
Measured: Baseline
Trans-cardiac uptake of glucose during exercise
Trans-cardiac uptake of glucose will be measured using arterial and coronary sinus blood samples collected during the exercise portion of the cardiac catheterization procedure.
Measured: Baseline
Trans-cardiac uptake of ketone bodies at rest
Trans-cardiac uptake of ketone bodies will be measured using arterial and coronary sinus blood samples collected at rest during the cardiac catheterization procedure.
Measured: Baseline
Trans-cardiac uptake of ketone bodies during exercise
Trans-cardiac uptake of ketone bodies will be measured using arterial and coronary sinus blood samples collected during the exercise portion of the cardiac catheterization procedure.
Measured: Baseline
Left ventricular (LV) global longitudinal strain
LV global longitudinal strain will be assessed by echocardiography conducted during the cardiac catheterization procedure
Measured: Baseline
Left Atrial (LA) reservoir strain
LA reservoir strain will be assessed by echocardiography conducted during the cardiac catheterization procedure
Measured: Baseline
Right Ventricular (RV) free wall strain
RV free wall strain will be assessed by echocardiography conducted during the cardiac catheterization procedure
Measured: Baseline
Myocardial mass
Myocardial mass will be measured by CMR imaging.
Measured: Baseline
Myocardial volume
Myocardial volume will be measured by CMR imaging.
Measured: Baseline
Myocardial fat content
Myocardial fat content will be measured by CMR imaging.
Measured: Baseline
Body fat mass
Body fat mass will be measured using dual X-ray absorptiometry (DEXA)
Measured: Baseline
Visceral fat content
Visceral fat content will be measured using limited abdominal MRI
Measured: Baseline
Total blood volume
Total blood volume will be assessed by using the radiolabeled iodinated albumin (131I, 5-25 μCu) indicator dilution technique (BVA-100 Blood Volume Analyzer, Daxor Corp, NY).
Measured: Baseline
Total plasma volume
Total plasma volume will be assessed by using the radiolabeled iodinated albumin (131I, 5-25 μCu) indicator dilution technique (BVA-100 Blood Volume Analyzer, Daxor Corp, NY).
Measured: Baseline
Quality of Life (QOL) as assessed by Kansas City Cardiomyopathy Questionnaire (KCCQ)
KCCQ was a 23-item, self-administered questionnaire that measure the participant's perception of their health status, including their heart failure (HF) symptoms, impact on physical and social function and how their HF impacts the quality of life. KCCQ quantifies 7 domains: physical limitations (6 items), symptom stability (1 item), symptom frequency (4 items), symptom burden (3 items), self-efficacy (2 items), quality of life (3 items) and social limitations (4 items). Scores were generated for each domain and scaled from 0 to 100, with 0 (worst) and 100 (the best possible status), where the higher score reflected better health status.
Measured: Baseline
Blood glucose level
Blood glucose level will be measured using oral glucose tolerance testing
Measured: Baseline
Blood insulin level
Blood insulin level will be measured using oral glucose tolerance testing
Measured: Baseline
Blood free fatty acids (FFA) level
Blood FFA level will be measured using oral glucose tolerance testing
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2024
- Study start22 Jan 2026
- Primary completionJan 2029 (estimated)
- Study completionJan 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Barry Borlaug, Mayo Clinic
- Investigators
- Barry Borlaug, MD, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06220396
- Sponsor's protocol ID
- 23-007522
- Acronym
- CAMERA
- Status last verified
- Aug 2026
- First submitted
- 28 Dec 2023
- Last updated
- 14 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
- ClinicalTrials.gov ID
- NCT06220396
- Acronym / sponsor ID
- CAMERA / 23-007522
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 22 Jan 2026 (actual)
- Primary completion
- Jan 2029 (estimated)
- Study completion
- Jan 2029 (estimated)
- First posted
- 23 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy Volunteers | Experimental | Procedure: Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, Procedure: Magnetic Resonance Imaging (MRI), Procedure: Dual X-ray absorptiometry (DEXA) scanHealthy volunteers with no history of Heart Failure (HF) will undergo a Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, MRI, and DEXA scan. |
Who may qualify
- Ages
- 30 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure.
- Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%.
- Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment.
- Informed consent were obtained.
- No history of heart failure.
Key exclusion criteria (13 listed)
- Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators.
- Any diagnosis of heart failure
- Symptomatic coronary artery disease (e.g., patients with chronic angina)
- Symptomatic valvular heart disease
- Pulmonary hypertension
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Right Heart Catheterization with Hemodynamics and Limited EchocardiogramRight Heart Catheterization (RHC) with Hemodynamics and Limited Echocardiogram is an invasive procedure that involves insertion of a catheter through a blood vessel in the neck, groin, or arm to the right side of the heart. Hemodynamic measurements such as the blood pressure inside the veins, heart, and arteries as well as measurements of blood flow and how much oxygen is in the blood will be completed during the catheterization procedure. It is a way to see how well the heart is working during your procedure. During the RHC procedure a limited echocardiogram, using ultrasound waves, will be collected to evaluate the structure and function of the heart. All measurements will be conducted at rest and during exercise using a supine cycle ergometer | Procedure or surgery | Healthy Volunteers |
| Magnetic Resonance Imaging (MRI)Also: CMR ImagingMRI is a medical imaging technique that uses a magnetic field and computer-generated radio waves to create detailed images of the organs and tissues in your body. CMR Imaging will assess myocardial structure, function, and fat content. An additional limited MRI sequence of the the abdomen and one sequence in the thigh will be used to evaluate for visceral adipose tissue (VAT) as a measurement of body composition. | Procedure or surgery | Healthy Volunteers |
| Dual X-ray absorptiometry (DEXA) scanA DEXA scan measures the amount of fat in the body using an x-ray that measures bone, calcium and fat. | Procedure or surgery | Healthy Volunteers |
Primary outcome
Pulmonary Capillary Wedge Pressure (PCWP) at rest
Time frame: Baseline
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter at rest.
Pulmonary Capillary Wedge Pressure (PCWP) during exercise
Time frame: Baseline
Pulmonary capillary wedge pressure is a measure of cardiac filling pressure, measured using a high-fidelity micromanometer advanced through the lumen of a fluid-filled catheter during exercise.
20 secondary outcomes
Trans-cardiac uptake of free fatty acids (FFA) at rest
Time frame: Baseline
Trans-cardiac uptake of free fatty acids (FFA) during exercise
Time frame: Baseline
Trans-cardiac uptake of glucose at rest
Time frame: Baseline
Trans-cardiac uptake of glucose during exercise
Time frame: Baseline
Trans-cardiac uptake of ketone bodies at rest
Time frame: Baseline
Trans-cardiac uptake of ketone bodies during exercise
Time frame: Baseline
Left ventricular (LV) global longitudinal strain
Time frame: Baseline
Left Atrial (LA) reservoir strain
Time frame: Baseline
Right Ventricular (RV) free wall strain
Time frame: Baseline
Myocardial mass
Time frame: Baseline
Myocardial volume
Time frame: Baseline
Myocardial fat content
Time frame: Baseline
Body fat mass
Time frame: Baseline
Visceral fat content
Time frame: Baseline
Total blood volume
Time frame: Baseline
Total plasma volume
Time frame: Baseline
Quality of Life (QOL) as assessed by Kansas City Cardiomyopathy Questionnaire (KCCQ)
Time frame: Baseline
Blood glucose level
Time frame: Baseline
Blood insulin level
Time frame: Baseline
Blood free fatty acids (FFA) level
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Barry Borlaug, MD contact
Barry Borlaug, MD principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Right Heart Catheterization with Hemodynamics and Limited Echocardiogram, Magnetic Resonance Imaging (MRI) and Dual X-ray absorptiometry (DEXA) scan in people with Healthy, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 14 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Brendon Urena (507-538-8305, Urena.brendon@mayo.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pulmonary Capillary Wedge Pressure (PCWP) at rest (time frame: Baseline). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Aug 2026.