Body Massage Oil From Snake FruitPhase 2NCT06227260
Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit
A Phase 2 study of Body Massage Oil From Snake Fruit and Facial Mask From Snake Fruit, run by Burapha University at 1 site in Thailand.
Trial summary
This study consisted of three sub-studies including 1) development and evaluation of body massage oil from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy… Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Body Massage Oil From Snake Fruit, Facial Mask From Snake Fruit, Jelly From Snake Fruit
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 178 participants
- Where
- 1 siteThailand
- Study dates
- 20 Mar 2023to 31 Oct 2023
- Phase
- Phase 2
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Man or woman
- Aged between 18 to 35 years
- Healthy
- Interested in body massage with oil or facial mask or jelly from Snake fruit
Who cannot join
- History of adverse effects from body massage
- Skin allergy
- Skin disorders
- Skin wounds
- History of allergy to coconut or plant oil
- History of allergy to facial mask, i.e., mask from fruit
Show all 13Show fewer
- History of allergy to Snake fruit or gelatin
- Signs or symptoms of fever or infection
- Abnormal body mass index
- Regular smokers or alcohol drinkers (>2 times per week)
- Regular exerciser (>2 times per week or >150 min per week)
- Regular intake of dietary supplements, i.e., vitamins, antioxidants
- Hypertension, diabetes, cardiovascular disease, respiratory disease, endocrine disease, neuromuscular disease, musculoskeletal disease, liver disease, renal disease, immune disease, infectious disease, or cancer
Trial locations and contacts
1 site in 1 country.
Thailand1 site
Faculty of Allied Health Sciences, Burapha University
Mueang, Changwat Chon Buri, 20131
About this study
Official title: Development and Evaluation of Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit (Salacca Edulis Reinw.)
This study consisted of three sub-studies including 1) development and evaluation of body massage oil from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from Snake fruit on controlling blood glucose and endurance time in healthy participants.
Read the detailed description
Study 1: senventy-one male and female participants, aged 23.99 ± 5.68 years were randomly assigned into 3 groups including 1) control group (n = 23): participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks 2) treatment-1 group (n = 23): participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks and 3) treatment-2 group (n = 25): participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks.
Study 2: fifty-nine male and female participants, aged 23.39 ± 4.84 years were randomly assigned into 2 groups including 1) control group (n = 29): participants did not receive any facial mask for 12 weeks and 2) treatment group (n = 30): participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks.
Study 3: this study was divided into 2 sub-stidies. Study 3.1: twenty-five male and female participants, aged 22.60 ± 3.33 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. All participants were analyzed for blood glucose level before consumption and after consumption at 30, 60, 90, and 120 min. Study 3.2: twenty-three male and female participants, aged 21.57 ± 1.88 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. After each consumption, all participants performed leg cycling at intensity 60% of maximal oxygen consumption as long as tolerance (time to exhaustion test).
- Being tested
- Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceOther
Interventions among the 3 studies were categorized as other.
| Study group | Role | What they receive |
|---|---|---|
| Study 1: Thai massage | Active comparator | Participants were randomized to receive an arm. In this arm, participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert. Receives: Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice |
| Study 1: Thai massage with pure coconut oil | Active comparator | Participants were randomized to receive an arm. In this arm, participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert. Receives: Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice |
| Study 1: Thai massage with oil mixed with Snake fruit extract | Experimental | Participants were randomized to receive an arm. In this arm, participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert. Receives: Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice |
| Study 2: Facial mask with Snake fruit extract | Experimental | Participants were randomized to receive an arm. In this arm, participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks. Receives: Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice |
| Study 3: Control jelly | Active comparator | Participants were randomized to receive an arm. In this arm, participants consumed with control jelly at 3.5 g/kg body weight. Consumption was taken at Burapha University. Receives: Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice |
| Study 3: Jelly with Snake fruit juice | Experimental | Participants were randomized to receive an arm. In this arm, participants consumed with jelly with Snake fruit juice at 3.5 g/kg body weight. Consumption was taken at Burapha University. Receives: Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice |
What is being measured
The primary outcome is the main question the study is designed to answer.
Level of skin moisture
Study 1 and 2 determined level of skin moisture in arbitrary unit (no unit) using Multiprobe Adapter System with Corneometer® CM 825 probe
Measured: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Level of skin elasticity
Study 1 and 2 determined level of skin elasticity in arbitrary unit (no unit) using Multiprobe Adapter System with Cutometer® 580 probe
Measured: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Level of skin oiliness
Study 1 and 2 determined level of skin oiliness in arbitrary unit (no unit) using Multiprobe Adapter System with Sebumeter® SM 815 probe
Measured: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Level of skin melanin
Study 1 and 2 determined level of skin melanin in arbitrary unit (no unit) using Multiprobe Adapter System with Mexameter® MX18 probe
Measured: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Level of blood glucose
Study 3.1 determined level of blood glucose in mg/dL unit
Measured: Before jelly consumption and after jelly consumption at 30, 60, 90, and 120 minutes
Endurance time
Study 3.2 determined endurance time by cycling at 60% of maximum oxygen consumption as long as possible (time to exhaustion test)
Measured: After jelly consumption for 30 minutes
Concentration of interferon-gamma
Study 3.2 determined concentration of interferon-gamma in serum in pg (picogram)/mL unit
Measured: Before and immediately after endurance time test
Concentration of tumor necrosis factor-alpha
Study 3.2 determined concentration of tumor necrosis factor-alpha in serum in pg (picogram)/mL unit
Measured: Before and immediately after endurance time test
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jan 2024
- Study start20 Mar 2023
- Primary completion30 Oct 2023
- Study completion31 Oct 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Body Massage Oil From Snake FruitStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Study 1 and 2 were parallel model, study 3 was crossover model.
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 178 participants (actual)
Sponsor and investigators
- Lead sponsor
- Burapha University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Piyapong Prasertsri, Burapha University
- Investigators
- Piyapong Prasertsri, Ph.D., Principal investigator, Burapha University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06227260
- Sponsor's protocol ID
- IRB1-028/2566
- Status last verified
- Jan 2024
- First submitted
- 21 Dec 2023
- Last updated
- 26 Jan 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is no plan to make individual participant data available to other researchers.
Publications
Intakhiao S, Suwannarat W, Subongkot T, Sirirak T, Piyaneeranat P, Koowattanatianchai S, Prasertsri P. Effects of Snake Fruit-Infused Massage Oil With Traditional Thai Massage on Skin Quality: A Randomized Controlled Trial. ScientificWorldJournal. 2026;2026(1):e2446967. doi: 10.1155/tswj/2446967.
PubMed 41947426Boonla O, Chancharoen P, Padkao T, Teethaisong Y, Tangwattanachuleeporn M, Koowattanatianchai S, Prasertsri P. Acute ingestion of snake fruit jelly improves glycemic response, enhances endurance performance and antioxidant defense, and reduces inflammatory markers in healthy adults. J Int Soc Sports Nutr. 2025 Dec;22(1):2579029. doi: 10.1080/15502783.2025.2579029. Epub 2025 Oct 26.
PubMed 41139389
Study at a glance
From the registry record, last updated by the sponsor on 26 Jan 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Development and Evaluation of Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit (Salacca Edulis Reinw.)
- ClinicalTrials.gov ID
- NCT06227260
- Acronym / sponsor ID
- IRB1-028/2566
- Phase
- Phase 2
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 178 participants (actual)
- Lead sponsor
- Burapha UniversityUniversity, hospital or other
- Study start
- 20 Mar 2023 (actual)
- Primary completion
- 30 Oct 2023 (actual)
- Study completion
- 31 Oct 2023 (actual)
- First posted
- 26 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study consisted of three sub-studies including 1) development and evaluation of body massage oil from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from Snake fruit on controlling blood glucose and endurance time in healthy participants.
Detailed description
Study 1: senventy-one male and female participants, aged 23.99 ± 5.68 years were randomly assigned into 3 groups including 1) control group (n = 23): participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks 2) treatment-1 group (n = 23): participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks and 3) treatment-2 group (n = 25): participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks.
Study 2: fifty-nine male and female participants, aged 23.39 ± 4.84 years were randomly assigned into 2 groups including 1) control group (n = 29): participants did not receive any facial mask for 12 weeks and 2) treatment group (n = 30): participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks.
Study 3: this study was divided into 2 sub-stidies. Study 3.1: twenty-five male and female participants, aged 22.60 ± 3.33 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. All participants were analyzed for blood glucose level before consumption and after consumption at 30, 60, 90, and 120 min. Study 3.2: twenty-three male and female participants, aged 21.57 ± 1.88 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. After each consumption, all participants performed leg cycling at intensity 60% of maximal oxygen consumption as long as tolerance (time to exhaustion test).
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 6
- Model description
- Study 1 and 2 were parallel model, study 3 was crossover model.
| Arm | Type | Receives |
|---|---|---|
| Study 1: Thai massage | Active comparator | Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceParticipants were randomized to receive an arm. In this arm, participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert. |
| Study 1: Thai massage with pure coconut oil | Active comparator | Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceParticipants were randomized to receive an arm. In this arm, participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert. |
| Study 1: Thai massage with oil mixed with Snake fruit extract | Experimental | Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceParticipants were randomized to receive an arm. In this arm, participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert. |
| Study 2: Facial mask with Snake fruit extract | Experimental | Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceParticipants were randomized to receive an arm. In this arm, participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks. |
| Study 3: Control jelly | Active comparator | Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceParticipants were randomized to receive an arm. In this arm, participants consumed with control jelly at 3.5 g/kg body weight. Consumption was taken at Burapha University. |
| Study 3: Jelly with Snake fruit juice | Experimental | Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceParticipants were randomized to receive an arm. In this arm, participants consumed with jelly with Snake fruit juice at 3.5 g/kg body weight. Consumption was taken at Burapha University. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Man or woman
- Aged between 18 to 35 years
- Healthy
- Interested in body massage with oil or facial mask or jelly from Snake fruit
Key exclusion criteria (13 listed)
- History of adverse effects from body massage
- Skin allergy
- Skin disorders
- Skin wounds
- History of allergy to coconut or plant oil
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juiceInterventions among the 3 studies were categorized as other. | Other | Study 1: Thai massage, Study 1: Thai massage with oil mixed with Snake fruit extract, Study 1: Thai massage with pure coconut oil, Study 2: Facial mask with Snake fruit extract, Study 3: Control jelly, Study 3: Jelly with Snake fruit juice |
Primary outcome
Level of skin moisture
Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin moisture in arbitrary unit (no unit) using Multiprobe Adapter System with Corneometer® CM 825 probe
Level of skin elasticity
Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin elasticity in arbitrary unit (no unit) using Multiprobe Adapter System with Cutometer® 580 probe
Level of skin oiliness
Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin oiliness in arbitrary unit (no unit) using Multiprobe Adapter System with Sebumeter® SM 815 probe
Level of skin melanin
Time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12
Study 1 and 2 determined level of skin melanin in arbitrary unit (no unit) using Multiprobe Adapter System with Mexameter® MX18 probe
Level of blood glucose
Time frame: Before jelly consumption and after jelly consumption at 30, 60, 90, and 120 minutes
Study 3.1 determined level of blood glucose in mg/dL unit
Endurance time
Time frame: After jelly consumption for 30 minutes
Study 3.2 determined endurance time by cycling at 60% of maximum oxygen consumption as long as possible (time to exhaustion test)
Concentration of interferon-gamma
Time frame: Before and immediately after endurance time test
Study 3.2 determined concentration of interferon-gamma in serum in pg (picogram)/mL unit
Concentration of tumor necrosis factor-alpha
Time frame: Before and immediately after endurance time test
Study 3.2 determined concentration of tumor necrosis factor-alpha in serum in pg (picogram)/mL unit
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jan 2024.
- Derived from this study: PubMed 41947426Intakhiao S, Suwannarat W, Subongkot T, Sirirak T, Piyaneeranat P, Koowattanatianchai S, Prasertsri P. Effects of Snake Fruit-Infused Massage Oil With Traditional Thai Massage on Skin Quality: A Randomized Controlled Trial. ScientificWorldJournal. 2026;2026(1):e2446967. doi: 10.1155/tswj/2446967.
- Derived from this study: PubMed 41139389Boonla O, Chancharoen P, Padkao T, Teethaisong Y, Tangwattanachuleeporn M, Koowattanatianchai S, Prasertsri P. Acute ingestion of snake fruit jelly improves glycemic response, enhances endurance performance and antioxidant defense, and reduces inflammatory markers in healthy adults. J Int Soc Sports Nutr. 2025 Dec;22(1):2579029. doi: 10.1080/15502783.2025.2579029. Epub 2025 Oct 26.
- Individual participant dataSharing planned: No. There is no plan to make individual participant data available to other researchers.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Piyapong Prasertsri, Ph.D. principal investigator
Burapha University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 2 study of Body Massage Oil From Snake Fruit and Facial Mask From Snake Fruit, run by Burapha University at 1 site in Thailand.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Jan 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Level of skin moisture (time frame: Before intervention, immediately after intervention, ends of week 4, week 8, and week 12). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06227260, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jan 2024.