StrokeNCT06231810
Tracking a Tactile Signal Along the Nervous System
A study testing Tactile stimulation in people with Stroke and Tactile Perception, run by Virginia Polytechnic Institute and State University at 1 site in United States.
Trial summary
Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Stroke, Tactile Perception
- What is being tested?
- Tactile stimulation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteUnited States
- Study dates
- 29 Feb 2024to 1 Jul 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- -right-hand dominance for participants who are neurotypical
- For Aim 1:
- -age range of 18-23
- For Aim 2:
- participants who are neurotypical will be a similar age to the participants with stroke
- participants who are neurotypical will have no musculoskeletal and neurological conditions
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- participants with stroke will have a single stroke incident resulting in a unilateral lesion (ischemic and hemorrhagic)
- participants with stroke will be in the chronic phase (>1 year from stroke onset)
- participants with stroke will have an onset of stroke after the age of 18
- participants with stroke who meet the criteria of having the capacity to provide informed consent, regardless of aphasia
Who cannot join
- minors
- pregnant women
- prisoners
- adults not capable of consenting on their own behalf.
- For Aim 2:
- participants with stroke who have used antispastic injections in the past six months
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- participants with stroke who have a lesion in the brainstem and/or cerebellum
- participants with stroke who have a stroke arising due to brain surgery
- participants with stroke who have hemineglect
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Virginia Tech
Blacksburg, Virginia, 24061
Netta Gurari, 540-231-3073, gurari@vt.edu
About this study
Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).
- Conditions
- Stroke, Tactile Perception
- Being tested
- Tactile stimulation
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tactile stimulationBehavioural
Tactile stimuli of differing magnitudes will be applied
| Study group | Role | What they receive |
|---|---|---|
| Stimulus magnitude | Experimental | Differing levels of tactile stimulus will be applied Receives: Behavioral: Tactile stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Conscious detection threshold
The magnitude at which a force stimulus applied to the finger can be first consciously detected. Different force levels will be applied, and the participant will indicate which of these forces can be detected. The changes in force applied will be in the units of N.
Measured: 30 minutes during the first session of a one session protocol
Secondary outcomes (1)
Brain activation
The magnitude and regions of brain activated in response to differing levels of force stimuli will be captured using fMRI. The % signal change in the brain will be used to define the brain activation in response to each force stimulus level.
Measured: 60 minutes during the first session of a one session protocol
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jan 2024
- Study start29 Feb 2024
- Primary completion1 Jul 2027 (estimated)
- Study completion1 Jul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Virginia Polytechnic Institute and State University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Netta Gurari, Virginia Polytechnic Institute and State University
- Investigators
- Netta Gurari, PhD, Principal investigator, Virginia Polytechnic Institute and State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06231810
- Sponsor's protocol ID
- 23-1256
- Status last verified
- Jun 2026
- First submitted
- 8 Jan 2024
- Last updated
- 17 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Tracking a Tactile Signal Along the Nervous System
- ClinicalTrials.gov ID
- NCT06231810
- Acronym / sponsor ID
- 23-1256
- Conditions
- Stroke, Tactile Perception
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Virginia Polytechnic Institute and State UniversityUniversity, hospital or other
- Study start
- 29 Feb 2024 (actual)
- Primary completion
- 1 Jul 2027 (estimated)
- Study completion
- 1 Jul 2028 (estimated)
- First posted
- 30 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Stimulus magnitude | Experimental | Behavioral: Tactile stimulationDiffering levels of tactile stimulus will be applied |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- -right-hand dominance for participants who are neurotypical
- -age range of 18-23
- participants who are neurotypical will be a similar age to the participants with stroke
- participants who are neurotypical will have no musculoskeletal and neurological conditions
- participants with stroke will have a single stroke incident resulting in a unilateral lesion (ischemic and hemorrhagic)
Key exclusion criteria (9 listed)
- minors
- pregnant women
- prisoners
- adults not capable of consenting on their own behalf.
- participants with stroke who have used antispastic injections in the past six months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tactile stimulationTactile stimuli of differing magnitudes will be applied | Behavioural | Stimulus magnitude |
Primary outcome
Conscious detection threshold
Time frame: 30 minutes during the first session of a one session protocol
The magnitude at which a force stimulus applied to the finger can be first consciously detected. Different force levels will be applied, and the participant will indicate which of these forces can be detected. The changes in force applied will be in the units of N.
1 secondary outcome
Brain activation
Time frame: 60 minutes during the first session of a one session protocol
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jun 2026.
- Individual participant dataSharing planned: No
Related trials for Stroke
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Web-Based Tele-Rehabilitation Using Action Observation and Mirror Therapy for Subacute Stroke: A Randomized Controlled Trial
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Netta Gurari, PhD principal investigator
Virginia Polytechnic Institute and State University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tactile stimulation in people with Stroke and Tactile Perception, run by Virginia Polytechnic Institute and State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Netta Gurari, PhD (540-231-3073, gurari@vt.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Conscious detection threshold (time frame: 30 minutes during the first session of a one session protocol). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jun 2026.