Multiple SclerosisNCT06232850
Wrist Position Sense in Individuals With Multiple Sclerosis
An observational study of Multiple Sclerosis, run by Pamukkale University at 1 site in Turkey (Türkiye).
Trial summary
No study has been found examining the effect of wrist position sense on manual dexterity in individuals with multiple sclerosis.The purpose of this study is to examine the effect of wrist position sense on manual dexterity of the hand. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Multiple Sclerosis
- What is being tested?
- Position sense and manual dexterity evaluate
- How many people
- 48 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 11 Jan 2024to 1 Apr 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: MS and healthy individuals who proper the inclusion and exclusion criteria
Who may be able to join
- Patient group:
- Disability score (EDSS: Expanded Disability Status Scale) should be between 0-3.
- Being between the ages of 18-50
- Not having had an attack in the last 3 months
- Scoring 24 points or above on the Mini-Mental State Examination
- Patients diagnosed with relapsing-remitting MS with a disease duration of at least 2 years
Show all 10Show fewer
- Patients without spasticity according to MAS
- Control group:
- Volunteers in a similar age range who agreed to participate in the study
- Being between the ages of 18-50
Who cannot join
- Patient group:
- Presence of diagnosed visual impairment
- Having other chronic diseases not related to MS
- Having any orthopedic, neurological, rheumatological or metabolic diagnosis that causes upper extremity involvement
- History of hand and upper extremity disorders, peripheral nerve disorders, and medical or psychiatric disorders that may significantly affect cognitive function
- Presence of wrist joint range of motion limitation
Show all 10Show fewer
- Control group:
- Having any orthopedic, neurological, rheumatological or metabolic diagnosis that causes upper extremity involvement
- History of hand and upper extremity disorders, peripheral nerve disorders, and medical or psychiatric disorders that may significantly affect cognitive function
- Presence of wrist joint range of motion limitation
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Examining the Relationship Between Wrist Position Sense and Manual Dexterity in Individuals With Multiple Sclerosis
No study has been found examining the effect of wrist position sense on manual dexterity in individuals with multiple sclerosis.The purpose of this study is to examine the effect of wrist position sense on manual dexterity of the hand.
Read the detailed description
Multiple sclerosis is a chronic demyelinating disease of the central nervous system that occurs in young adults and usually progresses with attacks and remissions. As the disease progresses, symptoms such as fatigue, muscle weakness, loss of balance, loss of sensation, spasticity, visual disturbances and bladder dysfunction are observed. In addition to these symptoms, hand functions may be affected even in the early stages of the disease.
Appropriate motor control and mobility skills are required to perform manual dexterity effectively. Joint stabilization and perception of the joint's position and movement in space are needed for motor control of hand functions. In this process, position sense signals contribute significantly to the target localization and performance of the hand. Position sense signals must be constantly updated for the coordination and integration of hand position during manual activities such as holding or grasping an object. This is possible with a healthy sense of position.
Although it is known that position sense is affected in MS patients, no study has been found examining the effect of wrist position sense on manual dexterity. The purpose of this study is to examine the effect of wrist position sense on hand dexterity. Patients' manual dexterity will be evaluated using the Purdue Pegboard Test, and wrist position sense will be evaluated using the K-FORCE Sens® electrogoniometer.
- Conditions
- Multiple Sclerosis
- Being tested
- Position sense and manual dexterity evaluate
- Keywords
- Multiple Sclerosis, Manual Dexterity, Position Sense
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Position sense and manual dexterity evaluateOther
Position sense and manual dexterity evaluate
| Study group | Role | What they receive |
|---|---|---|
| Multiple sclerosis patient | According to EDSS should be between 0-3, not having had an attack in the last 3 months and without spasticity according to MAS in patient with MS will assesment KFORCE Sens® device and Purdue Pegboard Test. Receives: Other: Position sense and manual dexterity evaluate | |
| Healthy group | Healthy people of similar age who agree to participate in the study will evaluate the KFORCE Sens® device and the Purdue Pegboard Test. Receives: Other: Position sense and manual dexterity evaluate |
What is being measured
The primary outcome is the main question the study is designed to answer.
Wrist Position Sense Assessment
Wrist position sense will be assessed with the KFORCE Sens® electrogoniometer. Target measurement values of 30° for wrist flexion, 30° for extension, 10° for radial deviation and 15° for ulnar deviation will be used.
Measured: four mounth
Secondary outcomes (1)
Purdue Pegboard Test (PPT)
PPT evaluates the gross motor skills of the arm, hand and fingers, as well as the fine motor skills of the fingers and fingertips, both unilaterally and bilaterally. It consists of pins, washers, nuts and assembly tests. The test consists of 5 sub-steps (inserting pins with the dominant/non-dominant hand/both hands, mathematical summation and assembly). The scoring of the test is the total number of pins, washers and nuts installed at the end of the given period. One trial will be made for each subtest.
Measured: four mounth
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jan 2024
- Study start11 Jan 2024
- Primary completion1 Apr 2024
- Study completion1 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- More trials run by Pamukkale UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pamukkale University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, müge içelli, Pamukkale University
- Investigators
- Müge İçelli Güneş, M.Sc., Principal investigator, Pamukkale University Denizli Health Services Vocational School of Higher Education
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06232850
- Sponsor's protocol ID
- PU-FTR-MI-02
- Status last verified
- Jul 2026
- First submitted
- 22 Jan 2024
- Last updated
- 6 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Examining the Relationship Between Wrist Position Sense and Manual Dexterity in Individuals With Multiple Sclerosis
- ClinicalTrials.gov ID
- NCT06232850
- Acronym / sponsor ID
- PU-FTR-MI-02
- Conditions
- Multiple Sclerosis
- Keywords
- Multiple Sclerosis, Manual Dexterity, Position Sense
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- Pamukkale UniversityUniversity, hospital or other
- Study start
- 11 Jan 2024 (actual)
- Primary completion
- 1 Apr 2024 (actual)
- Study completion
- 1 Apr 2024 (actual)
- First posted
- 31 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
No study has been found examining the effect of wrist position sense on manual dexterity in individuals with multiple sclerosis.The purpose of this study is to examine the effect of wrist position sense on manual dexterity of the hand.
Detailed description
Multiple sclerosis is a chronic demyelinating disease of the central nervous system that occurs in young adults and usually progresses with attacks and remissions. As the disease progresses, symptoms such as fatigue, muscle weakness, loss of balance, loss of sensation, spasticity, visual disturbances and bladder dysfunction are observed. In addition to these symptoms, hand functions may be affected even in the early stages of the disease.
Appropriate motor control and mobility skills are required to perform manual dexterity effectively. Joint stabilization and perception of the joint's position and movement in space are needed for motor control of hand functions. In this process, position sense signals contribute significantly to the target localization and performance of the hand. Position sense signals must be constantly updated for the coordination and integration of hand position during manual activities such as holding or grasping an object. This is possible with a healthy sense of position.
Although it is known that position sense is affected in MS patients, no study has been found examining the effect of wrist position sense on manual dexterity. The purpose of this study is to examine the effect of wrist position sense on hand dexterity. Patients' manual dexterity will be evaluated using the Purdue Pegboard Test, and wrist position sense will be evaluated using the K-FORCE Sens® electrogoniometer.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Multiple sclerosis patient | – | Other: Position sense and manual dexterity evaluateAccording to EDSS should be between 0-3, not having had an attack in the last 3 months and without spasticity according to MAS in patient with MS will assesment KFORCE Sens® device and Purdue Pegboard Test. |
| Healthy group | – | Other: Position sense and manual dexterity evaluateHealthy people of similar age who agree to participate in the study will evaluate the KFORCE Sens® device and the Purdue Pegboard Test. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- MS and healthy individuals who proper the inclusion and exclusion criteria
Key inclusion criteria (10 listed)
- Patient group:
- Volunteers in a similar age range who agreed to participate in the study
- Being between the ages of 18-50
Key exclusion criteria (10 listed)
- Patient group:
- Having any orthopedic, neurological, rheumatological or metabolic diagnosis that causes upper extremity involvement
- History of hand and upper extremity disorders, peripheral nerve disorders, and medical or psychiatric disorders that may significantly affect cognitive function
- Presence of wrist joint range of motion limitation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Position sense and manual dexterity evaluatePosition sense and manual dexterity evaluate | Other | Healthy group, Multiple sclerosis patient |
Primary outcome
Wrist Position Sense Assessment
Time frame: four mounth
Wrist position sense will be assessed with the KFORCE Sens® electrogoniometer. Target measurement values of 30° for wrist flexion, 30° for extension, 10° for radial deviation and 15° for ulnar deviation will be used.
1 secondary outcome
Purdue Pegboard Test (PPT)
Time frame: four mounth
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Müge İçelli Güneş, M.Sc. principal investigator
Pamukkale University Denizli Health Services Vocational School of Higher Education
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Multiple Sclerosis, run by Pamukkale University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Wrist Position Sense Assessment (time frame: four mounth). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jul 2026.