Glucose Metabolism DisordersNCT06242015
Ordered Eating and Acute Exercise
A study testing Carbohydrate-first meal and Carbohydrate-last meal in people with Glucose Metabolism Disorders and Hunger, run by Old Dominion University at 1 site in United States.
Trial summary
There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes… Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Glucose Metabolism Disorders, Hunger
- What is being tested?
- Carbohydrate-first meal and Carbohydrate-last meal
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 23 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Feb 2024to 30 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
- Ability to perform moderate-to-high intensity running for at least 30 minutes
Who cannot join
- Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
- Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
- Currently pregnant
- Implanted electrical devices such as a pacemaker.
Trial locations and contacts
1 site in 1 country.
United States1 site
ODU Human Performance Laboratory
Norfolk, Virginia, 23529
About this study
Official title: The Effect of Ordered Eating on Postprandial Glucose and Substrate Utilization During an Acute Exercise Bout
There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.
Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.
- Conditions
- Glucose Metabolism Disorders, Hunger
- Being tested
- Carbohydrate-first meal, Carbohydrate-last meal
- Keywords
- Exercise, Glucose, Fat metabolism, Hunger
- Medical subject headings
- Glucose Metabolism Disorders, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Carbohydrate-first mealOther
Rice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams)
Carbohydrate-last mealOther
Broccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams)
| Study group | Role | What they receive |
|---|---|---|
| Carbohydrate-first meal | Experimental | Not described Receives: Other: Carbohydrate-first meal |
| Carbohydrate-last meal | Experimental | Not described Receives: Other: Carbohydrate-last meal |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postprandial glucose
Blood glucose will be measured with fingerstick samples and a portable glucometer
Measured: 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)
Secondary outcomes (4)
Carbohydrate use
Carbohydrate utilization will be estimated from respiratory gas exchange
Measured: 100 minutes (premeal and continuously for 90 minutes after eating)
Fat use
fat utilization will be estimated from respiratory gas exchange
Measured: 100 minutes (premeal and continuously for 90 minutes after eating)
Hunger-satiety perceptions
Hunger, appetite, satiety, and fullness on a 0-10 Likert scale
Measured: 2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)
Rating of perceived exertion
Rating of effort during 30-minute exercise bout
Measured: 30 minutes (at 8, 18, 28 minutes of exercise)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2024
- Study start6 Feb 2024
- Primary completion30 Jul 2024
- Study completion30 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Glucose Metabolism DisordersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 23 participants (actual)
Sponsor and investigators
- Lead sponsor
- Old Dominion University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Patrick Wilson, PhD, Old Dominion University
- Investigators
- Patrick Wilson, Principal investigator, Old Dominion University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06242015
- Sponsor's protocol ID
- 24-003
- Status last verified
- Jul 2025
- First submitted
- 28 Jan 2024
- Last updated
- 1 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified IPD will be shared upon reasonable request. Requests should be made to the corresponding author.
Study at a glance
From the registry record, last updated by the sponsor on 1 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Ordered Eating on Postprandial Glucose and Substrate Utilization During an Acute Exercise Bout
- ClinicalTrials.gov ID
- NCT06242015
- Acronym / sponsor ID
- 24-003
- Conditions
- Glucose Metabolism Disorders, Hunger
- Keywords
- Exercise, Glucose, Fat metabolism, Hunger
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 23 participants (actual)
- Lead sponsor
- Old Dominion UniversityUniversity, hospital or other
- Study start
- 6 Feb 2024 (actual)
- Primary completion
- 30 Jul 2024 (actual)
- Study completion
- 30 Jul 2024 (actual)
- First posted
- 5 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.
Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Carbohydrate-first meal | Experimental | Other: Carbohydrate-first meal |
| Carbohydrate-last meal | Experimental | Other: Carbohydrate-last meal |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
- Ability to perform moderate-to-high intensity running for at least 30 minutes
Key exclusion criteria (4 listed)
- Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
- Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
- Currently pregnant
- Implanted electrical devices such as a pacemaker.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Carbohydrate-first mealRice (150 grams) eaten first, followed by broccoli (150 grams) and chicken (100 grams) | Other | Carbohydrate-first meal |
| Carbohydrate-last mealBroccoli (150 grams) and chicken (100 grams) eaten first, followed by rice (150 grams) | Other | Carbohydrate-last meal |
Primary outcome
Postprandial glucose
Time frame: 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)
Blood glucose will be measured with fingerstick samples and a portable glucometer
4 secondary outcomes
Carbohydrate use
Time frame: 100 minutes (premeal and continuously for 90 minutes after eating)
Fat use
Time frame: 100 minutes (premeal and continuously for 90 minutes after eating)
Hunger-satiety perceptions
Time frame: 2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)
Rating of perceived exertion
Time frame: 30 minutes (at 8, 18, 28 minutes of exercise)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Aug 2025.
- Individual participant dataSharing planned: Yes. De-identified IPD will be shared upon reasonable request. Requests should be made to the corresponding author.
Related trials for Glucose Metabolism Disorders
RecruitingObservational study
Early Tracking of Childhood Health Determinants (ETCHED) Study
Diabetes Mellitus, Obesity
Active, not recruitingObservational study
EFFECT OF HYBRID CLOSED-LOOP SYSTEMS ON CARDIOVASCULAR MARKERS IN TYPE 1 DIABETES.
Type 1 Diabetes
Active, not recruiting
Insulin Resistance and Coronary Microvascular Dysfunction in Patients With Myocardial Ischemia and Non-obstructive Coronary Artery Disease
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Active, not recruiting
Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life
Diabetes Type 2, Overweight or Obesity
RecruitingObservational study
A Natural History Study of Metabolic Sizing in Health and Disease
Metabolic Disorders, Cancer
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Patrick Wilson principal investigator
Old Dominion University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Carbohydrate-first meal and Carbohydrate-last meal in people with Glucose Metabolism Disorders and Hunger, run by Old Dominion University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postprandial glucose (time frame: 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Aug 2025.