Obstructive Sleep ApneaNCT06261034
A Study of Sex Differences in Neurocirculatory Control
An observational study of Obstructive Sleep Apnea, run by Mayo Clinic at 1 site in United States.
Trial summary
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA). Read more about this study
- Who is it for?
- Ages 20 to 70 years
- Conditions the study is for
- Obstructive Sleep Apnea
- How many people
- 60 participants
- Where
- 1 siteUnited States
- Study dates
- 29 Oct 2024to Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 70 years
- All sexes
- Adult, Older adult
Study population: Subjects with or without untreated obstructive sleep apnea will be recruited from Mayo Clinic in Rochester, MN.
Who may be able to join
- 20-70 years of age
Who cannot join
- Coronary artery disease
- Heart failure
- Pregnancy
- COPD
- Diabetes
- CKD
Show all 13Show fewer
- Sleep disorders other than OSA
- Shift workers
- Individuals who typically go to sleep after midnight
- Individuals who traveled across ≥2 time zones within one week of study visits
- BMI ≥40.0kg/m2
- Use of nicotine-containing products within the two years preceding study visits
- Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with outcome measures
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Joshua Bock, PhD, (507) 422-0768, bock.joshua@mayo.edu
Ian Greenlund, PhD, (507) 422-3411, Greenlund.Ian@mayo.edu
About this study
Official title: Sex Differences in Neurocirculatory Control With Obstructive Sleep Apnea
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
- Conditions
- Obstructive Sleep Apnea
- Medical subject headings
- Sleep Apnea, Obstructive
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood pressure
Measured in millimeters of mercury (mmHg).
Measured: Baseline
Arterial stiffness
Measured by applanation tonometry reported as aortic pulse wave velocity (m/sec)
Measured: Baseline
Endothelial function
Ultrasound assessment of flow-mediated vasodilation of the brachial artery. Brachial artery diameter and blood velocity will be measured after deflation to measure endothelial function.
Measured: Baseline
Secondary outcomes (4)
Sympathetic nerve burst frequency
Measured by Microneurography reported as number of nerve bursts per minute (burst/min)
Measured: Baseline
Sympathetic nerve burst incidence
Measured by Microneurography reported as number of nerve burst per 100 heart beats (burst/100 heart beats)
Measured: Baseline
Sympathetic nerve burst amplitude (AU)
Measured by Microneurography reported in arbitrary units (AU)
Measured: Baseline
Total muscle sympathetic nerve activity (MSNA)
Measured by Microneurography reported burst arbitrary units per minute (AU/min)
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Feb 2024
- Study start29 Oct 2024
- Primary completionMar 2027 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Obstructive Sleep ApneaStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- Responsible party
- Principal investigator, Joshua M. Bock, Mayo Clinic
- Investigators
- Joshua Bock, PhD, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06261034
- Sponsor's protocol ID
- 23-008765
- Other IDs
- 8K12AR084222-15
- Status last verified
- Jan 2026
- First submitted
- 7 Feb 2024
- Last updated
- 7 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Sex Differences in Neurocirculatory Control With Obstructive Sleep Apnea
- ClinicalTrials.gov ID
- NCT06261034
- Acronym / sponsor ID
- 23-008765
- Conditions
- Obstructive Sleep Apnea
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Collaborators
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- Study start
- 29 Oct 2024 (actual)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 15 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 20 to 70 years
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Subjects with or without untreated obstructive sleep apnea will be recruited from Mayo Clinic in Rochester, MN.
Key inclusion criteria (1 listed)
- 20-70 years of age
Key exclusion criteria (13 listed)
- Coronary artery disease
- Heart failure
- Pregnancy
- COPD
- Diabetes
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Blood pressure
Time frame: Baseline
Measured in millimeters of mercury (mmHg).
Arterial stiffness
Time frame: Baseline
Measured by applanation tonometry reported as aortic pulse wave velocity (m/sec)
Endothelial function
Time frame: Baseline
Ultrasound assessment of flow-mediated vasodilation of the brachial artery. Brachial artery diameter and blood velocity will be measured after deflation to measure endothelial function.
4 secondary outcomes
Sympathetic nerve burst frequency
Time frame: Baseline
Sympathetic nerve burst incidence
Time frame: Baseline
Sympathetic nerve burst amplitude (AU)
Time frame: Baseline
Total muscle sympathetic nerve activity (MSNA)
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Joshua Bock, PhD principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Obstructive Sleep Apnea, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Joshua Bock, PhD ((507) 422-0768, Bock.Joshua@mayo.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood pressure (time frame: Baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jan 2026.