Antibiotic Resistant StrainDyaspeoNCT06262009
Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
An observational study of Antibiotic Resistant Strain and Transmission, Close-Contact, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
Trial summary
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Antibiotic Resistant Strain, Transmission, Close-Contact
- What is being tested?
- human faecal collection and ancillary study
- How many people
- 525 participants
- Where
- 1 siteFrance
- Study dates
- 15 Dec 2025to Mar 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: The healthy volunteers (dog owners) will be recruited at a single recruitment centre, which is the National Veterinary School (Maisons-Alfort).
Who may be able to join
- Adult or child planning to live in the same household as his/her dog during the three months following inclusion.
- Planning to live in the same habitat in the next three months following inclusion (except for holidays).
- Written consent of all adults and of at least one of the two parents for minors under parental authority. A different information note will be elaborated for each age category (6-10 yr-old, 10-15 yr-old and 16-18 yr-old).
- Owning a dog recorded for a surgery at the National Veterinary School
Who cannot join
- Lack of signed informed consent
- Subject in alternating custody
- Subject under legal protection (guardianship)
- Subject deprived of liberty under judicial constraint
- Subject undergoing psychiatric care
- Lack of affiliation to a social security scheme
- Volunteers who do not speak/write French
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
the National Veterinary School Alfort
Maisons-Alfort, 94700
Jean-Yves Madec, PHD, 06 85 08 93 30 ext. +33, jean-yves.madec@anses.fr
About this study
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO
Read the detailed description
Antimicrobial resistance (AMR) is a global and multifaceted public health problem. Advanced knowledge on AMR has demonstrated that it not only affects humans but is also widely distributed across animals and the environment. A major cause of the AMR burden refers to the capability of AMR to transmit within and between individuals, including between humans and animals. Leading examples of internationally distributed AMR bacteria are Enterobacterial disseminating resistances to extended-spectrum cephalosporins (ESC-E) and carbapenems (CP-E). Yet, the magnitude and pathways of their cross-sectorial transfers are poorly understood.
There is a great concern that humans in contact with animals be at risk of ESC-E/CP-E acquisition. Whereas an increase in ESC-E carriage in farmers in contact with their food-producing animals was reported, AMR transmission to humans through direct contacts with companion animals has been much less studied. Owing the close relationships between pets and owners, and the fact that 50% of households host a dog or a cat in France, the hypothesis of pet ownership being a risk for humans to acquire ESC-E/CP-E appears strongly relevant. The DYASPEO project will investigate this question through a combination of several approaches from field to laboratory studies, and including epidemiology, ecology, molecular and population genomics, studies on intestinal microbiota, modelling and social sciences.
We hypothesize that the interface between humans and companion animals plays a significant role in the transfer of ESC-E/CP-E. This hypothesis is corroborated (i) by recent data in France showing that antibiotic exposure of companion animals is still increasing contrary to all other animal host (e.g. food-producing animals) and (ii) by a recent study from the consortium demonstrating a high AMR prevalence in dogs getting back home after hospitalization.
- Being tested
- human faecal collection, ancillary study
- Keywords
- antibiotic resistant transmission, transmission between dog and human
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
human faecal collectionOther
collecting stools 6 times over a 90 days period and complete a questionnaire at the same times: D1, D7, D15, D30, D60 and D90
ancillary studyOther
interviews and/or ethnographic observations for 50 volunteers
| Study group | Role | What they receive |
|---|---|---|
| household | House Members (adults and minors) from 175 households owning a dog Receives: Other: human faecal collection; Other: ancillary study |
What is being measured
The primary outcome is the main question the study is designed to answer.
generation of a list of priorities for future prevention and control strategies to mitigate antimicrobial resistance (AMR) transmission between companion animals and humans
mathematical models combining all the data (epidemiological, bacteriological, genomic, sociological) gathered in the project
Measured: over the 90 days follow up
Secondary outcomes (7)
Rates of AMR acquisitions in one or several housekeepers
Measured: over the 90 days follow up
A list in nature of changes in dog microbiota
Measured: over the 90 days follow up
A list in magnitude of changes in dog microbiota
Measured: over the 90 days follow up
A list in nature of changes in housekeepers microbiota
Measured: over the 90 days follow up
A list in magnitude of changes in housekeepers microbiota
Measured: over the 90 days follow up
explore unknown parameters of AMR colonization in dogs under various antibiotic exposures
Measured: over the 90 days follow up
the generation of a list of sociological factors and potential at-risk practices relevant in the transmission of AMR from dogs to housekeepers
Measured: during semi-directive interviews and/or observational periods
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Feb 2024
- Study start15 Dec 2025
- Primary completionSep 2028 (estimated)
- Study completionMar 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Antibiotic Resistant StrainStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 525 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Jean-Yves Madec, PHD, Principal investigator, ANSES
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06262009
- Sponsor's protocol ID
- APHP220101
- Other IDs
- 2023-A02282-43
- Acronym
- Dyaspeo
- Status last verified
- Apr 2026
- First submitted
- 8 Feb 2024
- Last updated
- 23 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 23 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
- ClinicalTrials.gov ID
- NCT06262009
- Acronym / sponsor ID
- Dyaspeo / APHP220101
- Keywords
- antibiotic resistant transmission, transmission between dog and human
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 525 participants (estimated)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Study start
- 15 Dec 2025 (actual)
- Primary completion
- Sep 2028 (estimated)
- Study completion
- Mar 2029 (estimated)
- First posted
- 15 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO
Detailed description
Antimicrobial resistance (AMR) is a global and multifaceted public health problem. Advanced knowledge on AMR has demonstrated that it not only affects humans but is also widely distributed across animals and the environment. A major cause of the AMR burden refers to the capability of AMR to transmit within and between individuals, including between humans and animals. Leading examples of internationally distributed AMR bacteria are Enterobacterial disseminating resistances to extended-spectrum cephalosporins (ESC-E) and carbapenems (CP-E). Yet, the magnitude and pathways of their cross-sectorial transfers are poorly understood.
There is a great concern that humans in contact with animals be at risk of ESC-E/CP-E acquisition. Whereas an increase in ESC-E carriage in farmers in contact with their food-producing animals was reported, AMR transmission to humans through direct contacts with companion animals has been much less studied. Owing the close relationships between pets and owners, and the fact that 50% of households host a dog or a cat in France, the hypothesis of pet ownership being a risk for humans to acquire ESC-E/CP-E appears strongly relevant. The DYASPEO project will investigate this question through a combination of several approaches from field to laboratory studies, and including epidemiology, ecology, molecular and population genomics, studies on intestinal microbiota, modelling and social sciences.
We hypothesize that the interface between humans and companion animals plays a significant role in the transfer of ESC-E/CP-E. This hypothesis is corroborated (i) by recent data in France showing that antibiotic exposure of companion animals is still increasing contrary to all other animal host (e.g. food-producing animals) and (ii) by a recent study from the consortium demonstrating a high AMR prevalence in dogs getting back home after hospitalization.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| household | – | Other: human faecal collection, Other: ancillary studyHouse Members (adults and minors) from 175 households owning a dog |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- The healthy volunteers (dog owners) will be recruited at a single recruitment centre, which is the National Veterinary School (Maisons-Alfort).
Key inclusion criteria (4 listed)
- Adult or child planning to live in the same household as his/her dog during the three months following inclusion.
- Planning to live in the same habitat in the next three months following inclusion (except for holidays).
- Written consent of all adults and of at least one of the two parents for minors under parental authority. A different information note will be elaborated for each age category (6-10 yr-old, 10-15 yr-old and 16-18 yr-old).
- Owning a dog recorded for a surgery at the National Veterinary School
Key exclusion criteria (7 listed)
- Lack of signed informed consent
- Subject in alternating custody
- Subject under legal protection (guardianship)
- Subject deprived of liberty under judicial constraint
- Subject undergoing psychiatric care
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| human faecal collectioncollecting stools 6 times over a 90 days period and complete a questionnaire at the same times: D1, D7, D15, D30, D60 and D90 | Other | household |
| ancillary studyinterviews and/or ethnographic observations for 50 volunteers | Other | household |
Primary outcome
generation of a list of priorities for future prevention and control strategies to mitigate antimicrobial resistance (AMR) transmission between companion animals and humans
Time frame: over the 90 days follow up
mathematical models combining all the data (epidemiological, bacteriological, genomic, sociological) gathered in the project
7 secondary outcomes
Rates of AMR acquisitions in one or several housekeepers
Time frame: over the 90 days follow up
A list in nature of changes in dog microbiota
Time frame: over the 90 days follow up
A list in magnitude of changes in dog microbiota
Time frame: over the 90 days follow up
A list in nature of changes in housekeepers microbiota
Time frame: over the 90 days follow up
A list in magnitude of changes in housekeepers microbiota
Time frame: over the 90 days follow up
explore unknown parameters of AMR colonization in dogs under various antibiotic exposures
Time frame: over the 90 days follow up
the generation of a list of sociological factors and potential at-risk practices relevant in the transmission of AMR from dogs to housekeepers
Time frame: during semi-directive interviews and/or observational periods
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Apr 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jean-Yves Madec, PHD principal investigator
ANSES
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Antibiotic Resistant Strain and Transmission, Close-Contact, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jean-Yves Madec, PHD (06 85 08 93 30 ext. +33, Jean-Yves.MADEC@anses.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
generation of a list of priorities for future prevention and control strategies to mitigate antimicrobial resistance (AMR) transmission between companion animals and humans (time frame: over the 90 days follow up). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Apr 2026.