VapingNCT06269003

Responses to Message Source and Presentation Using Psychophysiology

A study testing Expert, one-sided, Expert, two-sided and Peer, one-sided in people with Vaping, run by University of Massachusetts, Worcester at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

Search all trials

Trial summary

The goal of this clinical trial is to use psychophysiological methods to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who vape and do not vape. Read more about this study

Who is it for?: Ages 18 to 24 yearsHealthy volunteers can take part
Conditions the study is for: Vaping
What is being tested?: Expert, one-sided, Expert, two-sided and Peer, one-sided
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 112 participants
Where: 1 siteUnited States
Study dates: 18 Feb 2024to 10 Jun 2024
Phase: Interventional
Are there results?: Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 24 years
All sexes
Healthy volunteers accepted
Adult

Who may be able to join

Ages 18-24
Fluent in English
Either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping
Self-reported abstinence of combusted tobacco or marijuana at time of visit

Who cannot join

Ages below 18 or above 24
Not fluent in English
Not confirmed self-reported abstinence of combusted tobacco or marijuana at time of visit

Trial locations and contacts

1 site in 1 country.

United States1 site

UMass Chan Medical School Shaw Building
Worcester, Massachusetts, 01605

Other trials in United States

About this study

Official title: Identifying and Examining the Effects of Source and Presentation on Responses to Electronic Cigarette Public Education Messages in Young Adult Vapers and Non-vapers - Part 2

Conditions: Vaping
Being tested: Expert, one-sided, Expert, two-sided, Peer, one-sided, Peer, two-sided
Medical subject headings: Vaping

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Expert, one-sidedOther
Participants will view a brief description of an expert source and see one-sided e-cigarette education messages.
Expert, two-sidedOther
Participants will view a brief description of an expert source and see two-sided e-cigarette education messages.
Peer, one-sidedOther
Participants will view a brief description of a peer source and see one-sided e-cigarette education messages.
Peer, two-sidedOther
Participants will view a brief description of a peer source and see two-sided e-cigarette education messages.

Study groups in NCT06269003
Study group	Role	What they receive
Expert, one-sided	Experimental	Participants assigned to the expert, one-sidedness condition will receive one-sided e-cigarette messages from an expert source. Receives: Other: Expert, one-sided
Expert, two-sided	Experimental	Participants assigned to the expert, two-sidedness condition will receive two-sided e-cigarette messages from an expert source. Receives: Other: Expert, two-sided
Peer, one-sided	Experimental	Participants assigned to the peer, one-sidedness condition will receive one-sided e-cigarette messages from a peer source. Receives: Other: Peer, one-sided
Peer, two-sided	Experimental	Participants assigned to the peer, two-sidedness condition will receive two-sided e-cigarette messages from a peer source. Receives: Other: Peer, two-sided

What is being measured

The primary outcome is the main question the study is designed to answer.

Visual Attention
Visual attention was assessed by measuring dwell time, which is the length of time participants spent on looking at the specific areas of interest (AOIs) collected in miliseconds. Dwell time values were collected for 18 messages, and aggregated to provide the average dwell time scores for each arm. This was done for each vaping status (current vapers and susceptible non-vapers). Higher dwell time scores indicate higher visual attention, indicating better message outcomes.
Measured: The entire duration of message from beginning of its delivery to the completion of viewing, up to 45 minutes.
Allocation of Cognitive Resources
Heart rate values were collected in beats per minute (BPM) on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in the BPM values during the message exposure period by comparing the BPM values collected during each message second to the BPM values collected during the immediately preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean BPM value per condition, and this was done for each vaping status (current vapers and susceptible non-vapers). Lower BPM values reflect greater cognitive response, therefore indicate better message outcomes.
Measured: Baseline and immediately after viewing all the messages (approximately 45 minutes).
Arousal
Galvanic Skin Response (GSR) values were recorded in microsiemens on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in GSR values by comparing each message response to its preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean GSR score per condition, and this was done for each vaping status group (current vapers and susceptible non-vapers). Higher GSR values reflect greater physiological arousal, and indicate better message outcomes.
Measured: Baseline and immediately after viewing all the messages (approximately 45 minutes).

Secondary outcomes (2)

Attitudes
Participants' self-reported vaping attitudes were measured by using a five-point bipolar scale using 7 subscale items assessing whether participants thought vaping was enjoyable, healthy, safe, fun, smart, cool, and attractive on a scale from 1 (negative attitudes) to 5 (positive attitudes). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more positive e-cigarette attitudes, therefore worse outcomes.
Measured: After exposure to all messages, approximately up to 45 minutes.
Behavioral Intentions
Participants' vaping intentions was measured by using a 3 subscale items assessing participants' intentions to vape: soon/anytime during the next year/would use offered by one of their best friends, on a scale from 1 (Definitely not) to 5 (Definitely yes). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping intentions, therefore indicating worse outcome.
Measured: After exposure to all messages, approximately up to 45 minutes.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

18 Feb 202410 Jun 2024

First posted21 Feb 2024
Study start18 Feb 2024
Primary completion10 Jun 2024
Study completion10 Jun 2024

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
Other trials for VapingStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Health services research
Allocation: Randomised
Intervention model: Factorial
Masking: None (open label)
Enrolment: 112 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06269003
Sponsor's protocol ID: STUDY00001223
Other IDs: 1K99CA281094-01A1
Status last verified: Jul 2025
First submitted: 17 Jan 2024
Last updated: 1 Aug 2025
Results posted: Yes, on ClinicalTrials.gov
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Not yet recruiting
Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial
Tobacco Cessation, Electronic Nicotine Delivery Systems
Recruiting
Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes
Tobacco Products, Cigarettes
Recruiting
Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette Users
E Cigarette Use
Recruiting
A Behavioral Circuit Breathing Training Intervention on Smoking Cessation and Respiratory Function Among Youth Who Use E-cigarettes
E Cigarette Use
Not yet recruiting
Cardiovascular Impacts of E-cigarettes Among Older Adults
Hypertension, Tobacco Cigarette Smoking

All Vaping trials

Study at a glance

From the registry record, last updated by the sponsor on 1 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Identifying and Examining the Effects of Source and Presentation on Responses to Electronic Cigarette Public Education Messages in Young Adult Vapers and Non-vapers - Part 2
ClinicalTrials.gov ID: NCT06269003
Acronym / sponsor ID: STUDY00001223
Conditions: Vaping
Study type: Interventional
Recruitment status: Completed
Enrolment: 112 participants (actual)
Lead sponsor: University of Massachusetts, WorcesterUniversity, hospital or other
Collaborators: National Cancer Institute (NCI)
Study start: 18 Feb 2024 (actual)
Primary completion: 10 Jun 2024 (actual)
Study completion: 10 Jun 2024 (actual)
First posted: 21 Feb 2024 (actual)
Results: Posted 1 Aug 2025

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Study design

Primary purpose: Health services research
Allocation: Randomised
Intervention model: Factorial
Masking: None (open label)
Number of arms: 4

Arm	Type	Receives
Expert, one-sided	Experimental	Other: Expert, one-sidedParticipants assigned to the expert, one-sidedness condition will receive one-sided e-cigarette messages from an expert source.
Expert, two-sided	Experimental	Other: Expert, two-sidedParticipants assigned to the expert, two-sidedness condition will receive two-sided e-cigarette messages from an expert source.
Peer, one-sided	Experimental	Other: Peer, one-sidedParticipants assigned to the peer, one-sidedness condition will receive one-sided e-cigarette messages from a peer source.
Peer, two-sided	Experimental	Other: Peer, two-sidedParticipants assigned to the peer, two-sidedness condition will receive two-sided e-cigarette messages from a peer source.

Who may qualify

Ages: 18 to 24 years
Sex: All
Healthy volunteers: Accepted
Age groups: Adult

Key inclusion criteria (4 listed)

Ages 18-24
Fluent in English
Either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping
Self-reported abstinence of combusted tobacco or marijuana at time of visit

Key exclusion criteria (3 listed)

Ages below 18 or above 24
Not fluent in English
Not confirmed self-reported abstinence of combusted tobacco or marijuana at time of visit

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Expert, one-sidedParticipants will view a brief description of an expert source and see one-sided e-cigarette education messages.	Other	Expert, one-sided
Expert, two-sidedParticipants will view a brief description of an expert source and see two-sided e-cigarette education messages.	Other	Expert, two-sided
Peer, one-sidedParticipants will view a brief description of a peer source and see one-sided e-cigarette education messages.	Other	Peer, one-sided
Peer, two-sidedParticipants will view a brief description of a peer source and see two-sided e-cigarette education messages.	Other	Peer, two-sided

Primary outcome

Visual Attention
Time frame: The entire duration of message from beginning of its delivery to the completion of viewing, up to 45 minutes.
Visual attention was assessed by measuring dwell time, which is the length of time participants spent on looking at the specific areas of interest (AOIs) collected in miliseconds. Dwell time values were collected for 18 messages, and aggregated to provide the average dwell time scores for each arm. This was done for each vaping status (current vapers and susceptible non-vapers). Higher dwell time scores indicate higher visual attention, indicating better message outcomes.
Allocation of Cognitive Resources
Time frame: Baseline and immediately after viewing all the messages (approximately 45 minutes).
Heart rate values were collected in beats per minute (BPM) on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in the BPM values during the message exposure period by comparing the BPM values collected during each message second to the BPM values collected during the immediately preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean BPM value per condition, and this was done for each vaping status (current vapers and susceptible non-vapers). Lower BPM values reflect greater cognitive response, therefore indicate better message outcomes.
Arousal
Time frame: Baseline and immediately after viewing all the messages (approximately 45 minutes).
Galvanic Skin Response (GSR) values were recorded in microsiemens on a per-second basis during the presentation of each 18 distinct messages as well as during the immediately preceding black screen (baseline) for each message. Descriptive statistics were used to summarize changes in GSR values by comparing each message response to its preceding baseline period. These change scores were then averaged across all messages within each study arm to generate a mean GSR score per condition, and this was done for each vaping status group (current vapers and susceptible non-vapers). Higher GSR values reflect greater physiological arousal, and indicate better message outcomes.

2 secondary outcomes

Attitudes
Time frame: After exposure to all messages, approximately up to 45 minutes.
Behavioral Intentions
Time frame: After exposure to all messages, approximately up to 45 minutes.

Results and safety

Results posted to the registry on 1 Aug 2025, as reported by the sponsor. Figures are copied from the record, not re-analysed. Full results on ClinicalTrials.gov.

Participant flow

Group	Started	Completed
Expert, One-sided	28	28
Expert, Two-sided	28	28
Peer, One-sided	28	27
Peer, Two-sided	28	28

Primary outcome: Visual Attention

Time frame: The entire duration of message from beginning of its delivery to the completion of viewing, up to 45 minutes.. Mean (Standard Deviation). Unit: milliseconds

Measure	Expert, One-sided n = 28	Expert, Two-sided n = 28	Peer, One-sided n = 27	Peer, Two-sided n = 28
Current vapers	6217.016667 (1278.03706)	6333.70375 (909.82927)	6567.725714 (934.62436)	6667.185625 (633.14744)
Susceptible non-vapers	6750.67 (798.60759)	6423.3025 (1069.16916)	6701.923077 (604.30866)	6231.6275 (933.71167)

Population analysed: The data were stratified based on participants' vaping status ("Current vapers" and "Susceptible non-vapers"). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

Primary outcome: Allocation of Cognitive Resources

Time frame: Baseline and immediately after viewing all the messages (approximately 45 minutes).. Mean (Standard Error). Unit: Beats per minute

Measure	Expert, One-sided n = 20	Expert, Two-sided n = 18	Peer, One-sided n = 16	Peer, Two-sided n = 16
Current vapers	-4.885 (1.108)	-4.098 (1.324)	-2.079 (1.239)	-1.652 (1.168)
Susceptible non-vapers	-3.723 (0.834)	-3.444 (0.834)	-3.232 (0.945)	-4.696 (1.119)

Population analysed: n=41 were removed from analysis due to poor quality. The data were stratified based on participants' vaping status ("Current vapers" and "Susceptible non-vapers"). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

Primary outcome: Arousal

Time frame: Baseline and immediately after viewing all the messages (approximately 45 minutes).. Mean (Standard Error). Unit: microsiemens

Measure	Expert, One-sided n = 21	Expert, Two-sided n = 21	Peer, One-sided n = 19	Peer, Two-sided n = 21
Current vapers	17.225 (272.990)	597.772 (272.990)	-49.682 (285.129)	267.135 (272.990)
Susceptible non-vapers	215.883 (372.223)	-9.867 (372.223)	526.856 (394.802)	-157.043 (372.223)

Population analysed: n=29 were removed from analysis due to poor quality. The data were stratified based on participants' vaping status ("Current vapers" and "Susceptible non-vapers"). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

2 secondary outcomes are reported in the full results.

Adverse events

Time frame: Each adverse event or serious adverse event was monitored and assessed throughout the entire duration of the participant's lab visit, from the moment a participant showed up to the lab until the study completed, which lasted approximately 1 hour per participant.. Other adverse events reported at 0% frequency or more

Group	Serious adverse events	Other adverse events	Deaths
Expert 1-sided	0 of 28 (0%)	0 of 28 (0%)	0 of 28
Expert 2-sided	0 of 28 (0%)	0 of 28 (0%)	0 of 28
Peer 1-sided	0 of 27 (0%)	0 of 27 (0%)	0 of 27
Peer 2-sided	0 of 28 (0%)	0 of 28 (0%)	0 of 28

Loading the posted results from ClinicalTrials.gov…

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 1 Aug 2025.
Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Individual participant dataSharing planned: No

Related trials for Vaping

Not yet recruiting
Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial
Tobacco Cessation, Electronic Nicotine Delivery Systems
Recruiting
Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes
Tobacco Products, Cigarettes
Recruiting
Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette Users
E Cigarette Use
Recruiting
A Behavioral Circuit Breathing Training Intervention on Smoking Cessation and Respiratory Function Among Youth Who Use E-cigarettes
E Cigarette Use
Not yet recruiting
Cardiovascular Impacts of E-cigarettes Among Older Adults
Hypertension, Tobacco Cigarette Smoking

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Donghee N Lee, PhD principal investigator

University of Massachusetts, Worcester

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Expert, one-sided, Expert, two-sided and Peer, one-sided in people with Vaping, run by University of Massachusetts, Worcester at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 1 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 1 Aug 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Visual Attention (time frame: The entire duration of message from beginning of its delivery to the completion of viewing, up to 45 minutes.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06269003.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Aug 2025.