Dental PainICLIDNCT06269406
A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults
A study testing ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg and ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg in people with Dental Pain, run by S.LAB (SOLOWAYS) at 1 site in Russia.
Trial summary
Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Dental Pain
- What is being tested?
- ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg and ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 264 participants
- Where
- 1 siteRussia
- Study dates
- 28 Jul 2025to 28 Sep 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Removal of 2 to 4 impacted third molars
Who cannot join
- Pregnancy or breastfeeding
- Ibuprofen contraindications.
- Allergy to any of the intervention components.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Russia1 site
Nmsi Dentmaster
Novosibirsk, Novosibirsk Oblast, 630090
Gatilova A Tatyana, MD, 9529399919 ext. +7
About this study
Official title: A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults, Randomized, Double- Blind, Parallel-Group, Placebo-Controlled Study
Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.
- Conditions
- Dental Pain
- Being tested
- ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg, ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg, The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure
- Keywords
- Postoperative Dental Pain, Curcumin and Licorice Root, Ibuprofen, Anti-inflammatory Properties, molars
- Medical subject headings
- Toothache
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mgDietary supplement
The combination of ibuprofen 400 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure
ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mgDietary supplement
The combination of ibuprofen 200 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure
The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedureOther
The combination of ibuprofen 400 mg and placebo 100 mg in patients after 2-4 molars procedure
| Study group | Role | What they receive |
|---|---|---|
| Intervention Group ibuprofen 400 and Curcumin | Experimental | Not described Receives: Dietary Supplement: ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg |
| Intervention Group ibuprofen 200 and Curcumin | Experimental | Not described Receives: Dietary Supplement: ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg |
| Intervention Group ibuprofen 400 and placebo | Placebo comparator | Not described Receives: Other: The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Sum of pain intensity differences (SPID), SPID on the visual analog score VAS (points)
Measured: 8 hours
Secondary outcomes (4)
Total pain relief (TOTPAR) %
Measured: 8 hours
Time to pain half pain gone (in minutes)
Measured: 8 hours
Duration of pain half gone (in minutes)
Measured: 8 hours
Any adverse events (facial swelling, nausea, vomiting, headache) (%)
Measured: 8 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Feb 2024
- Study start28 Jul 2025 (estimated)
- Primary completion28 Jul 2025 (estimated)
- Study completion28 Sep 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 264 participants (estimated)
Sponsor and investigators
- Lead sponsor
- S.LAB (SOLOWAYS)
- Sponsor type
- University, hospital or other
- Collaborators
- NMSI DENTMASTER
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06269406
- Sponsor's protocol ID
- SW008
- Acronym
- ICLID
- Status last verified
- Jun 2025
- First submitted
- 12 Feb 2024
- Last updated
- 8 Jun 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults, Randomized, Double- Blind, Parallel-Group, Placebo-Controlled Study
- ClinicalTrials.gov ID
- NCT06269406
- Acronym / sponsor ID
- ICLID / SW008
- Conditions
- Dental Pain
- Keywords
- Postoperative Dental Pain, Curcumin and Licorice Root, Ibuprofen, Anti-inflammatory Properties, molars
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 264 participants (estimated)
- Lead sponsor
- S.LAB (SOLOWAYS)University, hospital or other
- Collaborators
- NMSI DENTMASTER
- Study start
- 28 Jul 2025 (estimated)
- Primary completion
- 28 Jul 2025 (estimated)
- Study completion
- 28 Sep 2025 (estimated)
- First posted
- 21 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Dental pain, a common issue in stomatology, requires a multifaceted treatment approach. This study explores the efficacy of combining Ibuprofen with curcumin and liquorice root supplements for managing postoperative dental pain. Curcumin, known for its antioxidant and anti-inflammatory properties, along with liquorice root, may enhance pain relief beyond conventional NSAIDs like Ibuprofen. This randomized, double-blind, placebo-controlled trial aims to evaluate the safety and effectiveness of this combination therapy in adults undergoing the removal of impacted third molars. Participants, aged 18-85, were divided into groups receiving different doses of Ibuprofen and curcumin with liquorice root, compared to a control group receiving Ibuprofen and placebo. The primary outcome is the sum of pain intensity differences over 8 hours, with secondary outcomes including total pain relief and the occurrence of any adverse events. The anticipated sample size, considering a 20% dropout rate, is 264 participants, ensuring the study is powered to detect significant differences in pain management efficacy.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Intervention Group ibuprofen 400 and Curcumin | Experimental | Dietary Supplement: ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg |
| Intervention Group ibuprofen 200 and Curcumin | Experimental | Dietary Supplement: ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg |
| Intervention Group ibuprofen 400 and placebo | Placebo comparator | Other: The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Removal of 2 to 4 impacted third molars
Key exclusion criteria (3 listed)
- Pregnancy or breastfeeding
- Ibuprofen contraindications.
- Allergy to any of the intervention components.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mgThe combination of ibuprofen 400 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure | Dietary supplement | Intervention Group ibuprofen 400 and Curcumin |
| ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mgThe combination of ibuprofen 200 mg and Curcumin covered with liquorice root 100 mg in patients after 2-4 molars procedure | Dietary supplement | Intervention Group ibuprofen 200 and Curcumin |
| The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedureThe combination of ibuprofen 400 mg and placebo 100 mg in patients after 2-4 molars procedure | Other | Intervention Group ibuprofen 400 and placebo |
Primary outcome
Sum of pain intensity differences (SPID), SPID on the visual analog score VAS (points)
Time frame: 8 hours
4 secondary outcomes
Total pain relief (TOTPAR) %
Time frame: 8 hours
Time to pain half pain gone (in minutes)
Time frame: 8 hours
Duration of pain half gone (in minutes)
Time frame: 8 hours
Any adverse events (facial swelling, nausea, vomiting, headache) (%)
Time frame: 8 hours
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jun 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg and ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg in people with Dental Pain, run by S.LAB (SOLOWAYS) at 1 site in Russia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Russia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Sum of pain intensity differences (SPID), SPID on the visual analog score VAS (points) (time frame: 8 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jun 2025.