HydrationNCT06272435
Beverage Hydration Index: Assessment of Four Rehydration Solutions
A study testing Multiplier, Sugar Free and Sugar Free with Amino Acids in people with Hydration, run by University of Memphis at 1 site in United States.
Trial summary
No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with… Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Hydration
- What is being tested?
- Multiplier, Sugar Free and Sugar Free with Amino Acids
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteUnited States
- Study dates
- 23 Dec 2023to 6 Sep 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- body mass index (BMI) <35 kilgrams per square meter
- consistent dietary intake and exercise throughout study period
- consumes 2 liters (women) or 2.5 liters (men) of water per day prior to study visits
- able to fast for 15 hours
Who cannot join
- sensitivity or be allergic to any components of the study product they will be excluded.
- tobacco user
- specialized diet (low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting, etc.)
- caffeine consumption within 12 hours of study visit
- strenuous activity within 24 hours of study visit
- history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder
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- conditions that alter fluid balance or electrolytes/hydration status
- consuming any medication which may alter fluid retention/electrolyte levels such as sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium.
- consuming nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening).
- employee of Liquid IV
- be enrolled in another clinical study within 30 days of the first study visit
- active infection or illness of any kind
Trial locations and contacts
1 site in 1 country.
United States1 site
Center for Nutraceutical and Dietary Supplement Research
Memphis, Tennessee, 38152
About this study
No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.
Read the detailed description
Many attempts have been made to improve and measure the hydration status of active individuals. This typically involves the ingestion of fluids leading up to activity (typically plain water), as well as the ingestion of fluids during the activity itself (water, along with a diluted carbohydrate/electrolyte beverage). This approach seems to work well; however, some debate remains over what the best fluid is to consume, in particular related to the macronutrient type and the specific electrolyte mix.
No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MultiplierDietary supplement
Subjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.
Sugar FreeDietary supplement
Subjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes.
Sugar Free with Amino AcidsDietary supplement
Subjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes.
WaterDietary supplement
Subjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes.
| Study group | Role | What they receive |
|---|---|---|
| Water, Multiplier, Sugar with Amino Acids, and Sugar Free | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Water, Multiplier, Sugar Free, and Sugar with Amino Acids | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Water, Sugar with Amino Acids, Multiplier, and Sugar Free | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Water, Sugar with Amino Acids, Sugar Free, and Multiplier | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Water, Sugar Free, Multiplier, and Sugar with Amino Acids | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Water, Sugar Free, Sugar with Amino Acids, and Multiplier | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Multiplier, Water, Sugar with Amino Acids, and Sugar Free | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Multiplier, Water, Sugar Free, and Sugar with Amino Acids | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Multiplier, Sugar with Amino Acids, Water, and Sugar Free | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Multiplier, Sugar with Amino Acids, Sugar Free, and Water | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Multiplier, Sugar Free, Water, and Sugar with Amino Acids | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Multiplier, Sugar Free, Sugar with Amino Acids, and Water | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar with Amino Acids, Water, Multiplier, and Sugar Free | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar with Amino Acids, Water, Sugar Free, and Multiplier | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar with Amino Acids, Multiplier, Water, and Sugar Free | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar with Amino Acids, Multiplier, Sugar Free, and Water | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar with Amino Acids, Sugar Free, Water, and Multiplier | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar with Amino Acids, Sugar Free, Multiplier, and Water | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar Free, Water, Multiplier, and Sugar with Amino Acids | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar Free, Water, Sugar with Amino Acids, and Multiplier | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar Free, Multiplier, Water, and Sugar with Amino Acids | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar Free, Multiplier, Sugar with Amino Acids, and Water | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar Free, Sugar with Amino Acids, Water, and Multiplier | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
| Sugar Free, Sugar with Amino Acids, Multiplier, and Water | Experimental | Subjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. Receives: Dietary Supplement: Multiplier; Dietary Supplement: Sugar Free; Dietary Supplement: Sugar Free with Amino Acids; Dietary Supplement: Water |
What is being measured
The primary outcome is the main question the study is designed to answer.
Beverage Hydration Index
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Measured: 0 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Measured: 60 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Measured: 120 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Measured: 180 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Measured: 240 minutes after beverage consumption
Secondary outcomes (48)
Net Fluid Balance
Net Fluid balance will be calculated subtracting total urine collected from total liquid consumed
Measured: 0 minutes after beverage consumption
Net Fluid Balance
Net Fluid balance will be calculated subtracting total urine collected from total liquid consumed
Measured: 60 minutes after beverage consumption
Net Fluid Balance
Net Fluid balance will be calculated subtracting total urine collected from total liquid consumed
Measured: 120 minutes after beverage consumption
Net Fluid Balance
Net Fluid balance will be calculated subtracting total urine collected from total liquid consumed
Measured: 180 minutes after beverage consumption
Net Fluid Balance
Net Fluid balance will be calculated subtracting total urine collected from total liquid consumed
Measured: 240 minutes after beverage consumption
Urine Osmolality
Urine Osmolality will be measured in milliosmoles per kilogram of water.
Measured: 0 minutes before beverage consumption
Urine Osmolality
Urine Osmolality will be measured in milliosmoles per kilogram of water.
Measured: 0 minutes after beverage consumption
Urine Osmolality
Urine Osmolality will be measured in milliosmoles per kilogram of water.
Measured: 60 minutes after beverage consumption
Urine Osmolality
Urine Osmolality will be measured in milliosmoles per kilogram of water.
Measured: 120 minutes after beverage consumption
Urine Osmolality
Urine Osmolality will be measured in milliosmoles per kilogram of water.
Measured: 180 minutes after beverage consumption
Urine Osmolality
Urine Osmolality will be measured in milliosmoles per kilogram of water.
Measured: 240 minutes after beverage consumption
Urine Sodium
Urine Sodium will be measured in millimoles per liter.
Measured: 0 minutes before beverage consumption
Urine Sodium
Urine Sodium will be measured in millimoles per liter.
Measured: 0 minutes after beverage consumption
Urine Sodium
Urine Sodium will be measured in millimoles per liter.
Measured: 60 minutes after beverage consumption
Urine Sodium
Urine Sodium will be measured in millimoles per liter.
Measured: 120 minutes after beverage consumption
Urine Sodium
Urine Sodium will be measured in millimoles per liter.
Measured: 180 minutes after beverage consumption
Urine Sodium
Urine Sodium will be measured in millimoles per liter.
Measured: 240 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per liter.
Measured: 0 minutes before beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per liter.
Measured: 0 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per liter.
Measured: 60 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per liter.
Measured: 120 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per liter.
Measured: 180 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per liter.
Measured: 240 minutes after beverage consumption
Urine Specific Gravity
Urine Specific Gravity will be measured via refractometry.
Measured: 150 minutes before beverage consumption
Urine Specific Gravity
Urine Specific Gravity will be measured via refractometry.
Measured: 0 minutes before beverage consumption urine
Urine Specific Gravity
Urine Specific Gravity will be measured via refractometry.
Measured: 0 minutes after beverage consumption urine
Urine Specific Gravity
Urine Specific Gravity will be measured via refractometry.
Measured: 60 minutes after beverage consumption urine
Urine Specific Gravity
Urine Specific Gravity will be measured via refractometry.
Measured: 120 minutes after beverage consumption urine
Urine Specific Gravity
Urine Specific Gravity will be measured via refractometry.
Measured: 180 minutes after beverage consumption urine
Urine Specific Gravity
Urine Specific Gravity will be measured via refractometry.
Measured: 240 minutes after beverage consumption urine
Sodium balance
Sodium Balance will be calculated subtracting total sodium in urine from total sodium consumed in beverage.
Measured: 0 minutes after beverage consumption
Sodium balance
Sodium Balance will be calculated subtracting total sodium in urine from total sodium consumed in beverage.
Measured: 60 minutes after beverage consumption
Sodium balance
Sodium Balance will be calculated subtracting total sodium in urine from total sodium consumed in beverage.
Measured: 120 minutes after beverage consumption
Sodium balance
Sodium Balance will be calculated subtracting total sodium in urine from total sodium consumed in beverage.
Measured: 180 minutes after beverage consumption
Sodium balance
Sodium Balance will be calculated subtracting total sodium in urine from total sodium consumed in beverage.
Measured: 240 minutes after beverage consumption
Potassium balance
Potassium Balance will be calculated subtracting total potassium in urine from total potassium consumed in beverage.
Measured: 0 minutes after beverage consumption
Potassium balance
Potassium Balance will be calculated subtracting total potassium in urine from total potassium consumed in beverage.
Measured: 60 minutes after beverage consumption
Potassium balance
Potassium Balance will be calculated subtracting total potassium in urine from total potassium consumed in beverage.
Measured: 120 minutes after beverage consumption
Potassium balance
Potassium Balance will be calculated subtracting total potassium in urine from total potassium consumed in beverage.
Measured: 180 minutes after beverage consumption
Potassium balance
Potassium Balance will be calculated subtracting total potassium in urine from total potassium consumed in beverage.
Measured: 240 minutes after beverage consumption
Body Mass
Body Mass in kilograms will be measured using a digital scale
Measured: 0 minutes before beverage consumption
Body Mass
Body Mass in kilograms will be measured using a digital scale
Measured: 240 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme)
Measured: 0 minutes before beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme)
Measured: 0 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme)
Measured: 60 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme)
Measured: 120 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme)
Measured: 180 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme)
Measured: 240 minutes after beverage consumption
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Feb 2024
- Study start23 Dec 2023
- Primary completion6 Sep 2024
- Study completion6 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HydrationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Semi-blinded, placebo controlled, crossover design
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Memphis
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Richard Bloomer, University of Memphis
- Investigators
- Richard Bloomer, PhD, Principal investigator, Center for Nutraceutical and Dietary Supplement Research
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06272435
- Sponsor's protocol ID
- PRO-FY2024-64
- Status last verified
- Dec 2024
- First submitted
- 1 Feb 2024
- Last updated
- 16 Dec 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Dec 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Beverage Hydration Index: Assessment of Four Rehydration Solutions
- ClinicalTrials.gov ID
- NCT06272435
- Acronym / sponsor ID
- PRO-FY2024-64
- Conditions
- Hydration
- Keywords
- Liquid IV, Electrolyte, Beverage Hydration Index
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- University of MemphisUniversity, hospital or other
- Study start
- 23 Dec 2023 (actual)
- Primary completion
- 6 Sep 2024 (actual)
- Study completion
- 6 Sep 2024 (actual)
- First posted
- 22 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.
Detailed description
Many attempts have been made to improve and measure the hydration status of active individuals. This typically involves the ingestion of fluids leading up to activity (typically plain water), as well as the ingestion of fluids during the activity itself (water, along with a diluted carbohydrate/electrolyte beverage). This approach seems to work well; however, some debate remains over what the best fluid is to consume, in particular related to the macronutrient type and the specific electrolyte mix.
No studies to date to evaluate the effects of the three different liquid IV electrolyte products on the beverage hydration index (BHI). Therefore, the purpose of this study is to determine the impact of three different LIV products (Hydration multiplier, Sugar Free formulation with Amino Acids, and Sugar Free with allulose) on hydration status in young and active men and women compared to a control (water). The study will follow the same approach as used by Maughan and colleagues (2016) to measure the fluid balance (the difference between the amount of water consumed and passed as urine) and BHI (the relative amount of urine passed after consumption of a drink compared to water) including time in positive fluid balance, as well as determining electrolyte concentrations, osmolality, specific gravity, and sodium and potassium in urine.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 24
- Model description
- Semi-blinded, placebo controlled, crossover design
| Arm | Type | Receives |
|---|---|---|
| Water, Multiplier, Sugar with Amino Acids, and Sugar Free | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Water, Multiplier, Sugar Free, and Sugar with Amino Acids | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Water, Sugar with Amino Acids, Multiplier, and Sugar Free | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Water, Sugar with Amino Acids, Sugar Free, and Multiplier | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Water, Sugar Free, Multiplier, and Sugar with Amino Acids | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Water, Sugar Free, Sugar with Amino Acids, and Multiplier | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Multiplier, Water, Sugar with Amino Acids, and Sugar Free | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Multiplier, Water, Sugar Free, and Sugar with Amino Acids | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Multiplier, Sugar with Amino Acids, Water, and Sugar Free | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Multiplier, Sugar with Amino Acids, Sugar Free, and Water | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Multiplier, Sugar Free, Water, and Sugar with Amino Acids | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Multiplier, Sugar Free, Sugar with Amino Acids, and Water | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar with Amino Acids, Water, Multiplier, and Sugar Free | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar with Amino Acids, Water, Sugar Free, and Multiplier | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar with Amino Acids, Multiplier, Water, and Sugar Free | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar with Amino Acids, Multiplier, Sugar Free, and Water | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar with Amino Acids, Sugar Free, Water, and Multiplier | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar with Amino Acids, Sugar Free, Multiplier, and Water | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar Free, Water, Multiplier, and Sugar with Amino Acids | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar Free, Water, Sugar with Amino Acids, and Multiplier | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar Free, Multiplier, Water, and Sugar with Amino Acids | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar Free, Multiplier, Sugar with Amino Acids, and Water | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar Free, Sugar with Amino Acids, Water, and Multiplier | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
| Sugar Free, Sugar with Amino Acids, Multiplier, and Water | Experimental | Dietary Supplement: Multiplier, Dietary Supplement: Sugar Free, Dietary Supplement: Sugar Free with Amino Acids, Dietary Supplement: WaterSubjects will follow control diet for 24 hours prior to visit. At the study visit, baseline measures will be collected prior to treatment. Subjects will then consume the assigned treatment (one treatment per visit in order above) and additional experimental measurements will be collected. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- body mass index (BMI) <35 kilgrams per square meter
- consistent dietary intake and exercise throughout study period
- consumes 2 liters (women) or 2.5 liters (men) of water per day prior to study visits
- able to fast for 15 hours
Key exclusion criteria (12 listed)
- sensitivity or be allergic to any components of the study product they will be excluded.
- tobacco user
- specialized diet (low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting, etc.)
- caffeine consumption within 12 hours of study visit
- strenuous activity within 24 hours of study visit
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MultiplierSubjects will consume 1 Liter (2 servings) of commercially available Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes. | Dietary supplement | Multiplier, Sugar Free, Sugar with Amino Acids, and Water, Multiplier, Sugar Free, Water, and Sugar with Amino Acids, Multiplier, Sugar with Amino Acids, Sugar Free, and Water, Multiplier, Sugar with Amino Acids, Water, and Sugar Free, Multiplier, Water, Sugar Free, and Sugar with Amino Acids, Multiplier, Water, Sugar with Amino Acids, and Sugar Free, Sugar Free, Multiplier, Sugar with Amino Acids, and Water, Sugar Free, Multiplier, Water, and Sugar with Amino Acids, Sugar Free, Sugar with Amino Acids, Multiplier, and Water, Sugar Free, Sugar with Amino Acids, Water, and Multiplier, Sugar Free, Water, Multiplier, and Sugar with Amino Acids, Sugar Free, Water, Sugar with Amino Acids, and Multiplier, Sugar with Amino Acids, Multiplier, Sugar Free, and Water, Sugar with Amino Acids, Multiplier, Water, and Sugar Free, Sugar with Amino Acids, Sugar Free, Multiplier, and Water, Sugar with Amino Acids, Sugar Free, Water, and Multiplier, Sugar with Amino Acids, Water, Multiplier, and Sugar Free, Sugar with Amino Acids, Water, Sugar Free, and Multiplier, Water, Multiplier, Sugar Free, and Sugar with Amino Acids, Water, Multiplier, Sugar with Amino Acids, and Sugar Free, Water, Sugar Free, Multiplier, and Sugar with Amino Acids, Water, Sugar Free, Sugar with Amino Acids, and Multiplier, Water, Sugar with Amino Acids, Multiplier, and Sugar Free, Water, Sugar with Amino Acids, Sugar Free, and Multiplier |
| Sugar FreeSubjects will consume 1 Liter (2 servings) of experimental Sugar Free Hydration Multiplier product at a rate of 250 milliliters per 7.5 minutes. | Dietary supplement | Multiplier, Sugar Free, Sugar with Amino Acids, and Water, Multiplier, Sugar Free, Water, and Sugar with Amino Acids, Multiplier, Sugar with Amino Acids, Sugar Free, and Water, Multiplier, Sugar with Amino Acids, Water, and Sugar Free, Multiplier, Water, Sugar Free, and Sugar with Amino Acids, Multiplier, Water, Sugar with Amino Acids, and Sugar Free, Sugar Free, Multiplier, Sugar with Amino Acids, and Water, Sugar Free, Multiplier, Water, and Sugar with Amino Acids, Sugar Free, Sugar with Amino Acids, Multiplier, and Water, Sugar Free, Sugar with Amino Acids, Water, and Multiplier, Sugar Free, Water, Multiplier, and Sugar with Amino Acids, Sugar Free, Water, Sugar with Amino Acids, and Multiplier, Sugar with Amino Acids, Multiplier, Sugar Free, and Water, Sugar with Amino Acids, Multiplier, Water, and Sugar Free, Sugar with Amino Acids, Sugar Free, Multiplier, and Water, Sugar with Amino Acids, Sugar Free, Water, and Multiplier, Sugar with Amino Acids, Water, Multiplier, and Sugar Free, Sugar with Amino Acids, Water, Sugar Free, and Multiplier, Water, Multiplier, Sugar Free, and Sugar with Amino Acids, Water, Multiplier, Sugar with Amino Acids, and Sugar Free, Water, Sugar Free, Multiplier, and Sugar with Amino Acids, Water, Sugar Free, Sugar with Amino Acids, and Multiplier, Water, Sugar with Amino Acids, Multiplier, and Sugar Free, Water, Sugar with Amino Acids, Sugar Free, and Multiplier |
| Sugar Free with Amino AcidsSubjects will consume 1 Liter (2 servings) of commercially available Sugar Free Hydration Multiplier product that contains amino acids at a rate of 250 milliliters per 7.5 minutes. | Dietary supplement | Multiplier, Sugar Free, Sugar with Amino Acids, and Water, Multiplier, Sugar Free, Water, and Sugar with Amino Acids, Multiplier, Sugar with Amino Acids, Sugar Free, and Water, Multiplier, Sugar with Amino Acids, Water, and Sugar Free, Multiplier, Water, Sugar Free, and Sugar with Amino Acids, Multiplier, Water, Sugar with Amino Acids, and Sugar Free, Sugar Free, Multiplier, Sugar with Amino Acids, and Water, Sugar Free, Multiplier, Water, and Sugar with Amino Acids, Sugar Free, Sugar with Amino Acids, Multiplier, and Water, Sugar Free, Sugar with Amino Acids, Water, and Multiplier, Sugar Free, Water, Multiplier, and Sugar with Amino Acids, Sugar Free, Water, Sugar with Amino Acids, and Multiplier, Sugar with Amino Acids, Multiplier, Sugar Free, and Water, Sugar with Amino Acids, Multiplier, Water, and Sugar Free, Sugar with Amino Acids, Sugar Free, Multiplier, and Water, Sugar with Amino Acids, Sugar Free, Water, and Multiplier, Sugar with Amino Acids, Water, Multiplier, and Sugar Free, Sugar with Amino Acids, Water, Sugar Free, and Multiplier, Water, Multiplier, Sugar Free, and Sugar with Amino Acids, Water, Multiplier, Sugar with Amino Acids, and Sugar Free, Water, Sugar Free, Multiplier, and Sugar with Amino Acids, Water, Sugar Free, Sugar with Amino Acids, and Multiplier, Water, Sugar with Amino Acids, Multiplier, and Sugar Free, Water, Sugar with Amino Acids, Sugar Free, and Multiplier |
| WaterSubjects will consume 1 Liter of water at a rate of 250 milliliters per 7.5 minutes. | Dietary supplement | Multiplier, Sugar Free, Sugar with Amino Acids, and Water, Multiplier, Sugar Free, Water, and Sugar with Amino Acids, Multiplier, Sugar with Amino Acids, Sugar Free, and Water, Multiplier, Sugar with Amino Acids, Water, and Sugar Free, Multiplier, Water, Sugar Free, and Sugar with Amino Acids, Multiplier, Water, Sugar with Amino Acids, and Sugar Free, Sugar Free, Multiplier, Sugar with Amino Acids, and Water, Sugar Free, Multiplier, Water, and Sugar with Amino Acids, Sugar Free, Sugar with Amino Acids, Multiplier, and Water, Sugar Free, Sugar with Amino Acids, Water, and Multiplier, Sugar Free, Water, Multiplier, and Sugar with Amino Acids, Sugar Free, Water, Sugar with Amino Acids, and Multiplier, Sugar with Amino Acids, Multiplier, Sugar Free, and Water, Sugar with Amino Acids, Multiplier, Water, and Sugar Free, Sugar with Amino Acids, Sugar Free, Multiplier, and Water, Sugar with Amino Acids, Sugar Free, Water, and Multiplier, Sugar with Amino Acids, Water, Multiplier, and Sugar Free, Sugar with Amino Acids, Water, Sugar Free, and Multiplier, Water, Multiplier, Sugar Free, and Sugar with Amino Acids, Water, Multiplier, Sugar with Amino Acids, and Sugar Free, Water, Sugar Free, Multiplier, and Sugar with Amino Acids, Water, Sugar Free, Sugar with Amino Acids, and Multiplier, Water, Sugar with Amino Acids, Multiplier, and Sugar Free, Water, Sugar with Amino Acids, Sugar Free, and Multiplier |
Primary outcome
Beverage Hydration Index
Time frame: 0 minutes after beverage consumption
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Beverage Hydration Index
Time frame: 60 minutes after beverage consumption
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Beverage Hydration Index
Time frame: 120 minutes after beverage consumption
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Beverage Hydration Index
Time frame: 180 minutes after beverage consumption
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
Beverage Hydration Index
Time frame: 240 minutes after beverage consumption
Beverage Hydration index calculated as mass of urine collected following control (water) consumption divided by the mass of urine collected following treatment.
48 secondary outcomes
Net Fluid Balance
Time frame: 0 minutes after beverage consumption
Net Fluid Balance
Time frame: 60 minutes after beverage consumption
Net Fluid Balance
Time frame: 120 minutes after beverage consumption
Net Fluid Balance
Time frame: 180 minutes after beverage consumption
Net Fluid Balance
Time frame: 240 minutes after beverage consumption
Urine Osmolality
Time frame: 0 minutes before beverage consumption
Urine Osmolality
Time frame: 0 minutes after beverage consumption
Urine Osmolality
Time frame: 60 minutes after beverage consumption
Urine Osmolality
Time frame: 120 minutes after beverage consumption
Urine Osmolality
Time frame: 180 minutes after beverage consumption
Urine Osmolality
Time frame: 240 minutes after beverage consumption
Urine Sodium
Time frame: 0 minutes before beverage consumption
Urine Sodium
Time frame: 0 minutes after beverage consumption
Urine Sodium
Time frame: 60 minutes after beverage consumption
Urine Sodium
Time frame: 120 minutes after beverage consumption
Urine Sodium
Time frame: 180 minutes after beverage consumption
Urine Sodium
Time frame: 240 minutes after beverage consumption
Urine Potassium
Time frame: 0 minutes before beverage consumption
Urine Potassium
Time frame: 0 minutes after beverage consumption
Urine Potassium
Time frame: 60 minutes after beverage consumption
Urine Potassium
Time frame: 120 minutes after beverage consumption
Urine Potassium
Time frame: 180 minutes after beverage consumption
Urine Potassium
Time frame: 240 minutes after beverage consumption
Urine Specific Gravity
Time frame: 150 minutes before beverage consumption
Urine Specific Gravity
Time frame: 0 minutes before beverage consumption urine
Urine Specific Gravity
Time frame: 0 minutes after beverage consumption urine
Urine Specific Gravity
Time frame: 60 minutes after beverage consumption urine
Urine Specific Gravity
Time frame: 120 minutes after beverage consumption urine
Urine Specific Gravity
Time frame: 180 minutes after beverage consumption urine
Urine Specific Gravity
Time frame: 240 minutes after beverage consumption urine
Sodium balance
Time frame: 0 minutes after beverage consumption
Sodium balance
Time frame: 60 minutes after beverage consumption
Sodium balance
Time frame: 120 minutes after beverage consumption
Sodium balance
Time frame: 180 minutes after beverage consumption
Sodium balance
Time frame: 240 minutes after beverage consumption
Potassium balance
Time frame: 0 minutes after beverage consumption
Potassium balance
Time frame: 60 minutes after beverage consumption
Potassium balance
Time frame: 120 minutes after beverage consumption
Potassium balance
Time frame: 180 minutes after beverage consumption
Potassium balance
Time frame: 240 minutes after beverage consumption
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Dec 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Richard Bloomer, PhD principal investigator
Center for Nutraceutical and Dietary Supplement Research
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multiplier, Sugar Free and Sugar Free with Amino Acids in people with Hydration, run by University of Memphis at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Dec 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Beverage Hydration Index (time frame: 0 minutes after beverage consumption). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Dec 2024.