VapingNCT06274723

Responses to E-cigarette Message Source and Presentation

A study testing Expert, one-sided, Expert, two-sided and Peer, one-sided in people with Vaping, run by University of Massachusetts, Worcester at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who vape and do not vape. Read more about this study

Who is it for?: Ages 18 to 24 yearsHealthy volunteers can take part
Conditions the study is for: Vaping
What is being tested?: Expert, one-sided, Expert, two-sided and Peer, one-sided
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 848 participants
Where: 1 siteUnited States
Study dates: 5 Nov 2024to 17 Dec 2024
Phase: Interventional
Are there results?: Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 24 years
All sexes
Healthy volunteers accepted
Adult

Who may be able to join

US residents ages 18-24
Fluent in English
Reporting either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping

Who cannot join

Age less than 18 or above 24
Not fluent in English
Not a member of partnering crowdsourcing behavioral research platform conducting the study

Trial locations and contacts

1 site in 1 country.

United States1 site

UMass Chan Medical School
Worcester, Massachusetts, 01605

Other trials in United States

About this study

Official title: Identifying and Examining the Effects of Source and Presentation on Responses to Electronic Cigarette Public Education Messages in Young Adult Vapers and Non-vapers - Part 1

Conditions: Vaping
Being tested: Expert, one-sided, Expert, two-sided, Peer, one-sided, Peer, two-sided
Medical subject headings: Vaping

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Expert, one-sidedOther
Participants will view a brief description of an expert source and see one-sided e-cigarette education messages.
Expert, two-sidedOther
Participants will view a brief description of an expert source and see two-sided e-cigarette education messages.
Peer, one-sidedOther
Participants will view a brief description of a peer source and see one-sided e-cigarette education messages.
Peer, two-sidedOther
Participants will view a brief description of a peer source and see two-sided e-cigarette education messages.

Study groups in NCT06274723
Study group	Role	What they receive
Expert, one-sided	Experimental	Participants assigned to the expert, one-sidedness condition will receive one-sided e-cigarette messages from an expert source. Receives: Other: Expert, one-sided
Expert, two-sided	Experimental	Participants assigned to the expert, two-sidedness condition will receive two-sided e-cigarette messages from an expert source. Receives: Other: Expert, two-sided
Peer, one-sided	Experimental	Participants assigned to the peer, one-sidedness condition will receive one-sided e-cigarette messages from a peer source. Receives: Other: Peer, one-sided
Peer, two-sided	Experimental	Participants assigned to the peer, two-sidedness condition will receive two-sided e-cigarette messages from a peer source. Receives: Other: Peer, two-sided

What is being measured

The primary outcome is the main question the study is designed to answer.

Message Acceptance
Participants' self-reported message acceptance were measured by using a five-point Likert scale using five items assessing whether participants thought the message was worth remembering, grabbed their attention, powerful, convincing, and meaningful on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more more message acceptance, therefore better outcomes.
Measured: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Harm Perceptions
Harm perceptions was measured by a single item e-cigarette harm perceptions question assessing participants' perceived absolute harm of e-cigarette use on a scale from 1 (Not at all harmful) to 10 (Very harmful). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping harm perceptions, therefore indicating better outcome.
Measured: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.

Secondary outcomes (6)

Negative Cognition
Negative cognition was measured by six-item reactance questionnaire, such as perceptions of messages being manipulative, misleading, distorted, overblown, exaggerated, and overstated on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Higher scores indicate greater negative cognition, indicating worse outcome.
Measured: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Message Anger
Message anger was measured by four item message anger question assessing the extent to which the messages made participants feel irritated, angry, annoyed, and aggravated on a scale from 1 (not at all) to 5 (very much). Items were summed and averaged. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater anger toward messages, indicating worse outcomes.
Measured: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Message Liking
Message liking will be measured by a single-item liking of the message on scale from 1 (Dislike very much) to 5 (Like very much). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater message liking, therefore indicating better outcome.
Measured: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Source Trust
Source trust was measured by a single-item trust in health information source questionnaire, such as trust in source about vaping information on a scale from 1(Not at all) to 5 (Very much so). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater source trust, therefore indicating better outcome
Measured: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Attitudes
Participants' self-reported vaping attitudes were measured by using a five-point bipolar scale using 7 subscale items assessing whether participants thought vaping was enjoyable, healthy, safe, fun, smart, cool, and attractive on a scale from 1 (negative attitudes) to 5 (positive attitudes). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more positive e-cigarette attitudes, therefore worse outcomes.
Measured: After exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.
Behavioral Intentions to Vape or Try Vaping
Participants' vaping or vaping trial intentions were measured by using a 3 subscale items assessing participants' intentions to vape: soon/anytime during the next year/would use offered by one of their best friends, on a scale from 1 (Definitely not) to 5 (Definitely yes). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping intentions, therefore indicating worse outcome.
Measured: After exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

5 Nov 202417 Dec 2024

First posted23 Feb 2024
Study start5 Nov 2024
Primary completion5 Dec 2024
Study completion17 Dec 2024

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
Other trials for VapingStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Health services research
Allocation: Randomised
Intervention model: Factorial
Masking: None (open label)
Enrolment: 848 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06274723
Sponsor's protocol ID: STUDY00001220
Other IDs: 1K99CA281094-01A1
Status last verified: Dec 2025
First submitted: 17 Jan 2024
Last updated: 14 Jan 2026
Results posted: Yes, on ClinicalTrials.gov
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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All Vaping trials

Study at a glance

From the registry record, last updated by the sponsor on 14 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Identifying and Examining the Effects of Source and Presentation on Responses to Electronic Cigarette Public Education Messages in Young Adult Vapers and Non-vapers - Part 1
ClinicalTrials.gov ID: NCT06274723
Acronym / sponsor ID: STUDY00001220
Conditions: Vaping
Study type: Interventional
Recruitment status: Completed
Enrolment: 848 participants (actual)
Lead sponsor: University of Massachusetts, WorcesterUniversity, hospital or other
Collaborators: National Cancer Institute (NCI)
Study start: 5 Nov 2024 (actual)
Primary completion: 5 Dec 2024 (actual)
Study completion: 17 Dec 2024 (actual)
First posted: 23 Feb 2024 (actual)
Results: Posted 14 Jan 2026

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Study design

Primary purpose: Health services research
Allocation: Randomised
Intervention model: Factorial
Masking: None (open label)
Number of arms: 4

Arm	Type	Receives
Expert, one-sided	Experimental	Other: Expert, one-sidedParticipants assigned to the expert, one-sidedness condition will receive one-sided e-cigarette messages from an expert source.
Expert, two-sided	Experimental	Other: Expert, two-sidedParticipants assigned to the expert, two-sidedness condition will receive two-sided e-cigarette messages from an expert source.
Peer, one-sided	Experimental	Other: Peer, one-sidedParticipants assigned to the peer, one-sidedness condition will receive one-sided e-cigarette messages from a peer source.
Peer, two-sided	Experimental	Other: Peer, two-sidedParticipants assigned to the peer, two-sidedness condition will receive two-sided e-cigarette messages from a peer source.

Who may qualify

Ages: 18 to 24 years
Sex: All
Healthy volunteers: Accepted
Age groups: Adult

Key inclusion criteria (3 listed)

US residents ages 18-24
Fluent in English
Reporting either vaping in the past 30 days or not having vaped in the past 30 days but susceptible to vaping

Key exclusion criteria (3 listed)

Age less than 18 or above 24
Not fluent in English
Not a member of partnering crowdsourcing behavioral research platform conducting the study

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Expert, one-sidedParticipants will view a brief description of an expert source and see one-sided e-cigarette education messages.	Other	Expert, one-sided
Expert, two-sidedParticipants will view a brief description of an expert source and see two-sided e-cigarette education messages.	Other	Expert, two-sided
Peer, one-sidedParticipants will view a brief description of a peer source and see one-sided e-cigarette education messages.	Other	Peer, one-sided
Peer, two-sidedParticipants will view a brief description of a peer source and see two-sided e-cigarette education messages.	Other	Peer, two-sided

Primary outcome

Message Acceptance
Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Participants' self-reported message acceptance were measured by using a five-point Likert scale using five items assessing whether participants thought the message was worth remembering, grabbed their attention, powerful, convincing, and meaningful on a scale from 1 (Strongly disagree) to 5 (Strongly agree). Items were summed and averaged to create a single composite score, and this was done for each arm for each vaping status. Higher scores indicate more more message acceptance, therefore better outcomes.
Harm Perceptions
Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Harm perceptions was measured by a single item e-cigarette harm perceptions question assessing participants' perceived absolute harm of e-cigarette use on a scale from 1 (Not at all harmful) to 10 (Very harmful). Items were summed and averaged to create a single composite score. This was done for each vaping status (current vapers and susceptible non-vapers). Higher scores indicate greater vaping harm perceptions, therefore indicating better outcome.

6 secondary outcomes

Negative Cognition
Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Message Anger
Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Message Liking
Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Source Trust
Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.
Attitudes
Time frame: After exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.
Behavioral Intentions to Vape or Try Vaping
Time frame: After exposure to all messages (approximately up to 45 minutes), measured during a single study visit on Day 1.

Results and safety

Results posted to the registry on 14 Jan 2026, as reported by the sponsor. Figures are copied from the record, not re-analysed. Full results on ClinicalTrials.gov.

Participant flow

Group	Started	Completed
Expert, One-Sided	209	191
Expert, Two-Sided	208	197
Peer, One-Sided	210	203
Peer, Two-Sided	210	194

Primary outcome: Message Acceptance

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.. Mean (Standard Deviation). Unit: units on a scale

Measure	Expert, One-Sided n = 182	Expert, Two-Sided n = 186	Peer, One-Sided n = 189	Peer, Two-Sided n = 182
Current vapers	3.01 (0.01)	3.00 (0.01)	2.88 (0.01)	2.76 (0.01)
Susceptible non-vapers	2.94 (0.09)	2.77 (0.03)	2.77 (0.09)	2.72 (0.09)

Population analysed: The data were stratified based on participants' vaping status ("Current vapers" and "Susceptible non-vapers"). The Number of Participants Analyzed for each row reflects the actual number of participants within that vaping status group who were included in the analysis. The Overall Number of Participants Analyzed represents the total number of both subgroups. Any differences have been clarified to specify participant numbers at the row level.

Primary outcome: Harm Perceptions

Time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.. Mean (Standard Deviation). Unit: units on a scale

Measure	Expert, One-Sided n = 182	Expert, Two-Sided n = 186	Peer, One-Sided n = 189	Peer, Two-Sided n = 182
Current vapers	7.39 (0.20)	7.45 (0.19)	7.27 (0.19)	7.44 (0.20)
Susceptible non-vapers	8.05 (0.19)	8.04 (0.20)	8.04 (0.20)	7.82 (0.19)

6 secondary outcomes are reported in the full results.

Adverse events

Time frame: Each adverse event or serious adverse event was monitored and assessed throughout the entire duration of the participant's study participation, from the moment a participant clicked on the study link until the study completed, which lasted approximately 45 minutes per participant during a single study visit on Day 1.. Other adverse events reported at 0% frequency or more

Group	Serious adverse events	Other adverse events	Deaths
Expert, One-sided	0 of 191 (0%)	0 of 191 (0%)	0 of 191
Expert, Two-sided	0 of 197 (0%)	0 of 197 (0%)	0 of 197
Peer, One-sided	0 of 203 (0%)	0 of 203 (0%)	0 of 203
Peer, Two-sided	0 of 194 (0%)	0 of 194 (0%)	0 of 194

Loading the posted results from ClinicalTrials.gov…

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 14 Jan 2026.
Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Individual participant dataSharing planned: No

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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Donghee N Lee, PhD principal investigator

UMass Chan Medical School

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Expert, one-sided, Expert, two-sided and Peer, one-sided in people with Vaping, run by University of Massachusetts, Worcester at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 14 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 14 Jan 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Message Acceptance (time frame: After exposure to each messages (approximately up to 20 minutes total), measured during a single study visit on Day 1.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06274723.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jan 2026.