HealthyMARA-TRAILNCT06282341
Fatigue and Recovery: a Comparison Between Trail and Marathon
A study testing Race: Simulated marathon, Race: Simulated trail and Race: Trail in nature in people with Healthy, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
Trial summary
Road marathon is a famous running race known for hundreds of years. Trail running is an emerging running discipline which count new runners every year. Trail running and road marathon are two running endurance disciplines which differed by variation of elevation and nature of the terrain. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Race: Simulated marathon, Race: Simulated trail and Race: Trail in nature
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 46 participants
- Where
- 1 siteFrance
- Study dates
- 28 Dec 2023to 17 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Common for MARASIM, TRAILSIM and TRAILNAT:
- Male or female
- 18-55 years old
- Endurance runners who run at least one running session of 20 km per week
- Being able to run a marathon under 5 h or finishing a trail of 30 km during the last 3 years
- Refrain from participating to a competition one month before the first visit and during the duration of the study
Show all 12Show fewer
- To have a medical certificate of no contraindication of running practise in competition
- Registered with a social security scheme
- Having given the written consent freely
- Specific for the 3 groups :
- Specialist of trail running (TRAILSIM and TRAILNAT)
- Specialist of road running (MARASIM)
Who cannot join
- Subjects who present cardiac or articular chronic pathologies (example: repeated sprain, patellar or joint problems)
- Subjects who present chronic or central neurological pathologies
- Subjects deprived of liberty or who should be legally deprived
- Subjects who report to take forbidden products by the World Anti-Doping Agency
- pregnant or breastfeeding woman
Trial locations and contacts
1 site in 1 country.
France1 site
Unités de Myologie et de Médecine du Sport
Saint-Etienne, France, 42055
About this study
Road marathon is a famous running race known for hundreds of years. Trail running is an emerging running discipline which count new runners every year. Trail running and road marathon are two running endurance disciplines which differed by variation of elevation and nature of the terrain. While marathon is essentially run on flat roads, trail races are realized on steep paths (mountain, desert…) with an important variation of elevation. Neuromuscular, biomechanical and physiological consequences are different depending on the discipline, especially with a greater eccentric contribution in trail running. In spite of this characteristic, trail runners take part in several races longer than 40 km per year, while road runners participate in one to two marathons per year.
Read the detailed description
Some studies focused on fatigue and recovery following 30-to-40-km trail races or marathon but no direct comparison between both disciplines have been done yet. A direct comparison between marathon and trail would aim to better understand if the occurrence of fatigue is more important or if the recovery is longer in one of the two disciplines. The comparison is also a way to better understand mechanisms involved in fatigue and recovery following a trail and a marathon. Then, this research could be applied to improve specificity of training and prevent risk of injuries. This project aims to compare fatigue and recovery following a trail and a marathon.
- Conditions
- Healthy
- Being tested
- Race: Simulated marathon, Race: Simulated trail, Race: Trail in nature
- Keywords
- Running, Marathon, Trail, Fatigue
- Medical subject headings
- Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Race: Simulated marathonOther
Participants will take part in a race: simulated marathon. Before, during, immediately after and the month after the race, neuromuscular, physiological and biomechanical assessments will take place.
Race: Simulated trailOther
Participants will take part in a race: simulated trail. Before, during, immediately after and the month after the race, neuromuscular, physiological and biomechanical assessments will take place.
Race: Trail in natureOther
Participants will take part in a race: trail in nature. Before, during, immediately after and the month after the race, neuromuscular, physiological and biomechanical assessments will take place.
| Study group | Role | What they receive |
|---|---|---|
| MARASIM | Active comparator | During visit 2, road runners will take part in a simulated marathon race on a treadmill. Receives: Other: Race: Simulated marathon |
| TRAILSIM | Active comparator | During visit 2, trail runners will take part in a simulated trail race on a treadmill. Receives: Other: Race: Simulated trail |
| TRAILNAT | Active comparator | During visit 2, trail runners will take part in a real trail race in the nature. Receives: Other: Race: Trail in nature |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in knee extensors maximal isometric torque output
The primary outcome will be changed (in % of baseline value) of the maximal voluntary torque (in Nm) produced by the knee extensors, measured at D0 (= day of the race) with an isometric knee dynamometer (ARS dynamometry, SP2, Ltd., Ljubljana, Slovenia), before (baseline value = 30 minutes before the race) and at the end (15 minutes after the race) of a marathon or a trail (depending on the group)
Measured: Day 0 (day of the race) baseline value = 30 minutes before the race and 15 minutes after the race
Secondary outcomes (19)
Change in plantar flexor maximal isometric torque output
Change (in % of baseline value) of the maximal voluntary torque (in Nm) produced by the plantar flexor measured at D0, by an instrumental pedal placed at 45 degrees with respect to the horizontal (ATI Industrial Automation, Inc., Apex, North Carolina USA), before (baseline value) and at the end of a marathon or a trail (depending on the group), and during recovery at Day1 Day2 Day7).
Measured: Day 0 (day of the race) baseline value = 30 minutes before the race and 15 minutes after the race, Days 1, 2, 7
Recovery of quadriceps maximal isometric torque output the month after the race
Change (in % of post-exercise baseline value) of the maximal voluntary torque (in Nm) produced by the knee extensors, measured with an isometric knee dynamometer (ARS dynamometry, SP2, Ltd., Ljubljana, Slovenia), during recovery at Day 1 Day 2 Day 7).
Measured: Day 0 (day of the race) baseline value = 30 minutes before the race, (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Voluntary activation level
Voluntary activation level (in %) of the plantar flexors and knee extensors will be assessed through neuromuscular assessments before, in the middle (except for the trail in the nature), after the marathon or trail of equivalent effort, and during recovery (Day 1, Day 2, and Day 7).
Voluntary activation level will be calculated as followed:
VA (%) = (1- (superimposed Db100/ resting Db100))x100
Measured: D0 (day of the race) baseline value = 30 min before the race, in the middle of the race (except for the trail in the nature) and 15 min after the race;D1 = 24h after the end of the race , D2 = 48h after the end of the race, D7 = 7 days after the end
Force assessed in dynamic
Force assessed in dynamic mode on a cycloergometer (Monark, Vansbro, Sweden) composed of strain gauges, a flywheel, a belt and an optical encoder allowing data collection. Force (N) will be measured in order to establish a force-velocity / power- velocity profile at Day 0 15 min before the race, after the marathon or trail ( 1 hour after the end) of equivalent effort, and during recovery (Day 1 (= 24h after the end of the race) , Day 2 (= 48 h after the end of the race), Day 7 (= 7 days after the end of the race).
Measured: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Velocity assessed in dynamic
Velocity assessed in dynamic mode on a cycloergometer (Monark, Vansbro, Sweden) composed of strain gauges, a flywheel, a belt and an optical encoder allowing data collection. Speed (rad/s) will be measured in order to establish a force-velocity / power-velocity profile before (=15 minutes before the race), after the marathon or trail (=1 hour after the end) of equivalent effort, and during recovery (Day 1 = 24hours after the end of the race, Day 2 = 48hours after the end of the race, Day 7 = 7 days after the end of the race).
Measured: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Power assessed in dynamic
Power assessed in dynamic mode on a cycloergometer (Monark, Vansbro, Sweden) composed of strain gauges, a flywheel, a belt and an optical encoder allowing data collection. Power (W) will be measured in order to establish a force-velocity / power-velocity profile before (=15 minutes before the race), after the marathon or trail (=1 hour after the end) of equivalent effort, and during recovery (Day 1 = 24hours after the enf of the race, Day 2 = 45hours after the end of the race, Day 7= 7 days after the race).
Measured: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscular power and stretch-shortening cycle assessed through squat jumps
Muscular power and stretch-shortening cycle assessed through squat jump ; Height (m) and duration (s) of jumps are calculated through force platform (90 x90 cm, Model 9287C, Kisler, Winterthur, Switzerland).
Measured: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscular power and stretch-shortening cycle assessed through countermovement jump
Muscular power and stretch-shortening cycle assessed through countermovement. Height (meter) and duration (seconde) of jumps are calculated through force platform (90 x90 centimeter, Model 9287C, Kisler, Winterthur, Switzerland)
Measured: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscular power and stretch-shortening cycle assessed through drop jump
Muscular power and stretch-shortening cycle assessed through drop jump. Height (m) and duration (s) of jumps are calculated through force platform (90 x90 cm, Model 9287C, Kisler, Winterthur, Switzerland)
Measured: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscle electrical activity
Muscle electrical activity (Trigno avanti Sensor, Delsys, Natick, MA including electrodes connected to thin-10-cm-long cables) are measured
Measured: Day 0: 30 minutes before the race, in the middle (except for the trail in the nature) 15 minutes after the end of the race
The kinetics of energy cost
The kinetics of energy cost (Ccr en J/kg/m) measured using a portable gas exchange measurement system (Ergospirometer Metamax 3B®, Cortex Medical, Leipzig, Germany) 1h30 before the race, in the middle (except for the trail in the nature) and 30 min after the race the marathon or simulated trail and during recovery Day 1, Day 2, Day 7 7)7).measurement system (Ergospirometer Metamax 3B®, Cortex Medical, Leipzig, Germany)
Measured: Day 0 1 hour 30 minutes before the race,in the middle, 30 minutes after the end of the race, and during recovery (Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Racing kinematics
Evolution of moments and hip joint angles, knee and ankle measured by a Markerless tracking system will be measured
1 hour before the race , in the middle (except for the trail in the nature), immediately after the simulated trail or marathon, and during recovery (Day 1 (= 24hours after the end of the race) , Day 2 (= 48hours after the end of the race), Day 7 (= 7 days after the end of the race).
Measured: 1 hour before, in the middle and immediately after the race and during recovery(Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Ground reaction force (in Newton)
Force will be measured by force platforms contained in the treadmill (h/p/Cosmos-Stellar, Germany). to get the ground reaction forces at each step 1hour before, in the middle (except for the trail in the nature) and immediately after the race and during recovery(Day 1 (= 24hours after the end of the race) , Day 2 (= 48hours after the end of the race), Day 7 (= 7 days after the end of the race).
Measured: 1hour before, in the middle (except for the trail in the nature) and immediately after the race and during recovery(Day 1 (= 24hours after the end of the race) , Day 2 (= 48hours after the end of the race), Day 7 (= 7 days after the end of the race).
Center of pressure (in Newton)
Force will be measured by force platforms contained in the treadmill (h/p/Cosmos-Stellar, Germany). to get the center of pressure each step before (=1 hour before), in the middle (except for the trail in the nature), after (=immediately after the race) the simulated trail or marathon, and during recovery (Day 1 = 24 hours after the race, Day 2 = 48 hours after the race, Day 7 = 7 days after the race)
Measured: 1hour before, in the middle (except for the trail in the nature) and immediately after the race and during recovery(Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscle damage blood markers
Witness muscle damage following a marathon or a trail of equivalent effort. Biological variables are taken 2h before the race and 2 h after the race: a marathon or a trail of equivalent effort, and during recovery ((Day 1 (= 24h after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race). Followed i- Inflammatory parameters are taken through blood test (2 tubes of 5 ml/blood test): ionogram (sodium [mmol/l], potassium [mmol/l], chlorine [mmol/l], bicarbonates [mmol/l], urea [mmol/l], creatinine [µmol/l], glucose [mmol/l], proteins [g/l], uric acid [[µmol/l ], osmolality [m0smol/kg]; Creatine Kinase (UI/l)myoglobine [µg/l ], C reactive Protein [mg/l], lactate [mmol/l]
Measured: Day 0: 2hours before the race, 2hours after the race and during recovery (Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Resting heart rate variability parameters
Evolution of resting heart rate variability, a marker of psychophysiological recovery will be assessed through a Polar H10 heart rate monitor before the race (at least 3 times in the 2 weeks before the race) and during recovery (at least every two days until one month after the race).
Analysis of time domain and frequency domain variables via measurement of heart rate variability will be achieved through HRV analysis software.
Measured: 3 times in the 2 weeks before the race and every other day for the month following the race
Effort perception
Perception of effort will be assessed during the marathon or trail of equivalent effort every 5 km effort on the modified Borg scale (from 0 - rest to 10 - Maximal perceived effort).
Measured: D0 (day of the race) : during the race, every 5 kilometers effort
Fatigue assessment
Fatigue assessment will be carried out before (=once during the 2 weeks before the race) the marathon or trail of equivalent effort , immediately after and during recovery (Day 1 = 24 hours after the race, Day 2 = 48 hours after the race, Day 3 = 72 hours after the race, Day 4 = 4 days after the race, Day 5 = 5 days after the race, Day 6 = 6 days after the race, Day 7 = 7 days after the race, Day 14 = 14 days after the race, Day 21 = 21 days after the race, Day 30 = 30 days after the race) via the of the "Rating scale of fatigue " (from 0 - Not fatigued at all to 10 - Total exhaustion nothing left).
Measured: Once during 2 weeks before, immediately after the race and during recovery (Day 1 = 24 hours after the race, Day 2 = 48 hours after, Day 3 = 72 hours after, Day 4, Day 5, Day 6, Day 7, Day 14, Day 21 and Day 30 after the race
Muscular pain
Muscle pain felt in the quadriceps and calves will be rated on a visual analog scale ranging from 0 (No muscular pain at all) at 10 (Unbearable muscle pain) during the marathon or trail of equivalent effort every 5 km-effort
Measured: Day 0 (day of the race) : during the race, every 5 kilometers effort
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Feb 2024
- Study start28 Dec 2023
- Primary completion3 Dec 2025
- Study completion17 Dec 2025
Why it stopped: Official premature termination is failure to be included in the marathon group.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de Saint EtienneThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Prospective study on healthy volunteers, comparing the neurophysiological, physiological and biomechanical effects at the end of a marathon compared with an equivalent effort trail in the open air, or simulated on a treadmill, in runners specialising in each of the 2 disciplines
- Masking
- None (open label)
- Enrolment
- 46 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Leonard FEASSON, MD PhD, Principal investigator, Centre Hospitalier Universitaire de Saint Etienne
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06282341
- Sponsor's protocol ID
- 23CH132
- Acronym
- MARA-TRAIL
- Status last verified
- Mar 2026
- First submitted
- 23 Oct 2023
- Last updated
- 11 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Fatigue and Recovery: a Comparison Between Trail and Marathon
- ClinicalTrials.gov ID
- NCT06282341
- Acronym / sponsor ID
- MARA-TRAIL / 23CH132
- Conditions
- Healthy
- Keywords
- Running, Marathon, Trail, Fatigue
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: Official premature termination is failure to be included in the marathon group.
- Enrolment
- 46 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de Saint EtienneUniversity, hospital or other
- Study start
- 28 Dec 2023 (actual)
- Primary completion
- 3 Dec 2025 (actual)
- Study completion
- 17 Dec 2025 (actual)
- First posted
- 28 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Road marathon is a famous running race known for hundreds of years. Trail running is an emerging running discipline which count new runners every year. Trail running and road marathon are two running endurance disciplines which differed by variation of elevation and nature of the terrain. While marathon is essentially run on flat roads, trail races are realized on steep paths (mountain, desert…) with an important variation of elevation. Neuromuscular, biomechanical and physiological consequences are different depending on the discipline, especially with a greater eccentric contribution in trail running. In spite of this characteristic, trail runners take part in several races longer than 40 km per year, while road runners participate in one to two marathons per year.
Detailed description
Some studies focused on fatigue and recovery following 30-to-40-km trail races or marathon but no direct comparison between both disciplines have been done yet. A direct comparison between marathon and trail would aim to better understand if the occurrence of fatigue is more important or if the recovery is longer in one of the two disciplines. The comparison is also a way to better understand mechanisms involved in fatigue and recovery following a trail and a marathon. Then, this research could be applied to improve specificity of training and prevent risk of injuries. This project aims to compare fatigue and recovery following a trail and a marathon.
Study design
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- Prospective study on healthy volunteers, comparing the neurophysiological, physiological and biomechanical effects at the end of a marathon compared with an equivalent effort trail in the open air, or simulated on a treadmill, in runners specialising in each of the 2 disciplines
| Arm | Type | Receives |
|---|---|---|
| MARASIM | Active comparator | Other: Race: Simulated marathonDuring visit 2, road runners will take part in a simulated marathon race on a treadmill. |
| TRAILSIM | Active comparator | Other: Race: Simulated trailDuring visit 2, trail runners will take part in a simulated trail race on a treadmill. |
| TRAILNAT | Active comparator | Other: Race: Trail in natureDuring visit 2, trail runners will take part in a real trail race in the nature. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (12 listed)
- Male or female
- 18-55 years old
- Endurance runners who run at least one running session of 20 km per week
- Being able to run a marathon under 5 h or finishing a trail of 30 km during the last 3 years
- Refrain from participating to a competition one month before the first visit and during the duration of the study
Key exclusion criteria (5 listed)
- Subjects who present cardiac or articular chronic pathologies (example: repeated sprain, patellar or joint problems)
- Subjects who present chronic or central neurological pathologies
- Subjects deprived of liberty or who should be legally deprived
- Subjects who report to take forbidden products by the World Anti-Doping Agency
- pregnant or breastfeeding woman
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Race: Simulated marathonParticipants will take part in a race: simulated marathon. Before, during, immediately after and the month after the race, neuromuscular, physiological and biomechanical assessments will take place. | Other | MARASIM |
| Race: Simulated trailParticipants will take part in a race: simulated trail. Before, during, immediately after and the month after the race, neuromuscular, physiological and biomechanical assessments will take place. | Other | TRAILSIM |
| Race: Trail in natureParticipants will take part in a race: trail in nature. Before, during, immediately after and the month after the race, neuromuscular, physiological and biomechanical assessments will take place. | Other | TRAILNAT |
Primary outcome
Change in knee extensors maximal isometric torque output
Time frame: Day 0 (day of the race) baseline value = 30 minutes before the race and 15 minutes after the race
The primary outcome will be changed (in % of baseline value) of the maximal voluntary torque (in Nm) produced by the knee extensors, measured at D0 (= day of the race) with an isometric knee dynamometer (ARS dynamometry, SP2, Ltd., Ljubljana, Slovenia), before (baseline value = 30 minutes before the race) and at the end (15 minutes after the race) of a marathon or a trail (depending on the group)
19 secondary outcomes
Change in plantar flexor maximal isometric torque output
Time frame: Day 0 (day of the race) baseline value = 30 minutes before the race and 15 minutes after the race, Days 1, 2, 7
Recovery of quadriceps maximal isometric torque output the month after the race
Time frame: Day 0 (day of the race) baseline value = 30 minutes before the race, (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Voluntary activation level
Time frame: D0 (day of the race) baseline value = 30 min before the race, in the middle of the race (except for the trail in the nature) and 15 min after the race;D1 = 24h after the end of the race , D2 = 48h after the end of the race, D7 = 7 days after the end
Force assessed in dynamic
Time frame: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Velocity assessed in dynamic
Time frame: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Power assessed in dynamic
Time frame: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscular power and stretch-shortening cycle assessed through squat jumps
Time frame: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscular power and stretch-shortening cycle assessed through countermovement jump
Time frame: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day1 (= 24 hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscular power and stretch-shortening cycle assessed through drop jump
Time frame: Day 0 15 minutes before the race, after the marathon or trail ( 1 hour after the end), and during recovery (Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscle electrical activity
Time frame: Day 0: 30 minutes before the race, in the middle (except for the trail in the nature) 15 minutes after the end of the race
The kinetics of energy cost
Time frame: Day 0 1 hour 30 minutes before the race,in the middle, 30 minutes after the end of the race, and during recovery (Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Racing kinematics
Time frame: 1 hour before, in the middle and immediately after the race and during recovery(Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Ground reaction force (in Newton)
Time frame: 1hour before, in the middle (except for the trail in the nature) and immediately after the race and during recovery(Day 1 (= 24hours after the end of the race) , Day 2 (= 48hours after the end of the race), Day 7 (= 7 days after the end of the race).
Center of pressure (in Newton)
Time frame: 1hour before, in the middle (except for the trail in the nature) and immediately after the race and during recovery(Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Muscle damage blood markers
Time frame: Day 0: 2hours before the race, 2hours after the race and during recovery (Day 1 (= 24hours after the end of the race) , Day 2 (= 48 hours after the end of the race), Day 7 (= 7 days after the end of the race).
Resting heart rate variability parameters
Time frame: 3 times in the 2 weeks before the race and every other day for the month following the race
Effort perception
Time frame: D0 (day of the race) : during the race, every 5 kilometers effort
Fatigue assessment
Time frame: Once during 2 weeks before, immediately after the race and during recovery (Day 1 = 24 hours after the race, Day 2 = 48 hours after, Day 3 = 72 hours after, Day 4, Day 5, Day 6, Day 7, Day 14, Day 21 and Day 30 after the race
Muscular pain
Time frame: Day 0 (day of the race) : during the race, every 5 kilometers effort
Results and safety
The study was stopped early (reason given: Official premature termination is failure to be included in the marathon group.). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Leonard FEASSON, MD PhD principal investigator
Centre Hospitalier Universitaire de Saint Etienne
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Race: Simulated marathon, Race: Simulated trail and Race: Trail in nature in people with Healthy, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 11 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: Official premature termination is failure to be included in the marathon group.). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in knee extensors maximal isometric torque output (time frame: Day 0 (day of the race) baseline value = 30 minutes before the race and 15 minutes after the race). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Mar 2026.