Alcohol Use DisorderBEAMNCT06283472
Enhancing Prospective Thinking in Early Recovery (BEAM)
A study testing High-Intensity Cue and Low-Intensity Cue in people with Alcohol Use Disorder, run by Indiana University at 1 site in United States.
Trial summary
The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Alcohol Use Disorder
- What is being tested?
- High-Intensity Cue and Low-Intensity Cue
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Jun 2024to 31 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Individuals who meet current heavy drinking (≥2 heavy drinking days/month OR ≥7 drinks/week for biological females, and ≥14 drinks/week if biological male [NIAAA definition] and/or AUDIT scores ≥8)
- English comprehension
Who cannot join
- Unstable medical disorders
- Outside the age range of 18-60
- Smell/taste disorders
- Unstable psychiatric conditions
Trial locations and contacts
1 site in 1 country.
United States1 site
Indiana University School of Medicine - Goodman Hall
Indianapolis, Indiana, 46202
About this study
Official title: Enhancing Prospective Thinking in Early Recovery
The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question[s] this trial aims to answer are:
- Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues?
- Will high-intensity EFT cues effect greater treatment-seeking interest?
- Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity)
- Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS?
- Will the novel behavioral SS decision-making task activate the nucleus accumbens?
Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.
- Conditions
- Alcohol Use Disorder
- Being tested
- High-Intensity Cue, Low-Intensity Cue
- Keywords
- Alcohol Use Disorder, Alcohol Abuse, Heavy Drinking, Alcohol
- Medical subject headings
- Alcoholism
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-Intensity CueBehavioural
Participants in the high-intensity group will receive high-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.
Low-Intensity CueBehavioural
Participants in the low-intensity group will receive low-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.
| Study group | Role | What they receive |
|---|---|---|
| High-Intensity | Experimental | Participants will receive high-intensity episodic future-thinking cue images, and high-intensity episodic recent-thinking cue images during an MRI decision-making task. Receives: Behavioral: High-Intensity Cue |
| Low-Intensity (Control) | Active comparator | Participants will receive low-intensity episodic future-thinking cue images, and low-intensity episodic recent-thinking cue images during an MRI decision-making task. Receives: Behavioral: Low-Intensity Cue |
What is being measured
The primary outcome is the main question the study is designed to answer.
Increase Prospective Thinking
High-intensity episodic future-thinking image cues will change prospective thinking.
Measured: Study Day Visit (Day 1)
Delayed Rewards
High-intensity episodic future-thinking image cues will change preference for delayed rewards, which will be measured using a behavioral delayed discounting task.
Measured: Study Day Visit (Day 1)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Feb 2024
- Study start17 Jun 2024
- Primary completion31 Dec 2025
- Study completion31 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alcohol Use DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Indiana University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Brandon G. Oberlin, PhD, Indiana University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06283472
- Sponsor's protocol ID
- 1805574553; Aims 14-16
- Other IDs
- 2P60AA007611-403343, 2P60AA007611
- Acronym
- BEAM
- Status last verified
- Aug 2026
- First submitted
- 21 Feb 2024
- Last updated
- 5 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Enhancing Prospective Thinking in Early Recovery
- ClinicalTrials.gov ID
- NCT06283472
- Acronym / sponsor ID
- BEAM / 1805574553; Aims 14-16
- Conditions
- Alcohol Use Disorder
- Keywords
- Alcohol Use Disorder, Alcohol Abuse, Heavy Drinking, Alcohol
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Indiana UniversityUniversity, hospital or other
- Study start
- 17 Jun 2024 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- 31 Dec 2025 (actual)
- First posted
- 28 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question[s] this trial aims to answer are:
- Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues?
- Will high-intensity EFT cues effect greater treatment-seeking interest?
- Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity)
- Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS?
- Will the novel behavioral SS decision-making task activate the nucleus accumbens?
Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High-Intensity | Experimental | Behavioral: High-Intensity CueParticipants will receive high-intensity episodic future-thinking cue images, and high-intensity episodic recent-thinking cue images during an MRI decision-making task. |
| Low-Intensity (Control) | Active comparator | Behavioral: Low-Intensity CueParticipants will receive low-intensity episodic future-thinking cue images, and low-intensity episodic recent-thinking cue images during an MRI decision-making task. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Individuals who meet current heavy drinking (≥2 heavy drinking days/month OR ≥7 drinks/week for biological females, and ≥14 drinks/week if biological male [NIAAA definition] and/or AUDIT scores ≥8)
- English comprehension
Key exclusion criteria (4 listed)
- Unstable medical disorders
- Outside the age range of 18-60
- Smell/taste disorders
- Unstable psychiatric conditions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-Intensity CueParticipants in the high-intensity group will receive high-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future. | Behavioural | High-Intensity |
| Low-Intensity CueParticipants in the low-intensity group will receive low-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future. | Behavioural | Low-Intensity (Control) |
Primary outcome
Increase Prospective Thinking
Time frame: Study Day Visit (Day 1)
High-intensity episodic future-thinking image cues will change prospective thinking.
Delayed Rewards
Time frame: Study Day Visit (Day 1)
High-intensity episodic future-thinking image cues will change preference for delayed rewards, which will be measured using a behavioral delayed discounting task.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-Intensity Cue and Low-Intensity Cue in people with Alcohol Use Disorder, run by Indiana University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Increase Prospective Thinking (time frame: Study Day Visit (Day 1)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Oct 2026.