Investigating the Effects of Periocular Acupressure on Ocular Biological IndicatorsNCT06293196
Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes
A study testing acupressure in people with Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators, run by Zhongnan Hospital at 1 site in China.
Trial summary
This study aims to investigate whether the acupoint eye exercise could impact the biological parameters of the eye. Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators
- What is being tested?
- acupressure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 55 participants
- Where
- 1 siteChina
- Study dates
- 1 Sep 2023to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- healthy people of all ages
Who cannot join
- presence of systemic diseases
- history of other eye diseases, surgeries, and/or medications, as well as eye trauma
- incomplete healing of the surgical site after eye surgery
- consumption of coffee, tea, or vasodilators within 6 hours before the commencement of the test
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, 430000
Min Ke, doctor of medicine, 18672395959, Keminyk@163.com
About this study
This study aims to investigate whether the acupoint eye exercise could impact the biological parameters of the eye.
- Being tested
- acupressure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
acupressureOther
Massage acupoints and non-acupoint areas around the eyes.
| Study group | Role | What they receive |
|---|---|---|
| standard Chinese acupoint eye exercise group | Experimental | The volunteers performed a set of standard Chinese acupoint eye health exercises. Receives: Other: acupressure |
| fake acupoint eye exercise group | Experimental | Volunteers performed a group of fake acupoint eye health exercises, the acupoint design in the place without acupoints. Receives: Other: acupressure |
| simple eye closure group | No intervention | The volunteers only closed their eyes and did not perform acupressure. |
| simple distance observation group | No intervention | The volunteers only looked far without acupressure. |
What is being measured
The primary outcome is the main question the study is designed to answer.
The effect of ocular acupoint massage on ocular blood flow.
Ocular blood flow indicators were obtained using Optical Coherence Tomography (OCT).
Measured: Ocular blood flow indicators were measured once at pre-intervention, immediately post-intervention, and at 10, 20, and 30 minutes post-intervention.
The effect of ocular acupoint massage on intraocular pressure.
Intraocular pressure (IOP) of patients was measured and recorded with the ICARE rebound tonometer.
Measured: Intraocular pressure was measured once before the intervention and once immediately after the intervention.
The effect of ocular acupoint massage on the diameter of Schlemm's canal.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The diameter of Schlemm's canal was measured manually.
Measured: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the diameter values of Schlemm's canal.
The effect of ocular acupoint massage on the area of Schlemm's canal.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The area of Schlemm's canal was measured manually.
Measured: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the area values of Schlemm's canal.
The effect of ocular acupoint massage on the width of the trabecular meshwork.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The width of the trabecular meshwork was measured manually.
Measured: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the width values of the trabecular meshwork.
The effect of ocular acupoint massage on the thickness of the trabecular meshwork.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The thickness of the trabecular meshwork was measured manually.
Measured: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the thickness values of the trabecular meshwork.
The effect of ocular acupoint massage on the tear film.
The Keratograph was used to dynamically monitor the tear film break-up location and break-up time in a non-contact manner before and after the intervention, with tear meniscus height measured manually.
Measured: The Keratograph was performed once before the intervention and once immediately after the intervention.
Secondary outcomes (2)
The effect of ocular acupoint massage on blood pressure.
Blood pressure was measured using the cuff pressurization method.
Measured: Blood pressure was measured once before the intervention and once immediately after it.
The effect of ocular acupoint massage on heart rate.
Heart rate was monitored using the cuff occlusion method.
Measured: Heart rate was measured once before the intervention and once immediately after it.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Mar 2024
- Study start1 Sep 2023
- Primary completion30 Jun 2026 (estimated)
- Study completion30 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Investigating the Effects of Periocular Acupressure on Ocular Biological IndicatorsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 55 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Zhongnan Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06293196
- Sponsor's protocol ID
- 20231107
- Status last verified
- Jan 2026
- First submitted
- 1 Feb 2024
- Last updated
- 21 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes
- ClinicalTrials.gov ID
- NCT06293196
- Acronym / sponsor ID
- 20231107
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 55 participants (estimated)
- Lead sponsor
- Zhongnan HospitalUniversity, hospital or other
- Study start
- 1 Sep 2023 (actual)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 30 Jun 2026 (estimated)
- First posted
- 5 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate whether the acupoint eye exercise could impact the biological parameters of the eye.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| standard Chinese acupoint eye exercise group | Experimental | Other: acupressureThe volunteers performed a set of standard Chinese acupoint eye health exercises. |
| fake acupoint eye exercise group | Experimental | Other: acupressureVolunteers performed a group of fake acupoint eye health exercises, the acupoint design in the place without acupoints. |
| simple eye closure group | No intervention | –The volunteers only closed their eyes and did not perform acupressure. |
| simple distance observation group | No intervention | –The volunteers only looked far without acupressure. |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- healthy people of all ages
Key exclusion criteria (4 listed)
- presence of systemic diseases
- history of other eye diseases, surgeries, and/or medications, as well as eye trauma
- incomplete healing of the surgical site after eye surgery
- consumption of coffee, tea, or vasodilators within 6 hours before the commencement of the test
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| acupressureMassage acupoints and non-acupoint areas around the eyes. | Other | fake acupoint eye exercise group, standard Chinese acupoint eye exercise group |
Primary outcome
The effect of ocular acupoint massage on ocular blood flow.
Time frame: Ocular blood flow indicators were measured once at pre-intervention, immediately post-intervention, and at 10, 20, and 30 minutes post-intervention.
Ocular blood flow indicators were obtained using Optical Coherence Tomography (OCT).
The effect of ocular acupoint massage on intraocular pressure.
Time frame: Intraocular pressure was measured once before the intervention and once immediately after the intervention.
Intraocular pressure (IOP) of patients was measured and recorded with the ICARE rebound tonometer.
The effect of ocular acupoint massage on the diameter of Schlemm's canal.
Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the diameter values of Schlemm's canal.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The diameter of Schlemm's canal was measured manually.
The effect of ocular acupoint massage on the area of Schlemm's canal.
Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the area values of Schlemm's canal.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The area of Schlemm's canal was measured manually.
The effect of ocular acupoint massage on the width of the trabecular meshwork.
Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the width values of the trabecular meshwork.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The width of the trabecular meshwork was measured manually.
The effect of ocular acupoint massage on the thickness of the trabecular meshwork.
Time frame: Anterior segment imaging was performed once before and once immediately after the intervention to obtain the thickness values of the trabecular meshwork.
Imaging of the nasal and temporal corneoscleral regions of the right eye was performed using swept-source anterior segment optical coherence tomography (SS-AS-OCT). The thickness of the trabecular meshwork was measured manually.
The effect of ocular acupoint massage on the tear film.
Time frame: The Keratograph was performed once before the intervention and once immediately after the intervention.
The Keratograph was used to dynamically monitor the tear film break-up location and break-up time in a non-contact manner before and after the intervention, with tear meniscus height measured manually.
2 secondary outcomes
The effect of ocular acupoint massage on blood pressure.
Time frame: Blood pressure was measured once before the intervention and once immediately after it.
The effect of ocular acupoint massage on heart rate.
Time frame: Heart rate was measured once before the intervention and once immediately after it.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jan 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing acupressure in people with Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators, run by Zhongnan Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Min Ke, doctor of medicine (18672395959, Keminyk@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The effect of ocular acupoint massage on ocular blood flow. (time frame: Ocular blood flow indicators were measured once at pre-intervention, immediately post-intervention, and at 10, 20, and 30 minutes post-intervention.). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jan 2026.