Acute Coronary SyndromeNCT06300294
Acute Coronary Syndrome and Acupressure
A study testing acupressure in people with Acute Coronary Syndrome and Nursing, run by Abant Izzet Baysal University at 1 site in Turkey (Türkiye).
Trial summary
This study aims to examine the effect of acupressure on physiological parameters and anxiety levels in individuals diagnosed with Acute Coronary Syndrome (ACS). H1-1: Acupressure applied to individuals with ACS has an effect on blood pressure. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Acute Coronary Syndrome, Nursing
- What is being tested?
- acupressure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 68 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 5 May 2024to 31 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Volunteer to participate in the study,
- Those aged 18 and over
- Able to speak Turkish
- Diagnosed with ACS for the first time
- Cardiopulmonary resuscitation not applied
- No orientation problems (those who score 15 on the Glasgow Coma Scale)
Show all 12Show fewer
- Not diagnosed with psychiatric disease
- No amputation, fistula, lymphedema, neuropathy or hemiplegia in any of the Upper Extremities
- Those who underwent femoral intervention for CAG procedure
- Those who have not used any integrative practices based on pressure and stimulation such as acupressure, acupuncture and reflexology in the last month.
- Vital signs (28) are within normal range:
- Blood pressure: 90/60-120/80 mmHg Heart rate: 60-100 min Respiratory rate: 12-18 min
Who cannot join
- Those with arrhythmia (AF, VT etc.)
- Patients who have previously undergone Coronary Angiography
- Diagnosed with myocarditis, pericarditis
- Those who do not take any speed-breaking drugs (beloc, arlec, etc.).
- Patients who underwent radial intervention for CAG procedure
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Acupressure on Anxiety And Physiological Parameters in Individuals Diagnosed With Acute Coronary Syndrome: A Randomized Controlled Study
This study aims to examine the effect of acupressure on physiological parameters and anxiety levels in individuals diagnosed with Acute Coronary Syndrome (ACS).
H1-1: Acupressure applied to individuals with ACS has an effect on blood pressure.
Read more
H1-2: Acupressure applied to individuals with ACS has an effect on heart rate. H1-3: Acupressure applied to individuals with ACS has an effect on respiratory rate.
H1-4: Acupressure applied to individuals with ACS has an effect on pain levels. H1-5: Acupressure applied to individuals with ACS has an effect on anxiety levels.
H1-6: Acupressure applied to individuals with ACS has an effect on cortisol levels.
H1-7: Acupressure applied to individuals with ACS has an effect on ECG changes.
Read the detailed description
Acute Coronary Syndrome (ACS) affects millions of people every year; It refers to three types of coronary artery disease: unstable angina pectoris, non-ST-elevation myocardial infarction (NSTE MI) and ST-elevation myocardial infarction (STEMI). It is known that 19 million people in the world and 161 thousand people in our country lost their lives due to Cardiovascular Disease (CVD). Approximately 3 million people worldwide die due to STEMI.Individuals experiencing ACS generally; It is observed that he/she experiences burning, stinging and compressive chest pain, tachycardia, sweating, fatigue, dizziness, dyspnea, nausea, anxiety and depression.Management of the disease is combined with pharmacological applications; It is tried to be provided with non-pharmacological applications such as education, acupuncture and acupressure. When the literature is examined, acupressure application; in the physiological parameters of individuals with myocardial infarction; It brings blood pressure, heart rate and respiratory rate to normal limits, and increases oxygen saturation and sleep quality; It appears to reduce anxiety and pain.For all these reasons, this study aims to examine the effect of acupressure on physiological parameters (blood pressure, heart rate, respiratory rate, pain and cortisol) and anxiety levels in individuals diagnosed with ACS.
- Conditions
- Acute Coronary Syndrome, Nursing
- Being tested
- acupressure
- Keywords
- Acupressure, Anxiety, Viral signs, Acute coronary syndrome
- Medical subject headings
- Acute Coronary Syndrome, Anxiety Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
acupressureOther
- First follow-up (first 0-30 minutes of admission): Participants received routine care and treatment within the first 0-30 minutes of admission, in accordance with hospital protocol.
- Second follow-up (6 hours after the CAG procedure): After the coronary angiography procedure was completed (after the sandbag was removed), the first acupressure application was performed on individuals whose vital signs were within the normal range.
- Third follow-up (12 hours after the CAG procedure): Approximately 12 hours after the coronary angiography procedure, the second acupressure application was performed on individuals.
- Fourth follow-up (Cortisol measurement): The fourth follow-up was conducted at 8:00 a.m. (sunrise) to determine cortisol levels. Physiological parameters were evaluated, and a venous blood sample was taken to determine cortisol levels.
| Study group | Role | What they receive |
|---|---|---|
| acupressure | Experimental | acupressure application and Routine care and treatment (filling out the initial hospitalization documents, measuring vital signs, taking an ECG, preparing for the CAG procedure, administering the ordered medications). Receives: Other: acupressure |
| control | No intervention | Routine care and treatment (filling out the initial hospitalization documents, measuring vital signs, taking an ECG, preparing for the CAG procedure, administering the ordered medications). |
What is being measured
The primary outcome is the main question the study is designed to answer.
means of blood pressure
In this study, blood pressure was measured using monitors in the intensive care unit.
Measured: up to 30 minutes
means of hear rate
Heart rate is the pressure exerted on the vessel wall by the blood thrown by the left ventricle from the skin surface to the aorta during systole. In the research, heart rate is measured using a monitor.
Measured: up to 30 minutes
means of respiratory rate
Respiratory rate is the patient's breaths per minute. In this study, respiratory rate was taken from the monitor.
Measured: up to 30 minutes
means of cortisol.
The cortisol value in the blood will be measured.
Measured: up to 60 minutes
Secondary outcomes (3)
means of subjective anxiety scores.
numerical anxiety scale. The total score between 0-10 obtained.
Measured: up to 30 minutes
means of subjective pain scores.
visual analog scale. It consists of a straight line with endpoints that define end limits such as "no pain" and "pain as bad as possible". The patient is asked to mark the level of pain on the line between the two endpoints.
Measured: up to 30 minutes
electrocardiography evaluation
Electrocardiography is the process of recording the electrical activity occurring in the heart to examine the functioning of the heart muscle and neural conduction system.
Measured: up to 30 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Mar 2024
- Study start5 May 2024
- Primary completion1 Apr 2025
- Study completion31 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Coronary SyndromeStudies of the same condition, open and under way.
- More trials run by Abant Izzet Baysal UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- experimental and control
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 68 participants (actual)
Sponsor and investigators
- Lead sponsor
- Abant Izzet Baysal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Saadet Can Çiçek, Abant Izzet Baysal University
- Investigators
- aynur açıkgöz, PhD student, Principal investigator, Abant Izzet Baysal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06300294
- Sponsor's protocol ID
- AIBU-SBF-AYN-3
- Status last verified
- May 2026
- First submitted
- 14 Feb 2024
- Last updated
- 26 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Acupressure on Anxiety And Physiological Parameters in Individuals Diagnosed With Acute Coronary Syndrome: A Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT06300294
- Acronym / sponsor ID
- AIBU-SBF-AYN-3
- Conditions
- Acute Coronary Syndrome, Nursing
- Keywords
- Acupressure, Anxiety, Viral signs, Acute coronary syndrome
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 68 participants (actual)
- Lead sponsor
- Abant Izzet Baysal UniversityUniversity, hospital or other
- Study start
- 5 May 2024 (actual)
- Primary completion
- 1 Apr 2025 (actual)
- Study completion
- 31 May 2025 (actual)
- First posted
- 8 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to examine the effect of acupressure on physiological parameters and anxiety levels in individuals diagnosed with Acute Coronary Syndrome (ACS).
H1-1: Acupressure applied to individuals with ACS has an effect on blood pressure.
H1-2: Acupressure applied to individuals with ACS has an effect on heart rate. H1-3: Acupressure applied to individuals with ACS has an effect on respiratory rate.
H1-4: Acupressure applied to individuals with ACS has an effect on pain levels. H1-5: Acupressure applied to individuals with ACS has an effect on anxiety levels.
H1-6: Acupressure applied to individuals with ACS has an effect on cortisol levels.
H1-7: Acupressure applied to individuals with ACS has an effect on ECG changes.
Detailed description
Acute Coronary Syndrome (ACS) affects millions of people every year; It refers to three types of coronary artery disease: unstable angina pectoris, non-ST-elevation myocardial infarction (NSTE MI) and ST-elevation myocardial infarction (STEMI). It is known that 19 million people in the world and 161 thousand people in our country lost their lives due to Cardiovascular Disease (CVD). Approximately 3 million people worldwide die due to STEMI.Individuals experiencing ACS generally; It is observed that he/she experiences burning, stinging and compressive chest pain, tachycardia, sweating, fatigue, dizziness, dyspnea, nausea, anxiety and depression.Management of the disease is combined with pharmacological applications; It is tried to be provided with non-pharmacological applications such as education, acupuncture and acupressure. When the literature is examined, acupressure application; in the physiological parameters of individuals with myocardial infarction; It brings blood pressure, heart rate and respiratory rate to normal limits, and increases oxygen saturation and sleep quality; It appears to reduce anxiety and pain.For all these reasons, this study aims to examine the effect of acupressure on physiological parameters (blood pressure, heart rate, respiratory rate, pain and cortisol) and anxiety levels in individuals diagnosed with ACS.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 2
- Model description
- experimental and control
| Arm | Type | Receives |
|---|---|---|
| acupressure | Experimental | Other: acupressureacupressure application and Routine care and treatment (filling out the initial hospitalization documents, measuring vital signs, taking an ECG, preparing for the CAG procedure, administering the ordered medications). |
| control | No intervention | –Routine care and treatment (filling out the initial hospitalization documents, measuring vital signs, taking an ECG, preparing for the CAG procedure, administering the ordered medications). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (12 listed)
- Volunteer to participate in the study,
- Blood pressure: 90/60-120/80 mmHg Heart rate: 60-100 min Respiratory rate: 12-18 min
Key exclusion criteria (5 listed)
- Those with arrhythmia (AF, VT etc.)
- Patients who have previously undergone Coronary Angiography
- Diagnosed with myocarditis, pericarditis
- Those who do not take any speed-breaking drugs (beloc, arlec, etc.).
- Patients who underwent radial intervention for CAG procedure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| acupressure* First follow-up (first 0-30 minutes of admission): Participants received routine care and treatment within the first 0-30 minutes of admission, in accordance with hospital protocol. * Second follow-up (6 hours after the CAG procedure): After the coronary angiography procedure was completed (after the sandbag was removed), the first acupressure application was performed on individuals whose vital signs were within the normal range. * Third follow-up (12 hours after the CAG procedure): Approximately 12 hours after the coronary angiography procedure, the second acupressure application was performed on individuals. * Fourth follow-up (Cortisol measurement): The fourth follow-up was conducted at 8:00 a.m. (sunrise) to determine cortisol levels. Physiological parameters were evaluated, and a venous blood sample was taken to determine cortisol levels. | Other | acupressure |
Primary outcome
means of blood pressure
Time frame: up to 30 minutes
In this study, blood pressure was measured using monitors in the intensive care unit.
means of hear rate
Time frame: up to 30 minutes
Heart rate is the pressure exerted on the vessel wall by the blood thrown by the left ventricle from the skin surface to the aorta during systole. In the research, heart rate is measured using a monitor.
means of respiratory rate
Time frame: up to 30 minutes
Respiratory rate is the patient's breaths per minute. In this study, respiratory rate was taken from the monitor.
means of cortisol.
Time frame: up to 60 minutes
The cortisol value in the blood will be measured.
3 secondary outcomes
means of subjective anxiety scores.
Time frame: up to 30 minutes
means of subjective pain scores.
Time frame: up to 30 minutes
electrocardiography evaluation
Time frame: up to 30 minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 May 2026.
- Individual participant dataSharing planned: No
Related trials for Acute Coronary Syndrome
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Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
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Early Single Antiplatelet Therapy After IVUS-Guided PCI in Acute Coronary Syndrome
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AI-Assisted Interpretation of Cardiac CT in the Emergency Department
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Enrolling by invitation
Optical Coherence Tomography in Acute Vessel Evaluation
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
aynur açıkgöz, PhD student principal investigator
Abant Izzet Baysal University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing acupressure in people with Acute Coronary Syndrome and Nursing, run by Abant Izzet Baysal University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
means of blood pressure (time frame: up to 30 minutes). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 May 2026.