Osteoporosis, OsteopeniaNCT06305156
Protocol Optimization in CT for the Quantification of BMD
A study testing Bone Mineral Density quantification in people with Osteoporosis, Osteopenia and Bone Loss, run by Hatem Alkadhi at 1 site in Switzerland.
Trial summary
Bone mineral density is an important measurement to detect osteoporosis. The goal of this clinical trial is to compare bone mineral density measurements in CT examinations and DXA scans. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Osteoporosis, Osteopenia, Bone Loss
- What is being tested?
- Bone Mineral Density quantification
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 167 participants
- Where
- 1 siteSwitzerland
- Study dates
- 13 Mar 2024to 19 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Informed Consent signed by the subject
- Referral to a regular clinically indicated CT examination covering the lumbar area (e.g., Abdomen, Thorax + Abdomen, Neck + Thorax +Abdomen)
- Informed written and oral consent (interpreter present in case of foreign language patients)
- No contraindication to the clinically indicated CT examination
Who cannot join
- Patients < 18 years
- Pregnant women
- Vulnerable subjects
- Contraindications to the clinically indicated CT scan
- Multiple Myeloma
- Diffuse bone metastasis
Show all 13Show fewer
- Fixateur interne in the lumbar spine
- Kyphoplasty in the lumbar spine
- Enterally administrated contrast agent
- Obtaining informed consent is not possible
- Withdrawal of consent orally or in writing
- Inability to follow the procedures of the investigation, e.g., due to language problems, psychological disorders, dementia, etc. of the subject
- Immobility (patients confined to a wheelchair or to bed)
Trial locations and contacts
1 site in 1 country.
Switzerland1 site
Diagnostic and Interventional Radiology, University Hospital Zurich
Zurich, Canton of Zurich, 8091
About this study
Official title: Protocol-optimization in Computed Tomography for the Quantification of Bone Mineral Density (BMD)
Bone mineral density is an important measurement to detect osteoporosis.
The goal of this clinical trial is to compare bone mineral density measurements in CT examinations and DXA scans. The main question it aims to answer is:
- How good is the measurement of bone mineral density in the new photon-counting CT in comparison to DXA
- How can we optimize the CT scan for bone mineral density
Participants will undergo:
- Clinically indicated CT scan on day of inclusion
- Study related DXA scan on a separate appointment
- Conditions
- Osteoporosis, Osteopenia, Bone Loss
- Being tested
- Bone Mineral Density quantification
- Medical subject headings
- Osteoporosis, Bone Diseases, Metabolic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Bone Mineral Density quantificationDiagnostic test
In the first visit, participants receive clinically indicated CT scan, where bone mineral density will be derived.
In a second, study related visit, participants will receive a DXA scan for bone mineral quantifications.
| Study group | Role | What they receive |
|---|---|---|
| Bone mineral density CT vs DXA | Other | Single arm study, all participants receive CT and DXA. Receives: Diagnostic Test: Bone Mineral Density quantification |
What is being measured
The primary outcome is the main question the study is designed to answer.
Bone mineral density CT
Bone mineral density derived from CT Scan
Measured: Immediately after CT scan of the participant.
Bone mineral density Dual-energy x-ray absorptiometry (DXA)
Bone mineral density derived from DXA Scan
Measured: Immediately after DXA scan of the participant.
Secondary outcomes (5)
Correlation between age and bone mineral density
Correlation analysis by means of linear regression and pearson correlation between age (in years) and bone mineral density
Measured: 1 year
Correlation between sex and bone mineral density
Correlation analysis by means of linear regression and pearson correlation between sex (male/female) and bone mineral density
Measured: 1 year
Correlation between height and bone mineral density
Correlation analysis by means of linear regression and pearson correlation between height (in cm) and bone mineral density
Measured: 1 year
Correlation between weight and bone mineral density
Correlation analysis by means of linear regression and pearson correlation between weight and bone mineral density
Measured: 1 year
Correlation between body mass index (BMI) and bone mineral density
Correlation analysis by means of linear regression and pearson correlation between body mass index (BMI, in kg/m^2) and bone mineral density
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Mar 2024
- Study start13 Mar 2024
- Primary completion19 Dec 2025
- Study completion19 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Osteoporosis, OsteopeniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 167 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hatem Alkadhi
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Hatem Alkadhi, University of Zurich
- Investigators
- Hatem Alkadhi, MD, MPH, Principal investigator, Diagnostic and Interventional Radiology, University Hospital Zurich
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06305156
- Sponsor's protocol ID
- CT_BMD_1
- Status last verified
- Jan 2026
- First submitted
- 22 Feb 2024
- Last updated
- 13 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Protocol-optimization in Computed Tomography for the Quantification of Bone Mineral Density (BMD)
- ClinicalTrials.gov ID
- NCT06305156
- Acronym / sponsor ID
- CT_BMD_1
- Conditions
- Osteoporosis, Osteopenia, Bone Loss
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 167 participants (actual)
- Lead sponsor
- Hatem AlkadhiUniversity, hospital or other
- Study start
- 13 Mar 2024 (actual)
- Primary completion
- 19 Dec 2025 (actual)
- Study completion
- 19 Dec 2025 (actual)
- First posted
- 12 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Bone mineral density is an important measurement to detect osteoporosis.
The goal of this clinical trial is to compare bone mineral density measurements in CT examinations and DXA scans. The main question it aims to answer is:
- How good is the measurement of bone mineral density in the new photon-counting CT in comparison to DXA
- How can we optimize the CT scan for bone mineral density
Participants will undergo:
- Clinically indicated CT scan on day of inclusion
- Study related DXA scan on a separate appointment
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Bone mineral density CT vs DXA | Other | Diagnostic Test: Bone Mineral Density quantificationSingle arm study, all participants receive CT and DXA. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Informed Consent signed by the subject
- Referral to a regular clinically indicated CT examination covering the lumbar area (e.g., Abdomen, Thorax + Abdomen, Neck + Thorax +Abdomen)
- Informed written and oral consent (interpreter present in case of foreign language patients)
- No contraindication to the clinically indicated CT examination
Key exclusion criteria (13 listed)
- Patients < 18 years
- Pregnant women
- Vulnerable subjects
- Contraindications to the clinically indicated CT scan
- Multiple Myeloma
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Bone Mineral Density quantificationIn the first visit, participants receive clinically indicated CT scan, where bone mineral density will be derived. In a second, study related visit, participants will receive a DXA scan for bone mineral quantifications. | Diagnostic test | Bone mineral density CT vs DXA |
Primary outcome
Bone mineral density CT
Time frame: Immediately after CT scan of the participant.
Bone mineral density derived from CT Scan
Bone mineral density Dual-energy x-ray absorptiometry (DXA)
Time frame: Immediately after DXA scan of the participant.
Bone mineral density derived from DXA Scan
5 secondary outcomes
Correlation between age and bone mineral density
Time frame: 1 year
Correlation between sex and bone mineral density
Time frame: 1 year
Correlation between height and bone mineral density
Time frame: 1 year
Correlation between weight and bone mineral density
Time frame: 1 year
Correlation between body mass index (BMI) and bone mineral density
Time frame: 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jan 2026.
- Individual participant dataSharing planned: No
Related trials for Osteoporosis, Osteopenia
RecruitingObservational study
A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older
Osteoporosis, Osteopenia
Active, not recruiting
Sickle Cell Disease (SCD) Bone Pain Study
Sickle Cell Disease, Sickle Cell Anemia
Active, not recruiting
Physical Activity Guarantees Bone Density.
Osteoporosis, Osteopenia
RecruitingPhase 4
The Comparison of Ibandronate and Zoledronic Acid After Denosumab Discontinuation
Postmenopausal Osteoporosis, Postmenopausal Osteopenia
Not yet recruiting
Calcium-Rich Food Versus Calcium Carbonate for Bone Health
Osteopenia, Osteoporosis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hatem Alkadhi, MD, MPH principal investigator
Diagnostic and Interventional Radiology, University Hospital Zurich
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Bone Mineral Density quantification in people with Osteoporosis, Osteopenia and Bone Loss, run by Hatem Alkadhi at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Bone mineral density CT (time frame: Immediately after CT scan of the participant.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jan 2026.