Heart Failure and Impaired Kidney FunctionPhase 3BalanceD-HFNCT06307652

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

A Phase 3 study of Heart Failure and Impaired Kidney Function, run by AstraZeneca at 852 sites in 39 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts

Official record

Search all trials

Trial summary

Who is it for?: Ages 18 to 130 years
Conditions the study is for: Heart Failure and Impaired Kidney Function
Type of treatment: Pill or oral medicine
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 3,850 participants
Where: 852 sitesin 39 countries
Study dates: 12 Apr 2024to 16 Apr 2027
Phase: Phase 3

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 130 years
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

Age ≥ 18 years
Documented diagnosis of symptomatic HF (NYHA functional class II-IV)
Having had a recent HF event within 6 months (hospitalization or urgent visit)
Have a LVEF value from an assessment within the last 12 months
Managed with SoC therapy for HF and renal impairment according to local guidelines
NT-proBNP must be >300 pg/mL (>600 pg/mL if concomitant atrial fibrillation or atrial flutter)

Show all 9Show fewer

Not taking an MRA
An eGFR ≥ 20 to < 60 mL/min/1.73 m2
Serum/plasma potassium ≤ 5.0 mmol/L

Who cannot join

Acute coronary syndrome (unstable angina or myocardial infarction), stroke or transient ischaemic attack within the previous 3 months prior to enrolment or during the screening period
Major cardiac surgery, coronary revascularisation or valvular repair or replacement, or implantation of a Cardiac resynchronisation therapy device within 3 months prior to enrolment or during the screening period, or planned to undergo any of these operations
History of hypertrophic obstructive cardiomyopathy
Complex congenital heart disease or severe uncorrected primary valvular disease
Symptomatic bradycardia or second- or third-degree heart block without a pacemaker
Systolic BP < 90 mmHg, or symptomatic hypotension within the past 24 hours

Show all 12Show fewer

Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including COPD or exacerbation of COPD requiring invasive mechanical ventilation assistance within 12 months prior to enrolment
Type 1 diabetes mellitus
Kidney replacement therapy in the past 4 weeks, currently requiring kidney replacement or imminent plan to start kidney replacement therapy
Acute or chronic liver disease with severe impairment of liver function, eg, ascites, oesophageal varices, coagulopathy, and encephalopathy
Suspected or confirmed COVID-19 infection within the last 4 weeks or hospitalisation for COVID-19 within the last 12 weeks
Treatment with strong or moderate CYP3A4 inhibitor or inducer

Trial locations and contacts

852 sites in 39 countries. Contact the study team or a site near you to ask about taking part.

AstraZeneca Clinical Study Information Center contact

1-877-240-9479

information.center@astrazeneca.com

Country

City, postcode or hospital

Sites recruiting now only

852 sites in 39 countries

United States166 sites, 104 recruiting

Research Site
Abington, Pennsylvania, 19001
Recruiting
Research Site
Albany, New York, 12208
Withdrawn
Research Site
Alexander City, Alabama, 35010
Recruiting
Research Site
Alexandria, Louisiana, 71301
Withdrawn
Research Site
Allen, Texas, 75013
Recruiting
Research Site
Altamonte Springs, Florida, 32701
Terminated
Research Site
Amarillo, Texas, 79106
Recruiting
Research Site
Amarillo, Texas, 79121
Recruiting
Research Site
Anderson, South Carolina, 29621
Terminated
Research Site
Ann Arbor, Michigan, 48109
Withdrawn
Research Site
Asheville, North Carolina, 28801
Recruiting
Research Site
Atlanta, Georgia, 30303
Recruiting
Research Site
Atlanta, Georgia, 30309
Withdrawn
Research Site
Augusta, Maine, 04330
Withdrawn
Research Site
Aurora, Colorado, 80045
Recruiting
Research Site
Beverly Hills, California, 90211
Recruiting
Research Site
Birmingham, Alabama, 35209
Withdrawn
Research Site
Bloomfield Hills, Michigan, 48304
Recruiting
Research Site
Boca Raton, Florida, 33486
Recruiting
Research Site
Boston, Massachusetts, 02114
Recruiting
Research Site
Bradenton, Florida, 34209
Recruiting
Research Site
Bridgewater, New Jersey, 08807
Withdrawn
Research Site
Brooklyn, New York, 11219
Recruiting
Research Site
Brooklyn, New York, 11220
Withdrawn
Research Site
Camp Hill, Pennsylvania, 17011
Recruiting
Research Site
Chapel Hill, North Carolina, 27517
Recruiting
Research Site
Charleston, South Carolina, 29401
Recruiting
Research Site
Charleston, South Carolina, 29425
Recruiting
Research Site
Charlotte, North Carolina, 28204
Recruiting
Research Site
Chicago, Illinois, 60612
Withdrawn
Research Site
Chicago, Illinois, 60637
Recruiting
Research Site
Cincinnati, Ohio, 45219
Withdrawn
Research Site
Cincinnati, Ohio, 45267
Recruiting
Research Site
Clearwater, Florida, 33756
Withdrawn
Research Site
Clifton Park, New York, 12065
Recruiting
Research Site
Columbia, Missouri, 65201
Recruiting
Research Site
Covina, California, 91723
Recruiting
Research Site
Cypress, Texas, 77429
Recruiting
Research Site
Dallas, Texas, 75204
Recruiting
Research Site
Dallas, Texas, 75216
Recruiting
Research Site
Dallas, Texas, 75390
Recruiting
Research Site
Dayton, Ohio, 45414
Withdrawn
Research Site
Dearborn, Michigan, 48126
Terminated
Research Site
Delray Beach, Florida, 33484
Recruiting
Research Site
Durham, North Carolina, 27710
Recruiting
Research Site
El Paso, Texas, 79905
Recruiting
Research Site
Elkhart, Indiana, 46514
Recruiting
Research Site
Encinitas, California, 92024
Terminated
Research Site
Evansville, Indiana, 47710
Recruiting
Research Site
Fairhope, Alabama, 36532
Recruiting
Research Site
Fall River, Massachusetts, 02721
Withdrawn
Research Site
Falls Church, Virginia, 22042
Recruiting
Research Site
Farmington Hills, Michigan, 48334
Withdrawn
Research Site
Flint, Michigan, 48504
Suspended
Research Site
Fort Lauderdale, Florida, 33308
Recruiting
Research Site
Gainesville, Florida, 32610
Recruiting
Research Site
Glenview, Illinois, 60026
Withdrawn
Research Site
Greensboro, North Carolina, 27405
Withdrawn
Research Site
Hammond, Indiana, 46324
Suspended
Research Site
Hazel Crest, Illinois, 60429
Recruiting
Research Site
Henderson, Nevada, 89074
Withdrawn
Research Site
Hershey, Pennsylvania, 17033
Recruiting
Research Site
Horsham, Pennsylvania, 19044
Terminated
Research Site
Houston, Texas, 77002
Terminated
Research Site
Houston, Texas, 77025
Recruiting
Research Site
Huntsville, Alabama, 35801
Recruiting
Research Site
Indianapolis, Indiana, 46237
Withdrawn
Research Site
Jackson, Mississippi, 39216
Recruiting
Research Site
Jackson, Tennessee, 38305
Recruiting
Research Site
Jacksonville, Florida, 32209
Recruiting
Research Site
Jersey City, New Jersey, 07302
Recruiting
Research Site
Kansas City, Missouri, 64111
Recruiting
Research Site
Kansas City, Missouri, 64128
Recruiting
Research Site
Katy, Texas, 77493
Terminated
Research Site
Knoxville, Tennessee, 37916
Recruiting
Research Site
Ladson, South Carolina, 29456
Withdrawn
Research Site
Lancaster, South Carolina, 29720
Recruiting
Research Site
Lincoln, Nebraska, 68506
Recruiting
Research Site
Lincoln, Nebraska, 68510
Recruiting
Research Site
Little Rock, Arkansas, 72205
Recruiting
Research Site
Los Angeles, California, 90073
Recruiting
Research Site
Los Angeles, California, 90089
Recruiting
Research Site
Louisville, Kentucky, 40202
Terminated
Research Site
Manhasset, New York, 11030
Withdrawn
Research Site
Mansfield, Texas, 76063
Terminated
Research Site
Maumee, Ohio, 43537
Withdrawn
Research Site
McKinney, Texas, 75069
Recruiting
Research Site
McKinney, Texas, 75071
Recruiting
Research Site
Memphis, Tennessee, 38120
Recruiting
Research Site
Memphis, Tennessee, 38128
Terminated
Research Site
Miami, Florida, 33133
Terminated
Research Site
Miami, Florida, 33176
Recruiting
Research Site
Miami Lakes, Florida, 33014
Recruiting
Research Site
Minneapolis, Minnesota, 55455
Withdrawn
Research Site
Muncie, Indiana, 47303
Recruiting
Research Site
Munster, Indiana, 46321
Recruiting
Research Site
Nashville, Tennessee, 37212
Recruiting
Research Site
New Orleans, Louisiana, 70121
Withdrawn
Research Site
New Windsor, New York, 12553
Withdrawn
Research Site
New York, New York, 10029
Recruiting
Research Site
Newport Beach, California, 92663
Terminated
Research Site
Newport News, Virginia, 23606
Recruiting
Research Site
North Chicago, Illinois, 60064
Terminated
Research Site
North Las Vegas, Nevada, 89086
Withdrawn
Research Site
Odessa, Texas, 79761
Recruiting
Research Site
Oklahoma City, Oklahoma, 73102
Withdrawn
Research Site
Orange, California, 92868
Withdrawn
Research Site
Palm Beach Gardens, Florida, 33410
Recruiting
Research Site
Peachtree City, Georgia, 30269
Recruiting
Research Site
Pearland, Texas, 77584
Suspended
Research Site
Pensacola, Florida, 32503
Recruiting
Research Site
Peoria, Illinois, 61614
Recruiting
Research Site
Philadelphia, Pennsylvania, 19104
Recruiting
Research Site
Phoenix, Arizona, 85016
Recruiting
Research Site
Phoenix, Arizona, 85044
Recruiting
Research Site
Pinehurst, North Carolina, 28374
Recruiting
Research Site
Port Charlotte, Florida, 33952
Withdrawn
Research Site
Portland, Oregon, 97225
Recruiting
Research Site
Providence, Rhode Island, 02908
Recruiting
Research Site
Puyallup, Washington, 98372
Withdrawn
Research Site
Rapid City, South Dakota, 57701
Recruiting
Research Site
Redding, California, 96001
Recruiting
Research Site
Richmond, Indiana, 47374
Withdrawn
Research Site
Rockville, Maryland, 20850
Recruiting
Research Site
Safety Harbor, Florida, 34695
Recruiting
Research Site
Saint Augustine, Florida, 32086
Recruiting
Research Site
Saint Paul, Minnesota, 55109
Recruiting
Research Site
Salt Lake City, Utah, 84107
Withdrawn
Research Site
Salt Lake City, Utah, 84148
Recruiting
Research Site
San Antonio, Texas, 78229
Recruiting
Research Site
San Diego, California, 92123
Recruiting
Research Site
San Francisco, California, 94110
Recruiting
Research Site
San Francisco, California, 94121
Terminated
Research Site
Santa Ana, California, 92704
Withdrawn
Research Site
Seattle, Washington, 98101
Withdrawn
Research Site
Sherman, Texas, 75092
Terminated
Research Site
Shreveport, Louisiana, 71105
Withdrawn
Research Site
Somerset, New Jersey, 08873
Recruiting
Research Site
Springfield, Ohio, 45504
Recruiting
Research Site
St. Petersburg, Florida, 33701
Recruiting
Research Site
Staten Island, New York, 10310
Recruiting
Research Site
Statesville, North Carolina, 28625
Withdrawn
Research Site
Stony Brook, New York, 11794
Withdrawn
Research Site
Tacoma, Washington, 98405
Withdrawn
Research Site
Tampa, Florida, 33617
Recruiting
Research Site
Temple, Texas, 76508
Recruiting
Research Site
The Bronx, New York, 10451
Suspended
Research Site
The Bronx, New York, 10455
Recruiting
Research Site
Thomasville, Georgia, 31792
Withdrawn
Research Site
Thousand Oaks, California, 91360
Terminated
Research Site
Troy, Michigan, 48098
Withdrawn
Research Site
Tucker, Georgia, 30084
Recruiting
Research Site
Tullahoma, Tennessee, 37388
Recruiting
Research Site
Tyler, Texas, 75701
Recruiting
Research Site
Tyler, Texas, 75702
Recruiting
Research Site
Vista, California, 92081
Recruiting
Research Site
Waterloo, Iowa, 50701
Recruiting
Research Site
West Hills, California, 91307
Recruiting
Research Site
West Monroe, Louisiana, 71291
Recruiting
Research Site
Wheat Ridge, Colorado, 80033
Terminated
Research Site
Wichita, Kansas, 67218
Withdrawn
Research Site
Wichita, Kansas, 67226
Recruiting
Research Site
Wilmington, North Carolina, 28401
Recruiting
Research Site
Winfield, Illinois, 60190
Recruiting
Research Site
Worcester, Massachusetts, 01655
Withdrawn
Research Site
Ypsilanti, Michigan, 48197
Recruiting

Other trials in United States

China51 sites, 44 recruiting

Research Site
Baotou, 14010
Recruiting
Research Site
Beijing, 100029
Withdrawn
Research Site
Beijing, 100029
Terminated
Research Site
Beijing, 100034
Recruiting
Research Site
Beijing, 100037
Recruiting
Research Site
Beijing, 100730
Recruiting
Research Site
Changchun, 130033
Recruiting
Research Site
Changsha, 410015
Recruiting
Research Site
Changsha, 430033
Recruiting
Research Site
Chengdu, 610041
Recruiting
Research Site
Chengdu, 610072
Recruiting
Research Site
Chifeng, 024000
Recruiting
Research Site
Chongqing, 404197
Recruiting
Research Site
Guangzhou, 510100
Recruiting
Research Site
Guangzhou, 510515
Recruiting
Research Site
Guangzhou, 510630
Recruiting
Research Site
Hangzhou, 310014
Recruiting
Research Site
Harbin, 150001
Recruiting
Research Site
Hengyang, 421001
Recruiting
Research Site
Heze, 274099
Recruiting
Research Site
Hohhot, 010017
Withdrawn
Research Site
Jinan, 250013
Recruiting
Research Site
Jining, 272029
Recruiting
Research Site
Lanzhou, 730030
Recruiting
Research Site
Liaocheng, 252000
Recruiting
Research Site
Linhai, 317000
Recruiting
Research Site
Nanchang, 330009
Recruiting
Research Site
Nanchong, 637900
Completed
Research Site
Nanjing, 2100008
Recruiting
Research Site
Nanjing, 210009
Recruiting
Research Site
Nanjing, 210011
Recruiting
Research Site
Nanjing, 210029
Recruiting
Research Site
Ningbo, 315040
Recruiting
Research Site
Pingxiang, 337055
Recruiting
Research Site
Quzhou, 342000
Recruiting
Research Site
Sanya, 572000
Recruiting
Research Site
Shanghai, 200025
Recruiting
Research Site
Shanghai, 200062
Recruiting
Research Site
Shenyang, 110004
Recruiting
Research Site
Shenzhen, 518053
Recruiting
Research Site
Ürümqi, CN-830004
Recruiting
Research Site
Wuhan, 430022
Withdrawn
Research Site
Wuhan, 430030
Withdrawn
Research Site
Xi'an, 710061
Recruiting
Research Site
Xi'an, 710068
Recruiting
Research Site
Xianyang, 750004
Withdrawn
Research Site
Xuzhou, 221000
Recruiting
Research Site
Xuzhou, 221009
Recruiting
Research Site
Yangzhou, 225001
Recruiting
Research Site
Zhangjiakou, 075061
Recruiting
Research Site
Zunyi, 563100
Recruiting

Other trials in China

Japan49 sites, 40 recruiting

Research Site
Beppu-shi, 874-0011
Recruiting
Research Site
Bunkyō City, 113-8431
Recruiting
Research Site
Fujisawa-shi, 251-8550
Recruiting
Research Site
Fukui-shi, 910-8526
Recruiting
Research Site
Fukuoka, 810-8563
Recruiting
Research Site
Fukuoka, 812-8582
Recruiting
Research Site
Fukuoka, 815-8555
Recruiting
Research Site
Fukutsu-shi, 811-3298
Recruiting
Research Site
Hakusan-shi, 924-8588
Recruiting
Research Site
Higashiibaraki-gun, 311-3193
Recruiting
Research Site
Himeji, 670-8560
Recruiting
Research Site
Iwakuni-shi, 740-8510
Recruiting
Research Site
Kanazawa, 920-8530
Recruiting
Research Site
Kanazawa, 920-8650
Withdrawn
Research Site
Kanonji-shi, 769-1695
Recruiting
Research Site
Kasuga-shi, 816-0864
Withdrawn
Research Site
Kasugai-shi, 486-8510
Recruiting
Research Site
Kawaguchi, 333-0842
Recruiting
Research Site
Kawanishi-shi, 666-0125
Recruiting
Research Site
Kishiwada-shi, 596-8522
Recruiting
Research Site
Kitakyusyu-shi, 806-8501
Withdrawn
Research Site
Kobe, 654-0155
Recruiting
Research Site
Kochi, 780-8535
Recruiting
Research Site
Kure-shi, 737-8505
Recruiting
Research Site
Maebashi, 371-8511
Recruiting
Research Site
Matsumoto-shi, 390-8621
Recruiting
Research Site
Meguro-ku, 152-8902
Recruiting
Research Site
Mito, 311-4198
Recruiting
Research Site
Moriyama-shi, 524-8524
Recruiting
Research Site
Nagoya, 460-0001
Withdrawn
Research Site
Ōita, 870-8511
Recruiting
Research Site
Osaka, 540-0006
Recruiting
Research Site
Osaka, 543-0035
Recruiting
Research Site
Sagamihara-shi, 252-5188
Recruiting
Research Site
Saitama Shi, 336 8522
Recruiting
Research Site
Saitama-shi, 339-0033
Withdrawn
Research Site
Sakaishi, 599-8247
Recruiting
Research Site
Sakata, 998-8501
Withdrawn
Research Site
Sanyoonoda-shi, 756-0095
Recruiting
Research Site
Toshima-ku, 171-0014
Recruiting
Research Site
Toyota, 470-0396
Recruiting
Research Site
Tsuchiura-shi, 300-0028
Terminated
Research Site
Ueda-shi, 386-8610
Recruiting
Research Site
Uji-shi, 611-0041
Recruiting
Research Site
Uwajima-shi, 798-8510
Recruiting
Research Site
Yanagawa-shi, 832-0077
Recruiting
Research Site
Yokohama, 221-0855
Recruiting
Research Site
Yokohama, 227-8501
Withdrawn
Research Site
Yokohama, 245-8575
Withdrawn

Other trials in Japan

Poland40 sites, 27 recruiting

Research Site
Biała Podlaska, 21-500
Recruiting
Research Site
Bielsko-Biala, 43-316
Withdrawn
Research Site
Bydgoszcz, 85-605
Withdrawn
Research Site
Bydgoszcz, 85-794
Terminated
Research Site
Chrzanów, 32-500
Recruiting
Research Site
Gdansk, 80-214
Recruiting
Research Site
Gdansk, 80-462
Recruiting
Research Site
Gdynia, 81-157
Withdrawn
Research Site
Katowice, 40-600
Recruiting
Research Site
Kazimierza Wielka, 28-500
Recruiting
Research Site
Kędzierzyn-Koźle, 47-200
Recruiting
Research Site
Krakow, 30-082
Recruiting
Research Site
Krakow, 30-688
Recruiting
Research Site
Krakow, 31-121
Recruiting
Research Site
Krakow, 31-322
Recruiting
Research Site
Krakow, 31-513
Withdrawn
Research Site
Lodz, 90-549
Recruiting
Research Site
Lodz, 91-053
Withdrawn
Research Site
Lodz, 93-513
Recruiting
Research Site
Lodz, 94-046
Suspended
Research Site
Lublin, 20-044
Completed
Research Site
Lublin, 20-068
Recruiting
Research Site
Lublin, 20-857
Recruiting
Research Site
Olsztyn, 10-165
Recruiting
Research Site
Ostrów Mazowiecka, 07-300
Recruiting
Research Site
Piekary Śląskie, 41-940
Recruiting
Research Site
Poznan, 60-266
Suspended
Research Site
Poznan, 61- 848
Recruiting
Research Site
Rzeszów, 35-055
Withdrawn
Research Site
Rzeszów, 35-205
Recruiting
Research Site
Szczecin, 71-526
Recruiting
Research Site
Tarnów, 33-100
Recruiting
Research Site
Torun, 87-100
Recruiting
Research Site
Tychy, 43-100
Recruiting
Research Site
Warsaw, 00-124
Recruiting
Research Site
Warsaw, 00-416
Withdrawn
Research Site
Warsaw, 04-501
Withdrawn
Research Site
Wroclaw, 53-602
Withdrawn
Research Site
Wroclaw, 53-605
Recruiting
Research Site
Zabrze, 41-800
Recruiting

Other trials in Poland

Germany34 sites, 13 recruiting

Research Site
Bad Nauheim, 61231
Terminated
Research Site
Bechhofen, 66894
Withdrawn
Research Site
Berlin, 12203
Recruiting
Research Site
Berlin, 13405
Recruiting
Research Site
Bernau bei Berlin, 16321
Suspended
Research Site
Chemnitz, 9113
Withdrawn
Research Site
Coburg, 96450
Recruiting
Research Site
Dresden, 01099
Withdrawn
Research Site
Dresden, 1307
Recruiting
Research Site
Elsterwerda, 04910
Suspended
Research Site
Frankfurt, 60590
Withdrawn
Research Site
Freiburg im Breisgau, 79106
Recruiting
Research Site
Goslar, 38642
Recruiting
Research Site
Göttingen, 37075
Recruiting
Research Site
Hagen, 58135
Recruiting
Research Site
Hamburg, 20246
Recruiting
Research Site
Hamburg, 22457
Withdrawn
Research Site
Hamburg, 22459
Withdrawn
Research Site
Heidelberg, 69120
Recruiting
Research Site
Kaiserslautern, 67655
Withdrawn
Research Site
Langen, 63225
Withdrawn
Research Site
Leipzig, 04103
Suspended
Research Site
Leverkusen, 51375
Withdrawn
Research Site
Mainz, 55122
Recruiting
Research Site
Mainz, 55131
Withdrawn
Research Site
Mönchengladbach, 41063
Suspended
Research Site
Münster, 48149
Withdrawn
Research Site
Paderborn, 33098
Withdrawn
Research Site
Papenburg, 26871
Recruiting
Research Site
Regensburg, 93053
Recruiting
Research Site
Rostock, 18059
Withdrawn
Research Site
Völklingen, 66333
Withdrawn
Research Site
Wermsdorf, 04779
Terminated
Research Site
Witten, 58455
Withdrawn

Other trials in Germany

India29 sites, 14 recruiting

Research Site
Ahmedabad, 380054
Withdrawn
Research Site
Ajmer, 305001
Withdrawn
Research Site
Amritsar, 143501
Withdrawn
Research Site
Bangalore, 560099
Suspended
Research Site
Belagavi, 590010
Recruiting
Research Site
Coimbatore, 641018
Recruiting
Research Site
Dehradun, 248001
Recruiting
Research Site
Delhi, 110029
Recruiting
Research Site
Delhi, 110062
Recruiting
Research Site
Hyderabad, 500018
Withdrawn
Research Site
Hyderabad, 500034
Terminated
Research Site
Hyderabad, 500035
Recruiting
Research Site
Kanpur, 208001
Recruiting
Research Site
Karamsad, 388345
Withdrawn
Research Site
Kolkata, 700014
Recruiting
Research Site
Kolkata, 700020
Suspended
Research Site
Ludhiana, 141001
Recruiting
Research Site
Manipal, 576104
Terminated
Research Site
Meerut, 250005
Recruiting
Research Site
Mysuru, 570015
Withdrawn
Research Site
Nagpur, 441108
Withdrawn
Research Site
New Delhi, 110002
Recruiting
Research Site
New Delhi, 110017
Recruiting
Research Site
New Delhi, 110029
Recruiting
Research Site
Pune, 411001
Withdrawn
Research Site
Rudrapur, 263153
Suspended
Research Site
Srinagar, 190015
Withdrawn
Research Site
Vadodara, 390022
Recruiting
Research Site
Vijayawada, 520 008
Terminated

Other trials in India

France28 sites, 17 recruiting

Research Site
Béziers, 34500
Recruiting
Research Site
Bron, 69667
Withdrawn
Research Site
Caen, 14033
Withdrawn
Research Site
Cholet, 49300
Recruiting
Research Site
Créteil, 94010
Recruiting
Research Site
Dijon, 21079
Recruiting
Research Site
La Roche-sur-Yon, 85925
Recruiting
Research Site
La Tronche, 38043
Withdrawn
Research Site
Le Coudray, 28630
Withdrawn
Research Site
Limoges, 87000
Recruiting
Research Site
Meaux, 77104
Recruiting
Research Site
Montauban, 82017
Withdrawn
Research Site
Montpellier, 34000
Recruiting
Research Site
Montpellier, 34295
Recruiting
Research Site
Nantes, 44093
Terminated
Research Site
Orléans, 45100
Withdrawn
Research Site
Paris, 75010
Recruiting
Research Site
Paris, 75015
Recruiting
Research Site
Poitiers, 86021
Recruiting
Research Site
Reims, 51092
Recruiting
Research Site
Rennes, 35033
Recruiting
Research Site
Rouen, 76031
Recruiting
Research Site
Saint-Quentin, 02100
Withdrawn
Research Site
Strasbourg, 67091
Withdrawn
Research Site
Toulon, 83100
Recruiting
Research Site
Toulouse, 31059
Terminated
Research Site
Tours, 37044
Withdrawn
Research Site
Valenciennes, 59300
Recruiting

Other trials in France

Canada27 sites, 16 recruiting

Research Site
Cambridge, Ontario, N1R 6V6
Completed
Research Site
Cambridge, Ontario, N1R 7R1
Recruiting
Research Site
Chicoutimi, Quebec, G7H 7K9
Withdrawn
Research Site
Greenfield Park, Quebec, J4V 2H1
Recruiting
Research Site
Hamilton, Ontario, L8L 5G4
Recruiting
Research Site
London, Ontario, N6A 5A5
Recruiting
Research Site
Montreal, Quebec, H1T 1C8
Recruiting
Research Site
Montreal, Quebec, H2X 0C1
Recruiting
Research Site
Montreal, Quebec, H3G 1A4
Withdrawn
Research Site
Montreal, Quebec, H4J 1C5
Recruiting
Research Site
New Westminster, British Columbia, V3L 3W4
Withdrawn
Research Site
Newmarket, Ontario, L3Y 2P6
Recruiting
Research Site
North Vancouver, British Columbia, V7M 2H4
Withdrawn
Research Site
North York, Ontario, M6B 3H7
Recruiting
Research Site
Oakville, Ontario, L6K 3W7
Withdrawn
Research Site
Oshawa, Ontario, L1J 2K1
Terminated
Research Site
Ottawa, Ontario, K1Y 4W7
Withdrawn
Research Site
Peterborough, Ontario, K9J 0B2
Withdrawn
Research Site
Saint-Jean-sur-Richelieu, Quebec, J3A 1J2
Withdrawn
Research Site
Sydney, Nova Scotia, B1P 1P3
Recruiting
Research Site
Thunder Bay, Ontario, P7B 7C7
Recruiting
Research Site
Toronto, Ontario, M6G 1M2
Recruiting
Research Site
Trois-Rivières, Quebec, G8T 7A1
Recruiting
Research Site
Trois-Rivières, Quebec, G9A 4P3
Recruiting
Research Site
Vancouver, British Columbia, V6Z 1Y6
Withdrawn
Research Site
Waterloo, Ontario, N2T 0C1
Recruiting
Research Site
Winnipeg, Manitoba, R2H 2A6
Recruiting

Other trials in Canada

South Korea25 sites, 23 recruiting

Research Site
Anyang-si, 14068
Recruiting
Research Site
Bucheon-si, 14754
Recruiting
Research Site
Busan, 47392
Recruiting
Research Site
Busan, 49201
Recruiting
Research Site
Busan, 49241
Recruiting
Research Site
Busan, 49267
Recruiting
Research Site
Cheongju-si, 28644
Recruiting
Research Site
Daegu, 42601
Recruiting
Research Site
Daejeon, 35015
Recruiting
Research Site
Gwangju, 61469
Recruiting
Research Site
Gwangmyeong, 14353
Recruiting
Research Site
Incheon, 21565
Recruiting
Research Site
Junggu, 22332
Recruiting
Research Site
Seongnam-si, 13620
Recruiting
Research Site
Seoul, 02841
Recruiting
Research Site
Seoul, 03080
Recruiting
Research Site
Seoul, 03722
Recruiting
Research Site
Seoul, 04763
Recruiting
Research Site
Seoul, 05505
Recruiting
Research Site
Seoul, 06351
Withdrawn
Research Site
Seoul, 06591
Recruiting
Research Site
Seoul, 08308
Recruiting
Research Site
Uijeongbu-si, 11765
Recruiting
Research Site
Wŏnju, 26426
Terminated
Research Site
Yangsan, 50612
Recruiting

Other trials in South Korea

Mexico24 sites, 12 recruiting

Research Site
Aguascalientes, 20230
Recruiting
Research Site
Aguascalientes, 20230
Withdrawn
Research Site
Chihuahua City, 31203
Recruiting
Research Site
Cuauhtémoc, 06700
Recruiting
Research Site
Cuauhtémoc, 6720
Withdrawn
Research Site
Culiacán, 80200
Recruiting
Research Site
Culiacán, 80230
Recruiting
Research Site
Guadalajara, 44670
Recruiting
Research Site
Mazatlán, 82110
Withdrawn
Research Site
Metepec, 52170
Recruiting
Research Site
México, 07020
Recruiting
Research Site
México, 11650
Withdrawn
Research Site
México, 14080
Withdrawn
Research Site
Mexico City, 03310
Withdrawn
Research Site
Mexico City, 07300
Withdrawn
Research Site
Monterrey, 64060
Withdrawn
Research Site
Monterrey, 64460
Withdrawn
Research Site
Morelia, 58260
Withdrawn
Research Site
Querétaro, 76000
Recruiting
Research Site
San Luis Potosí City, 78250
Withdrawn
Research Site
Tijuana, 22150
Recruiting
Research Site
Torreón, 27000
Recruiting
Research Site
Veracruz, 91910
Withdrawn
Research Site
Xalapa, 91193
Recruiting

Other trials in Mexico

Philippines20 sites, 17 recruiting

Research Site
Angeles City, 2009
Recruiting
Research Site
Cebu City, 6000
Withdrawn
Research Site
Cebu City, 6000
Recruiting
Research Site
City of Taguig, 1634
Recruiting
Research Site
Davao City, 8000
Recruiting
Research Site
Davao City, PH-8000
Withdrawn
Research Site
Davao City, PH-8000
Recruiting
Research Site
Iloilo City, 5000
Recruiting
Research Site
Las Piñas, PH-1704
Recruiting
Research Site
Mabalacat, 2023
Recruiting
Research Site
Makati, 1209
Recruiting
Research Site
Manadaluyong City, 1552
Recruiting
Research Site
Manila, 1008
Withdrawn
Research Site
Marikina City, 1800
Recruiting
Research Site
Pasig, 1605
Recruiting
Research Site
Quezon City, 1101
Recruiting
Research Site
Quezon City, 1112
Recruiting
Research Site
Quezon City
Recruiting
Research Site
Roxas City, 5800
Recruiting
Research Site
West San Juan City, 1502
Recruiting

Other trials in Philippines

Taiwan19 sites, 19 recruiting

Research Site
Changhua, 500
Recruiting
Research Site
Kaohsiung City, 80756
Recruiting
Research Site
Kaohsiung City, 81362
Recruiting
Research Site
New Taipei City, 220
Recruiting
Research Site
New Taipei City, 231
Recruiting
Research Site
New Taipei City, 25160
Recruiting
Research Site
Taichung, 40447
Recruiting
Research Site
Taichung, 40705
Recruiting
Research Site
Taichung, 433004
Recruiting
Research Site
Taipei, 0116
Recruiting
Research Site
Taipei, 10002
Recruiting
Research Site
Taipei, 10449
Recruiting
Research Site
Taipei, 110
Recruiting
Research Site
Taipei, 11101
Recruiting
Research Site
Taipei, 11217
Recruiting
Research Site
Taipei, TAIWAN
Recruiting
Research Site
Taoyuan, 333
Recruiting
Research Site
Yilan, 260
Recruiting
Research Site
Yung Kang City, 71044
Recruiting

Other trials in Taiwan

Argentina18 sites, 17 recruiting

Research Site
Buenos Aires, 1416
Recruiting
Research Site
Buenos Aires, C1056ABJ
Recruiting
Research Site
Buenos Aires, C1180AAX
Recruiting
Research Site
CABA, C1425HFA
Recruiting
Research Site
Ciudad de Buenos Aires, 1425DES
Recruiting
Research Site
Ciudad de Buenos Aires, C1419AHL
Recruiting
Research Site
Córdoba, X5003DCE
Recruiting
Research Site
Córdoba, X5006CBI
Recruiting
Research Site
Corrientes, W3400CDS
Recruiting
Research Site
Esperanza, S3080BQU
Recruiting
Research Site
Granadero Baigorria, S2152BOF
Recruiting
Research Site
Mar del Plata, B7600GNY
Recruiting
Research Site
Rosario, 2123
Recruiting
Research Site
San Juan Bautista, 1888
Recruiting
Research Site
San Miguel de Tucumán, 4000
Recruiting
Research Site
San Miguel de Tucumán, 4000
Withdrawn
Research Site
San Miguel de Tucumán, T4000ICL
Recruiting
Research Site
Santa Fe, S3000FWO
Recruiting

Other trials in Argentina

Brazil18 sites, 14 recruiting

Research Site
Aracaju, 49055-530
Recruiting
Research Site
Blumenau, 89020-430
Recruiting
Research Site
Brasília, 70200-730
Recruiting
Research Site
Campina Grande do Sul, 83.430-000
Recruiting
Research Site
Campinas, 13060-080
Recruiting
Research Site
Curitiba, 80730-150
Recruiting
Research Site
Goiânia, 74605-020
Recruiting
Research Site
Niterói, 24033-900
Withdrawn
Research Site
Porto Alegre, 90035-903
Recruiting
Research Site
Rio Branco, 69915-030
Recruiting
Research Site
Rio de Janeiro, 20241-180
Recruiting
Research Site
Rio de Janeiro, 20551-030
Recruiting
Research Site
Rio de Janeiro, 22061-080
Withdrawn
Research Site
São José dos Campos, 12230-001
Recruiting
Research Site
São Paulo, 04012-180
Suspended
Research Site
São Paulo, 05403-000
Withdrawn
Research Site
Teresina, 64049-550
Recruiting
Research Site
Uberlândia, 38400-500
Recruiting

Other trials in Brazil

Romania18 sites, 12 recruiting

Research Site
Afumaţi, 077010
Recruiting
Research Site
Arad, 310037
Recruiting
Research Site
Baia Mare, 430222
Recruiting
Research Site
Brasov, 500102
Recruiting
Research Site
Brasov, 500388
Recruiting
Research Site
Bucharest, 010825
Withdrawn
Research Site
Bucharest, 014461
Terminated
Research Site
Bucharest, 014461
Recruiting
Research Site
Bucharest, 022328
Recruiting
Research Site
Bucharest, 040883
Withdrawn
Research Site
Cluj-Napoca, 400437
Terminated
Research Site
Iași, 700010
Withdrawn
Research Site
Iași, 700503
Recruiting
Research Site
Satu Mare, 440055
Recruiting
Research Site
Târgu Mureş, 540099
Recruiting
Research Site
Târgu Mureş, 540136
Recruiting
Research Site
Timișoara, 300254
Recruiting
Research Site
Timișoara, 300310
Terminated

Other trials in Romania

United Kingdom18 sites, 12 recruiting

Research Site
Airdrie, ML6 0JS
Recruiting
Research Site
Barnet, EN5 3DJ
Recruiting
Research Site
Cambridge, CB2 0AY
Withdrawn
Research Site
Clydebank, G81 4DY
Recruiting
Research Site
Exeter, EX2 5DW
Recruiting
Research Site
Harefield, UB9 6JH
Recruiting
Research Site
Hastings, TN37 7RD
Recruiting
Research Site
High Wycombe, HP11 2TT
Withdrawn
Research Site
Kent, BR6 8ND
Recruiting
Research Site
Kings Lynn, PE30 4ET
Recruiting
Research Site
Lincoln, LN2 5QY
Withdrawn
Research Site
London, EC1M 6BQ
Completed
Research Site
London, SE5 9RS
Withdrawn
Research Site
Middlesbrough, TS4 3BW
Recruiting
Research Site
Portsmouth, PO6 3LY
Recruiting
Research Site
Sheffield, S5 7AU
Withdrawn
Research Site
Sunderland, SR4 7TP
Recruiting
Research Site
Wakefield, WF1 4DG
Recruiting

Other trials in United Kingdom

Chile17 sites, 10 recruiting

Research Site
Antofagasta, 1240000
Withdrawn
Research Site
Concepción, 4070196
Recruiting
Research Site
Independencia, 8380465
Recruiting
Research Site
Punta Arenas, 6200000
Withdrawn
Research Site
Region Metropolitana, 7550000
Recruiting
Research Site
San Bernardo, 8070996
Recruiting
Research Site
Santiago, 7500587
Withdrawn
Research Site
Santiago, 7500922
Terminated
Research Site
Santiago, 7770086
Withdrawn
Research Site
Santiago, 8330034
Terminated
Research Site
Santiago, 8380453
Recruiting
Research Site
Santiago, 8910259
Recruiting
Research Site
Talcahuano, 4270918
Recruiting
Research Site
Temuco, 4781156
Withdrawn
Research Site
Temuco, 4810345
Recruiting
Research Site
Valdivia, 5110683
Recruiting
Research Site
Victoria, 4720097
Recruiting

Other trials in Chile

Czechia17 sites, 11 recruiting

Research Site
Brno, 60200
Recruiting
Research Site
Brno, 639 00
Terminated
Research Site
Broumov, 55001
Recruiting
Research Site
Česká Lípa, 470 77
Recruiting
Research Site
Jaroměř, 551 01
Recruiting
Research Site
Louny, 440 01
Recruiting
Research Site
Ostrava, 702 00
Recruiting
Research Site
Ostrava, 702 00
Suspended
Research Site
Pilsen, 31001
Withdrawn
Research Site
Plzen - Bory, 305 99
Recruiting
Research Site
Prague, 120 00
Terminated
Research Site
Přerov, 75152
Completed
Research Site
Slaný, 274 01
Recruiting
Research Site
Svitavy, 568 02
Recruiting
Research Site
Ustí Nad Labem, 40011
Withdrawn
Research Site
Ústí nad Labem, 400 01
Recruiting
Research Site
Zlín, 760 01
Recruiting

Other trials in Czechia

Bulgaria16 sites, 13 recruiting

Research Site
Botevgrad, 2140
Recruiting
Research Site
Dupnitsa, 2600
Recruiting
Research Site
Haskovo, 6300
Recruiting
Research Site
Kozloduy, 3320
Withdrawn
Research Site
Pleven, 5800
Recruiting
Research Site
Plovdiv, 4000
Recruiting
Research Site
Plovdiv, 4003
Recruiting
Research Site
Sliven, 8800
Recruiting
Research Site
Sliven, 8800
Withdrawn
Research Site
Sofia, 1000
Recruiting
Research Site
Sofia, 1309
Recruiting
Research Site
Sofia, 1431
Withdrawn
Research Site
Sofia, 1606
Recruiting
Research Site
Sofia, 1618
Recruiting
Research Site
Sofia, 1756
Recruiting
Research Site
Stara Zagora, 6000
Recruiting

Other trials in Bulgaria

Peru15 sites, 8 recruiting

Research Site
Bellavista, CALLAO 2
Recruiting
Research Site
Cusco, CUSCO 01
Withdrawn
Research Site
Lima, 15024
Recruiting
Research Site
Lima, 15038
Withdrawn
Research Site
Lima, 15046
Withdrawn
Research Site
Lima, 15046
Recruiting
Research Site
Lima, 15072
Withdrawn
Research Site
Lima, 15088
Recruiting
Research Site
Lima, 15102
Withdrawn
Research Site
Lima, 15131
Withdrawn
Research Site
Lima, L18
Withdrawn
Research Site
Lima, LIMA 11
Recruiting
Research Site
Lima, LIMA 27
Recruiting
Research Site
Lima, LIMA 41
Recruiting
Research Site
Piura, 20001
Recruiting

Other trials in Peru

Colombia14 sites, 13 recruiting

Research Site
Armenia, 630004
Recruiting
Research Site
Barranquilla, 080020
Recruiting
Research Site
Barranquilla, 80007
Recruiting
Research Site
Bogotá, 110221
Completed
Research Site
Bogotá, 111211
Recruiting
Research Site
Cali, 760032
Recruiting
Research Site
Cali, 760036
Recruiting
Research Site
Cartagena, 130001
Recruiting
Research Site
Cartagena, 130013
Recruiting
Research Site
Manizales, 170004
Recruiting
Research Site
Medellín, 050030
Recruiting
Research Site
Medellín, 050034
Recruiting
Research Site
Piedecuesta, 681017
Recruiting
Research Site
Rionegro, 054047
Recruiting

Other trials in Colombia

Slovakia14 sites, 11 recruiting

Research Site
Banská Bystrica, 974 01
Recruiting
Research Site
Bratislava, 831 01
Recruiting
Research Site
Bratislava, 841 08
Recruiting
Research Site
Brezno, 977 01
Recruiting
Research Site
Košice, 040 01
Recruiting
Research Site
Košice, 04022
Recruiting
Research Site
Martin, 036 01
Recruiting
Research Site
Myjava, 90701
Recruiting
Research Site
Nitra, 949 01
Recruiting
Research Site
Nové Zámky, 940 01
Withdrawn
Research Site
Považská Bystrica, 017 01
Recruiting
Research Site
Prešov, 080 01
Withdrawn
Research Site
Rimavská Sobota, 979 01
Suspended
Research Site
Svidník, 08901
Recruiting

Other trials in Slovakia

Turkey (Türkiye)14 sites, 11 recruiting

Research Site
Adana, 01060
Recruiting
Research Site
Ankara, 06
Recruiting
Research Site
Antalya, 07059
Recruiting
Research Site
Antalya, 07100
Recruiting
Research Site
Bursa, 16059
Completed
Research Site
Center, 78200
Recruiting
Research Site
Dinar, 03400
Recruiting
Research Site
Eskişehir, 26480
Recruiting
Research Site
Istanbul, 34668
Withdrawn
Research Site
Izmir, 35340
Recruiting
Research Site
Kocaeli, 41380
Recruiting
Research Site
Kütahya, 43100
Recruiting
Research Site
Muğla, 48000
Completed
Research Site
Sivas, 58140
Recruiting

Other trials in Turkey (Türkiye)

Ukraine14 sites, 14 recruiting

Research Site
Chernivtsі, 58002
Recruiting
Research Site
Ivano-Frankivsk, 76018
Recruiting
Research Site
Kyiv, 01601
Recruiting
Research Site
Kyiv, 02081
Recruiting
Research Site
Kyiv, 03037
Recruiting
Research Site
Kyiv, 03151
Recruiting
Research Site
Kyiv, 03680
Recruiting
Research Site
Kyiv, 04050
Recruiting
Research Site
Ternopil, 46000
Recruiting
Research Site
Ternopil, 46002
Recruiting
Research Site
Uzhhorod, 88014
Recruiting
Research Site
Vinnytsia, 21001
Recruiting
Research Site
Vinnytsia, 21029
Recruiting
Research Site
Zhytomyr, 100002
Recruiting

Other trials in Ukraine

Hungary13 sites, 9 recruiting

Research Site
Balatonfüred, 8230
Recruiting
Research Site
Békéscsaba, 5600
Recruiting
Research Site
Budapest, 1033
Recruiting
Research Site
Budapest, 1036
Recruiting
Research Site
Budapest, 1122
Recruiting
Research Site
Budapest, 1145
Withdrawn
Research Site
Gyula, 5700
Withdrawn
Research Site
Hódmezővásárhely, 6800
Withdrawn
Research Site
Kecskemét, 6000
Recruiting
Research Site
Orosháza, 5900
Withdrawn
Research Site
Pécs, 7623
Recruiting
Research Site
Pécs, 7635
Recruiting
Research Site
Székesfehérvár, 8000
Recruiting

Other trials in Hungary

Italy13 sites, 9 recruiting

Research Site
Acquaviva delle Fonti, 70021
Withdrawn
Research Site
Bari, 70124
Recruiting
Research Site
Bergamo, 24127
Recruiting
Research Site
Brescia, 25100
Recruiting
Research Site
Catania, 95100
Recruiting
Research Site
Catanzaro, 88100
Recruiting
Research Site
Cona, 44124
Recruiting
Research Site
Cortona, 52044
Recruiting
Research Site
Florence, 50134
Withdrawn
Research Site
Milan, 20138
Recruiting
Research Site
Novara, 28100
Withdrawn
Research Site
Pavia, 27100
Recruiting
Research Site
San Giovanni Rotondo, 71013
Withdrawn

Other trials in Italy

Israel12 sites, 12 recruiting

Research Site
Afula, 1834111
Recruiting
Research Site
Ashkelon, 78278
Recruiting
Research Site
Be’er Ya‘aqov, 70300
Recruiting
Research Site
Beersheba, 8410101
Recruiting
Research Site
Haifa, 3109601
Recruiting
Research Site
Holon, 5840608
Recruiting
Research Site
Jerusalem, 00000
Recruiting
Research Site
Kfar Saba, 4428164
Recruiting
Research Site
Nahariya, 22100
Recruiting
Research Site
Petah Tikva, 49372
Recruiting
Research Site
Tel Aviv, 6423906
Recruiting
Research Site
Tiberias, 15208
Recruiting

Other trials in Israel

Spain12 sites, 12 recruiting

Research Site
A Coruña, 15006
Recruiting
Research Site
Barcelona, 08025
Recruiting
Research Site
Barcelona, 08035
Recruiting
Research Site
Barcelona, 08036
Recruiting
Research Site
Lugo, 27004
Recruiting
Research Site
Madrid, 28007
Recruiting
Research Site
Madrid, 28027
Recruiting
Research Site
Majadahonda, 28222
Recruiting
Research Site
Seville, 41004
Recruiting
Research Site
Seville, 41013
Recruiting
Research Site
Seville, 41071
Recruiting
Research Site
Valencia, 46010
Recruiting

Other trials in Spain

Australia11 sites, 9 recruiting

Research Site
Blacktown, 2148
Recruiting
Research Site
Cairns, 4870
Withdrawn
Research Site
Canberra, 2605
Recruiting
Research Site
Chermside, 4032
Withdrawn
Research Site
Clayton, 3168
Recruiting
Research Site
Concord, 2139
Recruiting
Research Site
Frankston, 3199
Recruiting
Research Site
Geelong, 3220
Recruiting
Research Site
Murdoch, WA6150
Recruiting
Research Site
North Tamworth, 2340
Recruiting
Research Site
Westmead, 2145
Recruiting

Other trials in Australia

Austria11 sites, 11 recruiting

Research Site
Bad Ischl, 4820
Recruiting
Research Site
Braunau am Inn, 5280
Recruiting
Research Site
Graz, 8036
Recruiting
Research Site
Linz, 4020
Recruiting
Research Site
Saint Stefan/Stainz, 8511
Recruiting
Research Site
Salzburg, 5020
Recruiting
Research Site
Sankt Pölten, 3100
Recruiting
Research Site
Vienna, 1090
Recruiting
Research Site
Vienna, 1100
Recruiting
Research Site
Vienna, 1160
Recruiting
Research Site
Vöcklabruck, 4840
Recruiting

Other trials in Austria

Greece11 sites, 10 recruiting

Research Site
Athens, 11521
Recruiting
Research Site
Athens, 11526
Recruiting
Research Site
Athens, 11527
Recruiting
Research Site
Athens, 11528
Recruiting
Research Site
Athens, 12462
Recruiting
Research Site
Athens, 14233
Recruiting
Research Site
Athens, 15123
Recruiting
Research Site
Dragana, 68100
Recruiting
Research Site
Heraklio, 71110
Completed
Research Site
Thessaloniki, 54636
Recruiting
Research Site
Thessaloniki, 54642
Recruiting

Other trials in Greece

South Africa11 sites, 10 recruiting

Research Site
Bloemfontein, 9301
Recruiting
Research Site
Centurion, 0157
Recruiting
Research Site
Durban, 4052
Recruiting
Research Site
Johannesburg, 2193
Recruiting
Research Site
KwaDukuza, 4449
Recruiting
Research Site
Panorama, 7500
Recruiting
Research Site
Parow, 7505
Recruiting
Research Site
Pietermaritzburg, 3201
Recruiting
Research Site
Somerset West, 7130
Recruiting
Research Site
Soweto, 2013
Recruiting
Research Site
Worcester, 6850
Withdrawn

Other trials in South Africa

Sweden11 sites, 10 recruiting

Research Site
Alingsås, 441 83
Withdrawn
Research Site
Gothenburg, 413 46
Recruiting
Research Site
Jönköping, 55305
Recruiting
Research Site
Karlstad, 651 85
Recruiting
Research Site
Mölndal, SE431 80
Recruiting
Research Site
Stockholm, 112 81
Recruiting
Research Site
Stockholm, 118 83
Recruiting
Research Site
Stockholm, 171 64
Recruiting
Research Site
Stockholm, 18288
Recruiting
Research Site
Uppsala, 751 85
Recruiting
Research Site
Västerås, 721 89
Recruiting

Other trials in Sweden

Vietnam11 sites, 11 recruiting

Research Site
Can Tho, 900000
Recruiting
Research Site
Da Nang, 550000
Recruiting
Research Site
Hà Nội, 100000
Recruiting
Research Site
Haiphong, 180000
Recruiting
Research Site
Hanoi, 100000
Recruiting
Research Site
Hồ Chí Minh, 700000
Recruiting
Research Site
Ho Chi Minh City, 700000
Recruiting
Research Site
Ho Chi Minh City, 70000
Recruiting
Research Site
Hochiminh, 70000
Recruiting
Research Site
Hochiminh City, 700000
Recruiting
Research Site
Huế, 530000
Recruiting

Other trials in Vietnam

Thailand8 sites, 8 recruiting

Research Site
Bangkok, 10330
Recruiting
Research Site
Bangkok, 10400
Recruiting
Research Site
Bangkok, 10700
Recruiting
Research Site
Chiang Mai, 50200
Recruiting
Research Site
Hat Yai, 90110
Recruiting
Research Site
Khon Kaen, 40002
Recruiting
Research Site
Naimuang, 30000
Recruiting
Research Site
Pathum Thani, 12120
Recruiting

Other trials in Thailand

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Saudi Arabia7 sites, 6 recruiting

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About this study

Official title: A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared With Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients With Heart Failure and Impaired Kidney Function

This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to evaluate the effect of balcinrenone/dapagliflozin vs dapagliflozin, given once daily on top of other classes of SoC, on CV death and HF events.

Read the detailed description

The purpose of this study is to investigate the effect of balcinrenone/dapagliflozin compared with dapagliflozin, on the risk of CV death, HF event with and without hospitalisation, in patients with chronic HF, impaired kidney function, and who have had a recent HF event.

Eligible patients will randomly be assigned with a 1:1:1 ratio to receive once daily administration of one capsule and one tablet of one of the following treatments:

Balcinrenone/dapagliflozin 15 mg/10 mg capsule and matching placebo for dapagliflozin 10 mg tablet
Balcinrenone/dapagliflozin 40 mg/10 mg capsule and matching placebo for dapagliflozin 10 mg tablet
Dapagliflozin 10 mg tablet and matching placebo for balcinrenone/dapagliflozin capsule

The study will be conducted at approximately 700 sites in approximately 40 countries globally.

Conditions: Heart Failure and Impaired Kidney Function
Being tested: balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg, balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg, dapagliflozin 10 mg and matching placebo for balcinrenone/dapagliflozin
Medical subject headings: Heart Failure

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mgDrug
1 capsule of balcinrenone/dapagliflozin 15 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use
balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mgDrug
1 capsule of balcinrenone/dapagliflozin 40 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use
dapagliflozin 10 mg and matching placebo for balcinrenone/dapagliflozinDrug
1 tablet of dapagliflozin 10 mg and 1 capsule of matching placebo for balcinrenone/dapagliflozin once daily, oral use

Study groups in NCT06307652
Study group	Role	What they receive
balcinrenone/dapagliflozin 15 mg/10 mg	Experimental	Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin Receives: Drug: balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg
balcinrenone/dapagliflozin 40 mg/10 mg	Experimental	Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin Receives: Drug: balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg
dapagliflozin 10 mg	Active comparator	Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin Receives: Drug: dapagliflozin 10 mg and matching placebo for balcinrenone/dapagliflozin

What is being measured

The primary outcome is the main question the study is designed to answer.

Time to first occurrence of any of the components of the composite of: •CV death •HF hospitalisation •HF event without hospitalisation
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the risk of CV death and HF events with and without hospitalisation
Measured: Approximately 36 months

Secondary outcomes (5)

Total occurrences (first and recurrent) of the components of the composite of: •CV death •HF hospitalisation •HF event without hospitalisation
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the rate of total occurrences of CV death, and HF events with and without hospitalisation
Measured: Approximately 36 months
Total occurrences (first and recurrent) of HF hospitalisations
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the rate of total HF hospitalisations
Measured: Approximately 36 months
Time to CV death
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the risk of CV death
Measured: Approximately 36 months
Time to death from any cause
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the risk of death from any cause
Measured: Approximately 36 months
Change in KCCQ total symptom score from baseline to 24 weeks post-randomisation
To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in improving patient reported symptoms of HF
Measured: Approximately 24 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

12 Apr 202416 Apr 2027

First posted13 Mar 2024
Study start12 Apr 2024
Primary completion16 Apr 2027 (estimated)
Study completion16 Apr 2027 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (1)Papers the sponsor has linked to this study.
Other trials for Heart Failure and Impaired Kidney FunctionStudies of the same condition, open and under way.
More trials run by AstraZenecaThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase 3
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Model description: international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven
Masking: Quadruple blind
Who is masked: Participant, Care provider, Investigator, Outcomes assessor
Enrolment: 3,850 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06307652
Sponsor's protocol ID: D6402C00012
Other IDs: 2023-508162-15-00, 2023
Acronym: BalanceD-HF
Status last verified: Oct 2026
First submitted: 6 Feb 2024
Last updated: 13 Oct 2026
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: Yes
FDA-regulated device: No
Individual data sharing: Yes: Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. "Yes", indicates that AZ are accepting requests for IPD, but this does not mean all requests will be approved.

Publications

Bhattacharya CS, Ericsson H, Johansson S, Parkinson J, Boca SM, Yang Y, Heijer M, Housler G, Leonsson-Zachrisson M, Hartleib-Geschwindner J, Pizzato PE. The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone. Br J Clin Pharmacol. 2025 Jul;91(7):1937-1946. doi: 10.1002/bcp.70017. Epub 2025 Feb 17.
PubMed 39962632