Calcified Cerebral EmbolismCCE CohorteNCT06309069
Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort
An observational study of Calcified Cerebral Embolism, run by Centre Hospitalier Universitaire de Nīmes at 1 site in France.
Trial summary
Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Calcified Cerebral Embolism
- What is being tested?
- None, purely observational study
- How many people
- 79 participants
- Where
- 1 siteFrance
- Study dates
- 16 Apr 2024to 30 Nov 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020, and patients with AIT/stroke with a CCE identified on CT between deceber 2019 and april 2023.
Who may be able to join
- Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020 managed at the CHU de Nîmes or Patients with TIA/stroke with ECC identified on CT between 12/2019 and 04/2023 managed at CHU de Nîmes
Who cannot join
- Patient's refusal to use his/her data
Trial locations and contacts
1 site in 1 country.
About this study
Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series. The aim of this study was to describe clinical and radiological characteristics of CCE in a large number of patients, and to compare patients with different radiological CCE characteristics.
- Conditions
- Calcified Cerebral Embolism
- Being tested
- None, purely observational study
- Keywords
- calcified cerebral embolism, cerebral infarction, radiological characteristics
- Medical subject headings
- Cerebral Infarction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
None, purely observational studyOther
None, purely observational study
| Study group | Role | What they receive |
|---|---|---|
| Patients with CCE | CCE patients identified between 2015 and 2023 Receives: Other: None, purely observational study |
What is being measured
The primary outcome is the main question the study is designed to answer.
Calcified aortic brachiocephalic
looking for calcified aortic brachiocephalic (presence or absence)
Measured: baseline
cardiovascular risk
Study of cardiovascular risk factors (presence or absence)
Measured: baseline
history of stroke
Presence of a history of stroke (y/n)
Measured: baseline
Population
demographic characteristics age (years)
Measured: baseline
Population
demographic characteristics sexe (M/F)
Measured: baseline
history of surgical/endovascular cardiovascular intervention
surgical/endovascular cardiovascular intervention (y/n)
Measured: baseline
NIHSS
NIHSS score (Score between 1 and 4: minor stroke, Score between 5 and 15: moderate, stroke, Score between 15 and 20: severe stroke) Score > 20: severe stroke
Measured: baseline
calcified aortic arch
looking for calcified aortic arch (presence/absence)
Measured: baseline
calcified carotid
looking for calcified carotid (presence/absence)
Measured: baseline
atherosclerotic plaques
looking for atherosclerotic plaques (presence/absence)
Measured: baseline
calcified aortic valves
looking for calcified aortic valves (presence/absence)
Measured: baseline
calcified mitral valves
looking for calcified mitral valves (presence/absence)
Measured: baseline
CCE diameter
CCE diameter measurement (mm)
Measured: baseline
density
CCE density (uh)
Measured: baseline
involved cerebral artery
description of involved cerebral artery
Measured: baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Mar 2024
- Study start16 Apr 2024
- Primary completion30 Nov 2024
- Study completion30 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Calcified Cerebral EmbolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 79 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de Nīmes
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Anissa MEGZARI, Study director, Centre Hospitalier Universitaire de Nīmes
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06309069
- Sponsor's protocol ID
- LOCAL/2024/TP-01
- Other IDs
- IRB 24.01.01
- Acronym
- CCE Cohorte
- Status last verified
- Dec 2025
- First submitted
- 26 Feb 2024
- Last updated
- 23 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Serghine Y, Laurent-Chabalier S, Thouvenot E, Parvu T, Renard D. Clinical and radiological characteristics of calcified cerebral embolism: a large case series including 242 calcified cerebral embolism. Acta Neurol Belg. 2025 Apr;125(2):463-468. doi: 10.1007/s13760-025-02719-w. Epub 2025 Jan 15.
PubMed 39813005
Study at a glance
From the registry record, last updated by the sponsor on 23 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort
- ClinicalTrials.gov ID
- NCT06309069
- Acronym / sponsor ID
- CCE Cohorte / LOCAL/2024/TP-01
- Conditions
- Calcified Cerebral Embolism
- Keywords
- calcified cerebral embolism, cerebral infarction, radiological characteristics
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 79 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de NīmesUniversity, hospital or other
- Study start
- 16 Apr 2024 (actual)
- Primary completion
- 30 Nov 2024 (actual)
- Study completion
- 30 Nov 2024 (actual)
- First posted
- 13 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series. The aim of this study was to describe clinical and radiological characteristics of CCE in a large number of patients, and to compare patients with different radiological CCE characteristics.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients with CCE | – | Other: None, purely observational studyCCE patients identified between 2015 and 2023 |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020, and patients with AIT/stroke with a CCE identified on CT between deceber 2019 and april 2023.
Key inclusion criteria (1 listed)
- Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020 managed at the CHU de Nîmes or Patients with TIA/stroke with ECC identified on CT between 12/2019 and 04/2023 managed at CHU de Nîmes
Key exclusion criteria (1 listed)
- Patient's refusal to use his/her data
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| None, purely observational studyNone, purely observational study | Other | Patients with CCE |
Primary outcome
Calcified aortic brachiocephalic
Time frame: baseline
looking for calcified aortic brachiocephalic (presence or absence)
cardiovascular risk
Time frame: baseline
Study of cardiovascular risk factors (presence or absence)
history of stroke
Time frame: baseline
Presence of a history of stroke (y/n)
Population
Time frame: baseline
demographic characteristics age (years)
Population
Time frame: baseline
demographic characteristics sexe (M/F)
history of surgical/endovascular cardiovascular intervention
Time frame: baseline
surgical/endovascular cardiovascular intervention (y/n)
NIHSS
Time frame: baseline
NIHSS score (Score between 1 and 4: minor stroke, Score between 5 and 15: moderate, stroke, Score between 15 and 20: severe stroke) Score > 20: severe stroke
calcified aortic arch
Time frame: baseline
looking for calcified aortic arch (presence/absence)
calcified carotid
Time frame: baseline
looking for calcified carotid (presence/absence)
atherosclerotic plaques
Time frame: baseline
looking for atherosclerotic plaques (presence/absence)
calcified aortic valves
Time frame: baseline
looking for calcified aortic valves (presence/absence)
calcified mitral valves
Time frame: baseline
looking for calcified mitral valves (presence/absence)
CCE diameter
Time frame: baseline
CCE diameter measurement (mm)
density
Time frame: baseline
CCE density (uh)
involved cerebral artery
Time frame: baseline
description of involved cerebral artery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jan 2026.
- Results publication: PubMed 39813005Serghine Y, Laurent-Chabalier S, Thouvenot E, Parvu T, Renard D. Clinical and radiological characteristics of calcified cerebral embolism: a large case series including 242 calcified cerebral embolism. Acta Neurol Belg. 2025 Apr;125(2):463-468. doi: 10.1007/s13760-025-02719-w. Epub 2025 Jan 15.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anissa MEGZARI study director
Centre Hospitalier Universitaire de Nīmes
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Calcified Cerebral Embolism, run by Centre Hospitalier Universitaire de Nīmes at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Calcified aortic brachiocephalic (time frame: baseline). The study lists 15 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06309069, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jan 2026.