Cervical Spine DiseaseNCT06320938

Effectiveness of Neuroscience-based Pain Education in Patients With Chronic Neck Pain

A study testing Neuroscience-Based Pain Education Combined with Home Exercise Program, Myofascial Induction Techniques Combined with Home Exercise Program and Home Exercises Group in people with Cervical Spine Disease, run by Turkoglu Dr. Kemal Beyazit State Hospital at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

Search all trials

Trial summary

The effectiveness of neuroscience-based pain education, myofascial induction technique, and home exercise programs will be compared in patients with chronic neck pain. Read more about this study

Who is it for?: Ages 18 to 60 years
Conditions the study is for: Cervical Spine Disease
What is being tested?: Neuroscience-Based Pain Education Combined with Home Exercise Program, Myofascial Induction Techniques Combined with Home Exercise Program and Home Exercises Group
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 60 participants
Where: 1 siteTurkey (Türkiye)
Study dates: 18 Apr 2024to 25 May 2025
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 60 years
All sexes
No healthy volunteers
Adult

Who may be able to join

Ages between 18-60 years old,
Patients with non-specific neck pain for at least 3 months,
Having pain severity of four or more according to the Visual analogue scale (VAS),
Patients with Pain Catastrophizing Scale score > 30
Patients with a Central Sensitization Inventory score > 30
Not having received physiotherapy and manual therapy within the last 3 months,
Those who have not received and will not receive medical treatment in the last 3 months.

Who cannot join

Having a history of neck and spine surgery,
Patients with whiplash injury, fracture history,
Having unstable neurological findings,
Presence of a pathology such as hernia and root compression in the cervical region,
Those who regularly use analgesic and anti-inflammatory drugs,
A communication problem may prevent the implementation of the evaluations or treatment program.

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site

Türkoğlu Dr. Kemal Beyazıt State Hospital
Kahramanmaraş

Other trials in Turkey (Türkiye)

About this study

Official title: Comparison of the Effects of Neuroscience-Based Pain Education and Myofascial Induction Technique on Pain and Quality of Life in Patients With Chronic Neck Pain

The effectiveness of neuroscience-based pain education, myofascial induction technique, and home exercise programs will be compared in patients with chronic neck pain.

Read the detailed description

The study aims to present the immediate and long-term effects of Neuroscience-based Pain Education (NPE) and Myofascial Induction Therapy (MIT). It will evaluate parameters such as pain, quality of life, pain catastrophizing, and neck disability after treatment completion and at the 6-month follow-up.

The investigators aim to illuminate future studies concerning neuroscience-based pain education, which has gained prominence in recent years and continues to increase in importance annually.

The participants will be randomly assigned to one of three groups:

1 Group: Neuroscience-Based Pain Education Combined with Home Exercise Program Participants in this group will receive Neuroscience-Based Pain Education (NPE) treatment in addition to the home exercise program. Training sessions will be organized as one-on-one conversation sessions focusing on the neurophysiology of pain, and participants will be reinforced through PowerPoint presentations and visual aids such as pictures, templates, and metaphors.

Group: Myofascial Induction Techniques Combined with Home Exercise Program In addition to the home exercise program, Myofascial Induction Techniques (MIT) group participants will have MIT applied to the cervical and upper thoracic regions.

Group: Home Exercise Program After undergoing general training, participants in this group will be taught an exercise program. The program will include neck muscle stretching, strengthening, and posture exercises.

Conditions: Cervical Spine Disease
Being tested: Neuroscience-Based Pain Education Combined with Home Exercise Program, Myofascial Induction Techniques Combined with Home Exercise Program, Home Exercises Group
Keywords: Pain neuroscience education, Myofascial induction technique, Myofascial treatment, Home exercises, Pain, Neck Disability
Medical subject headings: Pain

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Neuroscience-Based Pain Education Combined with Home Exercise ProgramOther
Neuroscience-Based Pain Education and Home Exercises will be applied.
Myofascial Induction Techniques Combined with Home Exercise ProgramOther
Myofascial Induction Techniques and Home Exercises will be applied.
Home Exercises GroupOther
Home Exercises wiil be applied

Study groups in NCT06320938
Study group	Role	What they receive
Neuroscience-Based Pain Education Combined with Home Exercise Program	Active comparator	Patients in this group will receive Neuroscience-Based Pain Education (NPE) treatment in addition to the home exercise program. Training sessions are planned once a week for an average of 35-45 minutes and 8 sessions. NPE will be performed by a physiotherapist who has an internationally recognized certificate in this regard. Training sessions will be organized as one-on-one conversation sessions focusing on the neurophysiology of pain, and patients will be reinforced through PowerPoint presentations and visual pictures, templates, and metaphors. Receives: Other: Neuroscience-Based Pain Education Combined with Home Exercise Program
Myofascial Induction Techniques Combined with Home Exercise Program	Active comparator	In addition to the home exercise program, Myofascial Induction Techniques (MIT) group patients will have MIT applied to the cervical and upper thoracic regions by a physiotherapist trained and experienced in myofascial treatments. The application will be once a week for 8 weeks, with an average duration of 35-45 minutes. Receives: Other: Myofascial Induction Techniques Combined with Home Exercise Program
Home Exercise Program	Active comparator	Patients in this group will be taught an exercise program after undergoing general training. Exercises will include stretching and strengthening exercises for neck muscles and posture exercises. Patients are asked to take 35-45 minutes once a day, five days a week, for 8 weeks. They will be asked to do the given home exercises and fill out follow-up charts. The continuity of the exercises will be ensured by sending reminder messages to this group of patients once a week by the physiotherapist about doing their exercises. Receives: Other: Home Exercises Group

What is being measured

The primary outcome is the main question the study is designed to answer.

Short Form McGill Pain Questionnaire
A short form of the McGill Pain Questionnaire (SF-MPQ) used in pain assessment consists of four sections. In the first section, participants are asked to mark the location of pain on a body diagram. In the second section, participants are asked to select the word that best describes their pain from twenty subgroups. The third section investigates the relationship of pain over time, while the fourth and final section requires participants to indicate the intensity of pain on a scale of 1 to 5 and provide written responses to six questions. The questionnaire is scored from 0 to 112. The higher the pain score, the greater the pain.
Measured: Baseline,8 weeks, 6 months
Algometric Digital Measurement
It is a digital device used to evaluate trigger point sensitivity.
Measured: Baseline,8 weeks, 6 months
Central Sensitization Inventory
The scale, which can be applied in chronic pain, is used in central sensitization syndromes. It consists of two parts. Section A questions health-related symptoms, and part B questions whether any central sensitization syndromes have been diagnosed before.
Measured: Baseline,8 weeks, 6 months
Head Posture Evaluation
Forward head posture is measured with a goniometer, which measures the angle between the horizontal plane and the seventh cervical vertebra and ear line.
Measured: Baseline,8 weeks, 6 months
Neck Disability Index
The scale consists of ten headings in total. It includes neck pain intensity, personal care, lifting, reading, headaches, concentration, driving, sleep, and leisure activities.
Measured: Baseline,8 weeks, 6 months
Pittsburgh Sleep Quality Index
This survey contains 24 questions about sleep status, both during the day and at night. Nineteen of these are to be answered personally, and five are to be answered by a spouse or roommate.
Measured: Baseline,8 weeks, 6 months
36-Item Short Form Health Survey Questionnaire
36-Item Short Form Health Survey (SF-36) questionnaire consists of eight subscales: physical functioning, social functioning, role limitations due to physical problems, pain, vitality, mental health, and general health perception. Each subscale is scored from 0 to 100, and the scores from these subscales are not summed. A high score indicates good health status.
Measured: Baseline,8 weeks, 6 months
Pain Catastrophizing Scale
The Pain Catastrophizing Scale (PCS) is a 13-item self-report measure of catastrophizing in the context of actual or anticipated pain. The PCS measures catastrophizing as a multidimensional construct with three subscales: rumination, magnification, and helplessness. Rumination focuses on thoughts related to pain, helplessness reflects feelings of helplessness in coping with a painful situation, and magnification is a general view of the threat of pain. High PCS scores are associated with greater pain and more functional impairment. A total score above 30 represents clinically significant levels of pain catastrophizing.
Measured: Baseline,8 weeks, 6 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

18 Apr 202425 May 2025

First posted20 Mar 2024
Study start18 Apr 2024
Primary completion15 Jan 2025
Study completion25 May 2025

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (3)Papers the sponsor has linked to this study.
Other trials for Cervical Spine DiseaseStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind
Who is masked: Participant
Enrolment: 60 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06320938
Sponsor's protocol ID: 2024/18
Status last verified: Aug 2024
First submitted: 13 Mar 2024
Last updated: 3 Sep 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Publications

Bernetti A, Agostini F, de Sire A, Mangone M, Tognolo L, Di Cesare A, Ruiu P, Paolucci T, Invernizzi M, Paoloni M. Neuropathic Pain and Rehabilitation: A Systematic Review of International Guidelines. Diagnostics (Basel). 2021 Jan 5;11(1):74. doi: 10.3390/diagnostics11010074.
PubMed 33466426
Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021 May 29;397(10289):2082-2097. doi: 10.1016/S0140-6736(21)00393-7.
PubMed 34062143
Javdaneh N, Saeterbakken AH, Shams A, Barati AH. Pain Neuroscience Education Combined with Therapeutic Exercises Provides Added Benefit in the Treatment of Chronic Neck Pain. Int J Environ Res Public Health. 2021 Aug 22;18(16):8848. doi: 10.3390/ijerph18168848.
PubMed 34444594

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Active, not recruiting
The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery
Cervical Degenerative Disc Disease
Enrolling by invitation
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
Spinal Cord Injuries
Not yet recruiting
Endoscopic Posterior Cervical Foraminotomy Versus Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy
Cervical Disc Herniation, Cervical Foraminal Stenosis
Enrolling by invitation
Assessing Microbiome in Primary Anterior Cervical Fusion Patients
Cervical Stenosis, Myelopathy
Not yet recruiting
Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials
Knee Osteoarthritis; Insomnia; Cervical Spondylosis; Chronic Low Back Pain; Allergic Rhinitis

All Cervical Spine Disease trials

Study at a glance

From the registry record, last updated by the sponsor on 3 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Comparison of the Effects of Neuroscience-Based Pain Education and Myofascial Induction Technique on Pain and Quality of Life in Patients With Chronic Neck Pain
ClinicalTrials.gov ID: NCT06320938
Acronym / sponsor ID: 2024/18
Conditions: Cervical Spine Disease
Keywords: Pain neuroscience education, Myofascial induction technique, Myofascial treatment, Home exercises, Pain, Neck Disability
Study type: Interventional
Recruitment status: Completed
Enrolment: 60 participants (actual)
Lead sponsor: Turkoglu Dr. Kemal Beyazit State HospitalUniversity, hospital or other
Study start: 18 Apr 2024 (actual)
Primary completion: 15 Jan 2025 (actual)
Study completion: 25 May 2025 (actual)
First posted: 20 Mar 2024 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

The effectiveness of neuroscience-based pain education, myofascial induction technique, and home exercise programs will be compared in patients with chronic neck pain.

Detailed description

The investigators aim to illuminate future studies concerning neuroscience-based pain education, which has gained prominence in recent years and continues to increase in importance annually.

The participants will be randomly assigned to one of three groups:

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind (participant)
Number of arms: 3

Arm	Type	Receives
Neuroscience-Based Pain Education Combined with Home Exercise Program	Active comparator	Other: Neuroscience-Based Pain Education Combined with Home Exercise ProgramPatients in this group will receive Neuroscience-Based Pain Education (NPE) treatment in addition to the home exercise program. Training sessions are planned once a week for an average of 35-45 minutes and 8 sessions. NPE will be performed by a physiotherapist who has an internationally recognized certificate in this regard. Training sessions will be organized as one-on-one conversation sessions focusing on the neurophysiology of pain, and patients will be reinforced through PowerPoint presentations and visual pictures, templates, and metaphors.
Myofascial Induction Techniques Combined with Home Exercise Program	Active comparator	Other: Myofascial Induction Techniques Combined with Home Exercise ProgramIn addition to the home exercise program, Myofascial Induction Techniques (MIT) group patients will have MIT applied to the cervical and upper thoracic regions by a physiotherapist trained and experienced in myofascial treatments. The application will be once a week for 8 weeks, with an average duration of 35-45 minutes.
Home Exercise Program	Active comparator	Other: Home Exercises GroupPatients in this group will be taught an exercise program after undergoing general training. Exercises will include stretching and strengthening exercises for neck muscles and posture exercises. Patients are asked to take 35-45 minutes once a day, five days a week, for 8 weeks. They will be asked to do the given home exercises and fill out follow-up charts. The continuity of the exercises will be ensured by sending reminder messages to this group of patients once a week by the physiotherapist about doing their exercises.

Who may qualify

Ages: 18 to 60 years
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult

Key inclusion criteria (7 listed)

Ages between 18-60 years old,
Patients with non-specific neck pain for at least 3 months,
Having pain severity of four or more according to the Visual analogue scale (VAS),
Patients with Pain Catastrophizing Scale score > 30
Patients with a Central Sensitization Inventory score > 30

Key exclusion criteria (6 listed)

Having a history of neck and spine surgery,
Patients with whiplash injury, fracture history,
Having unstable neurological findings,
Presence of a pathology such as hernia and root compression in the cervical region,
Those who regularly use analgesic and anti-inflammatory drugs,

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Neuroscience-Based Pain Education Combined with Home Exercise ProgramNeuroscience-Based Pain Education and Home Exercises will be applied.	Other	Neuroscience-Based Pain Education Combined with Home Exercise Program
Myofascial Induction Techniques Combined with Home Exercise ProgramMyofascial Induction Techniques and Home Exercises will be applied.	Other	Myofascial Induction Techniques Combined with Home Exercise Program
Home Exercises GroupHome Exercises wiil be applied	Other	Home Exercise Program

Primary outcome

Short Form McGill Pain Questionnaire
Time frame: Baseline,8 weeks, 6 months
A short form of the McGill Pain Questionnaire (SF-MPQ) used in pain assessment consists of four sections. In the first section, participants are asked to mark the location of pain on a body diagram. In the second section, participants are asked to select the word that best describes their pain from twenty subgroups. The third section investigates the relationship of pain over time, while the fourth and final section requires participants to indicate the intensity of pain on a scale of 1 to 5 and provide written responses to six questions. The questionnaire is scored from 0 to 112. The higher the pain score, the greater the pain.
Algometric Digital Measurement
Time frame: Baseline,8 weeks, 6 months
It is a digital device used to evaluate trigger point sensitivity.
Central Sensitization Inventory
Time frame: Baseline,8 weeks, 6 months
The scale, which can be applied in chronic pain, is used in central sensitization syndromes. It consists of two parts. Section A questions health-related symptoms, and part B questions whether any central sensitization syndromes have been diagnosed before.
Head Posture Evaluation
Time frame: Baseline,8 weeks, 6 months
Forward head posture is measured with a goniometer, which measures the angle between the horizontal plane and the seventh cervical vertebra and ear line.
Neck Disability Index
Time frame: Baseline,8 weeks, 6 months
The scale consists of ten headings in total. It includes neck pain intensity, personal care, lifting, reading, headaches, concentration, driving, sleep, and leisure activities.
Pittsburgh Sleep Quality Index
Time frame: Baseline,8 weeks, 6 months
This survey contains 24 questions about sleep status, both during the day and at night. Nineteen of these are to be answered personally, and five are to be answered by a spouse or roommate.
36-Item Short Form Health Survey Questionnaire
Time frame: Baseline,8 weeks, 6 months
36-Item Short Form Health Survey (SF-36) questionnaire consists of eight subscales: physical functioning, social functioning, role limitations due to physical problems, pain, vitality, mental health, and general health perception. Each subscale is scored from 0 to 100, and the scores from these subscales are not summed. A high score indicates good health status.
Pain Catastrophizing Scale
Time frame: Baseline,8 weeks, 6 months
The Pain Catastrophizing Scale (PCS) is a 13-item self-report measure of catastrophizing in the context of actual or anticipated pain. The PCS measures catastrophizing as a multidimensional construct with three subscales: rumination, magnification, and helplessness. Rumination focuses on thoughts related to pain, helplessness reflects feelings of helplessness in coping with a painful situation, and magnification is a general view of the threat of pain. High PCS scores are associated with greater pain and more functional impairment. A total score above 30 represents clinically significant levels of pain catastrophizing.

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2025.
Background: PubMed 33466426Bernetti A, Agostini F, de Sire A, Mangone M, Tognolo L, Di Cesare A, Ruiu P, Paolucci T, Invernizzi M, Paoloni M. Neuropathic Pain and Rehabilitation: A Systematic Review of International Guidelines. Diagnostics (Basel). 2021 Jan 5;11(1):74. doi: 10.3390/diagnostics11010074.
Background: PubMed 34062143Cohen SP, Vase L, Hooten WM. Chronic pain: an update on burden, best practices, and new advances. Lancet. 2021 May 29;397(10289):2082-2097. doi: 10.1016/S0140-6736(21)00393-7.
Background: PubMed 34444594Javdaneh N, Saeterbakken AH, Shams A, Barati AH. Pain Neuroscience Education Combined with Therapeutic Exercises Provides Added Benefit in the Treatment of Chronic Neck Pain. Int J Environ Res Public Health. 2021 Aug 22;18(16):8848. doi: 10.3390/ijerph18168848.
Individual participant dataSharing planned: No

Related trials for Cervical Spine Disease

Active, not recruiting
The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery
Cervical Degenerative Disc Disease
Enrolling by invitation
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
Spinal Cord Injuries
Not yet recruiting
Endoscopic Posterior Cervical Foraminotomy Versus Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy
Cervical Disc Herniation, Cervical Foraminal Stenosis
Enrolling by invitation
Assessing Microbiome in Primary Anterior Cervical Fusion Patients
Cervical Stenosis, Myelopathy
Not yet recruiting
Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials
Knee Osteoarthritis; Insomnia; Cervical Spondylosis; Chronic Low Back Pain; Allergic Rhinitis

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Aysenur Tuncer, Assoc. Prof. study director

Hasan Kalyoncu University

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Short Form McGill Pain Questionnaire (time frame: Baseline,8 weeks, 6 months). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06320938, which also lists 3 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025; AzTrials last refreshed its copy on 7 Nov 2026.