Hematopoietic and Lymphatic System NeoplasmNCT06322615
Acupressure for Reducing Anxiety in Patients Undergoing Chemotherapy
A study testing Acupressure Therapy, Educational Intervention and Electronic Health Record Review in people with Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Mayo Clinic at 1 site in United States.
Trial summary
This clinical trial evaluates whether acupressure is helpful to reduce anxiety related to chemotherapy. Anxiety is experienced by many patients with cancer. Anxiety can be related to chemotherapy and may contribute to other symptoms, such as nausea and poor quality of life. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- What is being tested?
- Acupressure Therapy, Educational Intervention and Electronic Health Record Review
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 8 Aug 2023to 1 Feb 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Be over 18 years of age
- Be actively undergoing chemotherapy in the Mayo Clinic chemotherapy unit
- Report anxiety as a 1 or higher, on a scale from 0 (no anxiety) to 4 (severe anxiety)
- Be willing to undergo a short acupressure session
Who cannot join
- Does not meet the inclusion criteria
Trial locations and contacts
1 site in 1 country.
United States1 site
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
About this study
Official title: Acupressure for Anxiety: A Pilot Study of a Nurse-Led Acupressure Intervention for Patients Receiving Chemotherapy
This clinical trial evaluates whether acupressure is helpful to reduce anxiety related to chemotherapy. Anxiety is experienced by many patients with cancer. Anxiety can be related to chemotherapy and may contribute to other symptoms, such as nausea and poor quality of life. Some patients diagnosed with cancer express interest in non-medicinal ways to manage symptoms. Acupressure is a noninvasive intervention that can be used for many different symptoms. Acupressure is well tolerated with minimal reports of adverse reactions, making it a good choice for patients with cancer. This study may help researchers learn whether acupressure is useful for managing anxiety in patients undergoing chemotherapy.
Read the detailed description
PRIMARY OBJECTIVES:
- Evaluate the feasibility of a nurse- and patient-applied acupressure intervention for patients with anxiety associated with active cancer-directed therapy.
II. Patient-reported changes in acute anxiety associated with both the nurse and self-led acupressure interventions will be ascertained.
OUTLINE:
Patients undergo acupressure over 15-120 seconds at a time for up to 15 minutes. After completion of the session, patients may optionally receive an education session on using acupressure at home.
After completion of study intervention, patients who opted to receive education about using acupressure at home are followed up at 1 week.
- Being tested
- Acupressure Therapy, Educational Intervention, Electronic Health Record Review, Questionnaire Administration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Acupressure TherapyProcedure or surgery
Also called Acupressure, Ischemic Compression
Undergo acupressure
Educational InterventionOther
Also called Education for Intervention, Intervention by Education, Intervention through Education, Intervention, Educational
Receive education session about using acupressure at home
Electronic Health Record ReviewOther
Ancillary studies
Questionnaire AdministrationOther
Ancillary studies
| Study group | Role | What they receive |
|---|---|---|
| Supportive Care (acupressure) | Experimental | Patients undergo acupressure over 15-120 seconds at a time for up to 15 minutes. After completion of the session, patients may optionally receive an education session on using acupressure at home. Receives: Procedure: Acupressure Therapy; Other: Educational Intervention; Other: Electronic Health Record Review; Other: Questionnaire Administration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of patients approached about undergoing acupressure intervention (Feasibility)
Assessed by the number of patients approached about undergoing acupressure intervention.
Measured: Up to 1 year
Number of patients interested in the initial acupressure intervention in the chemotherapy unit (Feasibility)
Assessed by the number of patients who express interest in the initial acupressure intervention in the chemotherapy unit.
Measured: Up to 1 year
Number of patients interested in the home acupressure intervention (Feasibility)
Assessed by the number of patients who express interest in the home acupressure intervention.
Measured: Up to 1 year
Time taken for each nurse-led acupressure intervention in the chemotherapy unit (Feasibility)
Assess by the time recorded for ach nurse-led acupressure intervention in the chemotherapy unit.
Measured: Up to 1 year
Patient-reported changes in acute anxiety
Assessed with a brief anxiety questionnaire that inquires about the three different domains of anxiety: cognitive symptoms, emotional symptoms, and physical symptoms. Seven questions are answered using 11-point (0-10) scales with different values assigned to the scale per question (e.g. 0=no anxiety/10=worst possible anxiety or 0=strongly disagree/10=strongly agree).
Measured: At baseline, after a one-time nurse-administered acupressure session, and after one week of self-administered acupressure sessions
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Mar 2024
- Study start8 Aug 2023
- Primary completion29 Jan 2024
- Study completion1 Feb 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hematopoietic and Lymphatic System NeoplasmStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Laura S. Rhee, D.O., Principal investigator, Mayo Clinic in Rochester
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06322615
- Sponsor's protocol ID
- MC221001
- Other IDs
- NCI-2024-00538, 23-004067, MC221001
- Status last verified
- Oct 2025
- First submitted
- 14 Mar 2024
- Last updated
- 29 Oct 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acupressure for Anxiety: A Pilot Study of a Nurse-Led Acupressure Intervention for Patients Receiving Chemotherapy
- ClinicalTrials.gov ID
- NCT06322615
- Acronym / sponsor ID
- MC221001
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- 8 Aug 2023 (actual)
- Primary completion
- 29 Jan 2024 (actual)
- Study completion
- 1 Feb 2024 (actual)
- First posted
- 21 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial evaluates whether acupressure is helpful to reduce anxiety related to chemotherapy. Anxiety is experienced by many patients with cancer. Anxiety can be related to chemotherapy and may contribute to other symptoms, such as nausea and poor quality of life. Some patients diagnosed with cancer express interest in non-medicinal ways to manage symptoms. Acupressure is a noninvasive intervention that can be used for many different symptoms. Acupressure is well tolerated with minimal reports of adverse reactions, making it a good choice for patients with cancer. This study may help researchers learn whether acupressure is useful for managing anxiety in patients undergoing chemotherapy.
Detailed description
PRIMARY OBJECTIVES:
- Evaluate the feasibility of a nurse- and patient-applied acupressure intervention for patients with anxiety associated with active cancer-directed therapy.
II. Patient-reported changes in acute anxiety associated with both the nurse and self-led acupressure interventions will be ascertained.
OUTLINE:
Patients undergo acupressure over 15-120 seconds at a time for up to 15 minutes. After completion of the session, patients may optionally receive an education session on using acupressure at home.
After completion of study intervention, patients who opted to receive education about using acupressure at home are followed up at 1 week.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Supportive Care (acupressure) | Experimental | Procedure: Acupressure Therapy, Other: Educational Intervention, Other: Electronic Health Record Review, Other: Questionnaire AdministrationPatients undergo acupressure over 15-120 seconds at a time for up to 15 minutes. After completion of the session, patients may optionally receive an education session on using acupressure at home. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Be over 18 years of age
- Be actively undergoing chemotherapy in the Mayo Clinic chemotherapy unit
- Report anxiety as a 1 or higher, on a scale from 0 (no anxiety) to 4 (severe anxiety)
- Be willing to undergo a short acupressure session
Key exclusion criteria (1 listed)
- Does not meet the inclusion criteria
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Acupressure TherapyAlso: Acupressure, Ischemic CompressionUndergo acupressure | Procedure or surgery | Supportive Care (acupressure) |
| Educational InterventionAlso: Education for Intervention, Intervention by Education, Intervention through Education, Intervention, EducationalReceive education session about using acupressure at home | Other | Supportive Care (acupressure) |
| Electronic Health Record ReviewAncillary studies | Other | Supportive Care (acupressure) |
| Questionnaire AdministrationAncillary studies | Other | Supportive Care (acupressure) |
Primary outcome
Number of patients approached about undergoing acupressure intervention (Feasibility)
Time frame: Up to 1 year
Assessed by the number of patients approached about undergoing acupressure intervention.
Number of patients interested in the initial acupressure intervention in the chemotherapy unit (Feasibility)
Time frame: Up to 1 year
Assessed by the number of patients who express interest in the initial acupressure intervention in the chemotherapy unit.
Number of patients interested in the home acupressure intervention (Feasibility)
Time frame: Up to 1 year
Assessed by the number of patients who express interest in the home acupressure intervention.
Time taken for each nurse-led acupressure intervention in the chemotherapy unit (Feasibility)
Time frame: Up to 1 year
Assess by the time recorded for ach nurse-led acupressure intervention in the chemotherapy unit.
Patient-reported changes in acute anxiety
Time frame: At baseline, after a one-time nurse-administered acupressure session, and after one week of self-administered acupressure sessions
Assessed with a brief anxiety questionnaire that inquires about the three different domains of anxiety: cognitive symptoms, emotional symptoms, and physical symptoms. Seven questions are answered using 11-point (0-10) scales with different values assigned to the scale per question (e.g. 0=no anxiety/10=worst possible anxiety or 0=strongly disagree/10=strongly agree).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2025.
- Mayo Clinic Clinical TrialsLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Laura S. Rhee, D.O. principal investigator
Mayo Clinic in Rochester
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acupressure Therapy, Educational Intervention and Electronic Health Record Review in people with Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of patients approached about undergoing acupressure intervention (Feasibility) (time frame: Up to 1 year). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2025.