Cognitive ImpairmentNCT06325085
Compensatory and Restorative Rehabilitation Techniques in Stroke
A study testing compensatory and restorative rehabilitation techniques and Traditional cognitive rehabilitation training in people with Cognitive Impairment, run by Riphah International University at 1 site in Pakistan.
Trial summary
The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke. Read more about this study
- Who is it for?
- Ages 50 to 70 years
- Conditions the study is for
- Cognitive Impairment
- What is being tested?
- compensatory and restorative rehabilitation techniques and Traditional cognitive rehabilitation training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 sitePakistan
- Study dates
- 16 Apr 2024to 29 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 50 and 70 years
- Both Genders
- Individuals diagnosed with stroke 6 months before enrollment
- Minimum 6 years of schooling
- Patients with mild cognitive impairment (score 18-25 on MOCA)
- Individuals able to maintain sitting and standing balance (score 41 on berg balance scale)
Who cannot join
- >10 on post stroke depression rating scale (PSDRS)
- Spasticity (>3 on Ashworth scale)
- Other psychological disorders
- Patients diagnosed with Alzheimer's and dementia
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Combined Effects of Restorative and Compensatory Rehabilitation Techniques on Executive Functions in Stroke With Mild Cognitive Impairment
The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.
Read the detailed description
Stroke is a prevalent medical neurological condition that often results in cognitive impairments, particularly in the domain of executive functions. Cognitive impairment has a significant impact on executive function in stroke subjects. Cognitive impairment on the stroke survivor exist on any single domain such as attention, spatial ability, language and executive ability more frequently than the multiple domains.
Cognitive training has been shown to be beneficial for rehabilitation of patients with cognitive impairment, but the underlying mechanisms remain unclear.
The combination of restorative and compensatory rehabilitation techniques is beneficial for gaining control over cognitive rehabilitation techniques will improve executive functions. The retention effects evaluated additionally will add a broad insight in this regard. It will improve the learning power of brain through neural plasticity. This leads to restoration of everyday functioning. This study aims to investigate the effects of two distinct rehabilitation approaches on the executive functions of stroke survivors with MCI. Understanding how these rehabilitation strategies impact cognitive recovery is essential for individuals living with post-stroke cognitive impairments.
- Conditions
- Cognitive Impairment
- Being tested
- compensatory and restorative rehabilitation techniques, Traditional cognitive rehabilitation training
- Keywords
- Compensatory rehabilitation, Restorative Rehabilitation, Cognition, Stroke, Executive Functioning
- Medical subject headings
- Cognitive Dysfunction, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
compensatory and restorative rehabilitation techniquesOther
compensatory and restorative rehabilitation techniques Frequency: 10 reps 2-3 times/week for 3 consecutive weeks then evaluation of the effects.
Continue the same techniques for 3 more weeks and then evaluate the retention effects of restorative and compensatory rehabilitation techniques will be evaluated by 9th week.
Traditional cognitive rehabilitation trainingOther
Naming words ( ask patient to name food, states, family members) Counting numbers backwards, backward counting of days and months) Spell the word backwards, remembering a piece of information Frequency: 10 reps 2-3 times/week for 3 consecutive weeks then evaluation of the effects.
Continue the same techniques for 3 more weeks and then evaluate the retention effects of restorative and compensatory rehabilitation techniques will be evaluated by 9th week.
| Study group | Role | What they receive |
|---|---|---|
| Compensatory and restorative rehabilitation techniques | Experimental | compensatory and restorative rehabilitation techniques in stroke patients Receives: Other: compensatory and restorative rehabilitation techniques |
| Traditional cognitive Rehabilitation training | Active comparator | Naming words Counting numbers backwards Spell the word backwards Receives: Other: Traditional cognitive rehabilitation training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Montreal cognitive assessment test (Urdu version)
MOCA assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuo-constructional skills, conceptual thinking and orientation. The test is one page,30 point test that can be administered in 10 minutes. MOCA is scored by obtaining an item total and the author recommend a clinical cutoff score of 26.is a Patient-completed, condition-specific functional status questionnaire with 10 items including pain, personal care, lifting, reading, headaches, concentration, work, driving, sleeping and recreation.
Measured: 6 weeks
Cognitive assessment scale for stroke patients (CASP)
Its a rapid test for screening post stroke cognitive impairment. It can be performed at the patient bedside by a non expert examiner. A CASP score of 35/36 should alert to possible presence of cognitive impairment. Score can help predict medium level cognitive impairment.
Measured: 6 weeks
Secondary outcomes (2)
Stroke specific quality of life questionnaire (Urdu version)
The SS-QOL questionnaire assesses health related quality of life specific to stroke survivors covering almost 12 domains
Measured: 6 weeks
Modified Rankin Scale (MRS)
It measures degree of disability or dependence in daily activities of people who have suffered stroke or other neurological disability. It is one of the most widely used clinical patients are graded
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Mar 2024
- Study start16 Apr 2024
- Primary completion28 Aug 2025
- Study completion29 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cognitive ImpairmentStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Aroosa Tariq, MS-NMPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06325085
- Sponsor's protocol ID
- Ayesha Saddiqa
- Status last verified
- Sep 2025
- First submitted
- 17 Mar 2024
- Last updated
- 3 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combined Effects of Restorative and Compensatory Rehabilitation Techniques on Executive Functions in Stroke With Mild Cognitive Impairment
- ClinicalTrials.gov ID
- NCT06325085
- Acronym / sponsor ID
- Ayesha Saddiqa
- Conditions
- Cognitive Impairment
- Keywords
- Compensatory rehabilitation, Restorative Rehabilitation, Cognition, Stroke, Executive Functioning
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 16 Apr 2024 (actual)
- Primary completion
- 28 Aug 2025 (actual)
- Study completion
- 29 Aug 2025 (actual)
- First posted
- 22 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.
Detailed description
Stroke is a prevalent medical neurological condition that often results in cognitive impairments, particularly in the domain of executive functions. Cognitive impairment has a significant impact on executive function in stroke subjects. Cognitive impairment on the stroke survivor exist on any single domain such as attention, spatial ability, language and executive ability more frequently than the multiple domains.
Cognitive training has been shown to be beneficial for rehabilitation of patients with cognitive impairment, but the underlying mechanisms remain unclear.
The combination of restorative and compensatory rehabilitation techniques is beneficial for gaining control over cognitive rehabilitation techniques will improve executive functions. The retention effects evaluated additionally will add a broad insight in this regard. It will improve the learning power of brain through neural plasticity. This leads to restoration of everyday functioning. This study aims to investigate the effects of two distinct rehabilitation approaches on the executive functions of stroke survivors with MCI. Understanding how these rehabilitation strategies impact cognitive recovery is essential for individuals living with post-stroke cognitive impairments.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Compensatory and restorative rehabilitation techniques | Experimental | Other: compensatory and restorative rehabilitation techniquescompensatory and restorative rehabilitation techniques in stroke patients |
| Traditional cognitive Rehabilitation training | Active comparator | Other: Traditional cognitive rehabilitation trainingNaming words Counting numbers backwards Spell the word backwards |
Who may qualify
- Ages
- 50 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age between 50 and 70 years
- Both Genders
- Individuals diagnosed with stroke 6 months before enrollment
- Minimum 6 years of schooling
- Patients with mild cognitive impairment (score 18-25 on MOCA)
Key exclusion criteria (4 listed)
- >10 on post stroke depression rating scale (PSDRS)
- Spasticity (>3 on Ashworth scale)
- Other psychological disorders
- Patients diagnosed with Alzheimer's and dementia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| compensatory and restorative rehabilitation techniquescompensatory and restorative rehabilitation techniques Frequency: 10 reps 2-3 times/week for 3 consecutive weeks then evaluation of the effects. Continue the same techniques for 3 more weeks and then evaluate the retention effects of restorative and compensatory rehabilitation techniques will be evaluated by 9th week. | Other | Compensatory and restorative rehabilitation techniques |
| Traditional cognitive rehabilitation trainingNaming words ( ask patient to name food, states, family members) Counting numbers backwards, backward counting of days and months) Spell the word backwards, remembering a piece of information Frequency: 10 reps 2-3 times/week for 3 consecutive weeks then evaluation of the effects. Continue the same techniques for 3 more weeks and then evaluate the retention effects of restorative and compensatory rehabilitation techniques will be evaluated by 9th week. | Other | Traditional cognitive Rehabilitation training |
Primary outcome
Montreal cognitive assessment test (Urdu version)
Time frame: 6 weeks
MOCA assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuo-constructional skills, conceptual thinking and orientation. The test is one page,30 point test that can be administered in 10 minutes. MOCA is scored by obtaining an item total and the author recommend a clinical cutoff score of 26.is a Patient-completed, condition-specific functional status questionnaire with 10 items including pain, personal care, lifting, reading, headaches, concentration, work, driving, sleeping and recreation.
Cognitive assessment scale for stroke patients (CASP)
Time frame: 6 weeks
Its a rapid test for screening post stroke cognitive impairment. It can be performed at the patient bedside by a non expert examiner. A CASP score of 35/36 should alert to possible presence of cognitive impairment. Score can help predict medium level cognitive impairment.
2 secondary outcomes
Stroke specific quality of life questionnaire (Urdu version)
Time frame: 6 weeks
Modified Rankin Scale (MRS)
Time frame: 6 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Aroosa Tariq, MS-NMPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing compensatory and restorative rehabilitation techniques and Traditional cognitive rehabilitation training in people with Cognitive Impairment, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Montreal cognitive assessment test (Urdu version) (time frame: 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025.