Healthy AdultsYM110099ENCT06333756
Effects of Muscle Strengthening and Fatigue on Activities in Cortex and Muscle
A study testing Cross education in people with Healthy Adults, run by National Yang Ming Chiao Tung University at 1 site in Taiwan.
Trial summary
We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction. Read more about this study
- Who is it for?
- Ages 20 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Adults
- What is being tested?
- Cross education
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 May 2021to 1 Aug 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy adults who are 20-40 years old
Who cannot join
- Upper extremity (UE) pain or discomfort
- Medical condition that substantially influenced their UE strength
- Experience of UE surgery
- Paresthesia in UE
- Open wound on UE
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Cross Education Training on Corticocortical and Corticomuscular Functional Connectivity
We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction.
Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity
Read the detailed description
Cross education (CE) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. CE has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. Although CE has several potential clinical application, the precise physiological mechanisms underlying CE remains unknown. Previous studies reported that CE may involve bilateral cortical activity in both contralateral primary motor cortex (cM1), and ipsilateral primary motor cortex (iM1).In addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but CE immediate change of functional connectivity in cortical network remains unknown.
The purposes of this study are to investigate the immediate effect of CE training of biceps brachii (1) Immediate change of functional connectivity in cortical network; (2) Immediate change of functional connectivity in cortex and target muscle; (3) Explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. We hypothesize that (1) Bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) Cross education would immediately enhance functional connectivity between cortex and target muscle; (3) Cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.
- Conditions
- Healthy Adults
- Being tested
- Cross education
- Keywords
- cross education, functional connectivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cross educationOther
Cross education training of the biceps brachii (12 rep./set, 3sets, 60%MVIC,180°/s, eccentric contraction)
| Study group | Role | What they receive |
|---|---|---|
| Cross education training group | Experimental | Cross education on elbow flexor Receives: Other: Cross education |
What is being measured
The primary outcome is the main question the study is designed to answer.
Corticocortical coherence
Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction
Measured: Measured immediately after cross education training
Corticomuscular coherence
Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction
Measured: Measured immediately after cross education training
Maximal voluntary contraction
The ability to generate maximal voluntary elbow flexor force
Measured: Measured immediately after cross education training
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2024
- Study start1 May 2021
- Primary completion30 Apr 2022
- Study completion1 Aug 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy AdultsStudies of the same condition, open and under way.
- More trials run by National Yang Ming Chiao Tung UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Parallel Assignment
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Yang Ming Chiao Tung University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Li-Wei Chou, Ph.D., Principal investigator, Department of Physical Therapy and Assistive and Technology ,National Yang-Ming University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06333756
- Sponsor's protocol ID
- YM110099E
- Acronym
- YM110099E
- Status last verified
- Dec 2022
- First submitted
- 20 Mar 2024
- Last updated
- 27 Mar 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Mar 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Cross Education Training on Corticocortical and Corticomuscular Functional Connectivity
- ClinicalTrials.gov ID
- NCT06333756
- Acronym / sponsor ID
- YM110099E / YM110099E
- Conditions
- Healthy Adults
- Keywords
- cross education, functional connectivity
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- National Yang Ming Chiao Tung UniversityUniversity, hospital or other
- Study start
- 1 May 2021 (actual)
- Primary completion
- 30 Apr 2022 (actual)
- Study completion
- 1 Aug 2022 (actual)
- First posted
- 27 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction.
Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity
Detailed description
Cross education (CE) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. CE has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. Although CE has several potential clinical application, the precise physiological mechanisms underlying CE remains unknown. Previous studies reported that CE may involve bilateral cortical activity in both contralateral primary motor cortex (cM1), and ipsilateral primary motor cortex (iM1).In addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but CE immediate change of functional connectivity in cortical network remains unknown.
The purposes of this study are to investigate the immediate effect of CE training of biceps brachii (1) Immediate change of functional connectivity in cortical network; (2) Immediate change of functional connectivity in cortex and target muscle; (3) Explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. We hypothesize that (1) Bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) Cross education would immediately enhance functional connectivity between cortex and target muscle; (3) Cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Parallel Assignment
| Arm | Type | Receives |
|---|---|---|
| Cross education training group | Experimental | Other: Cross educationCross education on elbow flexor |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Healthy adults who are 20-40 years old
Key exclusion criteria (5 listed)
- Upper extremity (UE) pain or discomfort
- Medical condition that substantially influenced their UE strength
- Experience of UE surgery
- Paresthesia in UE
- Open wound on UE
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cross educationCross education training of the biceps brachii (12 rep./set, 3sets, 60%MVIC,180°/s, eccentric contraction) | Other | Cross education training group |
Primary outcome
Corticocortical coherence
Time frame: Measured immediately after cross education training
Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction
Corticomuscular coherence
Time frame: Measured immediately after cross education training
Level of electroencephalography and electromyography synchronization in frequency domain when participants maintain 20% maximal voluntary contraction
Maximal voluntary contraction
Time frame: Measured immediately after cross education training
The ability to generate maximal voluntary elbow flexor force
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Mar 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Li-Wei Chou, Ph.D. principal investigator
Department of Physical Therapy and Assistive and Technology ,National Yang-Ming University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cross education in people with Healthy Adults, run by National Yang Ming Chiao Tung University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Mar 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Corticocortical coherence (time frame: Measured immediately after cross education training). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Mar 2024.