VoluntarySPEAKER 2NCT06357715
Effectiveness of Neurodynamic Sliding Mobilisation in the "Slump" Position in Relation to the Perceptible Pain Threshold in Asymptomatic People
A study testing "slump"position and no" slump" position in people with Voluntary, run by University Hospital, Rouen at 1 site in France.
Trial summary
According to the French National Health Agency, the use of manual therapy techniques is "possible" [grade B] as part of a multimodal combination of treatments for low back pain. These include so-called "neurodynamic" neural mobilisations, which aim in particular to desensitise the pain system and activate descending… Read more about this study
- Who is it for?
- Ages 30 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Voluntary
- What is being tested?
- "slump"position and no" slump" position
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 54 participants
- Where
- 1 siteFrance
- Study dates
- 23 Oct 2024to 6 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Subjects aged 30 years or older and less than 65 years;
- Subjects considered naive to neurodynamic mobilisation techniques;
- Volunteers who have read and understood the information letter and have given their written consent to participate in the study;
- Fluent in spoken and read French;
- Effective contraception in women of childbearing age (progestin-only or intrauterine device or tubal ligation) for at least 12 months;
- For postmenopausal women, a confirmatory diagnosis must be obtained (non-drug-induced amenorrhoea for at least 12 months prior to the enrolment visit);
- Subject affiliated to a social security scheme.
Who cannot join
- Positive slump test on the day of the selection visit (production of asymmetric lumbar symptoms or painful radiations in at least one lower limb or unilateral reduction in physiological knee extension range of motion compared with the contralateral side);
- Neurological and neuropathic pain assessment score (DN4) greater than 4;
- Increase or decrease in sensory function in the lower limb compared with the contralateral side, as measured by Clinical Sensory Testing (CST);
- Any physical exertion of perceived intensity greater than 17 on the Borg 6-20 scale in the 72 hours prior to the trial and during the trial;
- Injury, complaint or symptom affecting the spine (cervical, thoracic, lumbar) and/or lower limb(s) requiring absence from work, school or leisure activities in the 12 months prior to enrolment;
- History of major surgery, injury to the trunk, spine and/or lower limb(s), or history of progressive rheumatic, neurological or oncological pathology;
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
deborah lebedieff contact
France1 site, 1 recruiting
- Recruiting
Centre d'investigation clinique CIC ROUEN
Rouen, 76000
Timothée GILLOT
About this study
Official title: Effectiveness of Neurodynamic Sliding Mobilisation in the "Slump" Position in Relation to the Perceptible Pain Threshold in Asymptomatic People, a Cross-over Randomised Controlled Trial
According to the French National Health Agency, the use of manual therapy techniques is "possible" [grade B] as part of a multimodal combination of treatments for low back pain. These include so-called "neurodynamic" neural mobilisations, which aim in particular to desensitise the pain system and activate descending inhibitory pathways, with effects on pain and function in patients with nerve-related low back pain. Most of the available evidence does not explain the mechanisms involved in neural mobilisation in the slump position. Pain reduction is observed in more areas of the body with sliding techniques than with traction techniques.
In this cross-over, randomised controlled trial, we therefore hypothesise that the neurodynamic sliding technique in the slump position acts on mechanisms linked to central pain modulation processes
- Conditions
- Voluntary
- Being tested
- "slump"position, no" slump" position
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
"slump"positionOther
neurodynamic sliding mobilisation in the "slump" position
no" slump" positionOther
placebo
| Study group | Role | What they receive |
|---|---|---|
| neurodynamic sliding mobilisation in the "Slump" position | Active comparator | "slump"position Receives: Other: "slump"position; Other: no" slump" position |
| mobilisation, out of the "Slump" position | Placebo comparator | no "slump"position Receives: Other: "slump"position; Other: no" slump" position |
What is being measured
The primary outcome is the main question the study is designed to answer.
Difference in pressure at the moment when the volunteer indicates that the sensation of pressure becomes pain
Difference in pressure exerted on the territory of the sciatic nerve (gluteal region) at the moment when the volunteer indicates that the sensation of pressure becomes pain, on the dominant lower limb, between the same volunteer during two treatment sessions which differ only in the exposure to neurodynamic sliding mobilisation in the "Slump" position or to mobilisation outside the "Slump" position.
Measured: immediately after the mobilisation and 1 day after the mobilisation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Apr 2024
- Study start23 Oct 2024
- Primary completion6 Nov 2026 (estimated)
- Study completion6 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for VoluntaryStudies of the same condition, open and under way.
- More trials run by University Hospital, RouenThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 54 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Rouen
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06357715
- Sponsor's protocol ID
- 2021/0373/HP
- Acronym
- SPEAKER 2
- Status last verified
- Feb 2026
- First submitted
- 4 Apr 2024
- Last updated
- 7 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Neurodynamic Sliding Mobilisation in the "Slump" Position in Relation to the Perceptible Pain Threshold in Asymptomatic People, a Cross-over Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT06357715
- Acronym / sponsor ID
- SPEAKER 2 / 2021/0373/HP
- Conditions
- Voluntary
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 54 participants (estimated)
- Lead sponsor
- University Hospital, RouenUniversity, hospital or other
- Study start
- 23 Oct 2024 (actual)
- Primary completion
- 6 Nov 2026 (estimated)
- Study completion
- 6 Nov 2026 (estimated)
- First posted
- 10 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
According to the French National Health Agency, the use of manual therapy techniques is "possible" [grade B] as part of a multimodal combination of treatments for low back pain. These include so-called "neurodynamic" neural mobilisations, which aim in particular to desensitise the pain system and activate descending inhibitory pathways, with effects on pain and function in patients with nerve-related low back pain. Most of the available evidence does not explain the mechanisms involved in neural mobilisation in the slump position. Pain reduction is observed in more areas of the body with sliding techniques than with traction techniques.
In this cross-over, randomised controlled trial, we therefore hypothesise that the neurodynamic sliding technique in the slump position acts on mechanisms linked to central pain modulation processes
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| neurodynamic sliding mobilisation in the "Slump" position | Active comparator | Other: "slump"position, Other: no" slump" position"slump"position |
| mobilisation, out of the "Slump" position | Placebo comparator | Other: "slump"position, Other: no" slump" positionno "slump"position |
Who may qualify
- Ages
- 30 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Subjects aged 30 years or older and less than 65 years;
- Subjects considered naive to neurodynamic mobilisation techniques;
- Volunteers who have read and understood the information letter and have given their written consent to participate in the study;
- Fluent in spoken and read French;
- Effective contraception in women of childbearing age (progestin-only or intrauterine device or tubal ligation) for at least 12 months;
Key exclusion criteria (6 listed)
- Positive slump test on the day of the selection visit (production of asymmetric lumbar symptoms or painful radiations in at least one lower limb or unilateral reduction in physiological knee extension range of motion compared with the contralateral side);
- Neurological and neuropathic pain assessment score (DN4) greater than 4;
- Increase or decrease in sensory function in the lower limb compared with the contralateral side, as measured by Clinical Sensory Testing (CST);
- Any physical exertion of perceived intensity greater than 17 on the Borg 6-20 scale in the 72 hours prior to the trial and during the trial;
- Injury, complaint or symptom affecting the spine (cervical, thoracic, lumbar) and/or lower limb(s) requiring absence from work, school or leisure activities in the 12 months prior to enrolment;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| "slump"positionneurodynamic sliding mobilisation in the "slump" position | Other | mobilisation, out of the "Slump" position, neurodynamic sliding mobilisation in the "Slump" position |
| no" slump" positionplacebo | Other | mobilisation, out of the "Slump" position, neurodynamic sliding mobilisation in the "Slump" position |
Primary outcome
Difference in pressure at the moment when the volunteer indicates that the sensation of pressure becomes pain
Time frame: immediately after the mobilisation and 1 day after the mobilisation
Difference in pressure exerted on the territory of the sciatic nerve (gluteal region) at the moment when the volunteer indicates that the sensation of pressure becomes pain, on the dominant lower limb, between the same volunteer during two treatment sessions which differ only in the exposure to neurodynamic sliding mobilisation in the "Slump" position or to mobilisation outside the "Slump" position.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
deborah lebedieff contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing "slump"position and no" slump" position in people with Voluntary, run by University Hospital, Rouen at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact timothée GILLOT, PhD (0232880671 ext. +33, timothee.gillot@chu-rouen.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Difference in pressure at the moment when the volunteer indicates that the sensation of pressure becomes pain (time frame: immediately after the mobilisation and 1 day after the mobilisation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 May 2026.