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Diabetic Peripheral Neuropathic PainPhase 1NCT06361108

MAD Study to Assess the Safety, Tolerability, PKs and Efficacy of YJ001 for Spray Use in Patients With DPNP

A Phase 1 study testing YJ001 for Spray Use in people with Diabetic Peripheral Neuropathic Pain, run by Zhejiang Hanmai Pharmaceutical Technology Co., Ltd. at 1 site in United States.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This Phase I, randomized, double-blind and placebo controlled study is to evaluate the safety, tolerability, and PK, and to preliminarily assess the efficacy of topically administered YJ001 in a multiple-ascending dose (MAD) fashion in the patients with DPNP. The study will be conducted at a single study center. Read more about this study

Who is it for?
Ages 18 to 80 years
Conditions the study is for
Diabetic Peripheral Neuropathic Pain
What is being tested?
YJ001 for Spray Use
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
24 participants
Where
1 siteUnited States
Study dates
16 May 2024to 30 Jun 2026
Phase
Phase 1
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 80 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Male or female, between the ages of 18 to 80 years at screening, both inclusive.
  • Subjects voluntarily consenting for participation in the study and having signed informed consent document. Subjects are required to understand verbal and/or written English or any other language in which a certified translation of the informed consent is available.
  • Body mass index (BMI) between 19 to 42 kg/m2 (both inclusive) at screening, calculated as weight (kg)/height2 (m2). Subjects must have two feet. Each foot must have five digits. Each foot must have at least total surface area of 450 cm2 measured from below the ankle to the toes including both dorsum and plantar areas.
  • The subject is diagnosed with Type 1 or Type 2 diabetes, and has a history of DPNP for at least 3 months based on participant report or medical history.
  • The subject should have a glycemic control that has been optimized and has been stable for at least 3 months prior to randomization. The subject has used a stable regimen of antidiabetic agents (oral) and/or insulin for at least 3 months before screening.
  • Glycated hemoglobin (HbA1c) ≤ 10% at screening.
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  • Participants who have a weekly mean score of at least 4 based upon the daily mean scores using 11-point Numeric Rating Scale (NRS) in the daily diary (rated twice daily, once in the morning and the other in the evening) from Day -7 through Day 1 (should be calculated from records 7 days immediately prior to study drug administration).
  • Males must not donate sperm until 90 days after last dose of study drug and must be willing to use a condom during heterosexual activity for up to 90 days after the application of the study drug.
  • Females must be either postmenopausal for at least 1 year, surgically sterile (bilateral tubal ligation [including clip, cauterization methods and coil], bilateral oophorectomy or hysterectomy, and needs to be confirmed follicle-stimulating hormone [FSH] level \>40 IU/L), or of childbearing potential either practicing true abstinence or practicing 2 effective means of contraception for at least 4 weeks prior to randomization, and until 28 days after study drug administration:
  • Intrauterine device (IUD) or IUD hormone-releasing system.
  • Combined estrogen and progestogen containing hormonal contraception (oral, intravaginal, or transdermal) associated with inhibition of ovulation.
  • Progesterone-only hormonal contraception (oral, injectable, implantable) associated with inhibition of ovulation.
  • Intrauterine hormone-releasing system.
  • Double-barrier method (condoms, contraceptive sponge, diaphragm, or vaginal ring with spermicide).
  • Able and willing to comply with all study requirements.

Who cannot join

  • Current participation in another investigational drug or device study or treated with an investigational drug within 30 days or 5 half-lives, whichever is longer, before dosing.
  • History of clinically significant drug, food allergy, skin allergy, or sensitivity to drugs of the same class (e.g., 5-aminosalicylic acid, sulfasalazine, and salicylates) or known hypersensitivity to YJ001 or any of its components.
  • History of asthma. Adults with history of benign (resolved) childhood asthma may be included.
  • Any subject who suffers severe peripheral vascular disease (e.g., intermittent claudication) at screening, and is not suitable to be involved in the study as per investigator evaluation.
  • Any subject who suffers severe cardiovascular and cerebrovascular disease (e.g., severe arrhythmia, heart failure, myocardial infarction, unstable angina pectoris, atherosclerosis, stroke, sequela of stroke, etc.), severe gastrointestinal tract disease or other serious disease (e.g., cancer) which, in the opinion of the Investigator, would prevent the subject from fully participating in the study.
  • Any subject who suffers chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN).
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  • Any subject who has a history of moderate to severe depression, obvious neurological or mental disorder not related to neuropathic pain but may interfere with rating of pain, as well as poly neuropathy, numbness, feeling of pins and needles and weakness in extremities, other serious pain cannot be clearly differentiated from or conditions that may interfere with rating of neuropathic pain. Subjects with weakness but w/o sensory complaints may be included.
  • Any other medical, psychological, or social condition which, in the opinion of the Investigator, would prevent the subject from fully participating in the study, would represent a concern for study compliance, or would constitute a safety concern to the subject.
  • Any subject who has suffered one or more severe hypoglycemia event (defined as neurofunctional hypoglycemia that needs third-party assistance) within 6 months prior to screening.
  • Pain scores < 3 on the NRS over twice during the one-week run-in period.
  • Any subject with unstable or poorly controlled abnormality in blood pressure or lipid (blood pressure ≥ 160 mmHg/95 mmHg, total cholesterol ≥ 6.2 mmol/L, and/or triglyceride ≥ 6.3 mmol/L) at screening.
  • Any subject with abnormal renal function, estimated glomerular filtration rate (eGFR)<60 mL/min/1.73 m2.
  • eGFR=186×Scr^-1.154×Age^-0.203×(0.742 for Female)
  • Any subject with abnormal liver function, liver enzymes (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) greater than 2 times upper limit of normal.
  • Consumed 8 units or more of alcoholic beverages per week for women or 15 units or more of alcoholic beverages per week for men at any time in the 6 months before dosing (1 unit of ethanol is equivalent to 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of spirits) or history of drug or alcohol abuse within the 6 months before dosing or evidence of such abuse as indicated by inquiry, medical history or the laboratory assays conducted during screening. Any subject who has past history of heavy drinking or alcoholism.
  • Any subject who consumes more than 5 cigarettes per day within 30 days before study drug dosing or who cannot stop using any tobacco- or nicotine-containing product during the duration of the trial.
  • Positive screening or check-in alcohol/drugs of abuse/cotinine screen.
  • Positive test results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at Screening. SARS-CoV-2 testing will be either antigen, nasopharyngeal (NP) or nasal swab polymerase chain reaction (PCR) performed at Day -1, and in accordance with Centers for Disease Control and Prevention (CDC), FDA and local health authorities at the time of enrollment for this study. Participants not willing to comply with the investigational site's Coronavirus Disease 2019 (COVID 19) policy.
  • Female volunteers who are pregnant or lactating.
  • Have a significant acute illness within 7 days prior to study drug administration or have had a major illness or hospitalization within 1 month prior to study drug administration.
  • Systemic or topical use of aspirin or salicylic acid containing products or sulfasalazine/salicylic acid derivatives within 14 days of study drug dosing.
  • Use of other prescription and non-prescription medications (with the exception of permitted concomitant medications, oral contraceptives, combined estrogen and progestogen containing hormonal contraception and progestogen-only hormonal contraception), such as blood thinners, or sucralfate or herbal preparations within 14 days or 5 half-lives (whichever is longer) before study drug dosing, or use of an over-the-counter medication, vitamins, or supplements (including fish liver oils) within 14 days before study drug dosing.
  • Positive screen on Hepatitis B, Hepatitis C, or Human immunodeficiency virus (HIV) at the time of screening evaluations.
  • History of blood donation of more than 500 mL in the last 2 months prior to screening.
  • History or evidence of poor venous access.
  • History of bleeding disorders.
  • Any subject with foot ulcers and/or pedal oedema. Presence of skin disorders, tattoos, skin breakdown, or other skin conditions on either foot that may interfere with the objectives of the study (as per investigator evaluation).
  • Use of any kind of topical lotions, sunscreen, heating pads/cooling pads on feet for at least 24 hours before study drug is administered and until End-of-Study.
  • An employee of the study center or Sponsor or family member of a study center employee
  • Unwilling to stay in the clinical unit for the required duration as per the protocol or consume the standard meal to be provided as per the protocol.
  • Any subject considering or scheduled to undergo any surgical procedure from screening to at least 7 days post dose.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Jing Zhang contact

86+18602195085

zhangjing@zjhanmai.com

Hainan Yue contact

86+13166206612

yuehainan@yuejiabiotech.com

United States1 site, 1 recruiting

  • Clinical Trials of Texas,LLC

    Fredericksburg, Texas, 78229

    Douglas Scott Denham, 210-949-0122

    Recruiting

Other trials in United States

About this study

Official title: A Phase I, Randomized, Double-Blind, Placebo Controlled MAD Study to Assess the Safety, Tolerability, PKs and Efficacy of Topical Application of YJ001 for Spray Use in Patients With DPNP

This Phase I, randomized, double-blind and placebo controlled study is to evaluate the safety, tolerability, and PK, and to preliminarily assess the efficacy of topically administered YJ001 in a multiple-ascending dose (MAD) fashion in the patients with DPNP. The study will be conducted at a single study center.

In this study, 2 cohorts (N=24, 12 subjects for each cohort), each cohort will consist of 10 active and 2 placebo, with approximately equal numbers of male and female subjects.

Each subject will be administered a single dose of YJ001 as multiple sprays topically on both feet and below the ankle in the morning on Day 1 and Day 2, and will be administered as twice daily doses once in the morning and the other in the evening (with an interval of 11 to 13 h) from Day 3 through Day 11.

Read the detailed description

This Phase I, randomized, double-blind and placebo controlled study is to evaluate the safety, tolerability, and PK, and to preliminarily assess the efficacy of topically administered YJ001 in a multiple-ascending dose (MAD) fashion in the patients with DPNP between ages of 18 to 80 years. The study will be conducted at a single study center.

In this study, 2 cohorts (N=24, 12 subjects for each cohort), the doses of which are 296 mg/administration (Cohort M1) and 414 mg/administration (Cohort M2), are planned. Each cohort will enroll approximately equal numbers of male and female subjects. The administration area is set as 450 cm2 (both feet). Each subject will be administered a single dose of YJ001 as multiple sprays (16 sprays/foot for Cohort M1, and 12 sprays/foot for Cohort M2) topically on both feet and below the ankle in the morning on Day 1 and Day 2, and will be administered as twice daily doses once in the morning and the other in the evening (with an interval of 11 to 13 h) from Day 3 through Day 11.

Each cohort will consist of 12 subjects (10 active; 2 placebo), with approximately equal numbers of male and female subjects.

Each cohort will be evaluated separately for safety and PK to allow for dose escalation based on stopping criteria per protocol. The Safety Review Committee (SRC), comprised of the Principal Investigator, Medical Monitor, and Sponsor's qualified designee, will convene after completion of each cohort to evaluate available safety, PK, and other relevant data. The decision whether to escalate the dose will be made for a completed cohort based on available safety data through Day 17 (5 days post the last dose), and blinded PK data [maximum observed plasma concentration (Cmax,ss) and area under the concentration-time curve through the first 48 hours post the last dose (AUC0-48h,ss)]. The SRC will determine whether to proceed to the next planned dose level, continue with the study and add additional safety evaluations, expand the number of subjects at the current level, reduce the dose, or stop the study.

Subjects will be screened between Day -28 through Day -7, rate the scores on Numeric Rating Scale (NRS) twice daily (once in the morning and the other in the evening) from Day -7 to Day -1, and will be admitted to the clinic on Day-1. Subjects will be housed within the clinic from Day -1 through Day 17 and will be discharged on Day 17 after all scheduled study procedures have been completed. If necessary, subjects will receive a telephone follow-up 2 days post discharge for documentation of any adverse event or concomitant medication.

Safety,Pharmacokinetics and Efficacy will be evaluated.

Being tested
YJ001 for Spray Use, Placebo of YJ001 for Spray Use
Keywords
Diabetes, Diabetic Peripheral Neuropathic(DPN), Diabetic Peripheral Neuropathic Pain(DPNP)
Medical subject headings
Diabetes Mellitus

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • YJ001 for Spray UseDrug

    Granules for spray use; Preparation of Dosing Solution: Reconstitute with sterile water (50ml)

  • Placebo of YJ001 for Spray UseDrug

    Inactive Ingredient: Sterile water; Preparation of Dosing Solution: 50ml Sterile water

Study groups in NCT06361108
Study groupRoleWhat they receive
Cohort M1 (10active, 2 placebo)Experimental296 mg/administration
Receives: Drug: YJ001 for Spray Use; Drug: Placebo of YJ001 for Spray Use
Cohort M2 (10 active, 2 placebo)Experimental414 mg/administration
Receives: Drug: YJ001 for Spray Use; Drug: Placebo of YJ001 for Spray Use

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Safety Assessments - AEs

    Incidence and severity of adverse events (AEs) and serious adverse events (SAEs)

    Measured: through study completion, an average of 1year

  2. Safety Assessments -Number of Participants With Abnormal Laboratory Values

    Observed values and changes in baseline of clinical safety laboratory parameters

    Measured: through study completion, an average of 1year

  3. Safety Assessments - Skin Reaction

    Administration site assessment

    Measured: through study completion, an average of 1year

Secondary outcomes (10)

  1. Pharmacokinetics-AUC

    Pharmacokinetics of YJ001 and metabolites YJ001-A, YJ001-B, and YJ001-C will be evaluated.

    Area under the concentration-time curve (AUC)

    Measured: Day 1-Day 28

  2. Pharmacokinetics- Cmax

    Maximum observed plasma concentration post dose (Cmax)

    Measured: Day 1-Day 28

  3. Pharmacokinetics - tmax

    Time of maximum observed plasma concentration (tmax)

    Measured: Day 1-Day 28

  4. Pharmacokinetics - tlag

    Time to first quantifiable plasma concentration (tlag)

    Measured: Day 1

  5. Pharmacokinetics - t1/2

    t1/2: Apparent terminal elimination half-life post dose

    Measured: Day 1-Day 28

  6. Pharmacokinetics - CLr/f,ss

    CLr/f,ss: Apparent systemic clearance at steady-state

    Measured: Day 1 - Day 28

  7. Efficacy evaluation indicator

    Numerical Rating Scale (NRS): at screening, Day -7 to Day 12, NRS score from 0 to 10(integer), the higher score means the more pain

    Measured: Day -7 - Day 12

  8. Efficacy evaluation indicators

    Average Daily Sleep Interference score (ADSIS): Day 1 to Day 13, ADSIS score from 0 to 10(integer), the higher score means the sleep is more severely affected by pain

    Measured: Day 1 - Day 13

  9. Efficacy evaluation indicators

    Short-form McGill Pain Questionnaire (SF-MPQ) total scores: Day -1, Day 12.

    Measured: Day -1, Day 12

  10. Efficacy evaluation indicators

    Vibration perception thresholds (VPT) test (monofilament sensory test)

    Measured: Day -1, Day 7, Day 11

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Apr 2024
  2. Study start16 May 2024
  3. Primary completion20 Dec 2025 (estimated)
  4. Study completion30 Jun 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
24 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06361108
Sponsor's protocol ID
YJ001-103
Status last verified
Aug 2025
First submitted
19 Mar 2024
Last updated
13 Aug 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A Phase 1 study testing YJ001 for Spray Use in people with Diabetic Peripheral Neuropathic Pain, run by Zhejiang Hanmai Pharmaceutical Technology Co., Ltd. at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 15 inclusion and 31 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 13 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Jing Zhang (86+18602195085, zhangjing@zjhanmai.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Safety Assessments - AEs (time frame: through study completion, an average of 1year). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06361108.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2025.

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