ExerciseNCT06370286
The Effect of Acute Concurrent Exercise on Inhibitory Control: An Event-related Potential Study
A study testing concurrent exercise (CE) and aerobic exercise (AE) in people with Exercise and Cognition, run by National Taiwan Normal University at 1 site in Taiwan.
Trial summary
The present study aimed to determine the effects of acute concurrent exercise on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate among younger adults. Read more about this study
- Who is it for?
- Ages 20 to 30 yearsHealthy volunteers can take part
- What is being tested?
- concurrent exercise (CE) and aerobic exercise (AE)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 78 participants
- Where
- 1 siteTaiwan
- Study dates
- 15 Feb 2021to 15 Feb 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- aged between 20 and 30 years
- able to exercise without undue risk (i.e., the first seven questions of the Physical Activity Readiness Questionnaire for Everyone [PAR-Q+] were answered "No")
- right-handed dominance
- typical or corrected-to-typical eyesight
- limited physical activity in the previous month (i.e., < 150 minutes/week of moderate-intensity physical activity)
Who cannot join
- psychiatric or neurological ailments
- cardiorespiratory or neuromuscular conditions
- obese status (body mass index [BMI] > 27 kg/m2)
Trial locations and contacts
1 site in 1 country.
Taiwan1 site
Department of Physical Education and Sport Sciences, National Taiwan Normal University
Taipei, 106
About this study
The present study aimed to determine the effects of acute concurrent exercise on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate among younger adults. The main questions it aims to answer are: (1) Does acute concurrent exercise improve inhibitory control via behavioral and event-related potential approaches? (2) Does lactate play a potential mediational role in the effect of acute concurrent exercise on inhibitory control?
Read the detailed description
The present study aimed to determine the effects of acute concurrent exercise (CE) on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate. Participants were randomly assigned to either a CE, aerobic exercise (AE), or control (CON) group. Participants in the CE group engaged in 12-minutes of AE (40%-59% of heart rate reserve [HRR]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). The AE group participated in 25 minutes of AE (40%-59% HRR). Prior to and following exercise onset, participants in both the CE and AE groups completed a 5-minute warm-up and cool-down. Participants in the CON group read books for 35 minutes. Lactate concentrations were measured at timepoint of 0-, 17-, and 30-minutes relative to the treatment onset. Response time (RT) and accuracy in the Stroop test, as well as P3 amplitudes, were assessed before and after the treatment.
- Being tested
- concurrent exercise (CE), aerobic exercise (AE)
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
concurrent exercise (CE)Behavioural
Participants in the concurrent exercise group engaged in 12-minutes of aerobic exercise (40%-59% of heart rate reserve [HRR]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down.
aerobic exercise (AE)Behavioural
Participants in the aerobic exercise (AE) group participated in 25 minutes of AE (40%-59% of heart rate reserve [HRR]). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down.
| Study group | Role | What they receive |
|---|---|---|
| concurrent exercise (CE) | Experimental | Participants in the concurrent exercise group engaged in 12-minutes of aerobic exercise (40%-59% of heart rate reserve [HRR]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down. Receives: Behavioral: concurrent exercise (CE) |
| aerobic exercise (AE) | Experimental | Participants in the aerobic exercise (AE) group participated in 25 minutes of AE (40%-59% of heart rate reserve [HRR]). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down. Receives: Behavioral: aerobic exercise (AE) |
| control (CON) | No intervention | Participants in the control group read books for 35 minutes. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Inhibitory control
Inhibitory control was assessed using a modified computerized version of the Stroop test, which was administered through Neuroscan Stim2 software (Compumedics Neuroscan, Charlotte, NC). The test comprised four blocks, each consisting of 108 trials. Within each block, three types of trials were presented: neutral, congruent, and incongruent. The neutral trial involved displaying a square printed in red, green, or blue color. The congruent trial presented Chinese language prints in corresponding colors and words [i.e., 紅 (RED), 綠 (GREEN), or 藍 (BLUE)]. In contrast, the incongruent trial displayed Chinese language prints in different colors and words [e.g., 紅 (RED) printed in blue color]. Each block included 36 neutral trials, 36 congruent trials, and 36 incongruent trials. Participants were instructed to respond promptly and accurately to the color of the stimulus presented. Subsequently, the mean response time (RT) of correct trials and accuracy for each Stroop condition were examined.
Measured: 30 minutes
Secondary outcomes (1)
Blood lactate
Blood lactate levels were assessed using fingertip samples measured with a lactate analyzer (The EDGE, Taipei, Taiwan) at three distinct time points: Timepoint 1 (prior to the commencement of treatment), Timepoint 2 (17 minutes after the initiation of treatment), and Timepoint 3 (30 minutes after the start of treatment).
Measured: Timepoint 1 (prior to the commencement of treatment), Timepoint 2 (17 minutes after the initiation of treatment), and Timepoint 3 (30 minutes after the start of treatment).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Apr 2024
- Study start15 Feb 2021
- Primary completion15 Aug 2021
- Study completion15 Feb 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned to either a concurrent exercise (CE), aerobic exercise (AE), or control (CON) group. Participants in the CE group engaged in 12-minutes of AE (40%-59% of heart rate reserve \[HRR\]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). The AE group participated in 25 minutes of AE (40%-59% HRR). Prior to and following exercise onset, participants in both the CE and AE groups completed a 5-minute warm-up and cool-down. Participants in the CON group read books for 35 minutes. Lactate concentrations were measured at timepoint of 0-, 17-, and 30-minutes relative to the treatment onset. Response time (RT) and accuracy in the Stroop test, as well as P3 amplitudes, were assessed before and after the treatment.
- Masking
- None (open label)
- Enrolment
- 78 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Yu-Kai Chang, PhD, Study chair, Department of Physical Education and Sport Sciences, National Taiwan Normal UniversityRuei-Hong Li, MS, Principal investigator, Department of Physical Education and Sport Sciences, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06370286
- Sponsor's protocol ID
- PACNL_rueihongli_CE_IC
- Status last verified
- Apr 2024
- First submitted
- 12 Apr 2024
- Last updated
- 18 Apr 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Li RH, Chen TR, Gilson ND, Brazaitis M, Cheng YT, Wu HF, Lee JH, Chang YK. Acute Concurrent Exercise Improves Inhibitory Control Without Mediating the Role of Lactate: An Event-Related Potential Study. Sports Med Open. 2025 Jan 27;11(1):12. doi: 10.1186/s40798-024-00809-2.
PubMed 39871026
Study at a glance
From the registry record, last updated by the sponsor on 18 Apr 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Acute Concurrent Exercise on Inhibitory Control: An Event-related Potential Study
- ClinicalTrials.gov ID
- NCT06370286
- Acronym / sponsor ID
- PACNL_rueihongli_CE_IC
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 78 participants (actual)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 15 Feb 2021 (actual)
- Primary completion
- 15 Aug 2021 (actual)
- Study completion
- 15 Feb 2022 (actual)
- First posted
- 17 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The present study aimed to determine the effects of acute concurrent exercise on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate among younger adults. The main questions it aims to answer are: (1) Does acute concurrent exercise improve inhibitory control via behavioral and event-related potential approaches? (2) Does lactate play a potential mediational role in the effect of acute concurrent exercise on inhibitory control?
Detailed description
The present study aimed to determine the effects of acute concurrent exercise (CE) on inhibitory control via behavioral and event-related potential approaches and to examine its potential mediational role on lactate. Participants were randomly assigned to either a CE, aerobic exercise (AE), or control (CON) group. Participants in the CE group engaged in 12-minutes of AE (40%-59% of heart rate reserve [HRR]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). The AE group participated in 25 minutes of AE (40%-59% HRR). Prior to and following exercise onset, participants in both the CE and AE groups completed a 5-minute warm-up and cool-down. Participants in the CON group read books for 35 minutes. Lactate concentrations were measured at timepoint of 0-, 17-, and 30-minutes relative to the treatment onset. Response time (RT) and accuracy in the Stroop test, as well as P3 amplitudes, were assessed before and after the treatment.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- Participants were randomly assigned to either a concurrent exercise (CE), aerobic exercise (AE), or control (CON) group. Participants in the CE group engaged in 12-minutes of AE (40%-59% of heart rate reserve [HRR]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). The AE group participated in 25 minutes of AE (40%-59% HRR). Prior to and following exercise onset, participants in both the CE and AE groups completed a 5-minute warm-up and cool-down. Participants in the CON group read books for 35 minutes. Lactate concentrations were measured at timepoint of 0-, 17-, and 30-minutes relative to the treatment onset. Response time (RT) and accuracy in the Stroop test, as well as P3 amplitudes, were assessed before and after the treatment.
| Arm | Type | Receives |
|---|---|---|
| concurrent exercise (CE) | Experimental | Behavioral: concurrent exercise (CE)Participants in the concurrent exercise group engaged in 12-minutes of aerobic exercise (40%-59% of heart rate reserve [HRR]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down. |
| aerobic exercise (AE) | Experimental | Behavioral: aerobic exercise (AE)Participants in the aerobic exercise (AE) group participated in 25 minutes of AE (40%-59% of heart rate reserve [HRR]). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down. |
| control (CON) | No intervention | –Participants in the control group read books for 35 minutes. |
Who may qualify
- Ages
- 20 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- aged between 20 and 30 years
- able to exercise without undue risk (i.e., the first seven questions of the Physical Activity Readiness Questionnaire for Everyone [PAR-Q+] were answered "No")
- right-handed dominance
- typical or corrected-to-typical eyesight
- limited physical activity in the previous month (i.e., < 150 minutes/week of moderate-intensity physical activity)
Key exclusion criteria (3 listed)
- psychiatric or neurological ailments
- cardiorespiratory or neuromuscular conditions
- obese status (body mass index [BMI] > 27 kg/m2)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| concurrent exercise (CE)Participants in the concurrent exercise group engaged in 12-minutes of aerobic exercise (40%-59% of heart rate reserve [HRR]) coupled with 13-minutes of resistance exercise (1 set, with 75% of 10-repetition maximum, and 12 repetitions of 8 movements). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down. | Behavioural | concurrent exercise (CE) |
| aerobic exercise (AE)Participants in the aerobic exercise (AE) group participated in 25 minutes of AE (40%-59% of heart rate reserve [HRR]). Prior to and following exercise onset, participants completed a 5-minute warm-up and cool-down. | Behavioural | aerobic exercise (AE) |
Primary outcome
Inhibitory control
Time frame: 30 minutes
Inhibitory control was assessed using a modified computerized version of the Stroop test, which was administered through Neuroscan Stim2 software (Compumedics Neuroscan, Charlotte, NC). The test comprised four blocks, each consisting of 108 trials. Within each block, three types of trials were presented: neutral, congruent, and incongruent. The neutral trial involved displaying a square printed in red, green, or blue color. The congruent trial presented Chinese language prints in corresponding colors and words [i.e., 紅 (RED), 綠 (GREEN), or 藍 (BLUE)]. In contrast, the incongruent trial displayed Chinese language prints in different colors and words [e.g., 紅 (RED) printed in blue color]. Each block included 36 neutral trials, 36 congruent trials, and 36 incongruent trials. Participants were instructed to respond promptly and accurately to the color of the stimulus presented. Subsequently, the mean response time (RT) of correct trials and accuracy for each Stroop condition were examined.
1 secondary outcome
Blood lactate
Time frame: Timepoint 1 (prior to the commencement of treatment), Timepoint 2 (17 minutes after the initiation of treatment), and Timepoint 3 (30 minutes after the start of treatment).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Apr 2024.
- Derived from this study: PubMed 39871026Li RH, Chen TR, Gilson ND, Brazaitis M, Cheng YT, Wu HF, Lee JH, Chang YK. Acute Concurrent Exercise Improves Inhibitory Control Without Mediating the Role of Lactate: An Event-Related Potential Study. Sports Med Open. 2025 Jan 27;11(1):12. doi: 10.1186/s40798-024-00809-2.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yu-Kai Chang, PhD study chair
Department of Physical Education and Sport Sciences, National Taiwan Normal University
Ruei-Hong Li, MS principal investigator
Department of Physical Education and Sport Sciences, National Taiwan Normal University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing concurrent exercise (CE) and aerobic exercise (AE) in people with Exercise and Cognition, run by National Taiwan Normal University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Apr 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Inhibitory control (time frame: 30 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06370286, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Apr 2024.