Physical ExerciseNCT06370546
Cardiac Response to Strength Training in Hypertensive Individuals
A study testing Low intensity and high intensity in people with Physical Exercise and Hypertension, run by Universidad Católica del Maule at 1 site in Chile.
Trial summary
This study aims to determine the acute effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects Read more about this study
- Who is it for?
- Ages 30 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Physical Exercise, Hypertension
- What is being tested?
- Low intensity and high intensity
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteChile
- Study dates
- 20 Mar 2023to 20 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Participants exclusively diagnosed with hypertension by a medical professional
Who cannot join
- Participants with any other chronic medical condition
- Subjects with any upper or lower limb injury that prevents strength training
- Subjects with cardiovascular abnormalities other than hypertension
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of Cardiac Response to High and Low-Intensity Strength Training in Hypertensive Subjects
This study aims to determine the acute effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects
Read the detailed description
The present study aims to determine the cardiovascular response in hypertensive individuals between 30 and 60 years old to one session of high and low intensity strength training.
Participants will undergo a low-intensity strength training including squats, barbell rows, deadlifts and chest presses with a load dynamic of 12 repetitions for 6 sets at an execution speed of less than 55 % of your maximum weight. This is followed by a one-week washout period. Subsequently, high intensity strength training is performed with the same exercises but with a load of 6 repetitions for 6 series at an intensity greater than 80% of the maximum repetition speed. The order of the sessions will be random.
After each session, blood pressure will be recorded for 24 hours using a holter monitor, which will report pressures during both day and night
The results obtained will be determined by the differences in the before and after values. Consequently, the behavior of the following variables: 1) heart rate variability, 2) blood pressure and 3) heart rate will determine the final results of this research.
The entire study will be carried out at the Catholic University of Maule, in its Kinesiology laboratory.
- Conditions
- Physical Exercise, Hypertension
- Being tested
- Low intensity, high intensity
- Medical subject headings
- Motor Activity, Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low intensityOther
Low intensity group: participants will be requested to perform the following exercises: 1)squat, 2) rowing, 3)deadlift and 4)bench press. All exercises will be performed with low intensity (40% of the maximum velocity used in one-repetition maximum) and will be supervised by a researcher.
high intensityOther
High intensity group: participants will be requested to perform the following exercises: 1)squat, 2)rowing, 3)deadlift and 4)bench press. All exercises will be performed with high intensity (80% of the maximum velocity used in one-repetition maximum) and will be supervised by a researcher.
| Study group | Role | What they receive |
|---|---|---|
| Low Intensity | Experimental | The low-intensity group undergoes a strength training program using barbells, weights and dumbbells, consisting of 6 sets of 12 repetitions each, with an execution speed below 40% of the maximum velocity used in the one-repetition maximum Receives: Other: Low intensity |
| high intensity | Experimental | The low-intensity group undergoes a strength training program using barbells, weights and dumbbells consisting of 6 sets of 6 repetitions each, with an execution speed equal to or greater than 80% of the maximum velocity used in the one-repetition maximum Receives: Other: high intensity |
What is being measured
The primary outcome is the main question the study is designed to answer.
Heart rate variability
Determine the effects of high and low-intensity strength training on heart rate variability, based on the time between each heartbeat, during the assessment
Measured: 2 hours
Blood pressure systolic
Determine the effects of high and low intensity resistance training on blood pressure with a blood pressure monitor for 24 hours.
Measured: 24 hours
Blood pressure diastolic
Determine the effects of high and low intensity resistance training on blood pressure diastolic with a blood pressure monitor for 24 hours.
Measured: 24 hours
Blood pressure mean
Determine the effects of high and low intensity resistance training on blood pressure mean with a blood pressure monitor for 24 hours.
Measured: 24 hours
Heart Rate
Determine the effects of high and low intensity strength training on the behavior of heart rate, using a heart rate monitor, throughout the intervention.
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Apr 2024
- Study start20 Mar 2023
- Primary completion20 Jul 2024
- Study completion20 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Physical ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized clinical trial, single blinded.
- Masking
- None (open label)
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universidad Católica del Maule
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Antonio Roberto Zamunér, Universidad Católica del Maule
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06370546
- Sponsor's protocol ID
- 229/2022
- Status last verified
- Sep 2025
- First submitted
- 12 Apr 2024
- Last updated
- 16 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Cardiac Response to High and Low-Intensity Strength Training in Hypertensive Subjects
- ClinicalTrials.gov ID
- NCT06370546
- Acronym / sponsor ID
- 229/2022
- Conditions
- Physical Exercise, Hypertension
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Universidad Católica del MauleUniversity, hospital or other
- Study start
- 20 Mar 2023 (actual)
- Primary completion
- 20 Jul 2024 (actual)
- Study completion
- 20 Jul 2024 (actual)
- First posted
- 17 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to determine the acute effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects
Detailed description
The present study aims to determine the cardiovascular response in hypertensive individuals between 30 and 60 years old to one session of high and low intensity strength training.
Participants will undergo a low-intensity strength training including squats, barbell rows, deadlifts and chest presses with a load dynamic of 12 repetitions for 6 sets at an execution speed of less than 55 % of your maximum weight. This is followed by a one-week washout period. Subsequently, high intensity strength training is performed with the same exercises but with a load of 6 repetitions for 6 series at an intensity greater than 80% of the maximum repetition speed. The order of the sessions will be random.
After each session, blood pressure will be recorded for 24 hours using a holter monitor, which will report pressures during both day and night
The results obtained will be determined by the differences in the before and after values. Consequently, the behavior of the following variables: 1) heart rate variability, 2) blood pressure and 3) heart rate will determine the final results of this research.
The entire study will be carried out at the Catholic University of Maule, in its Kinesiology laboratory.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Randomized clinical trial, single blinded.
| Arm | Type | Receives |
|---|---|---|
| Low Intensity | Experimental | Other: Low intensityThe low-intensity group undergoes a strength training program using barbells, weights and dumbbells, consisting of 6 sets of 12 repetitions each, with an execution speed below 40% of the maximum velocity used in the one-repetition maximum |
| high intensity | Experimental | Other: high intensityThe low-intensity group undergoes a strength training program using barbells, weights and dumbbells consisting of 6 sets of 6 repetitions each, with an execution speed equal to or greater than 80% of the maximum velocity used in the one-repetition maximum |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Participants exclusively diagnosed with hypertension by a medical professional
Key exclusion criteria (3 listed)
- Participants with any other chronic medical condition
- Subjects with any upper or lower limb injury that prevents strength training
- Subjects with cardiovascular abnormalities other than hypertension
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low intensityLow intensity group: participants will be requested to perform the following exercises: 1)squat, 2) rowing, 3)deadlift and 4)bench press. All exercises will be performed with low intensity (40% of the maximum velocity used in one-repetition maximum) and will be supervised by a researcher. | Other | Low Intensity |
| high intensityHigh intensity group: participants will be requested to perform the following exercises: 1)squat, 2)rowing, 3)deadlift and 4)bench press. All exercises will be performed with high intensity (80% of the maximum velocity used in one-repetition maximum) and will be supervised by a researcher. | Other | high intensity |
Primary outcome
Heart rate variability
Time frame: 2 hours
Determine the effects of high and low-intensity strength training on heart rate variability, based on the time between each heartbeat, during the assessment
Blood pressure systolic
Time frame: 24 hours
Determine the effects of high and low intensity resistance training on blood pressure with a blood pressure monitor for 24 hours.
Blood pressure diastolic
Time frame: 24 hours
Determine the effects of high and low intensity resistance training on blood pressure diastolic with a blood pressure monitor for 24 hours.
Blood pressure mean
Time frame: 24 hours
Determine the effects of high and low intensity resistance training on blood pressure mean with a blood pressure monitor for 24 hours.
Heart Rate
Time frame: 24 hours
Determine the effects of high and low intensity strength training on the behavior of heart rate, using a heart rate monitor, throughout the intervention.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Sep 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Low intensity and high intensity in people with Physical Exercise and Hypertension, run by Universidad Católica del Maule at 1 site in Chile.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Chile. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Heart rate variability (time frame: 2 hours). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Sep 2025.