AgingMyAgeWellNCT06376656
Successful Aging and Age-related Decline
A study testing Cognitive stimulation and Physical activity in people with Aging and Elderly, run by Sunway University at 1 site in Malaysia.
Trial summary
Recent studies have shown promising cognitive and physical interventions aimed at slowing down ageing-related declines in quality of life, but they lack strong ecological validity (brief durations, unrealistic goals, no real-world application) and has yet to show robust evidence that such interventions are stable and… Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Aging, Elderly, Cognitive Decline
- What is being tested?
- Cognitive stimulation and Physical activity
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 400 participants
- Where
- 1 siteMalaysia
- Study dates
- 20 May 2022to 31 Aug 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy and this includes those seeking regular medical attention,
- Have some form of mobility (ability to walk short distances at least 3m),
- Able to communicate in at least one of the following languages: English, Malay, Mandarin, Tamil.
Who cannot join
- Older adults with a history of stroke,
- Diagnosis of neurodegenerative diseases (such as Alzheimer's disease or Parkinson's) or psychiatric disorders,
- Uncorrected auditory and/or visual impairments,
- Currently on psychiatric medications,
- Immobile,
- Require full-time caregiver assistance,
- With comprehension impediments from the assessment portion of this project,
- A Montreal Cognitive Assessment (MoCA) score of <13.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Successful Ageing: Evidence-based Interventions to Delay Ageing-related Decline
Recent studies have shown promising cognitive and physical interventions aimed at slowing down ageing-related declines in quality of life, but they lack strong ecological validity (brief durations, unrealistic goals, no real-world application) and has yet to show robust evidence that such interventions are stable and suitable in the long-term. The investigators aim to examine whether these interventions can, over four years, significantly slow down the normal rate of ageing-related decline.
Read the detailed description
This is a longitudinal, controlled, cohort study. The overarching aim in this intervention study is three-fold: (1) to test hypotheses derived from ageing-related theories, (2) to provide robust measurable evidence both in the long-term and validate meaningful interventions, and (3) provide quantifiable cost-benefit ratio to suggested solutions. A cohort of Malaysian older adults will be recruited and assigned to one of the groups, either cognitive stimulation, physical activity, combined cognitive stimulation and physical activity, or non-intervention control.
- Conditions
- Aging, Elderly, Cognitive Decline, Physical Decline, Intervention Study
- Being tested
- Cognitive stimulation, Physical activity
- Keywords
- Cognition, Physical Activity, Biological Aging, Intervention, Neuroscience, MRI, EEG, Biological Markers, Cost-benefit Analysis, Age-related Decline, Depression, Anxiety
- Medical subject headings
- Cognitive Dysfunction, Motor Activity, Depression, Anxiety Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cognitive stimulationBehavioural
The cognitive stimulation will comprise of psychoeducation, videogaming, book club and technology training workshop sessions. Participants will take part in weekly sessions that are an hour long each.
For every six months, the participants will alternate between psychoeducation, videogaming, book club and technology training workshop sessions.
Physical activityBehavioural
The physical activity intervention will comprise of walking, Zumba, resistance exercise and aerobics sessions. Participants will take part in weekly sessions that are an hour long each.
For every six months, the participants will alternate between walking, Zumba, resistance exercise and aerobics sessions until the end of intervention period.
| Study group | Role | What they receive |
|---|---|---|
| Cognitive stimulation | Experimental | Participants will take part in psychoeducation, videogaming, book club and technology training workshops. Receives: Behavioral: Cognitive stimulation |
| Physical activity | Experimental | Participants will take part in walking, Zumba, resistance exercise and aerobics sessions. Receives: Behavioral: Physical activity |
| Combined intervention | Experimental | Participants will take part in both cognitive stimulation and physical activity intervention sessions. Receives: Behavioral: Cognitive stimulation; Behavioral: Physical activity |
| Non-intervention control | No intervention | Participants will not take part in any intervention. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in cognitive scores
Changes in cognitive scores will be evaluated using Montreal Cognitive Assessment (MoCA). Possible scores range from 0-30. Higher scores indicate less cognitive impairment.
Measured: 4 years
Changes in electroencephalogram (EEG)
Onset of neural responses to errors in the Go/No Go task will be evaluated using EEG.
Measured: 4 years
Changes in structural magnetic resonance imaging (MRI)
Relationship between Wisconsin Card Sorting Test performance and grey matter volume will be evaluated using structural MRI.
Measured: 4 years
Cost-benefit analysis of intervention
The economic benefits from the interventions will be evaluated and will cover three aspects: financial, productivity and health.
Measured: 4 years
Changes in levels of human salivary lactoferrin
Changes in levels of human salivary lactoferrin (ng/mL) will be measured using salivary Enzyme-Linked Immunosorbent Assay (ELISA) kits. Low levels of lactoferrin can potentially indicate higher risk for cognitive impairment.
Measured: 4 years
Changes in levels of human salivary C-reactive proteins
Changes in levels of human salivary C-reactive proteins (CRP, mg/L) will be measured using salivary Enzyme-Linked Immunosorbent Assay (ELISA) kits. High levels of CRP can indicate inflammation and its association with greater cognitive decline.
Measured: 4 years
Changes in salivary telomere length
Changes in salivary telomere length (T/S ratio) will be measured using quantitative PCR. A higher T/S ratio indicates better preservation of telomere length hence better preservation of cognition.
Measured: 4 years
Secondary outcomes (8)
Changes in depression scores
Changes in depression scores will be measured using part of the Center for Epidemiologic Studies Depression Scale (CES-D). Possible scores range from 0-42. Higher scores indicating greater frequency of depressive experiences.
Measured: 4 years
Changes in anxiety scores
Changes in anxiety scores will be measured using part of the Form Y of the State-Trait Anxiety Inventory (STAI). Possible scores range from 6-24. Higher scores indicate greater anxiety.
Measured: 4 years
Changes in body composition
Changes in body composition will be measured using Bioelectrical Impedance Analysis (BIA), including parameters such as body fat percentage, muscle mass and visceral fat composition.
Measured: Throughout study participation, up to 4 years
Changes in Body Mass Index (BMI)
Changes in Body Mass Index (BMI, kg/m²) will be evaluated using participants' height and body weight measurements.
Measured: Throughout study participation, up to 4 years
Changes in blood pressure
Changes in systolic and diastolic blood pressure (mmHg) will be measured using a standard blood pressure monitoring device.
Measured: Throughout study participation, up to 4 years
Changes in falls risk
Changes in falls risk will be evaluated using the Falls Risk Assessment Tool (FRAT). Higher scores indicate greater risk of falls.
Measured: Throughout study participation, up to 4 years
Changes in sarcopenia risk
Changes in sarcopenia risk will be evaluated using the SARC-F questionnaire. Higher scores indicate greater risk of sarcopenia.
Measured: Throughout study participation, up to 4 years
Changes in frailty status
Changes in frailty status will be assessed using the Pictorial Fit-Frail Scale. Higher scores indicate greater frailty.
Measured: Throughout study participation, up to 4 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Apr 2024
- Study start20 May 2022
- Primary completion31 Aug 2029 (estimated)
- Study completion31 Aug 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- A cohort of older Malaysian adults will be recruited and assigned to one of the groups, either cognitive stimulation, physical activity, combined cognitive stimulation and physical activity, or non-intervention control.
- Masking
- None (open label)
- Enrolment
- 400 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sunway University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, YookChin Chia, Sunway University
- Investigators
- Yook Chin Chia Professor, Datin, Dr, MBBS, FRCP, Principal investigator, Sunway UniversityTin Tin Su, Study chair, Monash UniversityRozainee Khairudin, Study chair, The National University of MalaysiaNur Ain Shahrier, Study chair, Sunway UniversityAudrey Wei Ling Lim, Study chair, Sunway University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06376656
- Sponsor's protocol ID
- LRGS/1/2019/SYUC/02/1
- Acronym
- MyAgeWell
- Status last verified
- May 2026
- First submitted
- 3 Apr 2024
- Last updated
- 12 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: No. However, limited access to data could be shared upon reasonable request.
Publications
Bogataj S, Mesaric KK, Pajek M, Petrusic T, Pajek J. Physical exercise and cognitive training interventions to improve cognition in hemodialysis patients: A systematic review. Front Public Health. 2022 Oct 14;10:1032076. doi: 10.3389/fpubh.2022.1032076. eCollection 2022.
PubMed 36311587Erickson KI, Leckie RL, Weinstein AM. Physical activity, fitness, and gray matter volume. Neurobiol Aging. 2014 Sep;35 Suppl 2:S20-8. doi: 10.1016/j.neurobiolaging.2014.03.034. Epub 2014 May 14.
PubMed 24952993Murman DL. The Impact of Age on Cognition. Semin Hear. 2015 Aug;36(3):111-21. doi: 10.1055/s-0035-1555115.
PubMed 27516712Ogawa T, Hirose Y, Honda-Ogawa M, Sugimoto M, Sasaki S, Kibi M, Kawabata S, Ikebe K, Maeda Y. Composition of salivary microbiota in elderly subjects. Sci Rep. 2018 Jan 11;8(1):414. doi: 10.1038/s41598-017-18677-0.
PubMed 29323208Wells PM, Sprockett DD, Bowyer RCE, Kurushima Y, Relman DA, Williams FMK, Steves CJ. Influential factors of saliva microbiota composition. Sci Rep. 2022 Nov 7;12(1):18894. doi: 10.1038/s41598-022-23266-x.
PubMed 36344584Yong MH, Lawrie L, Schaefer A, Phillips LH. The Effects of Adult Aging and Culture on Theory of Mind. J Gerontol B Psychol Sci Soc Sci. 2022 Feb 3;77(2):332-340. doi: 10.1093/geronb/gbab093.
PubMed 34036302Chia YC, Low END, Jenkins M, Lee YL, Su TT, Khairudin R, Salehuddin K, Vaithilingam S, Chew J, Lim WL, Yong MH, Schaefer A. An Evidence-Based Cognitive Stimulation and Physical Activity Intervention to Delay Aging-Related Decline: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2026 Jul 8;15:e88268. doi: 10.2196/88268.
PubMed 42417457
Study at a glance
From the registry record, last updated by the sponsor on 12 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Successful Ageing: Evidence-based Interventions to Delay Ageing-related Decline
- ClinicalTrials.gov ID
- NCT06376656
- Acronym / sponsor ID
- MyAgeWell / LRGS/1/2019/SYUC/02/1
- Conditions
- Aging, Elderly, Cognitive Decline, Physical Decline, Intervention Study
- Keywords
- Cognition, Physical Activity, Biological Aging, Intervention, Neuroscience, MRI, EEG, Biological Markers
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 400 participants (estimated)
- Lead sponsor
- Sunway UniversityUniversity, hospital or other
- Study start
- 20 May 2022 (actual)
- Primary completion
- 31 Aug 2029 (estimated)
- Study completion
- 31 Aug 2030 (estimated)
- First posted
- 19 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Recent studies have shown promising cognitive and physical interventions aimed at slowing down ageing-related declines in quality of life, but they lack strong ecological validity (brief durations, unrealistic goals, no real-world application) and has yet to show robust evidence that such interventions are stable and suitable in the long-term. The investigators aim to examine whether these interventions can, over four years, significantly slow down the normal rate of ageing-related decline.
Detailed description
This is a longitudinal, controlled, cohort study. The overarching aim in this intervention study is three-fold: (1) to test hypotheses derived from ageing-related theories, (2) to provide robust measurable evidence both in the long-term and validate meaningful interventions, and (3) provide quantifiable cost-benefit ratio to suggested solutions. A cohort of Malaysian older adults will be recruited and assigned to one of the groups, either cognitive stimulation, physical activity, combined cognitive stimulation and physical activity, or non-intervention control.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
- Model description
- A cohort of older Malaysian adults will be recruited and assigned to one of the groups, either cognitive stimulation, physical activity, combined cognitive stimulation and physical activity, or non-intervention control.
| Arm | Type | Receives |
|---|---|---|
| Cognitive stimulation | Experimental | Behavioral: Cognitive stimulationParticipants will take part in psychoeducation, videogaming, book club and technology training workshops. |
| Physical activity | Experimental | Behavioral: Physical activityParticipants will take part in walking, Zumba, resistance exercise and aerobics sessions. |
| Combined intervention | Experimental | Behavioral: Cognitive stimulation, Behavioral: Physical activityParticipants will take part in both cognitive stimulation and physical activity intervention sessions. |
| Non-intervention control | No intervention | –Participants will not take part in any intervention. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Healthy and this includes those seeking regular medical attention,
- Have some form of mobility (ability to walk short distances at least 3m),
- Able to communicate in at least one of the following languages: English, Malay, Mandarin, Tamil.
Key exclusion criteria (8 listed)
- Older adults with a history of stroke,
- Diagnosis of neurodegenerative diseases (such as Alzheimer's disease or Parkinson's) or psychiatric disorders,
- Uncorrected auditory and/or visual impairments,
- Currently on psychiatric medications,
- Immobile,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cognitive stimulationThe cognitive stimulation will comprise of psychoeducation, videogaming, book club and technology training workshop sessions. Participants will take part in weekly sessions that are an hour long each. For every six months, the participants will alternate between psychoeducation, videogaming, book club and technology training workshop sessions. | Behavioural | Cognitive stimulation, Combined intervention |
| Physical activityThe physical activity intervention will comprise of walking, Zumba, resistance exercise and aerobics sessions. Participants will take part in weekly sessions that are an hour long each. For every six months, the participants will alternate between walking, Zumba, resistance exercise and aerobics sessions until the end of intervention period. | Behavioural | Combined intervention, Physical activity |
Primary outcome
Changes in cognitive scores
Time frame: 4 years
Changes in cognitive scores will be evaluated using Montreal Cognitive Assessment (MoCA). Possible scores range from 0-30. Higher scores indicate less cognitive impairment.
Changes in electroencephalogram (EEG)
Time frame: 4 years
Onset of neural responses to errors in the Go/No Go task will be evaluated using EEG.
Changes in structural magnetic resonance imaging (MRI)
Time frame: 4 years
Relationship between Wisconsin Card Sorting Test performance and grey matter volume will be evaluated using structural MRI.
Cost-benefit analysis of intervention
Time frame: 4 years
The economic benefits from the interventions will be evaluated and will cover three aspects: financial, productivity and health.
Changes in levels of human salivary lactoferrin
Time frame: 4 years
Changes in levels of human salivary lactoferrin (ng/mL) will be measured using salivary Enzyme-Linked Immunosorbent Assay (ELISA) kits. Low levels of lactoferrin can potentially indicate higher risk for cognitive impairment.
Changes in levels of human salivary C-reactive proteins
Time frame: 4 years
Changes in levels of human salivary C-reactive proteins (CRP, mg/L) will be measured using salivary Enzyme-Linked Immunosorbent Assay (ELISA) kits. High levels of CRP can indicate inflammation and its association with greater cognitive decline.
Changes in salivary telomere length
Time frame: 4 years
Changes in salivary telomere length (T/S ratio) will be measured using quantitative PCR. A higher T/S ratio indicates better preservation of telomere length hence better preservation of cognition.
8 secondary outcomes
Changes in depression scores
Time frame: 4 years
Changes in anxiety scores
Time frame: 4 years
Changes in body composition
Time frame: Throughout study participation, up to 4 years
Changes in Body Mass Index (BMI)
Time frame: Throughout study participation, up to 4 years
Changes in blood pressure
Time frame: Throughout study participation, up to 4 years
Changes in falls risk
Time frame: Throughout study participation, up to 4 years
Changes in sarcopenia risk
Time frame: Throughout study participation, up to 4 years
Changes in frailty status
Time frame: Throughout study participation, up to 4 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 May 2026.
- Background: PubMed 36311587Bogataj S, Mesaric KK, Pajek M, Petrusic T, Pajek J. Physical exercise and cognitive training interventions to improve cognition in hemodialysis patients: A systematic review. Front Public Health. 2022 Oct 14;10:1032076. doi: 10.3389/fpubh.2022.1032076. eCollection 2022.
- Background: PubMed 24952993Erickson KI, Leckie RL, Weinstein AM. Physical activity, fitness, and gray matter volume. Neurobiol Aging. 2014 Sep;35 Suppl 2:S20-8. doi: 10.1016/j.neurobiolaging.2014.03.034. Epub 2014 May 14.
- Background: PubMed 27516712Murman DL. The Impact of Age on Cognition. Semin Hear. 2015 Aug;36(3):111-21. doi: 10.1055/s-0035-1555115.
- Background: PubMed 29323208Ogawa T, Hirose Y, Honda-Ogawa M, Sugimoto M, Sasaki S, Kibi M, Kawabata S, Ikebe K, Maeda Y. Composition of salivary microbiota in elderly subjects. Sci Rep. 2018 Jan 11;8(1):414. doi: 10.1038/s41598-017-18677-0.
- Background: PubMed 36344584Wells PM, Sprockett DD, Bowyer RCE, Kurushima Y, Relman DA, Williams FMK, Steves CJ. Influential factors of saliva microbiota composition. Sci Rep. 2022 Nov 7;12(1):18894. doi: 10.1038/s41598-022-23266-x.
- Background: PubMed 34036302Yong MH, Lawrie L, Schaefer A, Phillips LH. The Effects of Adult Aging and Culture on Theory of Mind. J Gerontol B Psychol Sci Soc Sci. 2022 Feb 3;77(2):332-340. doi: 10.1093/geronb/gbab093.
- Derived from this study: PubMed 42417457Chia YC, Low END, Jenkins M, Lee YL, Su TT, Khairudin R, Salehuddin K, Vaithilingam S, Chew J, Lim WL, Yong MH, Schaefer A. An Evidence-Based Cognitive Stimulation and Physical Activity Intervention to Delay Aging-Related Decline: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2026 Jul 8;15:e88268. doi: 10.2196/88268.
- Individual participant dataSharing planned: No. No. However, limited access to data could be shared upon reasonable request.
Related trials for Aging
Enrolling by invitationPhase 2
Tirzepatide and Organ-specific Biological Aging
Longevity, Preventive Medicine
Active, not recruiting
Emotional Well-being and Measures of Healthy Aging
Aging, Aging, Healthy
RecruitingPhase 2
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Alzheimer's Disease
Active, not recruiting
Vascular Aging and Lp299v Study in Healthy Adults
Vascular Aging
RecruitingObservational study
Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging
Aging
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yook Chin Chia Professor, Datin, Dr, MBBS, FRCP principal investigator
Sunway University
Tin Tin Su study chair
Monash University
Rozainee Khairudin study chair
The National University of Malaysia
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cognitive stimulation and Physical activity in people with Aging and Elderly, run by Sunway University at 1 site in Malaysia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 12 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Malaysia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in cognitive scores (time frame: 4 years). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06376656, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 May 2026.